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Search Results: 1 - 10 of 8883 matches for " Ben Adida "
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GenePING: secure, scalable management of personal genomic data
Ben Adida, Isaac S Kohane
BMC Genomics , 2006, DOI: 10.1186/1471-2164-7-93
Abstract: We present the design and implementation of GenePING, an extension to the PING personal health record system that supports secure storage of large, genome-sized datasets, as well as efficient sharing and retrieval of individual datapoints (e.g. SNPs, rare mutations, gene expression levels). Even with full access to the raw GenePING storage, an attacker cannot discover any stored genomic datapoint on any single patient. Given a large-enough number of patient records, an attacker cannot discover which data corresponds to which patient, or even the size of a given patient's record. The computational overhead of GenePING's security features is a small constant, making the system usable, even in emergency care, on today's hardware.GenePING is the first personal health record management system to support the efficient and secure storage and sharing of large genomic datasets. GenePING is available online at http://ping.chip.org/genepinghtml webcite, licensed under the LGPL.Genomic data are becoming a routine component of clinical diagnosis and treatment. Prospective parents with familial or ethnic history of genetic disease have long been encouraged to undergo genetic counseling, including genotyping for disease alleles such as Tay-Sachs and Cystic Fibrosis [1,2]. Recent research [3], demonstrating that several treatment responses are conditional on genomic profile, promises to usher in the long-awaited era of personalized medicine, all based on the patient's gene sequence or gene expression signature.Clinically pertinent genomic data extends far beyond the patient's somatic genome sequence. Advanced cancer treatment options include genetic testing of cancer cells for specific markers, e.g. estrogen receptors in breast cancer or the Philadelphia chromosome in CML [4]. This type of diagnostic will likely expand into full genomic profiling of cancer cells to help determine appropriate treatment [5]. In addition, much recent literature has uncovered correlations between gene
Correction: What Are the Benefits and Risks of Fitting Patients with Radiofrequency Identification Devices?
Mark Levine,Ben Adida,Kenneth Mandl,Isaac Kohane,John Halamka
PLOS Medicine , 2008, DOI: 10.1371/journal.pmed.0050036
What Are the Benefits and Risks of Fitting Patients with Radiofrequency Identification Devices?
Mark Levine,Ben Adida,Kenneth Mandl,Isaac Kohane,John Halamka
PLOS Medicine , 2007, DOI: 10.1371/journal.pmed.0040322
Abstract: Background to the Debate In 2004, the United States Food and Drug Administration approved a radiofrequency identification (RFID) device that is implanted under the skin of the upper arm of patients and that stores the patient's medical identifier. When a scanner is passed over the device, the identifier is displayed on the screen of an RFID reader. An authorized health professional can then use the identifier to access the patient's clinical information, which is stored in a separate, secure database. Such RFID devices may have many medical benefits—such as expediting identification of patients and retrieval of their medical records. But critics of the technology have raised several concerns, including the risk of the patient's identifying information being used for nonmedical purposes.
Sharing Data for Public Health Research by Members of an International Online Diabetes Social Network
Elissa R. Weitzman,Ben Adida,Skyler Kelemen,Kenneth D. Mandl
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0019256
Abstract: Surveillance and response to diabetes may be accelerated through engaging online diabetes social networks (SNs) in consented research. We tested the willingness of an online diabetes community to share data for public health research by providing members with a privacy-preserving social networking software application for rapid temporal-geographic surveillance of glycemic control.
R2: Information or Noise? Textual Analysis Based on SSE E-Interaction  [PDF]
Ben Wang
Open Journal of Business and Management (OJBM) , 2019, DOI: 10.4236/ojbm.2019.72054
Abstract: The question whether R2 represents information or noise is still a fundamental question in the study of stock price synchronicity. There are two main difficulties. Firstly, the trait information of a company is hard to measure; Secondly, the investors’ sophistication is ignored when we discuss the effectiveness of market. Through the study of Chinese SSE E-interaction platform and the measurement by textual analysis method, this article argues that the improvement of investors’ sophistication has negative association with stock price synchronicity. This result is more salient in companies with lower opacity or with higher corporate governance. This paper contributes to the deepen understanding of stock price synchronicity and new method of measuring trait information of companies.
Using Labor Market Stocks to Identify Labor Market Flow Nissim Ben David  [PDF]
Ben-David Nissim
Modern Economy (ME) , 2011, DOI: 10.4236/me.2011.22021
Abstract: A technique that permits the calculation of the flow of agents between and within labor market states is pre-sented. A statistical agency having collected data on those flows easiest to collect and together with data on employment, unemployment and being out of the labor force, will be able to calculate the rest of the flows. The contribution of this paper is in suggesting an easy process which overcomes the difficulties statistical agencies usually have in collecting flow data.
The Rise and Fall of the Hydrophobic Effect in Protein Folding and Protein-Protein Association, and Molecular Recognition  [PDF]
Arieh Ben-Naim
Open Journal of Biophysics (OJBIPHY) , 2011, DOI: 10.4236/ojbiphy.2011.11001
Abstract: In the beginning everything was explained in Biochemistry in terms of hydrogen-bonds (HB). Then, the devastating blow, known as the HB-inventory argument came; hydrogen bonding with water molecules compete with intramolecular hydrogen-bonds. As a result, the HBs paradigm fell from grace. The void created was immediately filled by Kauzmann’s idea of hydrophobic (HφO) effect which reigned supreme in biochemical literature for over 50 years (1960-2010). Cracks in the HB-inventory argument on one hand, and doubts about the adequacy of Kauzmann’s model for the HφO effect, have led to a comeback of the HBs, along with a host of new hydrophilic (HφI) effects. The HφO effects lost much of its power - which it never really had - in explaining protein folding and protein-protein association. Instead, the more powerful and richer repertoire of HφI effects took over the reins. The interactions also offered simple and straightforward answers to the problems of protein folding, and protein-protein association.
Some No Longer Unknowns in Science  [PDF]
Arieh Ben-Naim
Open Journal of Biophysics (OJBIPHY) , 2012, DOI: 10.4236/ojbiphy.2012.21001
Abstract: Three out of 125 “big questions of science”, can now be claimed to have been answered. All of these questions involve water; its structure, its role in protein folding and its role in protein-protein association.
Experimentation of a Plane Solar Integrated Collector Storage Water Heater  [PDF]
Romdhane Ben Slama
Energy and Power Engineering (EPE) , 2012, DOI: 10.4236/epe.2012.42010
Abstract: In order to popularize the use of the solar-water heaters, especially in the residential and tertiary sectors with the third world, it appears to be necessary to reduce their cost while improving their performances. It is the object of this integrated storage collector thus created and tested in the south of Tunisia. It is simply made up of a tank playing the double part of solar absorber and storage tank of warm water, of a glazing to profit from the greenhouse effect and of an insulating case. Its measured energy performances, by the method of input-output proves its effectiveness to produce hot water, in spite of its simplicity of manufacture, usage and maintenance. Indeed a temperature of water exceeding 70?C is reached towards the afternoon True Solar Time, and for an efficiency of 7%. Thus, this type of collector with integrated storage is entirely satisfactory and could be available to larger mass.
Levinthal’s Paradox Revisited, and Dismissed  [PDF]
Arieh Ben-Naim
Open Journal of Biophysics (OJBIPHY) , 2012, DOI: 10.4236/ojbiphy.2012.22004
Abstract: This article is concerned with the so-called Levinthal’s paradox. It will be argued that many have sought a “solution” to Levinthal’s paradox, where in fact, the “solution” already appeared in Levinthal’s original articles. Most of the subsequent suggested “solutions” were inadequate solutions to a non-paradox. It is shown that the discovery of strong hydrophilic forces not only dismisses the Levintal paradox, but also provides a solution to the general problem of protein folding. A simple model based on the Markov process is presented to demonstrate how a strong biased-force can dramatically reduce the number of steps required to reach the stable native 3-D structure of the protein.
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