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Search Results: 1 - 10 of 2876 matches for " Bienvenido Grá Oramas "
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Influencia de factores epidemiológicos en la progresión de la fibrosis en la hepatitis crónica C
Vilar Gómez,Eduardo; Grá Oramas,Bienvenido; Llanio Navarro,Raimundo; Arús Soler,Enrique;
Revista Cubana de Medicina , 2003,
Abstract: approximately 80 % of hepatitis c evolves to chronicity. the epidemiological and viral factors as well as those of the guest take part in the progression of the disease. the behavior of the epidemiological variables associated with chronic hepatitis c was described and the possible association of these ones with the intensity of fibrosis was identified. 80 patients with hepatitis c were studied and the intensity of fibrosis was determined by the metavir scoring system. they were grouped into absence or little fibrosis (f0-f1) and marked fibrosis (f2-f4) seeking for the possible statistical association with the epidemiological factors. a significant association was found among the infection's oldness estimate, the way it was acquired, the patient's age on catching it and the intensity of fibrosis. the progression of hepatits c may be determined by some epidemiological factors influencing decisively the natural history of the disease.
Bases fisiopatológicas de la insuficiencia hepática aguda
Vilar Gómez,Eduardo; Grá Oramas,Bienvenido; Llanio Navarro,Raimundo; Arús Soler,Enrique;
Revista Cubana de Medicina , 2004,
Abstract: a review was made to explain how the diverse cellular processes occurring in the severely damaged liver tissue and in the mesenteric circulation influence on the different systemic alterations appearing in acute liver failure, and the close relation existing among them. the acute liver failure is a clinical syndrome resulting from a mass liver necrosis generating progressive dysfunction of the organ with the presence of deep alterations in its detoxicating, metabolic, sinthesizing and excreting functions.the hypothesis of critical mass, as well as that on endotoxins-cytokines and vasoactive substances explain somehow the different molecular changes supporting the physiopathological bases of this complex entity.
Hallazgos clínicos, bioquímicos y morfológicos en 103 pacientes con anticuerpos contra el virus de la hepatitis C
Infante Velázquez,Mirtha; Arús Soler,Enrique; Fernández Naranjo,Anayda; Grá Oramas,Bienvenido;
Revista Cubana de Medicina , 1998,
Abstract: 103 patients carriers of hepatitis c virus antibodies detected by the cuban diagnostic system (anti hcv, cigb, havana) were studied. active chronic hepatitis (23.2 %) was the predominant histological lesion, although there were 2 cases with acute severe hepatitis due to a combined infection with a and b viruses. a few symptoms were observed in most of the patients, who were blood donors and blood transfusion receptors (44.5 %). the latter were associated with the most severe hapatic lesions. it is stressed the presence of heal thy carriers of the virus.
Hallazgos clínicos, bioquímicos y morfológicos en 103 pacientes con anticuerpos contra el virus de la hepatitis C
Mirtha Infante Velázquez,Enrique Arús Soler,Anayda Fernández Naranjo,Bienvenido Grá Oramas
Revista Cubana de Medicina , 1998,
Abstract: Se estudiaron 103 pacientes portadores de anticuerpos contra el virus de la hepatitis C detectado mediante el empleo del sistema diagnóstico cubano (Anti VHC, CIGB, La Habana). La lesión histológica predominante fue la hepatitis crónica activa (23,2 %), aunque se presentaron 2 casos con hepatitis aguda grave por infección combinada con los virus A y B. En muchos de los enfermos la afección cursó con escasos síntomas. La mayoría de los pacientes eran donantes de sangre y receptores de transfusiones (44,5 %). Estos últimos se relacionaron con las lesiones hepáticas más severas. Se se aló la presencia de portadores sanos del virus. 103 patients carriers of hepatitis C virus antibodies detected by the Cuban diagnostic system (Anti HCV, CIGB, Havana) were studied. Active chronic hepatitis (23.2 %) was the predominant histological lesion, although there were 2 cases with acute severe hepatitis due to a combined infection with A and B viruses. A few symptoms were observed in most of the patients, who were blood donors and blood transfusion receptors (44.5 %). The latter were associated with the most severe hapatic lesions. It is stressed the presence of heal thy carriers of the virus.
Influencia de factores epidemiológicos en la progresión de la fibrosis en la hepatitis crónica C
Eduardo Vilar Gómez,Bienvenido Grá Oramas,Raimundo Llanio Navarro,Enrique Arús Soler
Revista Cubana de Medicina , 2003,
Abstract: Aproximadamente 80 % de la hepatitis C evoluciona a la cronicidad. Factores como los epidemiológicos, virales y del huésped intervienen en la progresión de la enfermedad. Se describió el comportamiento de variables epidemiológicas asociadas a la hepatitis crónica C y se identificó la posible asociación de estas con la intensidad de la fibrosis. Se estudiaron 80 pacientes con hepatitis C. Se determinó la intensidad de la fibrosis por el sistema de puntuación METAVIR. Se agruparon en: ausencia o poca fibrosis (F0-F1) y fibrosis marcada (F2 a F4) buscando la posible asociación estadística con los factores epidemiológicos. Se halló asociación significativa entre el estimado de antigüedad de la infección, la vía de adquisición y la edad al contraerla con la intensidad de la fibrosis. La progresión de la hepatitis C puede estar determinada por algunos factores epidemiológicos que influyen de forma decisiva en la historia natural de la enfermedad. Approximately 80 % of hepatitis C evolves to chronicity. The epidemiological and viral factors as well as those of the guest take part in the progression of the disease. The behavior of the epidemiological variables associated with chronic hepatitis C was described and the possible association of these ones with the intensity of fibrosis was identified. 80 patients with hepatitis C were studied and the intensity of fibrosis was determined by the METAVIR scoring system. They were grouped into absence or little fibrosis (f0-F1) and marked fibrosis (F2-F4) seeking for the possible statistical association with the epidemiological factors. A significant association was found among the infection's oldness estimate, the way it was acquired, the patient's age on catching it and the intensity of fibrosis. The progression of hepatits C may be determined by some epidemiological factors influencing decisively the natural history of the disease.
Bases fisiopatológicas de la insuficiencia hepática aguda Physiopathological bases of acute liver failure
Eduardo Vilar Gómez,Bienvenido Grá Oramas,Raimundo Llanio Navarro,Enrique Arús Soler
Revista Cubana de Medicina , 2004,
Abstract: Se hace una revisión para explicar cómo influyen y la estrecha relación que tienen los diversos procesos celulares que ocurren en el tejido hepático, severamente da ado, y en la circulación mesentérica con las distintas alteraciones sistémicas que aparecen en la insuficiencia hepática aguda, síndrome clínico resultado de una necrosis hepática masiva que genera disfunción progresiva del órgano con la presencia de profundas alteraciones en sus funciones detoxificadora, metabólica, sintetizadora y excretora. La hipótesis de la masa crítica, así como la de las endotoxinas-citoquinas y sustancias vasoactivas explican de cierta forma los diferentes cambios moleculares que sustentan las bases fisiopatológicas de esta compleja entidad. A review was made to explain how the diverse cellular processes occurring in the severely damaged liver tissue and in the mesenteric circulation influence on the different systemic alterations appearing in acute liver failure, and the close relation existing among them. The acute liver failure is a clinical syndrome resulting from a mass liver necrosis generating progressive dysfunction of the organ with the presence of deep alterations in its detoxicating, metabolic, sinthesizing and excreting functions.The hypothesis of critical mass, as well as that on endotoxins-cytokines and vasoactive substances explain somehow the different molecular changes supporting the physiopathological bases of this complex entity.
Interferón alfa 2b recombinante más ribavirina en el tratamiento de la hepatitis crónica C
Sánchez Rodríguez,Yoan Antonio; Arús Soler,Enrique; Grá Oramas,Bienvenido; López Saura,Pedro; Nodarse Cuní,Hugo;
Revista Cubana de Medicina , 2010,
Abstract: the hepatitis c virus becomes in leading cause of chronic hepatitis, hepatic cirrhosis, hepatocarcinoma and liver transplant at world level. objective: the aim of present study is to determine the virological, biochemical and histological course of patients presenting with chronic hepatitis c under a combination of recombinant interferon alfa-2b plus ribavirin and to identify the main factors associated with the rates obtained of virological response. methods: a non-controlled and multicenter phase iv clinical-therapeutical trial was sponsored by the institute of gastroenterology and the genetics and biotechnology engineering center from may, 2002 to may, 2006. sample included 122 patients diagnosed with chronic hepatitis c fulfilling the predetermined inclusion and exclusion criteria. recombinant interferon alfa-2b (3 millions of t.i.d units) was used plus ribavirin (1000 or 1200 mg daily depending on the body weight) during 48 weeks. results: we achieved a sustained biochemical and virological response rate of 32.8 and 50.8 %, respectively at week 72. a 41.3,% from the total of patients had a histological improvement at the expense of reduction of fibrosis and a few changes in inflammation level. conclusions: raking into account the global response rate achieved this combined treatment was considered effectiveness for chronic hepatitis c and we recommended to deepen in the knowledge of infection in cuba, as well as in more efficient treatment options for this disease.
Interferón alfa 2b recombinante más ribavirina en el tratamiento de la hepatitis crónica C Recombinant Interferon alfa-2b plus Ribavirin in treatment of chronic hepatitis C
Yoan Antonio Sánchez Rodríguez,Enrique Arús Soler,Bienvenido Grá Oramas,Pedro López Saura
Revista Cubana de Medicina , 2010,
Abstract: El virus de la hepatitis C se ha convertido en la causa principal de hepatitis crónica, cirrosis hepática, hepatocarcinoma, y trasplante de hígado a nivel mundial. OBJETIVO: El presente estudio estuvo dirigido a determinar la evolución virológica, bioquímica e histológica de los pacientes con hepatitis crónica C bajo terapia combinada Interferón a 2b recombinante más ribavirina e identifica los principales factores asociados a las tasas obtenidas de respuesta virológica sostenida. MéTODOS: Ensayo clínico-terapéutico fase IV, abierto, no controlado y multicéntrico rectorado por el Instituto de Gastroenterología y el Centro de Ingeniería Genética y Biotecnología en el período comprendido de mayo de 2001 a mayo de 2006. La muestra estuvo conformada por 122 pacientes con hepatitis crónica C que cumplieron con criterios de inclusión y exclusión predeterminados. Se utilizó interferón a 2b recombinante (3 millones de unidades 3 veces por semana) más ribavirina (1 000 o 1 200 mg diarios en dependencia del peso corporal) durante 48 sem. RESULTADOS: Se obtuvo una tasa de respuesta virológica y bioquímica sostenida a la semana 72 de 32,8 y 50,8 % respectivamente. Un 41,3 % del total de pacientes experimentó mejoría histológica a expensas de la reducción de la fibrosis y pocos cambios en la inflamación. CONCLUSIONES: Teniendo en cuenta la tasa de respuesta global obtenida, se consideró como tratamiento eficaz para la hepatitis crónica C y se recomendó profundizar en el conocimiento de las características de la infección en Cuba así como en opciones de tratamiento más eficaces para esta enfermedad. The hepatitis C virus becomes in leading cause of chronic hepatitis, hepatic cirrhosis, hepatocarcinoma and liver transplant at world level. OBJECTIVE: The aim of present study is to determine the virological, biochemical and histological course of patients presenting with Chronic hepatitis C under a combination of recombinant Interferon alfa-2b plus Ribavirin and to identify the main factors associated with the rates obtained of virological response. METHODS: A non-controlled and multicenter phase IV clinical-therapeutical trial was sponsored by the Institute of Gastroenterology and the Genetics and Biotechnology Engineering Center from May, 2002 to May, 2006. Sample included 122 patients diagnosed with chronic hepatitis C fulfilling the predetermined inclusion and exclusion criteria. Recombinant Interferon alfa-2b (3 millions of t.i.d units) was used plus Ribavirin (1000 or 1200 mg daily depending on the body weight) during 48 weeks. RESULTS: We achieved a sustained bio
Diagnóstico morfológico de Helicobacter pylori mediante citología gástrica por cepillado
Sara Mandado Pérez,Bienvenido Gra Oramas,Miguel González Carvajal,Manuel Paniagua Estévez
Revista Cubana de Medicina , 2003,
Abstract: Se conoce que en Cuba la citología gástrica por cepillado no había sido utilizada para el diagnóstico morfológico del Helicobacter pylori. Se realizó en el Instituto de Gastroenterología, mediante endoscopia, a 625 pacientes adultos, 585 con gastritis crónica y 40 con úlcera gástrica. Se fijaron las muestras en alcohol de 95° Se probaron las coloraciones de Papanicolaou, hematoxilina y eosina, Gram, safranina y azul de metileno al 2 %. Se observaron las muestras en un microscopio óptico previamente calibrado. Se diagnosticó H. pylori en 310 gastritis crónicas y en 28 úlceras, 2 de las cuales eran malignas. Se diagnosticó H. heilmannii en un caso con úlcera gástrica negativo de H. pylori. Se eligió el azul de metileno al 2 % para la coloración. It is known that in Cuba the gastric brush citology has not been used for the morphological diagnosis of Helicobacter pylori. It was performed by endoscopy to 625 adult patients , 585 with chronic gastritis and 40 with stomach ulcer, at the Institute of Gastroenterology. The samples were fixed in alcohol 95 %. Papanicolaou’s stains, hematoxylin and eosin , Gram’s stain, safranin and methylene blue were tested. The samples were observed on a previously calibrated optical microscope. H. pylori was diagnosed in 310 chronic gastritis and in 28 ulcers, 2 of them were malignant. H. heilmannii was diagnosed in a case with stomach ulcer negative to H. pylori. Methylene blue 2 % was selected for staining.
Helicobacter pylori y lesiones endoscópicas e histológicas en mucosa gástrica de pacientes de 50 a?os y más
Pi?ol Jiménez,Felipe; Paniagua Estévez,Manuel; Gra Oramas,Bienvenido; Reyes de la Cruz,M;
Revista Cubana de Medicina , 2008,
Abstract: it is accepted all over the world that helicobacter pylori infection increases with age and reaches levels between 40 and 60 % in asymptomatic individuals, and of 70 % in symptomatic patients over 50 with gastroduodenal diseases. taking into account the relation existing between helicobacter pylori infection and the gastroduodenal diseases, prevalences and incidences showing a sustained increase with age (50-70 % in patients over 50) are ciphered, and the significant growth of the cuban population above this age is considered. a prospective and descriptive study was undertaken at the institute of gastroenterology to know the frequency of this microorganism, as well as the presence of lesions in the gastric mucosa in patients aged 50 and over. it was concluded that 69.6 % of the patients had positive results to helicobacter pylori in the urease test. of the 132 fragments of samples taken for biopsies of the gastric mucosa, 37.8 % yielded positive to helicobacter pylori, of them, 25.7 % were located in the antral region. 68 endoscopic diagnoses were made in those patients positive to helicobacter pylori by urease test, 64.7 % corresponded to more acute gastritis at the antral level; followed in frequency by pangastritis, more serious chronic gastritis at the body level, gastric ulcer and duodenal ulcer. no endoscopic lesion of malignant aspect was observed. on studying the colonization density of helicobacter pylori in 84 histological diagnoses made, 69.0 % presented mild density; 29.9 %, moderate; and 1.1 %, severe. it was observed a tendency towards the colonization density as the histological lesion progressed. it was suggested to continue the study with more patients to characterize the behavior of the infection in patients aged 50 and over in order to take preventive measures to eradicate the bacteria and to improve the quality of life.
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