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Search Results: 1 - 10 of 667 matches for " Bindu Pillai "
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RADICAL SCAVENGING POTENTIAL OF CLEOME VISCOSA L. AND CLEOME BURMANNI W. & A. (CLEOMACEAE)
Lakshmi S. Pillai* and Bindu R. Nair
International Journal of Pharmaceutical Sciences and Research , 2013,
Abstract: The present study evaluates the reactive oxygen species (ROS) scavenging and in vitro antioxidant activities of two species of Cleome, C. viscosa and C. burmanni. The antioxidant potential of the methanol extracts of species of Cleome was tested using different assays such as FRAP, DPPH, ABTS, hydroxyl, superoxide, nitric oxide, and hydrogen peroxide. The extracts gave positive results for all the assays and the radical scavenging ability was detected to be comparable to those of the corresponding standards. Quantitative estimation of antioxidant phytochemicals, such as phenols, flavonoids and proanthocyanidins were also done in both species of Cleome. The results revealed that the phytochemicals content was greater in C. viscosa when compared to C. burmanni.
Perforating lichenoid reaction to amlodipine
Lakshmi Chembolli,Srinivas C,Ramachandran Bindu,Pillai Suma
Indian Journal of Dermatology , 2008,
Abstract:
Effect of Size of Tool on Peak Temperature & Viscosity during Friction Stir Welding of AA6061-T6 Aluminum Alloy Using HyperWorks
K.D.BHAT,T.BINDU PILLAI,A.M.TRIVEDI
International Journal of Innovative Research in Science, Engineering and Technology , 2013,
Abstract: Friction stir welding (FSW) of AA6061-T6 aluminum alloy has been attempted to overcome limitations of fusion welding of the same. The FSW tool, by not being consumed, produces a joint with predominant advantages of high joint strength, lower distortion and absence of metallurgical defects. Process parameters such as tool rotational speed, tool traverse speed and axial force and tool dimensions play an important role in obtaining a specific temperature distribution and subsequent viscosity distribution within the material being welded; the former controlling the mechanical properties and later the flow stresses within the material in turn. A software based study to find effect of tool dimensions on the peak temperatures generation during FSW for the said aluminum alloy was carried out to explore the capabilities of the same and provide basis for further research work related to the different aluminum alloys.
Exploring E Turkey: Rainfall Precursor Predicts 100% Earthquake in a Consistent Manner in Just 2 Weeks  [PDF]
Prakash Pillai
International Journal of Geosciences (IJG) , 2013, DOI: 10.4236/ijg.2013.44069
Abstract:

Rainfall event is the very specific, reliable unambiguous precursor for the earthquake event. Over the years scientists have hunted for some signal—a precursory sign, however faint—that would allow forecasters to pin-point exactly where and when the big ones will hit. After decades spent searching in vain, many seismologists now doubt whether such a signal even exists. But in a great surprise to everyone, from an ordinary lay man to eminent scientists, 100% earthquakes occur after rainfalls! Though I have the findings for the entire regions of the world, here E Turkey are the region for submission for the period Jan-November, 2012 to study the strong correlation and show the strong evidence to prove that the 100% earthquakes after rainfall in a consistence manner. Anyone can very easily verify the validity of the findings for any forthcoming earthquakes for any regions of E Turkey in just two weeks of period. Nature does not give two different results for the same phenomena, for two different observers. Though there exists a very strong relation between the rainfalls and the earthquakes, scientists and seismologists have not been able to detect and identify this rainfall precursory signal for hundreds of years that consistently occurs before earthquakes. The methodology of rainfall event before earthquakes, even works consistently for earthquake prediction purpose, especially in any regions of the world. Rainfall type precursor is the best approach to predict specific earthquakes, which provide the potential for estimating the epicenter and magnitude of any moderate to strong earthquakes. Earthquakes are more likely when there is rain than it is not. The magnitudes of a resulting individual earthquake depend on the severity of the weather changes. However, in a very few cases the time scales

Peroxynitrite Mediates Diabetes-Induced Endothelial Dysfunction: Possible Role of Rho Kinase Activation
Azza B. El-Remessy,Huda E. Tawfik,Suraporn Matragoon,Bindu Pillai,Ruth B. Caldwell,R. William Caldwell
Experimental Diabetes Research , 2010, DOI: 10.1155/2010/247861
Abstract: Endothelial dysfunction is characterized by reduced bioavailability of NO due to its inactivation to form peroxynitrite or reduced expression of eNOS. Here, we examine the causal role of peroxynitrite in mediating diabetes-induced endothelial dysfunction. Diabetes was induced by STZ-injection, and rats received the peroxynitrite decomposition catalyst (FeTTPs, 15 mg/Kg/day) for 4 weeks. Vasorelaxation to acetylcholine, oxidative-stress markers, RhoA activity, and eNOS expression were determined. Diabetic coronary arteries showed significant reduction in ACh-mediated maximal relaxation compared to controls. Diabetic vessels showed also significant increases in lipid-peroxides, nitrotyrosine, and active RhoA and 50% reduction in eNOS mRNA expression. Treatment of diabetic animals with FeTTPS blocked these effects. Studies in aortic endothelial cells show that high glucose or peroxynitrite increases the active RhoA kinase levels and decreases eNOS expression and NO levels, which were reversed with blocking peroxynitrite or Rho kinase. Together, peroxynitrite can suppress eNOS expression via activation of RhoA and hence cause vascular dysfunction.
Peroxynitrite Mediates Diabetes-Induced Endothelial Dysfunction: Possible Role of Rho Kinase Activation
Azza B. El-Remessy,Huda E. Tawfik,Suraporn Matragoon,Bindu Pillai,Ruth B. Caldwell,R. William Caldwell
Journal of Diabetes Research , 2010, DOI: 10.1155/2010/247861
Abstract: Endothelial dysfunction is characterized by reduced bioavailability of NO due to its inactivation to form peroxynitrite or reduced expression of eNOS. Here, we examine the causal role of peroxynitrite in mediating diabetes-induced endothelial dysfunction. Diabetes was induced by STZ-injection, and rats received the peroxynitrite decomposition catalyst (FeTTPs, 15?mg/Kg/day) for 4 weeks. Vasorelaxation to acetylcholine, oxidative-stress markers, RhoA activity, and eNOS expression were determined. Diabetic coronary arteries showed significant reduction in ACh-mediated maximal relaxation compared to controls. Diabetic vessels showed also significant increases in lipid-peroxides, nitrotyrosine, and active RhoA and 50% reduction in eNOS mRNA expression. Treatment of diabetic animals with FeTTPS blocked these effects. Studies in aortic endothelial cells show that high glucose or peroxynitrite increases the active RhoA kinase levels and decreases eNOS expression and NO levels, which were reversed with blocking peroxynitrite or Rho kinase. Together, peroxynitrite can suppress eNOS expression via activation of RhoA and hence cause vascular dysfunction. 1. Introduction Diabetes mellitus predisposes patients to premature atherosclerotic coronary artery disease, the leading cause of morbidity and mortality among patients with diabetes [1, 2]. The vascular endothelium is a target of the diabetic milieu, and endothelial dysfunction has been thought to play a central role in diabetic vascular diseases (reviewed in [3]). Diabetes-induced endothelial dysfunction is characterized by reduced bioavailability of nitric oxide (NO) in the vessel wall. NO, a major regulator of vascular tone, is produced by the activity of endothelial NO synthase (eNOS). Diminished capacity of eNOS to generate NO has been demonstrated when endothelial cells were exposed to elevated glucose levels either in vitro or in vivo [4–7]. In response to hyperglycemia, an imbalance between increased production of superoxide anion ( ) and NO drives the formation of peroxynitrite (ONOO?) within the vascular wall [8]. Peroxynitrite can oxidize the NOS cofactor tetrahydrobiopterin and also reduce cellular transport of L-arginine, eNOS substrate for NO production [9]. These events uncouple the enzyme, which then preferentially increases production over NO production leading to a vicious cycle of peroxynitrite formation and further inactivation of NO [4, 10]. Recent studies raised the possibility that diabetes-impaired NO bioavailability could be caused by reduced expression of eNOS, in addition to the known
Role of Matrix Metalloproteinase Activity in the Neurovascular Protective Effects of Angiotensin Antagonism
Tauheed Ishrat,Anna Kozak,Ahmed Alhusban,Bindu Pillai,Maribeth H. Johnson,Azza B. El-Remessy,Adviye Ergul,Susan C. Fagan
Stroke Research and Treatment , 2014, DOI: 10.1155/2014/560491
Abstract: Background and Purpose. Oxidative stress and matrix metalloproteinase (MMP) activity have been identified as key mediators of early vascular damage after ischemic stroke. Somewhat surprisingly, the angiotensin II type 1 receptor (AT1) blocker, candesartan, has been shown to acutely increase MMP activity while providing neurovascular protection. We aimed to determine the contribution of MMP and nitrative stress to the effects of angiotensin blockade in experimental stroke. Methods. Wistar rats (n?=?9–14/group; a total of 99) were treated in a factorial design with candesartan 1?mg/kg IV, alone or in combination with either a peroxynitrite decomposition catalyst, FeTPPs, 30?mg/kg IP or GM6001 50?mg/kg IP (MMP inhibitor). Neurological deficit, infarct, size and hemorrhagic transformation (HT) were measured after 3?h of middle cerebral artery occlusion (MCAO) and 21?h of reperfusion. MMP activity and nitrotyrosine expression were also measured. Results. Candesartan reduced infarct size and HT when administered alone ( ) and in combination with FeTPPs ( ). GM6001 did not significantly affect HT when administered alone, but the combination with candesartan caused increased HT ( ) and worsened neurologic score ( ). Conclusions. Acute administration of candesartan reduces injury after stroke despite increasing MMP activity, likely by an antioxidant mechanism. 1. Introduction Ischemic stroke, an obstruction of blood flow in a major cerebral vessel, remains a leading cause of adult disability and death in the United States [1]. Because of its complex pathology, a major research and clinical priority is to develop therapeutic interventions in the ischemic brain through the understanding of underlying mechanisms. Ischemia reperfusion leads to a cascade of pathophysiological processes, resulting in further brain damage. Accumulations of free radicals, oxygen/nitrogen species (ROS/RNS), not only increase the susceptibility of brain tissue to reperfusion-induced damage but also trigger numerous molecular cascades, leading to increased blood-brain barrier (BBB) permeability, brain edema, hemorrhage and inflammation, and brain death [2, 3]. As an important component of free radicals, RNS, including peroxynitrite (ONOO–), play important roles in the process of cerebral ischemia-reperfusion injury. Ischemia reperfusion results in the production of peroxynitrite in ischemic brain, which triggers numerous molecular cascades and leads to vascular damage. In vitro, peroxynitrite strongly activates matrix metalloproteinases (MMPs) [4, 5]. Peroxynitrite formation on
Accessible Copies of Copyright Work for Visually Impaired Persons in India  [PDF]
Priya R. Pillai
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.326159
Abstract: This article deals with copyright law in India and its impact on the education of millions of visually impaired persons in India. Due to lack of amendment in the copyright law print disabled in India was unable to access the published copyrighted works. The organization dealing with visually impaired can provide accessible materials to visually impaired persons without seeking copyright permission from the owners. This landmark decision of Indian government will benefit all educational institutions who are dealing with visually impaired students.
Analysis of DAR(1)/D/s Queue with Quasi-Negative Binomial-II as Marginal Distribution  [PDF]
Kanichukattu Korakutty Jose, Bindu Abraham
Applied Mathematics (AM) , 2011, DOI: 10.4236/am.2011.29161
Abstract: In this paper we consider the arrival process of a multiserver queue governed by a discrete autoregressive process of order 1 [DAR(1)] with Quasi-Negative Binomial Distribution-II as the marginal distribution. This discrete time multiserver queueing system with autoregressive arrivals is more suitable for modeling the Asynchronous Transfer Mode(ATM) multiplexer queue with Variable Bit Rate (VBR) coded teleconference traffic. DAR(1) is described by a few parameters and it is easy to match the probability distribution and the decay rate of the autocorrelation function with those of measured real traffic. For this queueing system we obtained the stationary distribution of the system size and the waiting time distribution of an arbitrary packet with the help of matrix analytic methods and the theory of Markov regenerative processes. Also we consider negative binomial distribution, generalized Poisson distribution, Borel-Tanner distribution defined by Frank and Melvin(1960) and zero truncated generalized Poisson distribution as the special cases of Quasi-Negative Binomial Distribution-II. Finally, we developed computer programmes for the simulation and empirical study of the effect of autocorrelation function of input traffic on the stationary distribution of the system size as well as waiting time of an arbitrary packet. The model is applied to a real data of number of customers waiting for checkout in an airport and it is established that the model well suits this data.
A Journey from floppy disk to cloud storage
Bindu Trikha
International Journal on Computer Science and Engineering , 2010,
Abstract: Data storage and backup needs have evolved over the years necessitating the need for evolution of data storage methods and devices. The needs for a higher storage capacity as well as versatility of storage devices and the need for technologically advanced storage devices became apparent.
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