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Search Results: 1 - 10 of 135236 matches for " Bei-han WANG "
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Epidemiological investigation of allergic rhinitis in servicemen of Chinese People’s Armed Police Force stationed at Urumqi
Hong-hong YUE,Xian-jie DONG,Xue-ping MA,Bei-han WANG
Medical Journal of Chinese People's Liberation Army , 2011,
Abstract: Objective To investigate the incidence and clinical features of allergic rhinitis in servicemen of Chinese People’s Armed Police Force stationed at Urumqi,Xinjiang Uygur Autonomous Region.Methods Of 2294 soldiers and officers stationed at Urumqi from Jul.to Aug.2010,2194 were enrolled as subjects of present study,and all of them completed the questionnaires.The incidence of allergic rhinitis was assessed by history analysis,skin fast prick and allergen-specific IgE assay.Results Two hundred and three cases were diagnosed as allergic rhinitis,the overall incidence was 9.3%.The incidence of allergic rhinitis was higher in officers(15.9%) than in soldiers(P < 0.05);seeds of Artemisia was the main allergen.Duration of service was positively correlated with the incidence of allergic rhinitis(r=0.8,P < 0.05).The incidence was also correlated with the place the servicemen stationed,showing a high to low tendency from suburbs(15.8%),forested area(7.9%) to urban area(5.7%,P < 0.05).The incidence was higher in servicemen from other regions(9.4%) than in soldiers of local origin(7.2%,P < 0.05),and was higher in Han nationality(10.5%) than in ethnic minorities(2.1%,P < 0.05).Conclusions The incidence of allergic rhinitis in servicemen of Chinese People’s Armed Police Force stationed at Urumqi is 9.3%,and and the incidence varies with the loeality they station.The severity of allergic rhinitis symptom is positively correlated with the duration of service in Urumqi.
Ex vivo development, expansion and in vivo analysis of a novel lineage of dendritic cells from hematopoietic stem cells
Han Shuhong,Wang Yichen,Wang Bei,Patel Ekta
Journal of Immune Based Therapies and Vaccines , 2010, DOI: 10.1186/1476-8518-8-8
Abstract: Dendritic cells (DCs) play a key role in innate and adaptive immunity but the access to sufficient amount of DCs for basic and translational research has been limited. We established a novel ex vivo system to develop and expand DCs from hematopoietic stem/progenitor cells (HPCs). Both human and mouse HPCs were expanded first in feeder culture supplemented with c-Kit ligand (KL, stem cell factor, steel factor or CD117 ligand), Flt3 ligand (fms-like tyrosine kinase 3, Flt3L, FL), thrombopoietin (TPO), IL-3, IL-6, and basic fibroblast growth factor (bFGF), and then in a second feeder culture ectopically expressing all above growth factors plus GM-CSF and IL-15. In the dual culture system, CD34+ HPCs differentiated toward DC progenitors (DCPs), which expanded more than five orders of magnitude. The DCPs showed myeloid DC surface phenotype with up-regulation of transcription factors PU.1 and Id2, and DC-related factors homeostatic chemokine ligand 17 (CCL17) and beta-chemokine receptor 6 (CCR6). Multiplex ELISA array and cDNA microarray analyses revealed that the DCPs shared some features of IL-4 and IL-15 DCs but displayed a pronounced proinflammatory phenotype. DCP-derived DCs showed antigen-uptake and immune activation functions analogous to that of the peripheral blood-derived DCs. Furthermore, bone marrow HPC-derived DCP vaccines of tumor-bearing mice suppressed tumor growth in vivo. This novel approach of generating DCP-DCs, which are different from known IL-4 and IL-15 DCs, overcomes both quantitative and qualitative limitations in obtaining functional autologous DCs from a small number of HPCs with great translational potential.
Timeout Problem of Page in Report Quality Control System from Water Resources

WANG Bei-Bei,HUI Xin,HAN Ning,

计算机系统应用 , 2012,
Abstract: In order to solve the timeout problem induced by the original report quality control system when dealing with large amount of data,the article proposes to use a combination of technology.Ajax and thread are used together to solve the weak point of overdue page which is caused by the long time backstage operation.The role of the Ajax and thread in the system is also analyzed in this article.
Effects of Inflorescence Stem Structure and Cell Wall Components on the Mechanical Strength of Inflorescence Stem in Herbaceous Peony
Daqiu Zhao,Chenxia Han,Jun Tao,Jing Wang,Zhaojun Hao,Qingping Geng,Bei Du
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms13044993
Abstract: Herbaceous peony ( Paeonia lactiflora Pall.) is a traditional famous flower, but its poor inflorescence stem quality seriously constrains the development of the cut flower. Mechanical strength is an important characteristic of stems, which not only affects plant lodging, but also plays an important role in stem bend or break. In this paper, the mechanical strength, morphological indices and microstructure of P. lactiflora development inflorescence stems were measured and observed. The results showed that the mechanical strength of inflorescence stems gradually increased, and that the diameter of inflorescence stem was a direct indicator in estimating mechanical strength. Simultaneously, with the development of inflorescence stem, the number of vascular bundles increased, the vascular bundle was arranged more densely, the sclerenchyma cell wall thickened, and the proportion of vascular bundle and pith also increased. On this basis, cellulose and lignin contents were determined, PlCesA3, PlCesA6 and PlCCoAOMT were isolated and their expression patterns were examined including PlPAL. The results showed that cellulose was not strictly correlated with the mechanical strength of inflorescence stem, and lignin had a significant impact on it. In addition, PlCesA3 and PlCesA6 were not key members in cellulose synthesis of P. lactiflora and their functions were also different, but PlPAL and PlCCoAOMT regulated the lignin synthesis of P. lactiflora. These data indicated that PlPAL and PlCCoAOMT could be applied to improve the mechanical strength of P. lactiflora inflorescence stem in genetic engineering.
Pair production of charged Higgs bosons in the Left-Right Twin Higgs model at the ILC and LHC
Liu, Yao-Bei;Han, Hong-Mei;Wang, Xue-Lei
High Energy Physics - Phenomenology , 2007, DOI: 10.1140/epjc/s10052-007-0492-3
Abstract: Left-Right twin Higgs(LRTH) model predicts the existence of a pair of charged Higgs $\phi^{\pm}$. In this paper, we study the production of the charged Higgs bosons pair $\phi^{\pm}$ via the process $e^{+}e^{-}\to \phi^{+}\phi^{-}$ at the International Linear Collider(ILC). The numerical results show that the production rates are at the level of several tens fb, this process can produce the adequate distinct multi-jet final states and the SM background can be efficiently reduced. We also discuss the charged Higgs boson pair production via the process $q\bar{q}\to \phi^{+}\phi^{-}$ at the $CERN$ Large Hadron Collider(LHC) and estimate there production rates. We find that, as long as the charged Higgs bosons are not too heavy, they can be abundantly produced at the LHC. The possible signatures of these new particles might be detected at the ILC and LHC experiments.
A Novel Strategy to Screen Bacillus Calmette-Guérin Protein Antigen Recognized by γδ TCR
XueYan Xi,XiaoYan Zhang,Bei Wang,Ji Wang,He Huang,LianXian Cui,XiQin Han,Liang Li,Wei He,ZhenDong Zhao
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0018809
Abstract: Phosphoantigen was originally identified as the main γδ TCR-recognized antigen that could activate γδ T cells to promote immune protection against mycobacterial infection. However, new evidence shows that the γδ T cells activated by phosphoantigen can only provide partial immune protection against mycobacterial infection. In contrast, whole lysates of Mycobacterium could activate immune protection more potently, implying that other γδ TCR-recognized antigens that elicit protective immune responses. To date, only a few distinct mycobacterial antigens recognized by the γδ TCR have been characterized.
Design of Real-Time Document Control Based on Zigbee and Surface Electromyography (sEMG)  [PDF]
Zhen Wang, Bei Wang, Xingyu Wang
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.510B036

The human-computer interaction (HCI) is now playing a great role in computer technology. This study introduces an automatic document control technique which is based on the human hand waving movements. The recognition of hand movement is realized according to the surface electromyography (sEMG). A collector is set on the forearm. The sEMG signal is recorded and conveyed to a PC terminal by using wireless Zigbee. An automatic algorithm is developed in order to extract the characteristics of sEMG, recognize the waving movements, and transmit to document control command. The developed human-computer interaction technique can be used as a new gallery for teaching, as well as an assistant tool for disabled person.

Double Stranded RNA (RNA inteference RNAi) in Different Creatures
双链RNA干涉技术(RNAi)在不同生物中应用的研究进展 Double Stranded RNA (RNA inteference RNAi) in Different Creatures

HAN Bei,WANG Xiu-min,GU Xue-fan,
,王秀敏,顾学范,HAN Bei,WANG Xiu-min,GU Xue-fan

遗传 , 2002,
Abstract: Double-stranded RNA could degrade mRNA of target gene.It is a useful way for studying gene function.It is used widely in different creatures,such as Arabidopsis thaliana,Caenorhabditis elegans,Drosophila melanogaster,Zebrafish,Mouse.This review is mainly related to the application of dsRNA in recent years
Pristimerin Causes G1 Arrest, Induces Apoptosis, and Enhances the Chemosensitivity to Gemcitabine in Pancreatic Cancer Cells
Yongwei Wang, Yinan Zhou, Haoxin Zhou, Guang Jia, Ji Liu, Bing Han, Zhuoxin Cheng, Hongchi Jiang, Shangha Pan, Bei Sun
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0043826
Abstract: Despite rapid advances in chemotherapy and surgical resection strategies, pancreatic cancer remains the fourth leading cause of cancer related deaths in the United States with a 5-year survival rate of less than 5%. Therefore, novel therapeutic agents for the prevention and treatment of pancreatic cancer are urgently needed. The aim of this study was to investigate the effect of pristimerin, a quinonemethide triterpenoid compound isolated from Celastraceae and Hippocrateaceae, on inhibition of cell proliferation and induction of apoptosis in three pancreatic cancer cells, BxPC-3, PANC-1 and AsPC-1, in both monotherapy and in combination with gemcitabine. Treatment with pristimerin decreased the cell proliferation of all three pancreatic cancer cells in a dose- and time-dependent manner. Treatment of pancreatic cancer cells with pristimerin also resulted in G1-phase arrest which was strongly associated with a marked decrease in the level of cyclins (D1 and E) and cyclin-dependent kinases (cdk2, cdk4 and cdk6 ) with concomitant induction of WAF1/p21 and KIP1/p27. Pristimerin treatment also resulted in apoptotic cell death, cleavage of caspase-3, modulation in the expressions of Bcl-2 family proteins, inhibition of the translocation and DNA-binding activity of NF-κB. In addition, pristimerin potentiated the growth inhibition and apoptosis inducing effects of gemcitabine in all three pancreatic cancer cells, at least in part, by inhibiting constitutive as well as gemcitabine-induced activation of NF-κB in both its DNA-binding activity and transcriptional activity. Taken together, these data provide the first evidence that pristimerin has strong potential for development as a novel agent against pancreatic cancer.
Induction of immune responses in ducks with a DNA vaccine encoding duck plague virus glycoprotein C
Bei Lian, Anchun Cheng, Mingshu Wang, Dekang Zhu, Qihui Luo, Renyong Jia, Fei Liu, Xinfeng Han, Xiaoyue Chen
Virology Journal , 2011, DOI: 10.1186/1743-422x-8-214
Abstract: After immunization by both routes virus-specific serum antibody and T-cell responses developed. Vaccination of ducks by IM injection induced a stronger humoral, but weaker cell-mediated immune response. In contrast, a better cell-mediated immune response was achieved by using a gene gun to deliver DNA-coated gold beads to the epidermis with as little as 6 μg of DNA.This demonstrated that both routes of DNA inoculation can be used for eliciting virus-specific immune responses. Although DNA vaccine containing DPV gC is effective in both intramuscular injection and gene gun bombardment, the latter could induce significantly higher cell-mediated responses against DPV.Duck plague virus (DPV), a member of the Alphaherpesvirinae, is the causative agent of duck plague (DP), one of most serious infectious diseases of waterfowl (duck, geese, and swans)[1,2]. Since the first outbreak in the Netherlands in 1923, this disease has caused heavy economic losses in the commercial duck industry due to mortality, condemnations, and decreased egg production[3,4].Vaccination is a desirable method to prevent DPV infection. The conventional DPV vaccine are inactivated and attenuated DPV preparations, and they have been shown to be able to confer protection against clinical disease[5,6]. However, as with all or most herpesvirus, DPV has the ability to establish latent infection[7], which adds difficulties in the control and prevention of the transmission of DPV or the establishment of latency. Thus, a more effective therapeutic vaccine will need to elicit sufficient cell-mediated and humoral immune responses.In recent years, naked DNA encoding immunogenic proteins of infectious agents has been introduced for vaccination. Injection of DNA results in its uptake into cells, expression of the gene and endogenous synthesis of the antigen[8,9]. DNA immunization provides some real advantages over conventional DPV vaccines, including major histocompatibility complex (MHC) class I and II presentati
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