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Search Results: 1 - 10 of 4459 matches for " Behro Mariana "
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Chimerism induction by nonmyeloablactive preconditioning and bone marrow infusion in rat small bowel transplantation
Bakonyi Neto Alexandre,Behro Mariana,Ruiz Phillip,Misiakos Evangelos P.
Acta Cirurgica Brasileira , 2003,
Abstract: In our previous work we demonstrated that the use of donor specific bone marrow infusions ( DSBMI ) after small bowel transplantation did not improve the graft survival after a short course of immunossupression. PURPOSE: In the current study, we evaluated whether recipient preconditioning with different regimens of radiation combined with DSBMI may enhance small bowel allograft survival with minimum recipient morbidity. METHODS: Heterotopic small bowel transplantation (SBTx) was performed with Lewis rats as recipients and DA rats as donors, which were immunossupressed with a short course of tacrolimus (FK 506 ) at 1mg/Kg/day for 5 days and distributed in 4 groups: group 1 (n= 4) without both irradiation and DSBMI; Groups 2 (n= 6), 3 (n= 9) and 4 (n= 6) received 100 x 10(6) DSBM cells at the time of the transplant. Groups 3 and 4 were irradiated with 250 and 400 rd respectively. Animals were examined daily for clinical signs of rejection or GVHD. Blood samples were taken weekly for chimeric studies by FC and intestinal biopsies were performed every 2 weeks. RESULTS: Animals in G1 and G2 had minimal rejection at day 15 after SBTx while GVHD was clinically and histologically characterized in G 3 and G 4. Total chimerism and T-cell chimerism was higher in irradiated groups when compared to non-irradiated groups. With exception of G1 and 2 where rejection was the cause of death, all animals in G3 and 4 died of GVHD. CONCLUSION:We concluded that low cytoreductive of irradiation can successfully decrease the graft rejection but not prevent the occurrence of GVHD.
Graft versus host disease in a rat small bowel transplant model after T-cell depleted donor specific bone marrow infusion
Bakonyi Neto Alexandre,Misiakos Evangelos P.,Tzakis Andreas G.,Behro Mariana
Acta Cirurgica Brasileira , 2003,
Abstract: Low cytoreductive regimen of irradiation associated to unmodified bone marrow infusion (UBM) does not prevent the occurrence of graft versus host disease (GVHD) after transplant. PURPOSE: In this study we evaluated the potential advantages of a long-term immunossupression and T-cell depleted bone marrow infusion (TCDBMI) in preventing the occurrence of GVHD after small bowel transplantation (SBTx). METHODS: Heterotopic SBTX was performed with Lewis rats as recipients and DA as donors and distributed into 5 groups according to the irradiation, duration of immunossupression and the use of UBM or TCDBMI: G1 (n=6), without irradiation and G2 (n=9), G3 (n=4), G4 (n=5) and G5 (n=6) was given 250 rd of irradiation. Groups 1,2,4 and G3 and 5 were infused with 100 x 10(6) UBM and TCDBM respectively. Animals in G1, 2, 3 were immunossupressed with 1mg/ FK506/Kg/IM for 5 days and G4 and G5 for 15 days. Anti CD3 monoclonal antibodies and immunomagnetic beads were used for T-cell depletion.Animals were examined for rejection, GVHD, chimerism characterization and ileal and skin biopsies. RESULTS: Minimal to mild rejection was observed in all groups; however, GVHD were present only in irradiated groups. Long-term immunossupression changed the severity of GVHD in G4 and G5. Rejection was the cause of death in G1 while GVHD in G2, 3, 4 and 5, not avoided by the use of TCDBMI. Total chimerism and T-cell chimerism was statistically higher in irradiated groups when compared to G1. CONCLUSION: Extended immunossupression associated to low dose of irradiation decrease the severity of GVHD, not avoided by the use of TCDBMI.
Graft versus host disease in a rat small bowel transplant model after T-cell depleted donor specific bone marrow infusion
Bakonyi Neto, Alexandre;Misiakos, Evangelos P.;Tzakis, Andreas G.;Behro, Mariana;Ruiz, Phillip;Miller, Joshua;Ricordi, Camilo;Takegawa, Bonifacio K.;
Acta Cirurgica Brasileira , 2003, DOI: 10.1590/S0102-86502003000200003
Abstract: low cytoreductive regimen of irradiation associated to unmodified bone marrow infusion (ubm) does not prevent the occurrence of graft versus host disease (gvhd) after transplant. purpose: in this study we evaluated the potential advantages of a long-term immunossupression and t-cell depleted bone marrow infusion (tcdbmi) in preventing the occurrence of gvhd after small bowel transplantation (sbtx). methods: heterotopic sbtx was performed with lewis rats as recipients and da as donors and distributed into 5 groups according to the irradiation, duration of immunossupression and the use of ubm or tcdbmi: g1 (n=6), without irradiation and g2 (n=9), g3 (n=4), g4 (n=5) and g5 (n=6) was given 250 rd of irradiation. groups 1,2,4 and g3 and 5 were infused with 100 x 106 ubm and tcdbm respectively. animals in g1, 2, 3 were immunossupressed with 1mg/ fk506/kg/im for 5 days and g4 and g5 for 15 days. anti cd3 monoclonal antibodies and immunomagnetic beads were used for t-cell depletion.animals were examined for rejection, gvhd, chimerism characterization and ileal and skin biopsies. results: minimal to mild rejection was observed in all groups; however, gvhd were present only in irradiated groups. long-term immunossupression changed the severity of gvhd in g4 and g5. rejection was the cause of death in g1 while gvhd in g2, 3, 4 and 5, not avoided by the use of tcdbmi. total chimerism and t-cell chimerism was statistically higher in irradiated groups when compared to g1. conclusion: extended immunossupression associated to low dose of irradiation decrease the severity of gvhd, not avoided by the use of tcdbmi.
Chimerism induction by nonmyeloablactive preconditioning and bone marrow infusion in rat small bowel transplantation
Bakonyi Neto, Alexandre;Behro, Mariana;Ruiz, Phillip;Misiakos, Evangelos P.;Miller, Joshua;Takegawa, Bonifacio K.;Ricordi, Camilo;Tzakis, Andreas G.;
Acta Cirurgica Brasileira , 2003, DOI: 10.1590/S0102-86502003000100003
Abstract: in our previous work we demonstrated that the use of donor specific bone marrow infusions ( dsbmi ) after small bowel transplantation did not improve the graft survival after a short course of immunossupression. purpose: in the current study, we evaluated whether recipient preconditioning with different regimens of radiation combined with dsbmi may enhance small bowel allograft survival with minimum recipient morbidity. methods: heterotopic small bowel transplantation (sbtx) was performed with lewis rats as recipients and da rats as donors, which were immunossupressed with a short course of tacrolimus (fk 506 ) at 1mg/kg/day for 5 days and distributed in 4 groups: group 1 (n= 4) without both irradiation and dsbmi; groups 2 (n= 6), 3 (n= 9) and 4 (n= 6) received 100 x 106 dsbm cells at the time of the transplant. groups 3 and 4 were irradiated with 250 and 400 rd respectively. animals were examined daily for clinical signs of rejection or gvhd. blood samples were taken weekly for chimeric studies by fc and intestinal biopsies were performed every 2 weeks. results: animals in g1 and g2 had minimal rejection at day 15 after sbtx while gvhd was clinically and histologically characterized in g 3 and g 4. total chimerism and t-cell chimerism was higher in irradiated groups when compared to non-irradiated groups. with exception of g1 and 2 where rejection was the cause of death, all animals in g3 and 4 died of gvhd. conclusion:we concluded that low cytoreductive of irradiation can successfully decrease the graft rejection but not prevent the occurrence of gvhd.
Fortines y pueblos en Buenos Aires del siglo XVIII: ?Una política de urbanización para la frontera?
Canedo,Mariana;
Mundo agrario , 2006,
Abstract: although the urban development in america was not exclusive of the european colonization, the foundation of towns and cities constituted a specific politics of conquest and colonial dominance. during the second half of the xviii century and under the government of the borbones, the politics established seemed to accompany the increase and growth of the cities and the towns in spanish america, and to incentivate the urbanization of the areas of frontier of their empire. two queries articulate this work. can the proposals formulated by the colonial authorities for buenos aires be located inside the urbanization politics proposed by the borbones for frontier areas in spanish america ? if this was this way, what concretion level has this politics had during the last decades of colonial bond? the establishment of towns will be studied for the case of buenos aires during the last decades of the xviii century.
Efecto del ganado sobre los niveles de polinización en especies vegetales del monte patagónico
Tadey,Mariana;
Ecolog?-a austral , 2008,
Abstract: livestock may indirectly affect plant pollination levels through changes in both plants and pollinators' assemblages. i studied the effect of livestock on the pollination level, estimated as the number of pollen tubes/style, on five frequent species of the patagonian monte desert (atriplex lampa, gutierrezia solbrigii, larrea cuneifolia, l. divaricata, monttea aphylla). in seven paddocks that share similar habitat characteristics but with different stocking rates, i counted pollen tubes per style of each species studied during four consecutive years. in general, pollination levels are affected more by variation between years than by stocking rates. only two of the five focal species showed changes in their pollination levels (e.g., pollen tubes/style) associated with changes in stocking rates. likewise, livestock did not affect the frequency of pollinator visits but affected cover of two of the studied species. the changes in cover (caused or not by livestock) affected directly and indirectly (e.g., through modification in pollinator visits frequency) pollination levels. results from the regressions and path analyses were consistent in relation to which species were more affected by livestock (e.g., gutierrezia solbrigii y monttea aphylla). additional information about pollen quality and nutritional plant resources would be necessary to better understand livestock indirect effects on pollination level.
Origen del melanocito normal y maligno
Aris,Mariana;
Acta bioqu?-mica cl?-nica latinoamericana , 2009,
Abstract: melanocytes are specialized cells that produce melanin, the most important pigment responsible for the coloration of skin, eyes and hair. the origin of melanocytes, their migration during the embryo development process from the neural crest to the epidermis, the molecular signals involved in the acquisition of both differentiated and functional states, and the issue of keeping undifferentiated reserve cells or stem cells will be discussed in this article. on the other hand, these facts will be related to the origin of melanoma, tumor pathology derived from the transformation of melanocytes. particularly, the etiology and the different models proposed to explain the origin of this disease will be discussed, especially the model of cancer stem cells.
Epidemiología molecular del virus sincicial respiratorio en pacientes pediátricos en un período de seis a?os
Viegas,Mariana;
Acta bioqu?-mica cl?-nica latinoamericana , 2011,
Abstract: human respiratory syncytial virus (hrsv) is the leading cause of acute lower respiratory tract infections (alri) in children. despite considerable efforts there is as yet no satisfactory vaccine available. in this work, nasopharyngeal aspirates taken from hospitalized children with alri were analyzed over six consecutive epidemic seasons (1999-2004). by rt-pcr, 353 positive samples for hrsv by direct immunofluorescence were subtypified. among them, 65.7% belonged to subtype a and 34.3% to subtype b. therefore, a phylogenetic analysis was performed using rflp and sequence analysis of the g-glycoprotein gene, the main neutralizing antigen. the results for a subtype, showed that there were two main restriction patterns (pa1 and pa2) and two genotypes (ga2 and ga5) cocirculating during the period studied. the phylodinamic analysis showed that there were some genetic clades which along this period of time alternated their circulation between argentina and other countries and that other clades cocirculated worldwide. the subtype b analysis enabled the description of an unusual genetic event such us a 60 nucleotide duplication. the phylodinamic analysis showed that all of these viruses, designated ba, circulated in our country during the period studied and were associated with strains reported wordlwide, showing a common ancestor which had probably been generated in a single genetic event between 1997 and 1999 in argentina. this work contributes to a better understandig of this virus evolution, giving a fundamental role to the virology laboratory in the active molecular surveillance.
La ense?anza media y la agenda de ocupación territorial del estado argentino, 1862-1945
Fiorito,Mariana;
Historia de la educaci?3n - anuario , 2012,
Abstract: the high schools that depended of the argentine state were milestones that marked, in many cities of the country, a double means of action: the territorial occupation and the modernization. these buildings represented an attempt of the national state to establish dynamic links with the inhabitants, to generate a sense of social citizenship and the feeling of belonging to a uniform nation: the argentine nation. the aim of this work is to rebuild the institutional occupation of argentine territory. the challenge is to see the path from the ideology to the actual occupation of the territory by defining the patterns of the consolidation of the national state, focusing not on the scholar architecture of buildings, but on their presence as media representing the nation-state. the methodology consists in the use, draft and analysis of a series of maps of the occupation of the territory, the expansion of transport networks and the location of the centers of different types of high schools (colegios nacionales, escuelas industriales, escuelas de artes y oficios, escuelas comerciales y escuelas normales) in the argentine territory, at three different moments in the history of the country: the project and construction of the possible republic (1862-1916), the real republic (1916-1930) and the impossible republic (1930-1945).
Direito à informa??o e direito à vida privada: os impasses em torno do acesso aos arquivos da ditadura militar brasileira
Joffily, Mariana;
Estudos Históricos (Rio de Janeiro) , 2012, DOI: 10.1590/S0103-21862012000100009
Abstract: discussing the access to documents produced in the 1960's and 1970's by the brazilian military dictatorship, the article emphasizes some points: the nature of the democratic transition, the history of archives legislation, the characteristics of the archives of political repression. it is argued that the right to privacy, although being the element that, in practice, restricts access to part of this documentation, has not yet been the subject of public debate, due to the (apparent) incompatibility between the demands of social movements to unrestricted access to the sources of military dictatorship, at the collective level, and the protection of privacy, at the individual level.
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