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OALib Journal期刊

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Effect of method of preparation on pioglitazone HCl-β-cyclodextrin inclusion complexes
Beloshe Shrikant,Chougule Dhanyakumar,Shah Rohit,Ghodke Dhananjay
Asian Journal of Pharmaceutics , 2010,
Abstract: Pioglitazone HCl is an antidiabetic agent with poor aqueous solubility. Inclusion complexes of pioglitazone HCl were prepared with β-cyclodextrin using various methods (physical mixing, kneading method, co-precipitation). The main aim of the present invention is to study the effect of the method of preparation on the dissolution profiles of pioglitazone HCl-β-Cyclodextrin inclusion complexes . The phase solubility profile of pioglitazone HCl with β-cyclodextrin was classified as AL-type and stability constant with 1:1 molar ratio was 115.45, calculated from the phase solubility diagram. Formation of the inclusion complex between pioglitazone HCl and β-cyclodextrin was confirmed by the Fourier Transform Infrared (FT-IR) spectroscopy. The dissolution profile of inclusion complexes were determined and compared with those of pioglitazone HCl alone and its physical mixtures. The dissolution rate of the pioglitazone HCl-β-cyclodextrin inclusion complex prepared by the co-precipitation method was six times higher when compared with the pure drug. The method of complexation of pioglitazone HCl in β-CD increased the dissolution rate of the drug in the following order: Coppt > KM > PM >Drug.
THE EFFECT OF SELECTED PLYOMETRIC EXERCISES ON EXPLOSIVE POWER
SABNIS SEEMA SHRIKANT
Golden Research Thoughts , 2013, DOI: 10.9780/22315063
Abstract: Human Being have consistently tried to run faster, jump higher and exhibit greater strength endurance and skill. We are naturally competitive and ambitious for excellence in athletic performances.By exercising regularly the muscles of the vital organs functioning is also get effected. Muscular Strength could be developed by systematic exercises on explosive power. Training represents a long-term Endeavour's. Athletes are not developed over night and coach cannot create miracle by cutting corners through over looking scientific and methodical theories.
Role of Multi Agent System for Qos Guarantee in Cellular Networks
Nupur Giri,Shrikant Bodhe
International Journal of Distributed and Parallel Systems , 2012,
Abstract: The paper highlights the benefits of Multi Agent System for maintaining QoS in cellular network by evaluating various multi agent based call admission control strategies for different traffic conditions. It establishes the effect of degree of distribution of agents on system performance by comparing the two service architectures, namely centralized and distributed, for reactivity, responsiveness, utilization of resources, communication overhead, sustainability, scalability, robustness and modifiability. It also establishes the relationship between the social attitude of an agent towards the other agents and fairness of resource distribution in distributed architecture. This evaluation helps in building knowledge for choosing the optimal multi agent based call admission and channel borrowing schemes, along with the most suitable service architecture for the required QoS and traffic conditions.
PERFORMANCE OF DCT BASED OFDM COMMUNICATION SYSTEM WORKING IN 60 GHz BAND
ACHALA DESHMUKH,SHRIKANT BODHE
International Journal of Engineering Science and Technology , 2012,
Abstract: The 60 GHz band is of much interest since this is the band in which a massive amount of spectral space (5 GHz) has been allocated unlicensed worldwide for dense wireless local communications. Orthogonal frequency division multiplexing (OFDM) has gained much popularity in the field of wireless communication because of its ability to transfer the data at higher rate, high bandwidth efficiency and its robustness with regard to multipath and delay.In this paper we consider a discrete cosine transform (DCT)-based OFDM system for calculating bit error rate with additive white Gaussian noise (AWGN) channel and Saleh-Valenzuela (SV) channel model at 60 GHz. The BER is calculated for signaling formats BPSK and the performance of DCT based OFDM is analyzed at 60 GHz. The results indicate that DCT-OFDM performs better than FFT-OFDM system with AWGN channel. DCT based OFDM system outshines FFT based OFDM scheme at 60GHz.
Performance Evaluation of Constant Envelope OFDM working in 60 GHz Band
Achala Deshmukh,Shrikant Bodhe
International Journal of Engineering and Technology , 2012,
Abstract: The 60 GHz band is of much interest since this is the band in which a massive amount of spectral space (5 GHz) has been allocated unlicensed worldwide for dense wireless local communications.OFDM has gained much popularity in the field of wireless communication because of its ability to transfer the data at higher rate, high bandwidth efficiency and its robustness with regard to multipath and delay. But the major hurdle is high PAPR leading to inter-modulation distortion and out-of-band spectral growth. Constant envelope OFDM transforms the OFDM signal, to a signal with nearly zero dB PAPR. The PAPR performance of conventional OFDM system improves with constant envelope OFDM system. CE OFDM scheme provides PAPR to 0 dB; this paper analyzes the performance of CE OFDM ongrounds of BER. A constant envelope OFDM system is considered for calculating bit error rate with additive white Gaussian noise (AWGN) channel and Saleh-Valenzuela (SV) channel model at 60 GHz. The BER is calculated for signalling format BPSK and the performance of CE OFDM is analyzed at 60 GHz
Assuring Sustainable Economic Benefit for Farmers by Using Ground Water in Semi-Arid, Hard Rock Areas in India & the Role of UNESCO-IUGS-IGCP Project 523 GROWNET
Shrikant Daji Limaye
Iranian Journal of Earth Sciences , 2012,
Abstract: Out of about 1.2 billion people in India, 68% people live on agriculture as their main occupation. Ground water is therefore an important resource which provides over 70% of rural drinking water supply and about 50% of water used for irrigation. Rains in Monsoon season from June to September, provide the main source of water but they last only for four months and the rest of the year is dry in most of the hard rock region. About 67% of India is occupied by hard rock terrain and about 30% of the hard rock area falls within semi-arid, drought-prone zone receiving less than 500 mm rainfall per year. In semi-arid, hard rock terrain in India and in many other low-income countries, the surface water resources are scarce and polluted. Ground water occurs in this area in the shallow weathered zone up to about 15 meters depth and in the deeper fractures and fissures up to about 100 m depth. Bore wells reaching up to 60 to 100 meters depth, installed with hand-pumps, are very common for providing safe drinking water supply to villages. This causes a positive improvement in the health of villagers and an economic advantage by reducing the number of working days lost due to illness. Agricultural production in these semi-arid areas is just marginal because the rain-fed crops suffer from the vagaries of Monsoon rains. The average farm-size per family of 5 persons is about 2 Ha. There are 3 to 5 drought years within a span of 10 years, which leave the dry-land farmer in perpetual poverty. In the past 3 years, over 4,200 farmers have committed suicide due to continued crop failures. Ground water, therefore, forms a very important and reliable resource which, if available in a farmer s plot of land and if utilized prudently for irrigation by digging or drilling a well, could transform the farmers lifestyle. Even if the farmers are able to save one rainy season (Monsoon) crop through protective irrigation from dug well, and if possible take winter and summer crops on small plots, they would stabilize in the rural scenario. Otherwise, the farmers would migrate to nearby cities and stay in slums. Many cities in India and other low-income countries are suffering from an ever-increasing flux of rural population thereby chocking and polluting the urban environment and putting stress on urban infrastructure. Ground water development for irrigation is the lifeline for rural economy. However, in many watersheds in semi-arid, hard rock areas, the pumping of ground water is increasing and in some watersheds it is more than the recharge available from rainfall. In these over-exploit
Observing geoethics in mining and in ground-water development: An Indian experience
Shrikant Daji Limaye
Annals of Geophysics , 2012, DOI: 10.4401/ag-5573
Abstract: Two famous quotes from ‘Mahatma Gandhi’, the Indian philosopher, are helpful in describing the foundation of geoethics: (a) “God has provided enough resources for everyone’s need but not for everyone’s greed” and (b) “Before starting a development project, first think about the effects which the project would have on the poorest of the poor people in the Society”. Geoethics is relatively a new branch in geosciences. It lies at the meeting point of geosciences, sociology and philosophy. Much earlier in the history of sciences such as nuclear physics, biology or chemistry, ethical principles attracted the attention of social leaders and philosophers while using laboratory research for field trials and applications on a large scale. Using the research not for atomic bombs but for atomic energy and not for chemical weapons but for chemical products and drugs was the priority of social leaders. In Italy, geoethics originated with philosophers and later on got the support from geologist. In other countries geoscientists working primarily in mining industry promoted geoethics for ensuring socially responsible behavior on the part of mining companies.
The effect of curcumin (turmeric) on Alzheimer′s disease: An overview
Mishra Shrikant,Palanivelu Kalpana
Annals of Indian Academy of Neurology , 2008,
Abstract: This paper discusses the effects of curcumin on patients with Alzheimer′s disease (AD). Curcumin (Turmeric), an ancient Indian herb used in curry powder, has been extensively studied in modern medicine and Indian systems of medicine for the treatment of various medical conditions, including cystic fibrosis, haemorrhoids, gastric ulcer, colon cancer, breast cancer, atherosclerosis, liver diseases and arthritis. It has been used in various types of treatments for dementia and traumatic brain injury. Curcumin also has a potential role in the prevention and treatment of AD. Curcumin as an antioxidant, anti-inflammatory and lipophilic action improves the cognitive functions in patients with AD. A growing body of evidence indicates that oxidative stress, free radicals, beta amyloid, cerebral deregulation caused by bio-metal toxicity and abnormal inflammatory reactions contribute to the key event in Alzheimer′s disease pathology. Due to various effects of curcumin, such as decreased Beta-amyloid plaques, delayed degradation of neurons, metal-chelation, anti-inflammatory, antioxidant and decreased microglia formation, the overall memory in patients with AD has improved. This paper reviews the various mechanisms of actions of curcumin in AD and pathology.
Boerhavia Erecta Linn. Stem Bark Extract A Natural Acid-Base Indicato
Shrikant Shivaji kavitake
Asian Journal of Biomedical and Pharmaceutical Sciences , 2013,
Abstract: Synthetic indicators have been tried as indicators in acid-base titrations but due to environmental pollution, availability and cost, natural compounds are best alternate. Natural pigments in plants are highly colored substances and may show sharp color changes with variation in pH .An attempt has been made to extract natural indicator by maceration from stem bark of Boerhavia erecta Linn. The equivalence points obtained by the BEI strong acid-strong base, strong acid-weak base, weak acid-strong base and weak acid weak base titrations were coincident with the equivalence points obtained by synthetic indicators. Thus natural indicator was found to be eco-friendly, economical, simple and accurate for all acid-base titrations. Phytochemical analysis and spectral studies confirmed presence of anthocyanins and flavonoids in BEI responsible for accurate and sharp colour change at equivalence point. The present study reports the use of this natural indicator in different acid base titrations.
EVALUATION OF JASMINUM GRANDIFLORUM FOR HEPATOPROTECTIVE ACTIVITY IN ISONIAZID INDUCED LIVER DAMAGE
Shrikant Pawar et al
International Journal of Pharmaceutical Sciences and Research , 2012,
Abstract: Objectives: The study was designed to evaluate hepatoprotective effect of the ethanolic leaves extract of Jasminum grandiflorum (JG) in Isoniazid (INH) induced hepatotoxicity in wistar albino rats. Materials and methods: Mature leaves of JG were collected, authenticated and subjected to successive ethanolic extraction. Hepatic damage was induced in wistar rats by administering INH (54mg/kg, p.o.) once a daily for 30 days followed by administration of JG (200mg/kg, p.o.) 1h.prior to the administration of INH (54mg/kg, p.o.) once daily. Silymarin (50mg/kg. p. o) was used as standard for 30 days.Result: Elevated levels of Aspartate transaminase, Alanine transaminase, and Lipid profile following INH administration were significantly lowered by JG treatment. Deposition of collagen was observed in liver and found to be less in JG treated animals; Pretreatment of rats with JG significantly decreases Lipid peroxidation (LPO) and increases the antioxidant activities.Conclusion: The study reveals the hepatoprotective activity of leaves extract of JG in isoniazid induced liver damage.
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