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Search Results: 1 - 10 of 672 matches for " Belmiro Parada "
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Chemopreventive Efficacy of Atorvastatin against Nitrosamine-Induced Rat Bladder Cancer: Antioxidant, Anti-Proliferative and Anti-Inflammatory Properties
Belmiro Parada,Flávio Reis,?ngela Pinto,José Sereno,Maria Xavier-Cunha,Paula Neto,Petronila Rocha-Pereira,Alfredo Mota,Arnaldo Figueiredo,Frederico Teixeira
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms13078482
Abstract: To investigate the anti-carcinogenic effects of Atorvastatin (Atorva) on a rat bladder carcinogenesis model with N-butyl- N -(4-hydroxibutil)nitrosamine (BBN), four male Wistar rat groups were studied: (1) Control: vehicle; (2) Atorva: 3 mg/kg bw/day; (3) Carcinogen: BBN (0.05%); (4) Preventive Atorva: 3 mg/kg bw/day Atorva + BBN. A two phase protocol was used, in which the drug and the carcinogen were given between week 1 and 8 and tumor development or chemoprevention were expressed between week 9 and 20, when the bladders were collected for macroscopic, histological and immunohistochemical (p53, ki67, CD31) evaluation. Serum was assessed for markers of inflammation, proliferation and redox status. The incidence of bladder carcinoma was: control 0/8 (0%); Atorva 0/8 (0%); BBN 13/20 (65%) and Atorva + BBN 1/8 (12.5%). The number and volume of tumors were significantly lower in the Atorva + BBN group, with a marked reduction in hyperplasia, dysplasia and carcinoma in situ lesions. An anti-proliferative, anti-inflammatory and antioxidant profile was also observed in the preventive Atorva group. p53 and ki67 immunostaining were significantly increased in the BBN-treated rats, which was prevented in the Atorva + BBN group. No differences were found for CD31 expression. In conclusion, Atorvastatin had a clear inhibitory effect on bladder cancer development, probably due to its antioxidant, anti-proliferative and anti-inflammatory properties.
Inhibition of Bladder Tumor Growth by Chitooligosaccharides in an Experimental Carcinogenesis Model
Jo?o C. Fernandes,José Sereno,Patricia Garrido,Belmiro Parada,Maria F. X. Cunha,Flávio Reis,Manuela E. Pintado,Alice Santos-Silva
Marine Drugs , 2012, DOI: 10.3390/md10122661
Abstract: Urinary bladder cancer is one of the most common cancers worldwide, with the highest incidence in industrialized countries. Patients with cancer commonly use unconventional and complementary therapy including nutraceuticals. In this study we evaluated the efficacy of chitooligosaccharides (in orange juice) in rat bladder cancer chemoprevention and as therapeutic agent, on a rat model of urinary bladder carcinogenesis induced with N-butyl- N-(4-hydroxybutyl) nitrosamine. Results indicate that chitooligosaccharides may have a preventive effect on bladder cancer development and a curative effect upon established bladder tumors, dependent on the concentration ingested 500 mg/kg b.w., every three days, showed capacity to inhibit and prevent the proliferation of bladder cancer; however, this was associated with secondary effects such as hypercholesterolemia and hypertriglyceridemia. The use of lower doses (50 and 250 mg/kg b.w.) showed only therapeutic effects. It is further suggested that this antitumor effect might be due to its expected anti-inflammatory action, as well as by mechanisms not directly dependent of COX-2 inhibition, such as cellular proliferation control and improvement in antioxidant profile.
Preventive but Not Curative Efficacy of Celecoxib on Bladder Carcinogenesis in a Rat Model
José Sereno,Belmiro Parada,Flávio Reis,Fernanda X. Cunha,Edite Teixeira-Lemos,Patrícia Garrido,Rui Pinto,Petronila Rocha-Pereira,Paula Neto,José Ruivo,Paulo Rodrigues-Santos,Sara Nunes,Alfredo Mota,Arnaldo Figueiredo,Frederico Teixeira
Mediators of Inflammation , 2010, DOI: 10.1155/2010/380937
Abstract: To evaluate the effect of a cyclooxygenase 2 inhibitor, celecoxib (CEL), on bladder cancer inhibition in a rat model, when used as preventive versus as curative treatment. The study comprised 52 male Wistar rats, divided in 5 groups, during a 20-week protocol: control: vehicle, carcinogen: 0.05% of N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN), CEL: 10?mg/kg/day of the selective COX-2 inhibitor Celebrex, preventive CEL (CEL+BBN-P), and curative CEL (BBN+CEL-C) groups. Although tumor growth was markedly inhibited by the preventive application of CEL, it was even aggravated by the curative treatment. The incidence of gross bladder carcinoma was: control 0/8(0%), BBN 13/20(65%), CEL 0/8(0%), CEL+BBN-P 1/8(12.5%), and BBN+CEL-C 6/8(75%). The number and volume of carcinomas were significantly lower in the CEL+BBN-P versus BBN, accompanied by an ample reduction in hyperplasia, dysplasia, and papillary tumors as well as COX-2 immunostaining. In spite of the reduction of tumor volumes in the curative BBN+CEL-C group, tumor malignancy was augmented. An anti-inflammatory and antioxidant profile was encountered only in the group under preventive treatment. In conclusion, preventive, but not curative, celecoxib treatment promoted a striking inhibitory effect on bladder cancer development, reinforcing the potential role of chemopreventive strategies based on cyclooxygenase 2 inhibition. 1. Introduction Bladder cancer is a prevalent tumor, accounting for 5%–10% of all malignancies in Western countries [1, 2]. It has a high recurrence and progression rate and the prognosis, except for superficial forms, is poor [3]. Furthermore, it has high mortality rates and socioeconomic costs [4, 5]. The conventional surgical techniques and therapeutic options might cause discomfort to patients, especially in invasive and aggressive forms of cancer [6, 7]. Therefore, the improvement of bladder cancer management and treatment could rely on better preventive strategies. The identification of promising drugs remains dependent on a better elucidation of the molecular/cellular mechanisms underlying cancer appearance and progression [8, 9]. Apart from the genetic features and markers already characterized [10, 11], the cellular and molecular mechanisms for development and/or progression might involve inflammatory, proliferative, and oxidative stress phenomena that should be better elucidated. Inflammation through the cyclooxygenase (COX) pathway has been involved in cancer development [12]. While COX-1 is constitutively expressed in a huge range of tissues, playing a role in
Effects of Sitagliptin Treatment on Dysmetabolism, Inflammation, and Oxidative Stress in an Animal Model of Type 2 Diabetes (ZDF Rat)
Liliana Ferreira,Edite Teixeira-de-Lemos,Filipa Pinto,Belmiro Parada,Cristina Mega,Helena Vala,Rui Pinto,Patrícia Garrido,José Sereno,Rosa Fernandes,Paulo Santos,Isabel Velada,Andreia Melo,Sara Nunes,Frederico Teixeira,Flávio Reis
Mediators of Inflammation , 2010, DOI: 10.1155/2010/592760
Abstract: The purpose of this paper is to evaluate the chronic effect of sitagliptin on metabolic profile, inflammation, and redox status in the Zucker Diabetic Fatty (ZDF) rat, an animal model of obese type 2 diabetes. Diabetic and obese ZDF (fa/fa) rats and their controls (ZDF
O financiamento do ensino superior em Portugal: entre o Estado e o mercado
Cabrito, Belmiro Gil;
Educa??o & Sociedade , 2004, DOI: 10.1590/S0101-73302004000300016
Abstract: this paper discusses the new trends in the funding of higher education in portugal. as the state contributes less, it highlights the importance of the market and of funding diversification to guarantee higher education functioning. however, considering that 1) the students are already the main funding source of higher education, 2) more equality must be created and 3) the state desertion has negative consequences on the individuals, the institutions and the society, the author concludes that funding higher education is a matter of the state, even though these institutions may look for other funding sources.
A imagem e suas formas de visualidade nos livros didáticos de Português
Belmiro, Celia Abicalil;
Educa??o & Sociedade , 2000, DOI: 10.1590/S0101-73302000000300002
Abstract: the importance of studying the image and its use in the media, mainly in the media with pedagogical features, establishes, in the school environment, the need to cope with the overwhelming presence of visual image in people's everyday life. this paper intends to analyze and understand the different aspects of visuality in portuguese didactic books used in the last grades of junior high school (from 5thto 8th grade of the fundamental school in the brazilian school system), during the 60s, 70s and 90s. which role does school play, since it takes hold of the imagetical speech and submits it to the pedagogical speech? how have images been built by a speech that is specific to the school process, along the decades mentioned above? three theoretical approaches, namely image seen form the functional, semiotical and cognitive points of view, aim at the constructing a set of reflections, the core of which is the teaching-learning relationship.
Entre modos de ver e modos de ler, o dizer
Belmiro, Celia Abicalil;
Educa??o em Revista , 2012, DOI: 10.1590/S0102-46982012000400005
Abstract: in this article, we compare the iconic and verbal natures that permeate the visual and verbal languages in order to analyze the meanings of literary reading for children and reflect on teacher education. writing is perceived as a mixed structure supported by two registers - verbal and graphic, while image is considered as a picture and support set. the approaches concerning the relation between the iconic and verbal aspects are supported by studies on the literature and the fine arts, which provide ground for the building of two major axes of analysis: the paradox and the parallel. children literature books provide examples for this discussion, since they present a dynamic and flexible behavior in face of the different types of media.
A equidade no sistema universitário português: Da universalidade do discurso à contradi??o das práticas
Cabrito,Belmiro Gil;
Análise Psicológica , 1997,
Abstract: in this article, the author argues about the equitity of the portuguese university system, using for the discussion the social composition of the university students. with the informations he got thanks to an inquiry that he applied to a representative sample of the students from the public and the private universities, allover the country, the author characterized these students and he compared them with the university students of the 60ties and with the portuguese population of nowadays. from these compairaisons, the author concludes about the strongly degree of inequitity of the portuguese university system, regarding the importance of the high classes between its students, although the igualitarist intentions existing in the speeches of the politicians.
Avaliar a qualidade em educa??o: avaliar o quê? Avaliar como? Avaliar para quê?
Cabrito, Belmiro Gil;
Cadernos CEDES , 2009, DOI: 10.1590/S0101-32622009000200003
Abstract: speaking of quality in education certainly centres our discourse on a central issue of public education policies. however, we should recall that assessing quality is an economic concept imported into education and take epistemological precautions when it comes to our matter. if we give in to the measurement temptation, we tend to forget the specificity of the educational processes and facts, which are always unique and original and hardly fit in any framework aimed at measuring objectives, even when those are partly financial. after reflecting on the meanings of assessment in the current context, this paper argues that initiating an assessment process in education entails thinking critically about both the measurement process and its underlying aims. in fact, one has reasons to doubt that any assessment is benevolent since this seldom an innocent process usually originates competition, rivalry and discrimination, thus reproducing social exclusion and inequality.
A multimodalidade na literatura infantil e a forma??o de professores leitores
Belmiro, Celia Abicalil;
Revista Brasileira de Linguística Aplicada , 2010, DOI: 10.1590/S1984-63982010000200007
Abstract: this paper presents a part of the results of a doctorate research on the relations between images and verbal texts in infant literature books and their contribution to the education of teachers. different discursive resources were found in images and texts in infant literature books towards the construction of the narrative and descriptive dimensions. bakhtin's concept of style helps providing structure and unity to the enunciated production of the enunciator and indicates the result of a world vision. in the works here analyzed, the relation between image and verbal text presents two fundamental resources: the enunciation, as the power of the narrator in guiding the reading, and intertextuality, as a device to update the plot. this methodology allows the recovering of teachers' reading experiences and indicates the importance of multimodality aspects in the construction of teachers' reading ability.
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