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Search Results: 1 - 10 of 14284 matches for " Bianca Pinto Cunha "
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Dunnigan-Type Familial Partial Lipodystrophy: Understanding and Treating the Syndrome  [PDF]
Ana Raisa Jatahy Santos, Sabrina Pinto Ferreira, Moacir Benazzi, Mara Capra, Helen Paula Apparicio Medeiros, Ana Luísa de Jesus, Mirella Hansen de Almeida, Larissa Bianca Paiva Cunha de Sá, Alberto Krayyem Arbex
Open Journal of Endocrine and Metabolic Diseases (OJEMD) , 2017, DOI: 10.4236/ojemd.2017.71003
Abstract: Dunnigan-type partial lipodystrophy, which is characterized by a number of metabolic alterations, change in body fat distribution, and autosomal dominant inheritance pattern, is rare in the general population. Objective: To report the case of an adolescent with clinical and laboratory findings suggestive of Dunnigan-type partial lipodystrophy. Methods: Case report and literature review. Results: A 15-year-old adolescent presented at the clinic complaining of darkening of skin folds on her trunk and back. During physical examination, the presence of serious acanthosis nigricans in her cervical region, axillae, and intergluteal space was noted. Hirsutism in androgen-dependent areas was also observed, as well as relevant reduction of subcutaneous adipose tissue in the limbs, gluteal region, abdomen, and trunk and fat accumulation in the face and chin. Discussion. Dunnigan-type familial partial lipodystrophy is a rare dominant autosomal disease resulting from a heterozygous missense mutation in the LMNA gene, known as LPF type 2 (Dunnigan variant), which encodes the nuclear protein A/C-type lamin. It is characterized by the progressive disappearance of the subcutaneous adipose tissue in the limbs, gluteal region, abdomen, and trunk, with onset in puberty, followed by fat accumulation in other areas such as the face, chin, labia majora, and intra-abdominal region, leading to hypertrophy that may mimic the Cushing’s syndrome phenotype. Affected patients display marked insulin resistance and may consequently develop diabetes mellitus, acanthosis nigricans, hirsutism, and polycystic ovary syndrome. Conclusion: This case report highlights the importance of suspecting Dunnigan-type familial partial lipodystrophy in clinical practice. Early clinical diagnosis allows for measures that minimize the severe metabolic disorders associated with this disease and, consequently, these adolescents’ self-esteem issues.
Qualitative and quantitative tear film abnormalities in dogs
Ribeiro, Alexandre Pinto;Brito, Fabio Luiz da Cunha;Martins, Bianca da Costa;Mamede, Fabrício;Laus, José Luiz;
Ciência Rural , 2008, DOI: 10.1590/S0103-84782008000200048
Abstract: tear film disorders in dogs can be classified into quantitative or qualitative abnormalities, or both, and are commonly observed in daily clinical practice. inadequate production of one or more tear film components can lead to variable degrees of ocular disorders, called keratoconjunctivitis sicca. keratoconjunctivitis sicca in dogs has several causes, but in most cases the disease is idiopathic, with t lymphocytes playing a role. in veterinary medicine, the diagnosis is made based on the results of the schirmer tear test. in this article, we review aspects related to the etiopathogenesis and diagnosis of keratoconjunctivitis sicca in dogs and discuss new therapeutic modalities for this disease.
Uso da informa o somatossensorial adicional no controle postural: efeito da dominancia manual The use of additional somatosensory information on postural control: effect of handedness
Iara Mont'Alv?o Guedes de Araújo,Sandra Regina Alouche,Bianca Pinto Cunha,Sandra Maria Sbeghen Ferreira de Freitas
Revista Brasileira de Educa??o Física e Esporte , 2013,
Abstract: Buscamos com o presente estudo investigar o efeito da dominancia manual e da vis o no uso da informa o somatossensorial adicional fornecida pelo toque suave no controle postural. Quinze adultos jovens e destros permaneceram em pé sobre uma plataforma de for a com a) olhos abertos ou fechados e b) bra os ao lado do corpo ou o dedo indicador direito ou esquerdo tocando a barra fixa. A área do centro de press o (CP), amplitude e velocidade médias do CP nas dire es anteroposterior e médio-lateral foram avaliadas. Os resultados indicaram uma redu o nas medidas nas condi es de toque e aumento com os olhos fechados, exceto quando o toque foi realizado com dedo indicador direito. A for a máxima foi maior para a m o direita, enquanto a sensibilidade cutanea e as for as aplicadas à barra foram similares entre os hemicorpos. Esses resultados sugerem um efeito da dominancia manual e vis o no uso da informa o somatossensorial adicional no controle postural. In this study we investigated the effect of handedness and vision on the use of additional somatosensory information provided by the light touch in postural control. Fifteen right-handed, young adults quietly stood on a force plate with a) eyes open or closed and b) arms hanging along the body or with the right or left index finger in contact with a rigid bar. We assessed the center of pressure (CP) area and CP mean sway amplitude and velocity in anterior-posterior and medial-lateral directions. The results revealed a reduction of these measures in the touch conditions and increase with the eyes closed, except when the touch was performed with right index fingertip. The grip strength was greater for the right hand, while the cutaneous sensitivity and the forces applied on the bar were similar between the two sides of the body. These results suggested an effect of the handedness and vision in the use of additional somatosensory information on the postural control.
Redistribui??o espacial da popula??o: tendências e trajetória
Cunha, José Marcos Pinto;
S?o Paulo em Perspectiva , 2003, DOI: 10.1590/S0102-88392003000300022
Abstract: an analysis of the transformation that occurred beginning in the 1980s and that had important consequences for the process of urbanization, in the urban systems and patterns of human settlement in brazil, with special emphasis on the role played by the state and the metropolitan region of s?o paulo in this process. data from the demographic censuses of 1980 and 2000 were used for this purpose.
Quality, indexing and durability are the targets of the RVq (Editorial) [Qualidade, Indexa o e Perenidade s o as Metas da RVq]
Angelo da Cunha Pinto
Revista Virtual de Química , 2010,
Abstract:
Editorial
Angelo da Cunha Pinto
Revista Virtual de Química , 2009,
Abstract:
Obituary: Professor Nuno Alvares Pereira [Obituário: Professor Nuno Alvares Pereira]
Angelo da Cunha Pinto
Revista Virtual de Química , 2011,
Abstract:
The Pos-Graduate in Chemistry in Rio Janeiro. New directions [A Pós-gradua o em Química no Estado do Rio Janeiro. Novos rumos]
Angelo da Cunha Pinto
Revista Virtual de Química , 2010,
Abstract:
Editorial
Pinto Angelo da Cunha
Journal of the Brazilian Chemical Society , 1999,
Abstract:
Growth Hormone Replacement Therapy in Patients without Adult Growth Hormone Deficiency: What Answers Do We Have So Far?  [PDF]
Karine Rucker, Larissa Bianca Paiva Cunha de Sá, Alberto Krayyem Arbex
Health (Health) , 2017, DOI: 10.4236/health.2017.95057
Abstract:
Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) have been suggested as “anti-aging” therapies, or for improving quality of life with aging. In this study, we focus on the actions of GH in the main organs and organ systems of the human body, like skeletal muscle, bones and brain, particularly in regard to data and research on the use of GH replacement therapy in adults without growth hormone deficiency, especially elderly patients. Several different studies have been carried out to show what the effects and side effects of GH replacement in healthy people and what would be the impact in quality of life and life span. In this review, we demonstrate what answers we have so far about the effects of GH replacement in many organs and systems in healthy people.
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