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Search Results: 1 - 10 of 461939 matches for " Bego?a Monge-Maillo "
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Begoa Monge-Maillo,Rogelio López-Vélez
Mediterranean Journal of Hematology and Infectious Diseases , 2012, DOI: 10.4084/mjhid.2012.
Abstract: The proportion of imported malaria cases due to immigrants in Europe has increased during the lasts decades, being the higher rates for those settled immigrants who travel to visit friends and relatives (VFRs) at their country of origin. Cases are mainly due to P. falciparum and Sub-Saharan Africa is the most common origin. Clinically, malaria in immigrants is characterized by a mild clinical presentation with even asymptomatic o delayed malaria cases and low parasitemic level. These characteristics may be explained by a semi-immunity acquired after long periods of time exposed to stable transmission of malaria. Malaria cases among immigrants, even those asymptomatic patients with sub-microscopic parasitemia, could increase the risk of transmission and reintroduction of malaria in certain areas with the adequate vectors and climate conditions. Moreover imported malaria cases by immigrants can also play an important role in the non-vectorial transmission out of endemic area, by blood transfusions, organ transplantation or congenital or occupational exposures. Probably, out of endemic areas, screening of malaria among recent arrived immigrants coming from malaria endemic countries should be performed. These aim to reduce the risk of clinical malaria in the individual as well as to prevent autochthonous transmission of malaria in areas where it had been eradicated.
Visceral Leishmaniasis and HIV Coinfection in the Mediterranean Region
Begoa Monge-Maillo,Francesca F. Norman,Israel Cruz,Jorge Alvar,Rogelio López-Vélez
PLOS Neglected Tropical Diseases , 2014, DOI: 10.1371/journal.pntd.0003021
Abstract: Visceral leishmaniasis is hypoendemic in Mediterranean countries, where it is caused by the flagellate protozoan Leishmania infantum. VL cases in this area account for 5%–6% of the global burden. Cases of Leishmania/HIV coinfection have been reported in the Mediterranean region, mainly in France, Italy, Portugal, and Spain. Since highly active antiretroviral therapy was introduced in 1997, a marked decrease in the number of coinfected cases in this region has been reported. The development of new diagnostic methods to accurately identify level of parasitemia and the risk of relapse is one of the main challenges in improving the treatment of coinfected patients. Clinical trials in the Mediterranean region are needed to determine the most adequate therapeutic options for Leishmania/HIV patients as well as the indications and regimes for secondary prophylaxis. This article reviews the epidemiological, diagnostic, clinical, and therapeutic aspects of Leishmania/HIV coinfection in the Mediterranean region.
Neglected Tropical Diseases outside the Tropics
Francesca F. Norman ,Ana Pérez de Ayala,José-Antonio Pérez-Molina,Begoa Monge-Maillo,Pilar Zamarrón,Rogelio López-Vélez
PLOS Neglected Tropical Diseases , 2010, DOI: 10.1371/journal.pntd.0000762
Abstract: Background The neglected tropical diseases (NTDs) cause significant morbidity and mortality worldwide. Due to the growth in international travel and immigration, NTDs may be diagnosed in countries of the western world, but there has been no specific focus in the literature on imported NTDs. Methods Retrospective study of a cohort of immigrants and travelers diagnosed with one of the 13 core NTDs at a Tropical Medicine Referral Unit in Spain during the period April 1989-December 2007. Area of origin or travel was recorded and analyzed. Results There were 6168 patients (2634 immigrants, 3277 travelers and 257 VFR travelers) in the cohort. NTDs occurred more frequently in immigrants, followed by VFR travelers and then by other travelers (p<0.001 for trend). The main NTDs diagnosed in immigrants were onchocerciasis (n = 240, 9.1%) acquired mainly in sub-Saharan Africa, Chagas disease (n = 95, 3.6%) in immigrants from South America, and ascariasis (n = 86, 3.3%) found mainly in immigrants from sub-Saharan Africa. Most frequent NTDs in travelers were: schistosomiasis (n = 43, 1.3%), onchocerciasis (n = 17, 0.5%) and ascariasis (n = 16, 0.5%), and all were mainly acquired in sub-Saharan Africa. The main NTDs diagnosed in VFR travelers were onchocerciasis (n = 14, 5.4%), and schistosomiasis (n = 2, 0.8%). Conclusions The concept of imported NTDs is emerging as these infections acquire a more public profile. Specific issues such as the possibility of non-vectorial transmission outside endemic areas and how some eradication programmes in endemic countries may have an impact even in non-tropical western countries are addressed. Recognising NTDs even outside tropical settings would allow specific prevention and control measures to be implemented and may create unique opportunities for research in future.
Management and Outcome of Cardiac and Endovascular Cystic Echinococcosis
Marta Díaz-Menéndez,José Antonio Pérez-Molina,Francesca Florence Norman,Ana Pérez-Ayala,Begoa Monge-Maillo,Pilar Zamarrón Fuertes,Rogelio López-Vélez
PLOS Neglected Tropical Diseases , 2012, DOI: 10.1371/journal.pntd.0001437
Abstract: Background Cystic echinococcosis (CE) can affect the heart and the vena cava but few cases are reported. Methods A retrospective case series of 11 patients with cardiac and/or endovascular CE, followed-up over a period of 15 years (1995–2009) is reported. Results Main clinical manifestations included thoracic pain or dyspnea, although 2 patients were asymptomatic. Cysts were located mostly in the right atrium and inferior vena cava. Nine patients were previously diagnosed with disseminated CE. Echocardiography was the diagnostic method of choice, although serology, electrocardiogram, chest X-ray, computed tomography/magnetic resonance imaging and histology aided with diagnosis and follow-up. Nine patients underwent cardiac surgery and nine received long-term antiparasitic treatment for a median duration of 25 months (range 4–93 months). One patient died intra-operatively due to cyst rupture and endovascular dissemination. Two patients died 10 and 14 years after diagnosis, due to pulmonary embolism (PE) and cardiac failure, respectively. One patient was lost to follow-up. Patients who had cardiac involvement exclusively did not have complications after surgery and were considered cured. There was only one recurrence requiring a second operation. Patients with vena cava involvement developed PEs and presented multiple complications. Conclusions Cardiovascular CE is associated with a high risk of potentially lethal complications. Clinical manifestations and complications vary according to cyst location. Isolated cardiac CE may be cured after surgery, while endovascular extracardiac involvement is associated with severe chronic complications. CE should be included in the differential diagnosis of cardiovascular disease in patients from endemic areas.
The Trypanosoma cruzi Satellite DNA OligoC-TesT and Trypanosoma cruzi Kinetoplast DNA OligoC-TesT for Diagnosis of Chagas Disease: A Multi-cohort Comparative Evaluation Study
Koen De Winne,Philippe Büscher,Alejandro O. Luquetti,Suelene B. N. Tavares,Rodrigo A. Oliveira,Aldo Solari,Ines Zulantay,Werner Apt,Patricio Diosque,Mercedes Monje Rumi,Nuria Gironès,Manuel Fresno,Rogelio Lopez-Velez,José A. Perez-Molina,Begoa Monge-Maillo,Lineth Garcia,Stijn Deborggraeve
PLOS Neglected Tropical Diseases , 2014, DOI: 10.1371/journal.pntd.0002633
Abstract: Background The Trypanosoma cruzi satellite DNA (satDNA) OligoC-TesT is a standardised PCR format for diagnosis of Chagas disease. The sensitivity of the test is lower for discrete typing unit (DTU) TcI than for TcII-VI and the test has not been evaluated in chronic Chagas disease patients. Methodology/Principal Findings We developed a new prototype of the OligoC-TesT based on kinetoplast DNA (kDNA) detection. We evaluated the satDNA and kDNA OligoC-TesTs in a multi-cohort study with 187 chronic Chagas patients and 88 healthy endemic controls recruited in Argentina, Chile and Spain and 26 diseased non-endemic controls from D.R. Congo and Sudan. All specimens were tested in duplicate. The overall specificity in the controls was 99.1% (95% CI 95.2%–99.8%) for the satDNA OligoC-TesT and 97.4% (95% CI 92.6%–99.1%) for the kDNA OligoC-TesT. The overall sensitivity in the patients was 67.9% (95% CI 60.9%–74.2%) for the satDNA OligoC-TesT and 79.1% (95% CI 72.8%–84.4%) for the kDNA OligoC-Test. Conclusions/Significance Specificities of the two T. cruzi OligoC-TesT prototypes are high on non-endemic and endemic controls. Sensitivities are moderate but significantly (p = 0.0004) higher for the kDNA OligoC-TesT compared to the satDNA OligoC-TesT.
Myxoid Meningioma: An Example of a Rare Brain Tumour of Difficult Diagnosis  [PDF]
Javier Ortiz, María Dolores Lude?a, Jesús Gon?alves, Sofía Del Carmen, ángel Maillo, Agustín Bullon
Open Journal of Pathology (OJPathology) , 2013, DOI: 10.4236/ojpathology.2013.31009

We present a case of a Myxoid Meningioma noticed in a 43-year-old woman. The patient, who had no noteworthy medical antecedents, showed repeated focal epileptic crisis. Imaging studies (MR and CT) showed a solitary and well delimited tumour located in the frontral lobe. Once extirpated, the histological study revealed a neoplasm of myxoid and benign appearance, with elongated and uniform cells, with no atypias and a very low mitotic index. Immunohistochemisty studies (positivity for Vimentin and Epithelial Membrane Antigen, and negativity for the other markers) as well as physical and radiological examination of the patient (absence of tumours in any other location), suggested the diagnosis of a Myxoid Meningioma, which was confirmed by electron microscopy (by the presence of desmosomes). We also revise the characteristics of Myxoid Meningiomas, an absolutely exceptional primary tumour of the central nervous system.

Meningiomas de la base de cráneo: Un sistema predictivo para conocer las posibilidades de su extirpación y pronóstico Skull base meningiomas: a predictive system to know the extent of their surgical resection and patient outcome
F. Morales,A. Maillo,A. Díaz-álvarez,M Merino
Neurocirugía , 2005,
Abstract: Objetivo. Encontrar un sistema predictivo que basándose únicamente en datos preoperatorios nos oriente, con fiabilidad, sobre : 1° qué meningiomas de la base de cráneo pueden ser extirpados total o parcialmente y 2° cuál es su pronóstico postquirúrgico. Métodos. Se ha revisado de forma retrospectiva, las historias clínicas e iconografías de 85 pacientes, con meningiomas de la base de cráneo, intervenidos entre 1990 al 2002. De ellas se han tomado nueve variables que han sido tratadas estadísticamente, mediante un test estándar, para correlacionarlas con: 1° resección total o parcial del tumor (Simpson, 5 grados) y 2° conocido el mencionado grado de resección total o parcial, éste se correlacionó con el pronóstico funcional postoperatorio del paciente (Karnofsky). Resultados. De las variables preoperatorios analizadas, solo dos demostraron tener una asociación significativa con la extirpación total o parcial del tumor, así como con el pronóstico postquirúrgico del paciente. Dichas variables fueron: a) las arterias englobadas por el tumor (p = 0.001) y b) la afectación de pares craneales (p< 0.0001). Seguidamente, se conjugaron las diversas posibilidades de cada una de ellas para conocer el grado de extirpación tumoral (total o parcial). Para predecir el pronóstico funcional postoperatorio del enfermo, se relacionó la extirpación total o parcial con la escala de Karnofsky. De ambos análisis, grado de extirpación y pronóstico, se obtuvo el siguiente sistema de gradación: Grado I: meningiomas, de la base de cráneo, que no afectan a pares craneales ni engloban arterias o bien solamente afectan a un par craneal o engloban sólo una arteria. En ellos las posibilidades de extirpación total se encuentran en un 98,3% (p<0.0001) y las perspectivas de alcanzar 70 puntos en la escala de Karnofsky son de un 96,5%. Grado II: meningiomas que afectan a un par craneal e incluyen dos o más arterias. La extirpación total en estos casos disminuye al 83,3% (p< 0.0001) y las perspectivas de alcanzar 70 puntos en la escala de Karnofsky descienden a un 70,6%. Grado III: meningiomas que afectan dos o más pares craneales e incluyen varias arterias. En este grupo, las posibilidades de una extirpación total son de un 42,9% (p<0.0001) con las perspectivas de alcanzar los 70 puntos en la escala de Karnofsky en sólo el 60%. Conclusiones. El sistema de gradación que se propone permite, en los casos de meningiomas de la base de cráneo: 1° predecir las posibilidades de una extirpación total o parcial y 2° conocer el pronóstico quirúrgico de los pacientes en cada grupo. Aplicando este siste
Sergio Martínez Maillo,Juan Luis Fari?as Almui?a
Didasc@lia : Didáctica y Educación , 2012,
Abstract: This paper deals with the formation of the Bachelor in Education in the speciality of Informatics from a professional competence approach, departing from the teaching-learning process of the discipline Programming Language and Techniques. It is analysed the contribution of didactic principles for a competent professional, as well as the conceptual and procedimental basic that prepares them to solve the problems the face in their professional performance.
Alfonso García Monge
ágora para la Educación Física y el Deporte , 2011,
Abstract: Resumen.- Introducción al monográfico titulado "Creación y modificación de juegos motores". Abstract.- Introduction to the monograph entitled "Creating and modifying (motor) games.
Alfonso García Monge
ágora para la Educación Física y el Deporte , 2001,
Abstract: : In this paper, we attempt to describe how (children) games are an agent to convey culture which normalizes some uses, customs and corporal experiences as well as the learning of attitudes and values in each context, those processes are verified the same way in sessions of PE. To show these relationships between bodily ruled games and the cultural context in which these take place, we will go through three sections. Firstly, we will show by means of examples some initial hypotheses about relationships that are established between games and culture. Secondly, we will focus on some of the cultural elements that are assimilated through ludic activities. Finally, we conclude making some considerations about the cultural values that are transmitted by the practice of bodily games in PE.Resumen: Intentamos en este artículo describir cómo el juego motor reglado es un agente de enculturación que va normalizando unos usos, prácticas y vivencias corporales así como el aprendizaje de actitudes y valores de cada contexto, unos procesos que se verifican de igual forma en las sesiones de EF. Para mostrar estas relaciones entre los juegos motores reglados y los contextos culturales en los que se reproducen pasaremos por tres apartados. En el primero mostraremos mediante ejemplos algunas hipótesis de partida sobre las relaciones que se establecen entre el juego y la cultura. Vistas estas relaciones nos centraremos, en el segundo apartado, en algunos de los elementos culturales que se interiorizan a través de las actividades lúdicas. Y finalizaremos haciendo algunas consideraciones sobre los valores culturales que transmiten las prácticas con juegos motores en la EF.
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