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Search Results: 1 - 10 of 5239 matches for " Bernard LaSalle "
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Whole-drawer imaging for digital management and curation of a large entomological collection
Beth Mantle,John LaSalle,Nicole Fisher
ZooKeys , 2012, DOI: 10.3897/zookeys.209.3169
Abstract: Whole-drawer imaging is shown to be an effective tool for rapid digitisation of large insect collections. On-line, Whole-drawer images facilitate more effective collection management, virtual curation, and public engagement. The Whole-drawer imaging experience at the Australian National Insect Collection is discussed, with an explanation of workflow and examples of benefits.
SMA CARNI-VAL TRIAL PART II: A Prospective, Single-Armed Trial of L-Carnitine and Valproic Acid in Ambulatory Children with Spinal Muscular Atrophy
John T. Kissel,Charles B. Scott,Sandra P. Reyna,Thomas O. Crawford,Louise R. Simard,Kristin J. Krosschell,Gyula Acsadi,Bakri Elsheik,Mary K. Schroth,Guy D'Anjou,Bernard LaSalle,Thomas W. Prior,Susan Sorenson,Jo Anne Maczulski,Mark B. Bromberg,Gary M. Chan,Kathryn J. Swoboda
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0021296
Abstract: Multiple lines of evidence have suggested that valproic acid (VPA) might benefit patients with spinal muscular atrophy (SMA). The SMA CARNIVAL TRIAL was a two part prospective trial to evaluate oral VPA and l-carnitine in SMA children. Part 1 targeted non-ambulatory children ages 2–8 in a 12 month cross over design. We report here Part 2, a twelve month prospective, open-label trial of VPA and L-carnitine in ambulatory SMA children.
Phase II Open Label Study of Valproic Acid in Spinal Muscular Atrophy
Kathryn J. Swoboda, Charles B. Scott, Sandra P. Reyna, Thomas W. Prior, Bernard LaSalle, Susan L. Sorenson, Janine Wood, Gyula Acsadi, Thomas O. Crawford, John T. Kissel, Kristin J. Krosschell, Guy D'Anjou, Mark B. Bromberg, Mary K. Schroth, Gary M. Chan, Bakri Elsheikh, Louise R. Simard
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0005268
Abstract: Preliminary in vitro and in vivo studies with valproic acid (VPA) in cell lines and patients with spinal muscular atrophy (SMA) demonstrate increased expression of SMN, supporting the possibility of therapeutic benefit. We performed an open label trial of VPA in 42 subjects with SMA to assess safety and explore potential outcome measures to help guide design of future controlled clinical trials. Subjects included 2 SMA type I ages 2–3 years, 29 SMA type II ages 2–14 years and 11 type III ages 2–31 years, recruited from a natural history study. VPA was well-tolerated and without evident hepatotoxicity. Carnitine depletion was frequent and temporally associated with increased weakness in two subjects. Exploratory outcome measures included assessment of gross motor function via the modified Hammersmith Functional Motor Scale (MHFMS), electrophysiologic measures of innervation including maximum ulnar compound muscle action potential (CMAP) amplitudes and motor unit number estimation (MUNE), body composition and bone density via dual-energy X-ray absorptiometry (DEXA), and quantitative blood SMN mRNA levels. Clear decline in motor function occurred in several subjects in association with weight gain; mean fat mass increased without a corresponding increase in lean mass. We observed an increased mean score on the MHFMS scale in 27 subjects with SMA type II (p≤0.001); however, significant improvement was almost entirely restricted to participants <5 years of age. Full length SMN levels were unchanged and Δ7SMN levels were significantly reduced for 2 of 3 treatment visits. In contrast, bone mineral density (p≤0.0036) and maximum ulnar CMAP scores (p≤0.0001) increased significantly. Conclusions While VPA appears safe and well-tolerated in this initial pilot trial, these data suggest that weight gain and carnitine depletion are likely to be significant confounding factors in clinical trials. This study highlights potential strengths and limitations of various candidate outcome measures and underscores the need for additional controlled clinical trials with VPA targeting more restricted cohorts of subjects. Trial Registration ClinicalTrials.gov
SMA CARNI-VAL Trial Part I: Double-Blind, Randomized, Placebo-Controlled Trial of L-Carnitine and Valproic Acid in Spinal Muscular Atrophy
Kathryn J. Swoboda,Charles B. Scott,Thomas O. Crawford,Louise R. Simard,Sandra P. Reyna,Kristin J. Krosschell,Gyula Acsadi,Bakri Elsheik,Mary K. Schroth,Guy D'Anjou,Bernard LaSalle,Thomas W. Prior,Susan L. Sorenson,Jo Anne Maczulski,Mark B. Bromberg,Gary M. Chan,John T. Kissel
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0012140
Abstract: Valproic acid (VPA) has demonstrated potential as a therapeutic candidate for spinal muscular atrophy (SMA) in vitro and in vivo.
New Formulas for Irregular Sampling of Two-Bands Signals  [PDF]
Bernard Lacaze
Journal of Signal and Information Processing (JSIP) , 2011, DOI: 10.4236/jsip.2011.24035
Abstract: Many sampling formulas are available for processes in baseband (-a,a) at the Nyquist rate a/π. However signals of telecommunications have power spectra which occupate two bands or more. We know that PNS (periodic non-uniform sampling) allow an errorless reconstruction at rate smaller than the Nyquist one. For instance PNS2 can be used in the two-bands case (-a,-b)∪(b,a) at the Landau rate (a-b)/π We prove a set of formulas which are available in cases more general than the PNS2. They take into account two sampling sequences which can be periodic or not and with same mean rate or not.
Pairing Effect on the Binding Energy Curve of N = Z Atomic Nuclei  [PDF]
Bernard Schaeffer
World Journal of Nuclear Science and Technology (WJNST) , 2013, DOI: 10.4236/wjnst.2013.33013

The saw-tooth phenomenon on the binding energy curve of N = Z nuclei is due to the low binding energy between the α-particles. It was suspected by Gamow to be of van der Waals type, found here to be deuteron bonds. The binding energy per nucleon, in absolute value, of an α-particle is larger than any other combination of 4 nucleons. Therefore, the binding energy per nucleon is low for odd-odd N = Z nuclei and maximum for even-even N = Z nuclei. The assumption of N = Z nuclei to be an assembly of α-particles and deuteron bonds predicts the binding energy of the 32 first N = Z nuclei with a rms deviation of 0.25 MeV.

Magic of Language  [PDF]
Bernard Korzeniewski
Open Journal of Philosophy (OJPP) , 2013, DOI: 10.4236/ojpp.2013.34067
Abstract: Language, through the discrete nature of linguistic names and strictly determined grammatical rules, creates absolute, “quantized”, sharply separated “facts” within the external world that is continuous, “fuzzy” and relational in its essence. Therefore, it is similar, in some important sense, to magic, which attributes causal and creative power to magical words and formulas. On the one hand, language increases greatly the effectiveness of the processes of thinking and interpersonal communication, yet, on the other hand, it determines and distorts to a large extent the picture of the world created within the mind. The relatively smallest (but still significant) magical admixture is present in science, because of its relatively reliable methodology, while the largest is found in religion and a large part of philosophy. The magical nature of language also manifests itself in logic and mathematics that refer to ill determined, fuzzy objects, sets and relations in the real world. The meaning of linguistic names is based on the conceptual network—an epiphenomenon (continuous in its essence) of the neural network—where interactions between particular concepts are based on the relation of connotation. The names and formulas of language correspond to these concepts which are best separated and determined. A direct relation of denotation between the elements of language and “facts” of the world is an illusion. While we cannot dispense with language because of its immense usefulness, we must remember about its “fact-creating” nature and influence on our thought and cognitive processes. The picture of the reality created as the result of them is to a large extent formed and deformed by the nature of language, and not by the “immanent” properties of the world in itself.
Formal Similarities between Cybernetic Definition of Life and Cybernetic Model of Self-Consciousness: Universal Definition/Model of Individual  [PDF]
Bernard Korzeniewski
Open Journal of Philosophy (OJPP) , 2013, DOI: 10.4236/ojpp.2013.32049
Abstract: The previously proposed cybernetic definition of a living (biological) individual and the cybernetic model of a psychical individual (a self endowed with subjective consciousness) are extended and compared, and their formal similarities are isolated and highlighted. It is argued that the emergence of the biological level of reality from the physical level and of the psychical level from the biological level is closely analogous. The (biological or psychical) individual is constituted by a network of elements (negative feedbacks/ regulatory mechanisms or neurons/concepts, respectively) that possesses the following common properties: 1) it is intentional (in the operational sense); 2) its elements signify (have sense) by connotation (through relations to each other); 3) it contains an instrumental representation of (some aspects of) the world and 4) it is self-referential i.e. recurrently directed on itself (its own reproduction or representation, respectively). Thus life and self-consciousness have deep, formal, structural similarities when viewed abstractly. The cybernetic definition/model of an individual is also referred to societies/states, companies and other systems. It is postulated that this definition/model is a universal one and can be applied to all possible systems/objects existing in the Universe or constructed in the future by humans.
IUPAC Periodic Table Quantum Mechanics Consistent  [PDF]
Bernard Schaeffer
Journal of Modern Physics (JMP) , 2014, DOI: 10.4236/jmp.2014.53020

Most periodic tables of the chemical elements are between 96% and 100% in accord with quantum mechanics. Three elements only do not fit correctly into the official tables, in disagreement with the spherical harmonics and the Pauli exclusion principle. Helium, belonging to the s-block, should be placed beside hydrogen in the s-block instead of the p-block. Lutetium and lawrencium belonging to the d-block of the transition metals should not be in the f-block of the lanthanides or the actinoids. With these slight modifications, the IUPAC table becomes quantum mechanics consistent.

Assessing the quality of the management skills required for lower respiratory tract infections in Kilimanjaro, Tanzania  [PDF]
Bernard Mbwele
Health (Health) , 2014, DOI: 10.4236/health.2014.61004
Abstract: Background: Lower respiratory tract infections (LRTI) are among the leading causes of morbidity and mortality. A severe form of atypical pneumonia, Q fever, has been found in Northern Tanzania. Assessment of the quality of health care for lower respiratory tract infection from the clinicians’ performance has rarely been performed. Methods: A cross sectional descriptive study using the qualitative and quantitative approaches for assessing clinicians and patient files from 11 health facilities of Kilimanjaro region. The facilities were of 4 different levels of public health care delivery and 1 private independent hospital. Results: Medications for LRTI were highly variable in 346 files and from attempts of treatment reported in 53 clinician’s interviews. No file showed attempts for assessing the severity of Pneumonia. Only 6 (11.1%) clinicians could mention causes of atypical pneumonia. Only 7 clinicians (13.0%) were aware of Q-fever and could mention the cause. The quality of clinical records for monitoring the progress was not the same in all levels of care and the difference in availability was statistically significant as level of mental state χ2 (4) = 139.4; P value < 0.001, blood pressure χ2 (8) = 75.2; P value < 0.001, temperature χ2 (4) = 78.7; P value < 0.001, pulse rate χ2 (4) = 139.1; P value < 0.001, respiratory rate χ2 (4) = 197.7; P value < 0.001, auscultation χ2 (4) = 92.2; P value < 0.001. Conclusion: National guidelines for LRTI in Tanzania shall include severity assessments and how to rule out atypical pneumonia using evidence base approaches.
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