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Search Results: 1 - 10 of 331 matches for " Bijan Keikhaei "
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Better differential diagnosis of iron deficiency anemia from beta-thalassemia trait
Fakher Rahim,Bijan Keikhaei
Turkish Journal of Hematology , 2009,
Abstract: Objective: Iron deficiency anemia (IDA) and beta-thalassemia trait ( -TT) are the most common forms of microcytic anemia. This study was conducted to compare the validity of various discrimination indices in differentiating β-TT from IDA by calculating their sensitivity, specificity and Youden's index.Methods: Totally 323 subjects (173 children and 150 adults) with microcytic anemia were involved in this study. We calculated 10 discrimination indices in all patients with IDA and β-TT. We divided the patients into two different groups as younger or older than 10 years. Results: None of the indices showed sensitivity and specificity of 100% in the patients older than 10 years, and in the patients younger than 10 years, only Shine & Lal index showed sensitivity close to 90% and specificity of 100%. The most accurate discriminative index for patients younger than 10 years was Shine & Lal and for those older than 10 years it was RDW index. According to Youden's index, Shine & Lal and RBC count showed the greatest diagnostic value in patients younger than 10 years and RDW and RBC count indices in those older than 10 years. Conclusion: None of the indices was completely sensitive and specific in differentiation between β-TT and IDA. Mean and median mean cell Hb density (MCHD) were very close to normal values in both IDA and β-TT patients, but in the case of mean density of Hb/liter (MDHL), we found that the mean and median were significantly higher than normal values in β-TT and lower than normal values in IDA patients. In our study, Youden's index of RBC and Shine & Lal were the highest and most reliable indices in differentiating β-TT from IDA in the patients younger than 10 years. For patients older than 10 years, the most reliable discrimination indices were RBC and RDW.
Spontaneous iliopsoas muscle hematoma in a patient with von Willebrand disease: a case report
Bijan Keikhaei, Ahmad Soltani Shirazi
Journal of Medical Case Reports , 2011, DOI: 10.1186/1752-1947-5-274
Abstract: A 20-year-old Iranian man was referred to our emergency ward because of the gradual onset of right flank pain. He was known to have been diagnosed with von Willebrand disease type 3 at age two years old. Magnetic resonance imaging showed a mass in the right iliopsoas muscle. The diagnosis of iliopsoas hemorrhage and partial femoral nerve palsy was established, and he responded to medical treatment.We report a case of von Willebrand disease type 3 with spontaneous iliopsoas hematoma associated with femoral nerve palsy that was well managed with Humate-P treatment.Von Willebrand disease (vWD) is a hereditary bleeding disorder caused by a quantitative or qualitative defect of von Willebrand factor. The prevalence of this disease is estimated to be 1% to 2% of the general population. Von Willebrand factor is a coagulation factor for initial stages of blood clotting and is also a carrier for factor VIII. Patients with vWD develop coagulation platelet plugs and red coagulation clots are unable to form. vWD consists of a broad variation of clinical manifestations, with one extreme being a minimal bleeding tendency and the other being a severe presentation such as severe hemophilia A. Luckily, most of these patients present with mild to moderate clinical symptoms. The severe type of the vWD, type 3, occurs in less than 5% of patients. The inheritance pattern of this type is usually autosomal recessive. Patients with vWD usually show clinical features such as recurrent nosebleeds, easy bruising, bleeding post-tooth extraction, post-tonsillectomy or other surgical bleeding, and excessive menstrual bleeding.Musculoskeletal hemorrhage occurs commonly in vWD type 3-like hemophilia A. Iliopsoas hemorrhage is a potentially serious complication because a delay in beginning treatment may result in permanent femoral nerve palsy [1]. The present case report describes a man with vWD type 3 who had a spontaneous iliopsoas hematoma that responded well to Humate-P treatment (CSL Behring,
Hematological Disorders in Ibotonic Acid-Induced Rat Model of Alzheimer's Disease
Fakher Rahim,Bijan Keikhaei,Alireza Sarkaki,Abdol Hassan Doulah
Journal of Animal and Veterinary Advances , 2012,
Abstract: The present research was conducted in order to investigate the effects of right-unilateral lesion of substantia nigra neurons by means of Ibotonic acid, a cholinergic-selective neurotoxin, on hematological parameters in rats. Thirty male Wistar rats weighing 200±50 g at the start of the experiment were used. The substantia nigra was right-unilateral lesioned by stereotaxic microinjections of 8 μg (free base) ibotonic acid, dissolved in 4 μL physiological saline containing 0.1% ascorbic acid, administered through the Hamilton microsyringe over 4.50 min. Seven days after neurosurgery, we assessed the total number of White Blood Cells (WBC), the total number of Red Blood Cells (RBC), Red cell Distribution (RDW), platelet and hemoglobin level and the erythrocyte indexes, Mean Cell Volume (MCV), Mean Cell Hemoglobin (MCH), Mean Cell Hemoglobin Concentration (MCHC). Ibotonic acid treatment induced a highly significantly decrease of white blood cells (p<0.001), followed by significant decrease in red blood cells (p = 0.02) and hemoglobin level (p = 0.03) comparative with sham-operated rats. Also, in the ibotonic acid-lesioned rats the erythrocyte indexes, Mean Cell Volume (MCV) (p = 0.04); Mean Cell Hemoglobin (MCH) (p = 0.02)) were significantly decreased comparative with sham-operated rats. By contrast, in the ibotonic acid-lesioned rat's platelet (0.34), Mean Cell Hemoglobin Concentration (MCHC) (p = 0.41) and Red blood cell Distribution Width (RDW) (p = 0.03) were significantly enhanced comparative with sham-operated rats. On the whole, the obtained data indicate the important role of the central nerves system in the regulation of erythrocyte dynamics.
Adrenal extramedullary hematopoiesis associated with β-thalassemia major
Bijan Keikhaei,Ahmad Soltani Shirazi,Mahboob Mohammad Pour
Hematology Reports , 2012, DOI: 10.4081/hr.2012.e7
Abstract: The presence of apparently normal hematopoietic tissue outside of bone marrow cavity is defined as extramedullary hema - topoiesis (EMH). EMH is a rare complication in thalassemia major (TM) and adrenal gland as well. This report describes a case of adrenal EMH in a 26-year-old man with β-TM. He has been transfused with regular blood transfusion since 9 months. During the routine physical examination he was incidentally found to have a hypoechoic mass at his abdominal ultrasonography. Abdominal computed tomography scan revealed a right well-defined suprarenal mass 7.7¥7.3¥5.8 cm in size. The diagnosis of EMH was confirmed with ultrasonographic-guided fine needle biopsy. Treatment options which include intensified regular blood transfusion and hydroxyurea have been started.
Sequential Deferoxamine - Deferasirox in Treatment of Major Thalassemia with Iron Overload
Keikhaei B
Iranian Journal of Pediatric Hematology Oncology , 2013,
Abstract: BackgroundIron overload is a major problem in patients with major thalassemia. An effective and safe iron chelator protocol with high compliance rate plays an important role in treatment of these patients. This study was done to assess the efficacy and safety of the sequential deferoxamine and deferasirox protocol in major thalassemia patients in Khuzestan province, Iran.Material and MethodSixty two patients were studied aged between 2 to 30 years old. A regimen consisted of 4 days deferasirox followed by 3 days deferoxamine. The duration of trial was 6 months. The efficacy was determined by comparison of ferritin level before and after treatment.ResultsSerum ferritin changed from 3590 ng/ml to 2563 ng /ml, which decreased significantly. During study 21% of patients experienced at least one side effect.ConclusionThis is a new regimen with high efficacy, low toxicity and acceptable compliance.
Hybrid Imaging: A New Frontier in Medical Imaging
Bijan Bijan
Iranian Journal of Radiology , 2010,
Abstract: Introduction of hybrid imaging in the arena of medical imaging calls for re-strategizing in current practice. Operating PET-CT and upcoming PET-MRI is a turf battle between Radiologists, Nuclear Medicine Physicians, Oncologists, Cardiologists and other related fields.
A Novel Approach in Estimation of the Soilcrete Column’s Diameter and Optimization of the High Pressure Jet Grouting Using Adaptive Neuro Fuzzy Inference System (ANFIS)  [PDF]
Bijan Ehsanzadeh, Kaveh Ahangari
Open Journal of Geology (OJG) , 2014, DOI: 10.4236/ojg.2014.48030

For achieving optimized jet grout parameters and W/C ratio it is concluded to set trial tests in constant local soil as the conclusion depends on local soil and presence of the extensive range of the effective parameters. Considering the benefits, due to abundance of the involved variables and the intrinsic geological complexity, this system follows a great expense in the trial and implementation phases. Utilizing the soft computing methods, this paper proposes a new approach to reduce or to eliminate the cost of the trial phase. Therefore, the Adaptive Neuro Fuzzy Inference System (ANFIS) was utilized to study the possibility of anticipating the diameter of the jet grout (Soilcrete) columns on the trial phase based on the Trial and Error procedure. Data were collected from several projects and formed three sets of data. Consequently, parameters were held constant (as input) and the diameters of the Soilcrete columns were recorded (as output). To increase the precision, aforementioned data sets were combined and ten different data sets were created and studied, with all the results being assessed in two different approaches. Accordingly, Gaussian Function results in a huge number of precise and acceptable outcomes among available functions. Based on the measurements, Gaussian Function achieves the values of the R which are frequently more than 0.8 and lower values of the RMSE. Therefore, utilizing Gaussian Function, mainly a congruent relation between the R and RMSE is experienced and it leads to close proximity of the actual and predicted values of the Soilcrete diameter.

Clinical Manifestation of Pulmonary Dysfunction in β-Thalassemia Major
F. Rahim,B. Keikhaei,A. Ebadi
Journal of Medical Sciences , 2008,
Abstract: Respiratory function tests and arterial blood gas analysis were performed on 59 patients with β-thalassemia major (27 M, 22 F, age range: 18-45 years). All investigations were performed 24 h before the patients received a blood transfusion or when they were in a stable state hematologic condition. Echocardiography was performed in all patients and the ejection fraction was employed as a measure of cardiac function. No patient had clinical signs of pulmonary dysfunction. Pulmonary function tests, however, showed a reduction of all main parameters (TLC, FEV1, FEV1/FVC, FEF 25-75% and RV) in most patients with β-thalassemia major, indicating a restrictive type of dysfunction. Arterial blood gas values were within the normal range. There was no evidence that the observed abnormalities in pulmonary function were secondary to congestive heart failure. The low hemoglobin concentration and a fall in the diffusing capacity of the alveolar-capillary membrane, together with the dependence of the reduced pulmonary diffusing capacity on age and serum ferritin levels, as well as of the entity of restrictive disease on age, suggests that pulmonary dysfunctions in patients with TM are due mainly to lung fibrosis and/or interstitial edema related to iron overload. Also iron deposition due to repeated blood transfusions may play a central role in determining lung alterations although the majority of patients are well chelated, suggesting that more than one causal mechanism could be involved.
Mass as the Fifth Dimension of the Universe  [PDF]
Bijan Nikouravan, Jitendra J. Rawal
International Journal of Astronomy and Astrophysics (IJAA) , 2013, DOI: 10.4236/ijaa.2013.33030

Newton considered three-dimensional universe endowed with flat space Euclidean geometry, and treated the time as an outside parameter and established his dynamics of the universe. Einstein along with space, considered time, and generated a four-dimensional universe endowed with non-Euclidean curved space-time geometry with time as its fourth dimension, and set up his field equations. Schwarzschild solved Einstein’s field equations around a star in space, which is, otherwise, flat, and obtained a solution. We, along with space and time, considered mass which also included energy according to Einstein’s mass-energy equivalence relation: E = mc2, and generated a five-dimensional universe with the mass as its fifth dimension, and solved the Einstein’s field equations, in some simple cases, and obtained solutions around a star in space, which is otherwise, flat.

Letter to Editor
Bijan Sadrizadeh
Iranian Journal of Public Health , 2009,
Abstract: Dear Dr Farhud Editor in Chief It is a well-known fact that in our daily life we can learn from everything including the good com-munica-tion practices among health professionals. Delayed communication is a challenge for effective health management in many parts of the world in par-ticular the developing countries. Sometimes we learn lessons from a simple exchange of emails between a national public health officer and a WHO program manager. As an example, few weeks ago I sent the following email message to Dr Keiji Fukuda the Special Adviser on Pandemic Influenza to the Director General, World Health Organiza-tion as follows: Dear Dr Fukuda First of all I should congratulate you for your excellent work including valuable information being con-veyed to the Member States through the WHO Site concerning the most recent developments in the area of the new Influenza A (H1N1) so called Pandemic (H1N1) 2009. However, sometimes there is contra-dictory information placed on some of the popular sites of the world which is misleading .As an exam-ple, I would like to refer to the Yahoo News which refers to the interview of the Director General in Paris. I am sure the text published by the (AFP) is at least to some extent manipulated. Also the text of the Article is somehow different with the title. This is in contrast with the excellent document placed on the WHO site under the Global Alert and Response (GAR) entitled "preparing for the second wave: les-sons from current outbreaks of Pandemic (H1N1)2009, briefing note 9. Whereas I have no doubt about the fast and extensive spread of the pandemic. I personally disagree with the exaggerations being made by the media/press concerning the intensity and the dangers of the pandemic which creates a lot of tension among the populations and results in a great deal of unnecessary expenses due to over doings by the Member States. I believe, while we should closely and seriously continue to monitor the spread, trend and intensity of the pandemic and its impact on the health system, at the same time we should miti-gate its harmful effects on the populations and be prepared for unusual /unexpected changes of the vi-rus. In my view, we should not overestimate the magnitude of the problem as it may result in overspend-ing of the limited resources which are badly needed for other priority problems of the coun-tries. Furthermore, we may lose the trust and confidence of the decision ma
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