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Search Results: 1 - 10 of 11403 matches for " Biju George "
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TREATMENT OF ACUTE PROMYELOCYTIC LEUKEMIA WITH SINGLE-AGENT ARSENIC TRIOXIDE
Vikram Mathews,Ezhilarasi Chendamarai,Biju George,Auro Viswabandya
Mediterranean Journal of Hematology and Infectious Diseases , 2011, DOI: 10.4084/mjhid.2011.
Abstract: It is well recognized that arsenic trioxide (ATO) is an efficacious agent for the treatment of acute promyelocytic leukemia (APL). Use of single agent ATO in the treatment of APL leads to remissions which are durable in the majority. ATO is probably the most effective single agent in the treatment of APL and there have been very few reports of primary resistance. It has been used both as a single agent and in combination with other conventional drugs to treat APL. Use of ATO is the accepted standard of care in the management of relapsed APL, where it is often used effectively as a bridge to a stem cell transplant. However, its role in newly diagnosed APL remains controversial. ATO probably has multiple mechanisms of action. Better understanding of its mechanisms of action/s is likely to lead to more rationale use of this agent or its derivatives either alone or in combination with other drugs. There is limited data on the kinetics of leukemia clearance and normal haematopoietic recovery after the administration of single agent ATO for the treatment of APL, preliminary data suggests that it is likely to be different from conventional therapy. There have been a number of concerns of the potential short and long term toxicity of this agent. Most such concerns arise from the toxicity profile noted in people exposed to long term arsenic exposure in the environment. With the therapeutic doses and schedules of administration of ATO in the treatment of malignancies the overall toxicity profile has been favorable. In a resource constrained environments the use of a single agent ATO based regimen is a realistic and acceptable option to treat almost all patients. In the developed world it has the potential in combination with other agents to improve the clinical outcome with reduction of dose intensity of chemotherapy and remains an option for patients who would not tolerate conventional therapy. In this review we focus on the use of single agent ATO for the treatment of APL and summarize our experience and review the literature.
Risk factors of thrombosis in abdominal veins
Amit Kumar Dutta, Ashok Chacko, Biju George, Joseph Anjilivelil Joseph, Sukesh Chandran Nair, Vikram Mathews
World Journal of Gastroenterology , 2008,
Abstract: AIM: To estimate the prevalence of inherited and acquired thrombophilic risk factors in patients with abdominal venous thrombosis and to compare the risk factor profiles between Budd-Chiari syndromes (BCS) and splanchnic vein thrombosis (SVT).METHODS: In this retrospective study, 36 patients with abdominal venous thrombosis were studied. The patients were divided into Budd-Chiari group (hepatic vein, IVC thrombosis) and splanchnic venous thrombosis group (portal, splenic, superior mesenteric veins) based on the veins involved. Hereditary and acquired thrombophilic risk factors were evaluated in all patients.RESULTS: Twenty patients had SVT, 14 had BCS, and 2 had mixed venous thrombosis. Ten patients (28%) had hereditary and 10 patients (28%) acquired thrombophilic risk factors. The acquired risk factors were significantly more common in the SVT group (SVT vs BCS: 45% vs 7%, χ2 = 5.7, P = 0.02) while hereditary risk factors did not show significant differences between the two groups (SVT vs BCS: 25% vs 36%, χ2 = 0.46, P = 0.7). Multiple risk factors were present in one (7%) patient with BCS and in 3 patients (15%) with SVT. No risk factors were identified in 57% of patients with BCS and in 45% of patients with SVT.CONCLUSION: Hereditary and acquired risk factors play an important role in the etiopathogenesis of abdominal venous thrombosis. Acquired risk factors are significantly more common in SVT patients while hereditary factors are similar in both groups.
Seasonal Demand Dynamics of Residential Water End-Uses
Kumudu Rathnayaka,Hector Malano,Shiroma Maheepala,Biju George,Bandara Nawarathna,Meenakshi Arora,Peter Roberts
Water , 2015, DOI: 10.3390/w7010202
Abstract: Water demand prediction by end-use at an appropriate spatial and temporal resolution is essential for planning water supply systems that will supply water from a diversified set of sources on a fit-for-purpose basis. Understanding seasonal, daily and sub-daily water demand including peak demand by end-uses is an essential planning requirement to implement a fit-for-purpose water supply strategy. Studies in the literature assume that all indoor water uses except evaporative cooler water use are weather independent and do not exhibit seasonal variability. This paper presents an analysis undertaken to examine seasonal variability of residential water end-uses. The analysis was repeated using two sets of data to ensure the validity of findings. The study shows that shower water use is significantly different between winter and summer, in addition to irrigation, evaporative cooler and pool water end-uses, while other water end-uses are not. Weather is shown to be a significant determinant of shower water use; in particular it affects shower duration which increases with lower temperature. Further analysis on shower water use suggests that it is driven by behavioural factors in addition to weather, thus providing useful insights to improve detailed end-use water demand predictions.
An unusual case of capecitabine hyperpigmentation: Is hyperpigmentation a part of hand-foot syndrome or a separate entity?
Vasudevan Biju
Indian Journal of Pharmacology , 2010,
Abstract: A 59-year-old man with adenocarcinoma of stomach was prescribed capecitabine as adjuvant chemotherapy. After two cycles of therapy, patient developed hyperpigmentation on hands and feet. Examination revealed a peculiar distribution of hyperpigmentation on hands and feet and in addition, hyperpigmented spots on the dorsum of tongue. Although hand-foot syndrome (HFS) to capecitabine solely manifesting as palmoplantar hyperpigmentation has been described earlier, this is probably the first instance wherein oral pigmentation has also been found in association. In addition, this finding lends support to the growing argument of hyperpigmentation being a separate entity: different from HFS, both therefore being separate adverse effects of the same drug.
Secure ARP and Secure DHCP Protocols to Mitigate Security Attacks
Biju Issac
International Journal of Network Security , 2009,
Abstract: For network computers to communicate to one another, they need to know one another's IP address and MAC address. Address Resolution Protocol (ARP) is developed to find the Ethernet address that map to a specific IP address. The source computer broadcasts the request for Ethernet address and eventually the target computer replies. The IP to Ethernet address mapping would later be stored in an ARP Cache for some time duration, after which the process is repeated. Since ARP is susceptible to ARP poisoning attacks, we propose to make it unicast, centralized and secure, along with a secure design of DHCP protocol to mitigate MAC spoofing. The secure protocol designs are explained in detail. Lastly we also discuss some performance issues to show how the proposed protocols work.
Improved Clinical Outcomes of High Risk β Thalassemia Major Patients Undergoing a HLA Matched Related Allogeneic Stem Cell Transplant with a Treosulfan Based Conditioning Regimen and Peripheral Blood Stem Cell Grafts
Vikram Mathews, Biju George, Auro Viswabandya, Aby Abraham, Rayaz Ahmed, Abhijeet Ganapule, Eunice Sindhuvi, Kavitha M. Lakshmi, Alok Srivastava
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0061637
Abstract: Improving clinical outcomes among high risk Class III β thalassemia major patients (Class IIIHR) receiving an allogeneic SCT remains a challenge. From October, 2009 a treosulfan based regimen (TreoFluT) was used for all consecutive Class III patients (n = 50). The clinical outcomes were compared with the historical conventional busulfan (BuCy) based regimen (n = 139). Use of TreoFluT was associated with a significantly reduced incidence of sinusoidal obstruction syndrome (SOS) among Class IIIHR cases (78% to 30%; P = 0.000) and early TRM (46% to 13%; p = 0.005). There was also a trend towards better engraftment in the Class IIIHR subset (P = 0.055). However, the use of bone marrow (BM) as source of stem cells along with the TreoFluT regimen was associated with 50% early mixed chimerism which reduced to 8.5% with the use of a peripheral blood stem cell graft (PBSC). Use of a PBSC graft was not associated with a significant increase in the incidence of acute or chronic graft versus host disease (GVHD). The overall and event free survival was significantly better among the Class IIIHR subset with the use of TreoFluT Vs. BuCy (86.6±7.3 Vs. 39.4±6.8%; P = 0.002 and 77.8±8.8 Vs. 32.4±6.5%; P = 0.003 respectively). A TreoFluT conditioning regimen with a PBSC graft can significantly improve clinical outcomes of Class IIIHR patients.
RELATIONSHIP BETWEEN ENGLISH LANGUAGE ANXIETY AND ENGLISH LANGUAGE COMPETENCE: A CORRELATION STUDY
BIJU M.A
Golden Research Thoughts , 2013, DOI: 10.9780/22315063
Abstract: English language has become a global language with the advent of Globalisation. Naturally English language learning has got increased importance as English is the language for the global communication. English is a second language for Indian sand often mother tongue hampers the English acquisition of most of the Indians. NCF 2005 has underlined that significance of teaching of English as early as possible so that the learners may have a native speaker like fluency in English. Based on these guidelines Kerala government introduced English Language teaching from class 1 onwards. Teaching of English also affects the quality student acquisition of English. Anxiety is often produced when one tries to interact in English which can affect the language proficiency of the learners. Teacher competence in English and their anxiety can have an influential impact on learners. This study found out that there is a negative correlation between English language anxiety and English language competence of Elementary teacher trainees in Kerala. As elementary teachers have an influential role in developing different competence of the young learners including English language competence, this paper puts foreword a number of suggestion to reduce the anxiety evoking situations and to improve English language competence of the trainees.
Violaceous discoloration around the eyes
Vasudevan Biju,Sawhney MPS
Indian Journal of Dermatology, Venereology and Leprology , 2009,
Abstract:
Commentaires à propos d'un essai de reconstitution de la genèse de la Méditerranée Comments on an Effort to Reconstruct the Geneis of the Mediterranean
Biju-Duval B.
Oil & Gas Science and Technology , 2006, DOI: 10.2516/ogst:1977030
Abstract: A partir des données et des publications les plus récentes sur l'origine des bassins méditerranéens, la question est posée de savoir si les concepts de la tectonique des plaques peuvent être appliqués et aider la recherche pétrolière en Méditerranée. Malgré les difficultés qui sont rappelées, la réponse est affirmative car cette notion de tectonique globale a obligé les géologues à revoir un certain nombre de données classiques dans une optique nouvelle, en particulier sur le plan sédimentologique où des progrès indiscutables ont été effectués. De plus elle a conduit à distinguer d'une manière plus satisfaisante différents types de bassins dont l'age et le mode de formation, la nature du remplissage sédimentaire, le degré géothermique et donc les possibilités pétrolières sont différents. On the basis of the most recent data and publications on the origin of Mediterranean basins, the question arises of knowing whether plate-tectonics concepts can be applied and can help with petroleum prospection in the Mediterranean. Despite the difficulties that are reviewed here, the answer is affirmative because this concept of global tectonics has forced geologists ta review various classic data fram a new vantage point, in particular with regard ta sedimentology in which indisputable advances have been made. Likewise, it leads ta making a more satisfactory distinction between different types of basins having different ages and formation processes, different types ofsedimentary fill, a different geothermal degreeand hence petroleum potentials.
Carte géologique et Structurale des bassins tertiaires du domaine méditerranéen : commentaires Geological and Structural Map of Tertiary Basins in the Mediterranean Domain : Comments
Biju-Duval B.
Oil & Gas Science and Technology , 2006, DOI: 10.2516/ogst:1974028
Abstract: Cette note est destinée à commenter la représentation adoptée sur la Carte géologique et structurale des bassins tertiaires du domaine méditerranéen publiée par l'IFP, le CNEXO et l'INAG. On y précise les principes de réalisation, le but principal étant de situer les informations marines disponibles dans leur cadre géologique s les données en mer sont principalement relatives aux séries quaternaires et tertiaires récentes : seules celles-ci ont été détaillées sur la carte et inscrites dans le cadre structural des bassins. Dans une première partie, des commentaires techniques précisent les différentes représentations utilisées à terre et en mer, situent les simplifications effectuées et donnent un aper u sur la bibliographie et l'évolution des connaissances. La seconde partie permet de survoler rapidement les problèmes des bassins tertiaires méditerranéens par quelques commentaires géologiques qui donnent une esquisse de l'histoire de ces bassins. En conclusion, on essaie de faire ressortir les points importants qui se dégagent après lecture attentive de la carte. The aim of this article is ta comment on the representation adopted for the Geological and Structural Map of Tertiary Basins in the Mediterranean Domain published by IFP, CNEXO and INAG. The main goals are shaded, with the principal one being to situate available marine data in their geological setting. Offshore data mainly have ta do with recent Quartenary and Tertiary series which are the only cries itemized on the map and included within the structural setting of the basins. The first part contains technical comments on the different representations used, both onshore and offshore, to situate the simplifications used and to give some insight into the bibliography and how our understanding has evolved. The second part makes a brief review of problems relating to Mediterranean Tertiary basins with the help of various geological comments sketching out the history of these basins. To conclude, an attempt is made to bring out the important points revealed by a careful reading of the map.
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