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Search Results: 1 - 10 of 1112 matches for " Benito Morentin "
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A forensic pathology approach to sudden death in children and young adults in Biscay and Seville (Spain)
Benito Morentin,Beatriz Aguilera,Ma Paz Suárez-Mier,Pilar Molina
Medwave , 2012,
Abstract: Sudden death (SD) in children and young adults is a complex multifactorial problem that entails medical forensic and socio-familial implications. Forensic pathology plays an important role in these cases due to the fact that they tend to occur unexpectedly, and therefore a postmortem examination is needed to determine cause and mechanism of death. Most of these deaths are of cardiovascular origin and many of them have a hereditary component. The autopsy may be the only way to establish the correct diagnosis of the underlying condition enabling the family to receive proper medical counseling, to identify asymptomatic relatives at risk, and to prevent subsequent deaths. A proper approach requires the collaboration of various medical specialties (coroners, pathologists, pediatricians, cardiologists, microbiologists, geneticians), who must work in coordination in accordance to international protocols. In this article, the epidemiologic and clinical-pathological features of the main conditions that may lead to SD in children and young adults are reviewed and a case series from Seville and Biscay provinces is presented. Finally, the importance of forensic pathology in the management and prevention of these cases is underlined.
Alcohol-Related Brain Damage in Humans
Amaia M. Erdozain, Benito Morentin, Lynn Bedford, Emma King, David Tooth, Charlotte Brewer, Declan Wayne, Laura Johnson, Henry K. Gerdes, Peter Wigmore, Luis F. Callado, Wayne G. Carter
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0093586
Abstract: Chronic excessive alcohol intoxications evoke cumulative damage to tissues and organs. We examined prefrontal cortex (Brodmann’s area (BA) 9) from 20 human alcoholics and 20 age, gender, and postmortem delay matched control subjects. H & E staining and light microscopy of prefrontal cortex tissue revealed a reduction in the levels of cytoskeleton surrounding the nuclei of cortical and subcortical neurons, and a disruption of subcortical neuron patterning in alcoholic subjects. BA 9 tissue homogenisation and one dimensional polyacrylamide gel electrophoresis (PAGE) proteomics of cytosolic proteins identified dramatic reductions in the protein levels of spectrin β II, and α- and β-tubulins in alcoholics, and these were validated and quantitated by Western blotting. We detected a significant increase in α-tubulin acetylation in alcoholics, a non-significant increase in isoaspartate protein damage, but a significant increase in protein isoaspartyl methyltransferase protein levels, the enzyme that triggers isoaspartate damage repair in vivo. There was also a significant reduction in proteasome activity in alcoholics. One dimensional PAGE of membrane-enriched fractions detected a reduction in β-spectrin protein levels, and a significant increase in transmembranous α3 (catalytic) subunit of the Na+,K+-ATPase in alcoholic subjects. However, control subjects retained stable oligomeric forms of α-subunit that were diminished in alcoholics. In alcoholics, significant loss of cytosolic α- and β-tubulins were also seen in caudate nucleus, hippocampus and cerebellum, but to different levels, indicative of brain regional susceptibility to alcohol-related damage. Collectively, these protein changes provide a molecular basis for some of the neuronal and behavioural abnormalities attributed to alcoholics.
La(s) semiótica(s) de la imagen visual
Magari?os De Morentin,Juan;
Cuadernos de la Facultad de Humanidades y Ciencias Sociales. Universidad Nacional de Jujuy , 2001,
Abstract: most problems that affect the semiotic study of the visual images is originated with the pretension of giving an account of its variety from a unique point of view. however, the different mental operating that are required to identify them, recognize and interpret them, being them, perceptual, visual or mainly qualitative, figurative, or normative propositions, as it habitually is, that integrate in different propositions these three aspects, demand a specific treatment for each case. in this sense, without being subject to a dogmatic exegesis, this paper explores, from peirce triad: iconic qualisings, iconic sinsigns, and iconic legisings, and of the contemporary cognitive research, specially d. marr′s vision theory, the differencial, and necessary fundaments for a rigorous study of the construction of meaning theory of these a three great sets of material images.
La producción de conocimiento en la universidad de la calle (Un proyecto de investigación)
Magari?os de Morentin,Juan;
Cuadernos de la Facultad de Humanidades y Ciencias Sociales. Universidad Nacional de Jujuy , 2010,
Abstract: in this paper i will pose the university of the street question as the object of knowledge of a research work into the field of the social sciences. its development and proper achievement require to applying a semiotic methodology. the study of this phenomenon and the explanation of its pedagogical efficacy need analytical and critical operations to be derived from the possible development of a specific indexical semiotics, just as it can be taken (avoiding to be cloistered in a dogmatic derivation) from ch. s. peirce′s proposal concerning the indexical sign′s treatment (ch. s. peirce, 1913/1965, paragraph 2.283 and following). the aim of this research will be to collect the pertaining information, which will consist mainly of: (nota 1) the descriptive enunciation of a set of experience generating behaviors; (nota 2) the generalized enunciation of acquired experiential knowledge. this will permit the identification, out of the formal and informal pedagogical processes, of the effective existence of concrete learning situations that have fundamental importance in the achievement of the goals concerning social improvement and even survival.
Mortalidad por hipertermia en Bizkaia durante la ola de calor del verano de 2003: experiencia forense
Morentin,B.; Biritxinaga,B.; Peci?a,T.;
Cuadernos de Medicina Forense , 2004, DOI: 10.4321/S1135-76062004000200002
Abstract: during severe heat waves, like that experienced in the summer of 2003 in southern europe, mortality can increase sharply, sometimes even acquiring epidemic proportions. according to the provisional official reports in the basque country there were 3 deaths by heatstroke. in this article we describe the experience of the forensic pathologhy departament of bizkaia during the heat wave last summer- autopsy reports were reviewed. two deaths were due to heat stroke (fatal hyperthermia), but neither of them had been included in the provisional official reports. both cases were adult males with known risk factors: in the first one alcoholic liver disease and acute alcohol intoxication; and in the second one hypertensive cardiopathy and possible overexertion. in both cases there were external thermic injuries and rectal temperature was > 41oc. the histological findings were nonspecific. in the first case vitreous humor electrolyte analysis suggested dehydration. this article shows the importance of information about rectal and ambient temperature in the diagnosis of heat stroke, because autopsy findings are nonspecific. the definitive diagnosis requires a valoration of all the information: medical, pathological and laboratory data, as well as facts of the circumstances of the death. this, also, proves the convenience of fluid information from forensic systems to health departments, in charge of the epidemiolgy and prevention of heat stroke in alarm situations.
Mortalidad por hipertermia en Bizkaia durante la ola de calor del verano de 2003: experiencia forense Heat-related mortality in Bizkaia during the Summer 2003 heat wave: Forensic experience
B. Morentin,B. Biritxinaga,T. Peci?a
Cuadernos de Medicina Forense , 2004,
Abstract: Durante las olas de calor la mortalidad puede incrementar marcadamente, a veces hasta alcanzar proporciones epidémicas, como ha ocurrido en Francia este verano. Según las estadísticas oficiales provisionales en el País Vasco hubo 3 casos de muerte por golpe de calor. Describimos 2 casos de muerte por golpe de calor (hipertermia) diagnosticas en el Departamento de Patología Forense de Bizkaia ocurridas durante la ola de calor que azotó a Europa el pasado verano. Ninguna de ellas fue incluida en las estadísticas oficiales provisionales. Se trataba de 2 varones adultos con factores de riesgo: alcoholismo e intoxicación alcohólica en uno y cardiopatía y posible sobreejercicio en el otro. Se describen los resultados de la autopsia que mostraron quemaduras térmicas de 2o grado y hallazgos histopatológicos inespecíficos. El estudio bioquímico de humor vítreo mostró un patrón de deshidratación en uno de ellos. La temperatura rectal fue de 41o C en uno y de 43o C en el otro. Este trabajo demuestra la importancia de la toma de la temperatura rectal y ambiente en situaciones de posible muerte por golpe de calor. El diagnóstico final requiere una valoración integrada de todos los datos circunstanciales, médicos, patológicos y de laboratorio. También subraya la conveniencia de un flujo rápido de la información desde el sistema forense al sistema sanitario encargado de la epidemiología y prevención del golpe de calor en situaciones de alarma. During severe heat waves, like that experienced in the summer of 2003 in southern Europe, mortality can increase sharply, sometimes even acquiring epidemic proportions. According to the provisional official reports in the Basque Country there were 3 deaths by heatstroke. In this article we describe the experience of the Forensic Pathologhy Departament of Bizkaia during the heat wave last summer- Autopsy reports were reviewed. Two deaths were due to heat stroke (fatal hyperthermia), but neither of them had been included in the provisional official reports. Both cases were adult males with known risk factors: in the first one alcoholic liver disease and acute alcohol intoxication; and in the second one hypertensive cardiopathy and possible overexertion. In both cases there were external thermic injuries and rectal temperature was > 41oC. The histological findings were nonspecific. In the first case vitreous humor electrolyte analysis suggested dehydration. This article shows the importance of information about rectal and ambient temperature in the diagnosis of heat stroke, because autopsy findings are nonspecific. The definitive d
A General Criterion of Choice, with Discussion of Borch Paradox  [PDF]
Benito V. Frosini
Theoretical Economics Letters (TEL) , 2014, DOI: 10.4236/tel.2014.48087
Abstract: The author resumes a proposal by Frosini of a criterion of choice between probability prospects, which realizes a suggestion by Allais of taking account, beside the expected utility of the dispersion or variability of utilities. The suggested criterion is unidimensional, and is increasing with expected utility, and decreasing, for most people, who are risk averse, with the absolute deviation of utilities; a parameter multiplying this dispersion measure allows for risk-averse or risk-prone behaviour, according to its sign, and also for more or less departure from a certain prospect. This composite criterion shares practically all desirable conditions of rationality, and allows explaining all popular paradoxes in the literature about utility theory. Then the author deals with an apparent, but really false paradox, raised by Borch in connection with the representation of probability prospects in a Markowitz-type plot. This kind of analysis is modified from the traditional reference to points of type (mean, standard deviation) to the reference which replaces the standard deviation with the mean absolute deviation; no essential change is involved. The paper closes with some numerical examples which show the correctness of the suggested criterion, as compared to unaccettable conclusions of the expected utility approach.
“Mens Sana In Corpore Sano”: Exercise and Hypothalamic ER Stress
Pablo Blanco Martínez de Morentin,Miguel López
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.1000464
Abstract:
Protocolo de actuación forense ante la sospecha de meningitis bacteriana y shock séptico fulminante
Fernández-Rodríguez,A.; Morentin Campillo,B.;
Cuadernos de Medicina Forense , 2004, DOI: 10.4321/S1135-76062004000300003
Abstract: one of the main duties of medical-legal institutions is to collaborate with authorities to recognise and prevent risks to public health. one such risk is meningoceal infection, wich can progress rapidly and fataly, causing sudden death. in such cases, it is urgent to identify "neisseria meningitidis" urgently in order to assure the appropiate treatment of people who have come into contact. this agent is a leading cause of bacterial meningitis and septicemia in children and young adults. due to the rapid development of such infections, ante-mortem cultures sometimes are not taken, making the forensic diagnosis essential. although post-mortem findings are often typical of the waterhouse-friderichsen syndrome, they may sometimes be overlooked or caused by other organisms. for these reasons, a microbiological forensic diagnosis is crucial. this article presents a forensic procedure to diagnose the etiology of fulminant bacterial meningitis or septic shock. the aseptic sampling should include blood, sera, lcr, pleural effusions, urine and fresh tissues. these samples can be submitted to the instituto nacional de toxicología y ciencias forenses for their early analyses. antigenic tests are performed as screening techniques, and real-time pcr assays are also done to detect meningococcus and identify its serogroup. the results of these analyses are reported in 3 hours. bacterial cultures are also performed. additional pcr may be performed to diagnose other fragile bacteria that are difficult to recover post-mortem. the collaboration within all legal institutions and between those and health authorities is essential to best deal with this issue.
Protocolo de actuación forense ante la sospecha de meningitis bacteriana y shock séptico fulminante Protocol for the forensic action with regard to the suspicion of bacterial meningitis and fulminant septicemia
A. Fernández-Rodríguez,B. Morentin Campillo
Cuadernos de Medicina Forense , 2004,
Abstract: Una importante tarea de las instituciones médico-legales es la colaboración con las autoridades sanitarias en la prevención de riesgos para la salud pública. Uno de ellos es la infección meningocócica, que puede cursar rápidamente y con evolución fatal, causando muerte súbita. Neisseria meningitidis es la principal causa de meningitis bacteriana y septicemia en ni os y adultos jóvenes. Su temprana detección es de extrema urgencia, ya que permite el adecuado tratamiento de los contactos. El rápido desarrollo de estas infecciones imposibilita en ocasiones el diagnóstico antemortem, resultando imprescindible el diagnóstico forense. Aunque los hallazgos postmortem suelen ser los del síndrome de Waterhouse-Friderichsen, estos, a veces, pueden pasar desapercibidos, o estar causados por otras bacterias. Todo ello hace necesario un diagnóstico microbiológico forense. Este artículo presenta un protocolo forense de actuación ante la sospecha de meningitis bacteriana y shock séptico fulminante. La toma de muestras para microbiología debe ser aséptica e incluir sangre, suero, LCR, líquido pleural, tejidos en fresco y orina. Estas muestras pueden remitirse al Instituto Nacional de Toxicología y Ciencias Forenses, donde se realizarán análisis específicos, que incluyen un screening antigénico y un diagnóstico de confirmación mediante PCR a tiempo real que identifica meningococo y su serogrupo. Los resultados de estas técnicas son informados 3 horas tras el inicio del análisis. También se realiza el cultivo bacteriano y PCR adicionales para detectar otras bacterias difíciles de aislar postmortem. La colaboración entre las distintas instituciones médico-legales y entre estas y las autoridades sanitarias es esencial para el adecuado manejo de estas graves infecciones. One of the main duties of medical-legal institutions is to collaborate with authorities to recognise and prevent risks to public health. One such risk is meningoceal infection, wich can progress rapidly and fataly, causing sudden death. In such cases, it is urgent to identify "Neisseria meningitidis" urgently in order to assure the appropiate treatment of people who have come into contact. This agent is a leading cause of bacterial meningitis and septicemia in children and young adults. Due to the rapid development of such infections, ante-mortem cultures sometimes are not taken, making the forensic diagnosis essential. Although post-mortem findings are often typical of the Waterhouse-Friderichsen syndrome, they may sometimes be overlooked or caused by other organisms. For these reasons, a microbiological f
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