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Search Results: 1 - 10 of 2774 matches for " Bhaskar Pal "
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Analytical Estimation of Elastic Properties of Polypropylene Fiber Matrix Composite by Finite Element Analysis  [PDF]
Bhaskar Pal, Mohamed Riyazuddin Haseebuddin
Advances in Materials Physics and Chemistry (AMPC) , 2012, DOI: 10.4236/ampc.2012.21004
Abstract: A structural composite is a material system consisting of two or more phases on a macroscopic scale, whose mechanical performance and properties are designed to be superior to those of constituent materials acting independently. Fiber reinforced composites (FRP) are slowly emerging from the realm of advanced materials and are replacing conventional materials in a variety of applications. However, the mechanics of FRPs are complex owing to their anisotropic and heterogeneous characteristics. In this paper a representative volume model has been considered and a finite element model incorporating the necessary boundary conditions is developed using available FEA package ANSYS to predict the elastic property of the composite. For verification, the numerical results of elastic properties are compared with the analytical solution and it is found that there is a good agreement between these results.
Liposomal Iron for Iron Deficiency Anemia in Women of Reproductive Age: Review of Current Evidence  [PDF]
Parag Biniwale, Bhaskar Pal, Tripura Sundari, Gorakh Mandrupkar, Nikhil Datar, Amandeep Singh Khurana, Amit Qamra, Salman Motlekar, Rishi Jain
Open Journal of Obstetrics and Gynecology (OJOG) , 2018, DOI: 10.4236/ojog.2018.811100
Abstract: Iron deficiency anemia is the most frequent nutritional deficiency disorder. Conventionally administered oral iron is associated with gastrointestinal intolerance that affects the outcomes and compliance. Liposomal iron is associated with increased absorption without causing significant adverse effects. In this review, we have discussed the technology of liposomal iron preparation, mechanisms of its absorption and clinical evidence on its utility in iron deficiency states in pregnant and non-pregnant women. Based on the available evidence, we compared liposomal iron to conventional oral iron. Encapsulation of micronized iron in liposomes is associated with lesser exposure to gastric contents, lesser interaction with food contents, no exposure to different digestive juices, targeted delivery of iron and allows lower doses to be administered in lieu of direct absorption without need for protein carriers. The available evidence suggests that liposomal iron significantly increases hemoglobin, ferritin levels in pregnant women as well as in women with iron deficiency.
Heme Iron Polypeptide in Iron Deficiency Anemia of Pregnancy: Current Evidence  [PDF]
Bhaskar Pal, Hemant Deshpande, Tripura Sundari, Parag Biniwale, Kamlesh Shah, Sugandh Goel, Amandeep Singh Khurana, Amit Qamra, Salman Motlekar, Hanmant Barkate
Open Journal of Obstetrics and Gynecology (OJOG) , 2017, DOI: 10.4236/ojog.2017.74044
Abstract: Iron deficiency is the most common nutritional deficiency leading to anemia in pregnancy. Conventionally, non-heme form of iron salts has been the mainstay of treatment. However, patient compliance is an important concern with existing oral iron therapy due to gastrointestinal side effects. Heme iron, a better bioavailable and tolerable form of iron can be suitable form of iron for supplementation in pregnancy. Evidence suggests its utility in pregnancy for treatment of iron deficiency anemia with benefits extending to postpartum period. Effective transfer across placenta to fetus further supports its utility in pregnancy. This review discusses in details the absorption kinetics along with clinical evidence on efficacy, safety, and tolerability of heme-iron supplementation in iron deficiency anemia of pregnancy.
Community Based Health Insurance in India: Prospects and Challenges  [PDF]
Bhaskar Purohit
Health (Health) , 2014, DOI: 10.4236/health.2014.611152
Abstract: The health inequities remain high in India with government and private health expenditures clearly favoring the rich, urban population and organized sector workers and the Out Of Pocket (OOP) spending as high as 80%, afflicting the poor in the worst manner. The focus of the paper is to examine the potential Community Based Health Insurance (CBHI) offers to improve the healthcare access to rural, low-income population and the people in unorganized sector. This is done by drawing empirical evidence from various countries on their experiences of implementing CBHI schemes and its potential for applications to India, problems and challenges faced and the policy and management lessons that may be applicable to India. It can be concluded that CBHI schemes have proved to be effective in reducing the Catastrophic Health Expenditure (CHE) of people. But success of such schemes depends on its design, benefit package it offers, its management, economic and non-economic benefits perceived by enrollees and solidarity among community members. Collaboration of government, NGO’s and donor agencies is very crucial in extending coverage; similarly overcoming the mistrust that people have from such schemes and subsidizing the insurance for the many who cannot pay the premiums are important factors for success of CBHI in India. One of the biggest challenges for the health system is to address the piecemeal approach of CBHI schemes in extending health insurance and inability of such schemes to cover a large number of poor and the unorganized sector workers. Also, there is a need for a stronger policy research to demonstrate: 1) how such schemes can create a larger risk pool, 2) how such schemes can enroll a large number of people in the unorganized sector, 3) the interaction of CBHI schemes with other financing schemes and its link to the health system.
Nutritional Aspects of Grape (Vitis vinifera L.) Clusters Afflicted with SOUR Shrivel Is Related to Functionality of Its Vascular Tissues  [PDF]
Bhaskar Bondada
American Journal of Plant Sciences (AJPS) , 2016, DOI: 10.4236/ajps.2016.71020
Abstract: Mineral nutrition is essential to growth and development of various plant organs including fruits; consequently deficiency of any element leads to a myriad of physiological disorders, which in fruits are manifested as ripening anomalies. In this study, nutritional composition in tandem with vascular structure of healthy grape clusters and clusters afflicted with SOUR shrivel, a ripening disorder has been examined to unravel its mechanistic basis. The healthy berries without any affliction accumulated the highest amounts of all nutrients, which paralleled with functional xylem and phloem tissues in their cluster framework. Among the macro nutrients, K occurred as the dominant element followed by P, Ca, Mg and S whereas B was the predominant micro nutrient followed by Fe, Cu, and Zn. Although, the SOUR shrivel berries and the healthy appearing berries of afflicted clusters followed similar accumulation patterns, their amounts were significantly lower than the perfectly healthy berries without any SOUR shrivel. The low nutrient levels of SOUR shrivel berries corresponded to necrosis of phloem tissues and a red discoloration of xylem tissues in their cluster framework indicating that a lack of functional vascular tissues provoked the induction of SOUR shrivel by reducing influx of xylem and phloem mobile nutrients into the afflicted berries. Hence, periodic nutritional checks starting before veraison may aid in curbing the incidence of SOUR shriveling.
Gastric adenocarcinoma in a patient re-infected with H. pylori after regression of MALT lymphoma with successful anti-H. pylori therapy and gastric resection: a case report
Uday C Ghoshal, Debashish Guha, Santu Bandyopadhyay, Chiranjib Pal, Srikanta Chakraborty, Ujjala Ghoshal, Tamal K Ghosh, Bhaskar B Pal, Prabir K Banerjee
BMC Gastroenterology , 2002, DOI: 10.1186/1471-230x-2-6
Abstract: We report a patient with PGL in whom the tumor regressed after surgical resection combined with eradication of H. pylori infection. However, he developed GC on follow up; this was temporally associated with recrudescence / re-infection of H. pylori. This is perhaps first report of such occurrence.Possible cause and effect relationship between H. pylori infection and both PGL and GC is discussed. This case also documents a unique problem in management of PGL in tropical countries where re-infection with H. pylori is supposed to be high.Helicobacter pylori (H. pylori) has been etiologically linked with primary gastric lymphoma (PGL) and gastric carcinoma (GC) [1,2]. Evidences in favor of cause and effect relationship between H. pylori and PGL include: higher frequency of isolation in PGL than in controls [3]; development of the disease during long-term follow up of infected subjects [4]; regression after eradication of the organism [5]; and rapid recurrence following re-infection [6]. Therefore, all components of Koch's postulates for establishing cause and effect relationship between H. pylori and PGL are fulfilled [7]. Evidences in favor of etiological relationship between H. pylori and GC are somewhat incomplete. In most studies from developed countries H. pylori infection has been correlated with GC [8]; however, the data from developing world where H. pylori infection is more frequent and is acquired at an early age is somewhat contradictory [9,10]. There is no report of regression of GC after eradication of H. pylori. Recently, GC has been shown to develop in Mongolian gerbils after infection with H. pylori[11]. However, development of GC during follow up after fresh infection with H. pylori in humans has not been documented despite such report in PGL [4]. Accordingly we report a patient with PGL from India in whom surgical resection of the tumor combined with eradication of H. pylori was followed by regression of PGL. This patient developed metachronous GC asso
Immune response to dna vaccine expressing transferrin binding protein a gene of Pasteurella multocida
Singh, Satparkash;Singh, Vijendra Pal;Cheema, Pawanjit Singh;Sandey, Maninder;Ranjan, Rajeev;Gupta, Santosh Kumar;Sharma, Bhaskar;
Brazilian Journal of Microbiology , 2011, DOI: 10.1590/S1517-83822011000200043
Abstract: haemorrhagic septicaemia (hs), an acute and fatal disease of cattle and buffalo is primarily caused by serotype b:2 or e:2 of pasteurella multocida. the transferrin binding protein a (tbpa) has been found to act as immunogen and potent vaccine candidate in various gram negative bacteria including p. multocida. the present study was carried out to evaluate the potential of this antigen as a dna vaccine against hs in mice model. the tbpa gene of p. multocida serotype b:2 was cloned in a mammalian expression vector alone and along with murine il2 gene as immunological adjuvant to produce monocistronic and bicistronic dna vaccine constructs, respectively. the immune response to dna vaccines was evaluated based on serum antibody titres and lymphocyte proliferation assay. a significant increase in humoral and cell mediated immune responses was observed in mice vaccinated with dna vaccines as compared to non immunized group. additionally, the bicistronic dna vaccine provided superior immune response and protection level following challenge as compared to monocistronic construct. the study revealed that dna vaccine presents a promising approach for the prevention of hs.
Organisational climate from view point of motivation in district hospital, India  [PDF]
Bhaskar Purohit, Ashok Wadhwa
Health (Health) , 2012, DOI: 10.4236/health.2012.47063
Abstract: Organisational Climate (OC) has been an important topic of research in Organisational Development. There are several frameworks and approaches to study OC. One such framework focuses on the effect of OC on motivation. Although studying OC from viewpoint of motivetion is an important one, there is very limited research in Indian public health system on assessing OC from the view point of motivation. The present study uses a comprehensive framework that focuses on assessing OC from the view point of motivation in a government district hospital. The overall objective of the study was to assess the OC of a District Hospital (DH) from the view point of motivation. A total of 66 staff (all from the same district hospital) participated in the study that included 12 Class I doctor specialists; 14 Class II doctors and 40 Class III staff The data was collected using a validated instrument called Motivational Analysis of Climate (MAO-C). The instrument included six needs or motives and twelve dimensions of organisational climate that were ranked by individuals according to their perception. Based on the ranks, final scores were calculated that reflected the dominant climate (highest score for a particular motive) and backup climates (second highest score for a particular motive). Also a combination of the two motives, dominant and back up motives or climates indicated a particular OC. According to the study, the dominant climate in the organisation was that for Dependency motive while the backup climate for the organisation was for Control motive. According to the literature, both Dependency and Control motives are dysfunctional climates. A high dependency motive indicates that the overall organisational climate is characterized by no initiatives by the people and the employees always look for approval from their seniors; assistance of others in developing oneself; a need to check with others who are more knowledgeable. Similarly high score for control motive indicates that order is maintained in organisation; indicates display of personal power; a desire to stay informed and an urge to monitor events and to take corrective action when needed. When the two motives are combined, the study indicates a dependency-control climate profile which means that the organisational practices are similar to government offices, where subordinates have no say in decision making and they have to follow the established rules of the organisation. Such organisations have clearly laid communication channels controlled from higher authority indicating typical characteristics of a
Understanding Differential Responses of Grapevine (Vitis vinifera L.) Leaf and Fruit to Water Stress and Recovery Following Re-Watering  [PDF]
Bhaskar Bondada, Janani Shutthanandan
American Journal of Plant Sciences (AJPS) , 2012, DOI: 10.4236/ajps.2012.39149
Abstract: Among all fruit crops of horticultural importance, grapevines (Vitis vinifera L.) stand out as the most drought tolerant crop species whose tolerance is credited to their proficiency to recover from water stress in both the natural and vineyard growing conditions. However, information on the recovery responses is relatively scant. Studies were conducted to address this issue using potted vines of the grapevine cultivar, Cabernet Sauvignon, which was subjected to water stress and along with anatomical and ultrastructural characterizations, physiological status was assessed in healthy and water stressed vines, and following recovery via rewatering from the water stressed vines. Water stress induced wilting of leaves, drooping of tendrils, and desiccation followed by abscission of shoot tip leaving behind a brown scar at the shoot apex. The wilted leaves accumulated ABA, which correspondingly reduced stomatal conductance and leaf water potential. Upon re-watering, both these parameters made a recovery with values similar to healthy leaves. Likewise, leaf anatomical features following rewatering resembled to that of healthy leaves. In clusters, water stress caused shriveling of preveraison (unripened) berries, which regained full turgor following water resupply, whereas the postveraison (ripening) berries in the same cluster remained unaffected as evidenced by the presence of viable mesocarp cells and epicuticular wax in the form of platelets. The study revealed that shoot tip with leaf primordia was most sensitive to water stress followed by fully expanded leaves and preveraison berries, whereas the postveraison berries remained unaffected. This information could be valuable to implementing irrigation strategies towards sustaining grape production in existing vineyards experiencing episodic droughts and targeted areas prone to drought.
Incidence of Sickle Cell Anaemia and Thalassaemia in Central India  [PDF]
Bhaskar P. Urade
Open Journal of Blood Diseases (OJBD) , 2012, DOI: 10.4236/ojbd.2012.24014
Abstract: Haemoglobinopathies are group of diseases characterized by abnormalities both quantitative and qualitative in the synthesis of haemoglobin. Haemoglobinopathies consist of sickle cell anaemia (SCA), thalassaemia (βT) and variant haemoglobins. In India, they are responsible for the largest number of genetic disorders and hence are of great public health hazardous. In India major concerned haemoglobinopathic disorders are sickle cell anaemia and β-thalassaemia. Of the several abnormal haemoglobin molecules, four which are widely prevalent in India include: HbS, HbβT, HbE and HbD. Examination of 6463 individuals showed high incidences for haemoglobin variants, HbS and HbβT in different ethnic groups, the frequency being varies from 0% - 20% and 0% - 9% respectively. The frequency of HbS in Brahmins is 4.17%, in Kalar 5.41%, in Rajput 2.04%, in Muslims 3.73% in Maratha 2.08% in Bania 9.09% while in Teli it is 3.65%. Among the Scheduled castes and Nomadic tribal groups HbS ranges from 1% - 12%; in backward caste categories it varies from 3% - 16%; while in Scheduled tribes it ranges from 0% - 20%. The high magnitude of sickle cell trait has been noticed in the Pardhan (20.31%) followed by the Marar (16.10%), the Dhiwar (11.90%), the Gond (11.89%), the Mahar (11.81%) and the Bania (9.90%). A considerable high frequency (9.27%) of β-thalassaemia has been observed among the Sindhi population. Sporadic occurrence of HbβT and HbD among other communities suggested the gradual spread of the genes into the region. The present findings in 11 communities with the thalassaemia syndrome suggest that the β-thalassaemia is accompanied by raised level of HbA2. Unusual greater mean RBC and WBC suggest the high concentration of hypochromic microcytosis in anaemia. The mean MCV and MCH in HbβT and HbD are much lower than the normal ranges compared to HbS. The mean MCHC is much lower in HbβT, HbDD and HbS than the normal range. The cumulative gene frequency of haemoglobinopathies in India is 4.2%. With a population of over 1 billion and a birth rate of 28 per 1000, there are over 42 million carriers and over 12,000 infants are born each year with a major and clinical significant haemoglobinopathy. Out of these, clinically significant sickle cell anaemia and β-thalassaemic disorders account for almost equal numbers.
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