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Search Results: 1 - 10 of 657 matches for " Bhatt Rupal "
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Single lens to lens duplication: The missing link
Bhatt Rupal,Jethani Jitendra,Saluja Praveen,Bharti Vinay
Indian Journal of Ophthalmology , 2008,
Abstract: Congenital anomalies of the lens include a wide range from lens coloboma to primary aphakia and doubling of lens. There have been few case reports of double lens; the etiology suggested is metaplastic changes in the surface ectoderm that leads to formation of two lens vesicles and hence resulting in double lens. We report a case with bilobed lens, which raises the possibility of explaining the etiology of double lens.
Use of Waste Plastic in Flexible Pavements-Green Roads  [PDF]
Yash Menaria, Rupal Sankhla
Open Journal of Civil Engineering (OJCE) , 2015, DOI: 10.4236/ojce.2015.53030
Abstract: Wrappers of betel nuts, chocolates, chips, hand bags, cold drink bottles and all other forms of plastic create significant environmental and economic problem. They consume massive energy and other natural resources, depleting the environment in various ways. In manufacturing firms, construction industries and products delivery services, use of plastic is a priority to handle and pack things comfortably due to its light weight, cost effectiveness and strength. Plastics cannot be banned as it will result in usage of natural resources like paper, wood at a great extent. It is made up of various chemical elements and is regarded as a highly pestilent material which does not easily degrade in the natural environment after its usage. Waste plastics are made up of Polyethylene, Polystyrene and Polypropylene. Temperature varying between 120 - 160 gives the softening point of these plastics [5]. They do not produce any toxic gases during heating but the softened plastics have tendency to form a lamination or coating over the aggregate, when it is sprayed over the hot aggregate at 160. The main objective of this paper is to discuss the significance of plastic in terms of cost reduction, increase in strength and durability when these plastics are heated and coated upon the aggregates (160) to compensate the air voids with plastic and binds with aggregate to provide stability.
Spectral and Timing Analysis of the Prompt Emission of Gamma Ray Bursts
Rupal Basak
Physics , 2014,
Abstract: A Thesis Submitted to the Tata Institute of Fundamental Research, Mumbai for the degree of Doctor of Philosophy in Physics (supervisor: Prof. A. R. Rao)
High dose intermittent sorafenib shows improved efficacy over conventional continuous dose in renal cell carcinoma
Xiaoen Wang, Liang Zhang, S Nahum Goldberg, Manoj Bhasin, Victoria Brown, David C Alsop, Sabina Signoretti, James W Mier, Michael B Atkins, Rupal S Bhatt
Journal of Translational Medicine , 2011, DOI: 10.1186/1479-5876-9-220
Abstract: Mice bearing xenografts derived from the 786-O RCC cell line were treated with sorafenib according to multiple doses and schedules: 1) Conventional dose (CD) continuous therapy; 2) high dose (HD) intermittent therapy, 3) CD intermittent therapy and 4) HD continuous therapy. Tumor diameter was measured daily. Microvessel density was assessed after 3 days to determine the early effects of therapy, and tumor perfusion was assessed serially by arterial spin labeled (ASL) MRI at day 0, 3, 7 and 10.Tumors that were treated with HD sorafenib exhibited slowed tumor growth as compared to CD using either schedule. HD intermittent therapy was superior to CD continous therapy, even though the total dose of sorafenib was essentially equivalent, and not significantly different than HD continuous therapy. The tumors exposed to HD sorafenib had lower microvessel density than the untreated or the CD groups. ASL MRI showed that tumor perfusion was reduced to a greater extent with the HD sorafenib at day 3 and at all time points thereafter relative to CD therapy. Further the intermittent schedule appeared to maintain RCC sensitivity to sorafenib as determined by changes in tumor perfusion.A modification of the sorafenib dosing schedule involving higher dose intermittent treatment appeared to improve its efficacy in this xenograft model relative to conventional dosing. MRI perfusion imaging and histologic analysis suggest that this benefit is related to enhanced and protracted antiangiogenic activity. Thus, better understanding of dosing and schedule issues may lead to improved therapeutic effectiveness of VEGF directed therapy in RCC and possibly other tumors.Recently, several new agents targeting the VEGF pathway have demonstrated promising activity in patients with advanced renal cell carcinoma (RCC). Sorafenib is a multi-tyrosine kinase inhibitor (mTKI) whose targets include vascular endothelial growth factor receptor-2 (VEGFR2) and its activity is thought to be based on its inhibi
Novel Therapeutic Options for the Treatment of Nonvalvular Atrial Fibrillation  [PDF]
Rupal Patel Mansukhani, Lucio R. Volino
Pharmacology & Pharmacy (PP) , 2014, DOI: 10.4236/pp.2014.511116
Abstract: Objective: To review the literature for the emerging oral anticoagulants, dabigatran, rivaroxaban, and apixaban currently available in the United States. Data Source: A literature review was performed in MEDLINE (1947–July 2014) using the keywords atrial fibrillation AND dabigatran OR rivaroxaban OR apixaban. The references identified from the literature review were then evaluated. All of the literature retrieved from MEDLINE that was published as an original clinical trial was included in this review. Other pertinent articles published related to the original clinical trials were also considered. The references included in this review were limited to studies conducted in humans and written in the English language. Conclusion: The new oral anticoagulant agents have demonstrated benefit over warfarin. The pharmacologic profiles of the newer agents are predictable, with rapid onsets of action. The newer agents are also more convenient for patients since they do not require regular INR monitoring. Although there are many advantages to the newer agents, a patient evaluation must be considered prior to initiating them.
Resistance of Renal Cell Carcinoma to Sorafenib Is Mediated by Potentially Reversible Gene Expression
Liang Zhang,Manoj Bhasin,Rachel Schor-Bardach,Xiaoen Wang,Michael P. Collins,David Panka,Prabhakar Putheti,Sabina Signoretti,David C. Alsop,Towia Libermann,Michael B. Atkins,James W. Mier,S. Nahum Goldberg,Rupal S. Bhatt
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0019144
Abstract: Resistance to antiangiogenic therapy is an important clinical problem. We examined whether resistance occurs at least in part via reversible, physiologic changes in the tumor, or results solely from stable genetic changes in resistant tumor cells.
Controls on Gosaikunda Lake Chemistry within Langtang National Park in High Himalaya, Nepal  [PDF]
Maya P. Bhatt, Seema Bhatt, Birgit Gaye
International Journal of Geosciences (IJG) , 2014, DOI: 10.4236/ijg.2014.510094
Abstract: Surface water samples and lake bed sediments were collected and analyzed from Gosaikunda Lake within Langtang National Park (28°05'N, 85°25'E; 4380 m a.s.l.) in the central Himalayan region of Nepal during fall 2011. The major cations and anions in equivalents were present in the following order: \"\" and \"\", respectively. Sulfide oxidation coupled with carbonate dissolution and aluminosilicate dissolution appeared to be the dominant geochemical processes determining lake water dissolved ions. Sulfate concentration was much higher than the alkalinity which is
Characterization of Negative Exponential Distribution through Expectation  [PDF]
Milind Bhatt B.
Open Journal of Statistics (OJS) , 2013, DOI: 10.4236/ojs.2013.35042

For characterization of negative exponential distribution one needs any arbitrary non-constant function only in place of approaches such as identical distributions, absolute continuity, constant regression of order statistics, continuity and linear regression of order statistics, non-degeneracy etc. available in the literature. Path breaking different approach for characterization of negative exponential distribution through expectation of non-constant function of random variable is obtained. An example is given for illustrative purpose.

Characterization of Power-Function Distribution through Expectation  [PDF]
Milind Bhanuprasad Bhatt
Open Journal of Statistics (OJS) , 2013, DOI: 10.4236/ojs.2013.36052

For the characterization of the power function distribution, one needs any arbitrary non constant function only in place of independence of suitable function of order statistics, linear relation of conditional expectation, recurrence relations between expectations of function of order statistics, distributional properties of exponential distribution, record valves, lower record statistics, product of order statistics and Lorenz curve, etc. available in the literature. The goal of this research is not to give a different path-breaking approach for the characterization of power function distribution through the expectation of non constant function of random variable and provide a method to characterize the power function distribution as remark. Examples are given for the illustrative purpose.

Characterization of Generalized Uniform Distribution through Expectation  [PDF]
Milind B. Bhatt
Open Journal of Statistics (OJS) , 2014, DOI: 10.4236/ojs.2014.48052
Abstract: Normally the mass of a root has a uniform distribution but some have different uniform distributions named Generalized Uniform Distribution (GUD). The characterization result based on expectation of function of random variable has been obtained for generalized uniform distribution. Applications are given for illustrative purpose including a special case of uniform distribution.
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