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Search Results: 1 - 10 of 87930 matches for " Beverly I Neugeboren "
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Genetic drift opposes mutualism during spatial population expansion
Melanie JI Muller,Beverly I Neugeboren,David R Nelson,Andrew W Murray
Quantitative Biology , 2014, DOI: 10.1073/pnas.1313285111
Abstract: Mutualistic interactions benefit both partners, promoting coexistence and genetic diversity. Spatial structure can promote cooperation, but spatial expansions may also make it hard for mutualistic partners to stay together, since genetic drift at the expansion front creates regions of low genetic and species diversity. To explore the antagonism between mutualism and genetic drift, we grew cross-feeding strains of the budding yeast S. cerevisiae on agar surfaces as a model for mutualists undergoing spatial expansions. By supplying varying amounts of the exchanged nutrients, we tuned strength and symmetry of the mutualistic interaction. Strong mutualism suppresses genetic demixing during spatial expansions and thereby maintains diversity, but weak or asymmetric mutualism is overwhelmed by genetic drift even when mutualism is still beneficial, slowing growth and reducing diversity. Theoretical modeling using experimentally measured parameters predicts the size of demixed regions and how strong mutualism must be to survive a spatial expansion.
Heterotrophic and Autotrophic Soil Respiration under Simulated Dormancy Conditions  [PDF]
Daniel Beverly, Scott Franklin
Open Journal of Forestry (OJF) , 2015, DOI: 10.4236/ojf.2015.53024
Abstract: Carbon cycling research has increased over the past 20 years, but less is known about the primary contributors to soil respiration (i.e. heterotrophic and autotrophic) under dormant conditions. It is understood that soil CO2 effluxes are significantly lower during the winter of temperate ecosystems and assumed microorganisms dominate efflux origination. We hypothesized that heterotrophic contributions would be greater than autotrophic under simulated dormancy conditions. To test this hypothesis, we designed an experiment with the following treatments: combined autotrophic heterotrophic respiration, heterotrophic respiration, autotrophic respiration, no respiration, autotrophic respiration in vermiculite, and no respiration in vermiculite. Engelmann spruce seedlings and soil substrates were placed in specially designed respiration chambers and soil CO2 efflux measurements were taken four times over the course of a month. Soil microbial densities and root volumes were measured for each chamber after day thirty-three. Seedling presence resulted in significantly higher soil CO2 efflux rates for all soil substrates. Autotrophic respiration treatments were not representative of solely autotrophic soil CO2 efflux due to soil microbial contamination of autoclaved soil substrates; however, the mean autotrophic contributions averaged less than 25% of the total soil CO2 efflux. Soil microorganism communities were likely the primary contributor to soil CO2 efflux in simulated dormant conditions, as treatments with the greatest proportions of microbial densities had the highest soil CO2 efflux rates. Although this study is not directly comparable to field dormant season soil CO2 effluxes of Engelmann spruce forest, as snowpack is not maintained throughout this experiment, relationships, and metrics from such small-scale ecosystem component processes may yield more accurate carbon budget models.
Management of superficial basal cell carcinoma: focus on imiquimod
Beverly Raasch
Clinical, Cosmetic and Investigational Dermatology , 2009, DOI: http://dx.doi.org/10.2147/CCID.S3507
Abstract: nagement of superficial basal cell carcinoma: focus on imiquimod Review (12989) Total Article Views Authors: Beverly Raasch Published Date June 2009 Volume 2009:2 Pages 65 - 75 DOI: http://dx.doi.org/10.2147/CCID.S3507 Beverly Raasch Skin Cancer Research Group, North Queensland Centre for Cancer Research, James Cook University, Queensland, Australia Abstract: Superficial basal cell carcinoma comprise up to 25% of all histological sub-types. They are more likely to occur on younger persons and females and although generally more common on the trunk, also occur frequently on the exposed areas of the head and neck especially in areas of high sun exposure. In the last decade, new treatment options such as topical applications that modify the immune response have been trialed for effectiveness in treating these lesions. Imiquimod 5% cream has been shown to stimulate the innate and cell mediated immune system. The short-term success of imiquimod 5% cream in randomized controlled trials comparing different treatment regimes and dosing as a treatment for small superficial basal cell carcinoma (BCC) not on the face or neck is in the range of 82% for 5 times per week application. A high proportion of participants with good response rates to topical treatment (58%–92%) experience local side effects such as itching and burning, less commonly erosion and ulceration, but the proportion of participants ceasing treatment has not been high. To date one long-term study indicates a treatment success rate of 78%–81% and that initial response is a predictor of long-term outcome. Recurrences tend to occur within the first year after treatment. Future research will compare this preparation to the gold standard treatment for superficial BCC – surgical excision.
Management of superficial basal cell carcinoma: focus on imiquimod
Beverly Raasch
Clinical, Cosmetic and Investigational Dermatology , 2009,
Abstract: Beverly RaaschSkin Cancer Research Group, North Queensland Centre for Cancer Research, James Cook University, Queensland, AustraliaAbstract: Superficial basal cell carcinoma comprise up to 25% of all histological sub-types. They are more likely to occur on younger persons and females and although generally more common on the trunk, also occur frequently on the exposed areas of the head and neck especially in areas of high sun exposure. In the last decade, new treatment options such as topical applications that modify the immune response have been trialed for effectiveness in treating these lesions. Imiquimod 5% cream has been shown to stimulate the innate and cell mediated immune system. The short-term success of imiquimod 5% cream in randomized controlled trials comparing different treatment regimes and dosing as a treatment for small superficial basal cell carcinoma (BCC) not on the face or neck is in the range of 82% for 5 times per week application. A high proportion of participants with good response rates to topical treatment (58%–92%) experience local side effects such as itching and burning, less commonly erosion and ulceration, but the proportion of participants ceasing treatment has not been high. To date one long-term study indicates a treatment success rate of 78%–81% and that initial response is a predictor of long-term outcome. Recurrences tend to occur within the first year after treatment. Future research will compare this preparation to the gold standard treatment for superficial BCC – surgical excision.Keywords: superficial basal cell carcinoma, imiquimod, skin cancer
Leaders Exhibiting High Emotional Intelligence Are More Dedicated to Their Job Performance  [PDF]
Donnisha Beverly, James A. Williams, Miranda Kitterlin
Open Journal of Leadership (OJL) , 2012, DOI: 10.4236/ojl.2012.14006
Abstract: The purpose of this study was to identify the effect of information technology leaders’ emotional intelligence on subordinate job performance. Participants consisted of information technology leaders, and were recruited from the Association for Information Technology Professionals (AITP) and the Information Technology (IT) Specialist group in LinkedIn (a business-oriented network website). A quantitative, correlational approach was taken by an online administration of two validated instruments—the Emotional Quotient Inventory (EQ-i) and Van Scotter and Motowidlo’s measures for contextual performance (interpersonal facilitation and job dedication). Findings indicated that there was a positive relationship between IT leaders’ emotional intelligence scores and subordinates’ job performance ratings. Specifically, higher IT leaders’ general mood scores, and optimism scores are associated with subordinates’ higher interpersonal facilitation and job dedication scores. Further, results provided insight on IT leaders’ EI training needs, career development, and guidelines for areas of improvement.
Intraocular pressure in genetically distinct mice: an update and strain survey
Olga V Savinova, Fumihiro Sugiyama, Janice E Martin, Stanislav I Tomarev, Beverly J Paigen, Richard S Smith, Simon WM John
BMC Genetics , 2001, DOI: 10.1186/1471-2156-2-12
Abstract: Based on over 30 studied mouse strains, average IOP ranges from approximately 10 to 20 mmHg. Gender does not typically affect IOP and aging results in an IOP decrease in some strains. Most tested strains exhibit a diurnal rhythm with IOP being the highest during the dark period of the day. Homozygosity for a null allele of the carbonic anhydrase II gene (Car2n) does not alter IOP while homozygosity for a mutation in the leptin receptor gene (Leprdb) that causes obesity and diabetes results in increased IOP. Albino C57BL/6J mice homozygous for a tyrosinase mutation (Tyrc-2J) have higher IOPs than their pigmented counterparts.Genetically distinct mouse strains housed in the same environment have a broad range of IOPs. These IOP differences are likely due to interstrain genetic differences that create a powerful resource for studying the regulation of IOP. Age, time of day, obesity and diabetes have effects on mouse IOP similar to those in humans and other species. Mutations in two of the assessed candidate genes (Lepr and Tyr) result in increased IOP. These studies demonstrate that mice are a practical and powerful experimental system to study the genetics of IOP regulation and disease processes that raise IOP to harmful levels.Glaucoma is a leading cause of blindness but its molecular etiology is poorly understood. Glaucoma involves retinal ganglion cell death and optic nerve damage that is often associated with elevated intraocular pressure (IOP) [1-5].It is becoming increasingly clear that many forms of glaucoma have a genetic component [6,7], and much current research is focused on identifying chromosomal regions and genes that contribute to glaucoma [8-10]. Identifying such loci allows screening for individuals with an increased risk of developing glaucoma [11]. Identifying genes contributing to elevated IOP and glaucoma is only the first step, however, and animal models will provide systems for subsequent hypothesis testing and experimental dissection of pathoge
Intraocular pressure in genetically distinct mice: an update and strain survey: Correction
Olga V Savinova, Fumihiro Sugiyama, Janice E Martin, Stanislav I Tomarev, Beverly J Paigen, Richard S Smith, Simon WM John
BMC Genetics , 2001, DOI: 10.1186/1471-2156-2-16
Abstract: 1) Legend to figure 7 should read: "There is no strong correlation between the average systolic blood pressure of each strain and the average IOP of that strain (R2 = 0.1). All mice were female and 2 to 4 months old, with the exception that the female CBA/CaJ used for IOP assessment were 6 to 7 months old. If the CBA/CaJ mice are excluded, R2 drops to 0.01. Of ARK/J, C57BL/6J and SJL/J, strain ARK/J had the highest IOP and strain SJL/J the lowest IOP.2) In table 1, the strain NZB/BiNJ should read: NZB/B1NJ.3) In the results section dealing with Myoc alleles, the MYOC and Myoc should both be in italics.
Sex difference in response to stress by lunar month: A pilot study of four years' crisis-call frequency
Nicholas Kollerstrom, Beverly Steffert
BMC Psychiatry , 2003, DOI: 10.1186/1471-244x-3-20
Abstract: Four years of telephone-call frequency data were obtained from a single crisis-call centre. We used the method of lunar-day numbers 1 to 29 for analysis. We also tested the concept of 'strong moons' as occurring when the Sun was near to the lunar-node axis.An increase in calls was recorded from females and a decrease in calls by males during the new moon period, suggesting a sex difference in response, and there were proportionally more calls by males a fortnight later. A comparable swing in the male/female call-ratio on a weekly basis over Fridays and Saturdays was noted. Limitations of staffing at the call-centre prohibited comment on seasonal correlations.Lunar-related studies of stress should endeavour to separate the data by sex or the effect can be lost. Distress-calls by women were more strongly linked to the lunar month than were those by men.Centuries of folklore attest to a relationship between the moon and human response, and both positive and negative-result surveys continue to appear. Of two recent UK studies, one reported a 'small but significant' increase in visits to doctors on days around full moons [1], while the other found a sharp peak in reports of persons bitten by animals during the same monthly period [2]. The general concept of increased stress at full moon or at certain full moons to account for these traditions was proposed by Lieber [3] and more recently reviewed by Dubrov [4]. If this concept has validity it should be evident in crisis-call frequencies.Published investigations of possible lunar cycle influence on crisis call frequency since 1974 have been mainly American: Weiskot [5], De Voge & Mikawa [6], Michelson, Wilson & Michelson [7], Wilson & Tobacyk [8], but also Canadian: Byrnes and Kelly [9] and Bickis, Kelly & Byrnes [10]. Reviews of these by Rotton & Kelly [11] (reviewed refs. 5,6 & 7), Bickis et al. [10] (reviewed refs 8 & 9), and Kelly, Rotton & Culver [12] (reviewed refs. 9 & 10), emphasised the negative nature of the resu
Numerical Approaches to Spacetime Singularities
Berger Beverly K.
Living Reviews in Relativity , 2002,
Abstract: This Living Review updates a previous version which is itself an update of a review article. Numerical exploration of the properties of singularities could, in principle, yield detailed understanding of their nature in physically realistic cases. Examples of numerical investigations into the formation of naked singularities, critical behavior in collapse, passage through the Cauchy horizon, chaos of the Mixmaster singularity, and singularities in spatially inhomogeneous cosmologies are discussed.
Numerical Approaches to Spacetime Singularities
Beverly K. Berger
Living Reviews in Relativity , 1998,
Abstract: This review updates a previous review article. Numerical explorationof the properties of singularities could, in principle, yield detailed understanding of their nature in physically realistic cases. Examples of numerical investigations into the formation of naked singularities, critical behavior in collapse, passage through the Cauchy horizon, chaos of the Mixmaster singularity, and singularities in spatially inhomogeneous cosmologies are discussed.
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