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Search Results: 1 - 10 of 805 matches for " Beate Wild "
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A graphical vector autoregressive modelling approach to the analysis of electronic diary data
Beate Wild, Michael Eichler, Hans-Christoph Friederich, Mechthild Hartmann, Stephan Zipfel, Wolfgang Herzog
BMC Medical Research Methodology , 2010, DOI: 10.1186/1471-2288-10-28
Abstract: We propose to analyse the temporal interrelationships among the variables by a structural modelling approach based on graphical vector autoregressive (VAR) models. We give a comprehensive description of the underlying concepts and explain how the dependence structure can be recovered from electronic diary data by a search over suitable constrained (graphical) VAR models.The graphical VAR approach is applied to the electronic diary data of 35 obese patients with and without binge eating disorder (BED). The dynamic relationships for the two subgroups between eating behaviour, depression, anxiety and eating control are visualized in two path diagrams. Results show that the two subgroups of obese patients with and without BED are distinguishable by the temporal patterns which influence their respective eating behaviours.The use of the graphical VAR approach for the analysis of electronic diary data leads to a deeper insight into patient's dynamics and dependence structures. An increasing use of this modelling approach could lead to a better understanding of complex psychological and physiological mechanisms in different areas of medical care and research.In recent years, the use of electronic diaries in clinical research has become increasingly popular [1,2]. In many different medical areas--such as neurology [3], sleep medicine [4], paediatrics [5], dermatology [6], gynaecology [7], psychosomatic medicine [8], and rheumatology [9]--electronic diary data provide new insights into processes and temporal relationships. Particularly, in clinical practice and research regarding chronic pain electronic diary assessment is frequently used to examine day-to-day variation in symptoms as well as to investigate the impact of constant self-monitoring on the patient's behaviour [10-12]. Also, in psychosomatic research, the application of electronic diaries is of particular interest to mirror development processes over time and to capture complex dynamical systems with several inter
Prevalence of Wild-Type Butyrylcholinesterase Genotype in Patients with Alzheimer’s Dementia  [PDF]
Beate Mueller, Georg Adler
World Journal of Neuroscience (WJNS) , 2015, DOI: 10.4236/wjns.2015.53019
Abstract: Approximately, two-thirds patients with Alzheimer’s disease (AD) are reported to have homozygous wild-type butyrylcholinesterase (BuChE) gene expression. It is associated with a higher rate of hydrolysis of acetylcholine, which ultimately leads to increase in the levels of BuChE in advanced stages of the disease. Rivastigmine, a dual inhibitor of acetylcholinesterase (AChE) and BuChE, might be of additional benefit in patients with AD with wild-type BuChE allele.
Temporal Predictors of Health-Related Quality of Life in Elderly People with Diabetes: Results of a German Cohort Study
Imad Maatouk, Beate Wild, Daniela Wesche, Wolfgang Herzog, Elke Raum, Heiko Müller, Dietrich Rothenbacher, Christa Stegmaier, Dieter Schellberg, Hermann Brenner
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0031088
Abstract: Background The aim of the study was to determine predictors that influence health-related quality of life (HRQOL) in a large cohort of elderly diabetes patients from primary care over a follow-up period of five years. Methods and Results At the baseline measurement of the ESTHER cohort study (2000–2002), 1375 out of 9953 participants suffered from diabetes (13.8%). 1057 of these diabetes patients responded to the second-follow up (2005–2007). HRQOL at baseline and follow-up was measured using the SF-12; mental component scores (MCS) and physical component scores (PCS) were calculated; multiple linear regression models were used to determine predictors of HRQOL at follow-up. As possible predictors for HRQOL, the following baseline variables were examined: treatment with insulin, glycated hemoglobin (HbA1c), number of diabetes related complications, number of comorbid diseases, Body-Mass-Index (BMI), depression and HRQOL. Regression analyses were adjusted for sociodemographic variables and smoking status. 1034 patients (97.8%) responded to the SF-12 both at baseline and after five years and were therefore included in the study. Regression analyses indicated that significant predictors of decreased MCS were a lower HRQOL, a higher number of diabetes related complications and a reported history of depression at baseline. Complications, BMI, smoking and HRQOL at baseline significantly predicted PCS at the five year follow-up. Conclusions Our findings expand evidence from previous cross-sectional data indicating that in elderly diabetes patients, depression, diabetes related complications, smoking and BMI are temporally predictive for HRQOL.
The Renin-Angiotensin System in the Development of Salt-Sensitive Hypertension in Animal Models and Humans
Beate Rassler
Pharmaceuticals , 2010, DOI: 10.3390/ph3040940
Abstract: Hypertension is still one of the major causes of death from cardiovascular failure. Increased salt intake may aggravate the rise in blood pressure and the development of consequential damage of the heart, the vessels and other organs. The general necessity of restricted salt intake regardless of blood pressure or salt sensitivity has been a matter of debate over the past decades. This review summarizes the main pathogenic mechanisms of hypertension and salt sensitivity in rat models, particularly in the spontaneously hypertensive rat (SHR), and in patients with essential hypertension (EH). Although SHRs are commonly considered to be salt-resistant, there is much evidence that salt loading may deteriorate blood pressure and cardiovascular function even in these animals. Similarly, EH is not a homogenous disorder – some patients, but not all, exhibit pronounced salt sensitivity. The renin-angiotensin system (RAS) plays a key role in the regulation of blood pressure and salt and fluid homeostasis and thus is one of the main targets of antihypertensive therapy. This review focuses on the contribution of the RAS to the pathogenesis of salt-sensitive hypertension in SHRs and patients with EH.
Organizaciones sociales y anclaje territorial Escenarios y componentes de la transformación socioterritorial y local en Venezuela
Cuadernos del Cendes , 2008,
Abstract: in latin america, social movements and organizations engage in a struggle for better living conditions, demanding more participation in public policies, from and in their territories. for the democratization of society, the socioterritorial anchoring of social organizations is very important. this article examines if in the venezuelan case new public spaces are being built in the microlocal level, based on the practices of communitarian organizations. the analysis of organizations such as communal councils and health committees shows achievements, difficulties and contradictions in which their communitarian practices are embedded. the difficult construction of institutionalized public spaces for the exercise of a citizenship anchored in the socioterritorial realm has begun in venezuela.
Bibliotheken und Portale - ein überblick / Libraries and portals - a survey
Guba, Beate
GMS Medizin-Bibliothek-Information , 2006,
Abstract: Initially a definition of the term portal is given by which the main functionalities of portals are described. Furthermore a distinction is made between two different types of portals: a) Subject-oriented information portals and b) MyLibrary portals. The progress in this area and future tendencies are illustrated by various examples. This article focuses on the scientific context, public libraries are excluded.
Review: Lewis A. Dexter (2006). Elite and Specialized Interviewing. With a New Introduction by Alan Ware and Martín Sánchez-Jankowski Review: Lewis A. Dexter (2006). Elite and Specialized Interviewing. With a New Introduction by Alan Ware and Martín Sánchez-Jankowski Rese a: Lewis A. Dexter (2006). Elite and Specialized Interviewing. With a New Introduction by Alan Ware and Martín Sánchez-Jankowski
Beate Littig
Forum : Qualitative Social Research , 2008,
Abstract: Der Eigenverlag des European Consortium for Political Research (ECPR) besorgte 2006 in der Reihe ECPR Classics die Neuauflage des Buches "Elite and Specialized Interviewing" des Politikwissenschaftlers L.A. DEXTER, das zuerst 1969 erschienen ist. Eliteinterviews sind in DEXTERs Verst ndnis nicht-standardisierte, offene Interviews mit Angeh rigen der politischen oder wirtschaftlichen Elite, die es den Befragten erm glichen, ihre eigenen Relevanzen darzulegen. Was heute als Gemeinplatz qualitativer Sozialforschung gilt, kann zur Zeit der Ersterscheinung von DEXTERs Buch und unter der Vorherrschaft quantitativer Sozialforschung als methodische Innovation angesehen werden. DEXTERs Buch, das weniger ein Methodenbuch als ein Essay über seine umfangreichen Erfahrungen mit dem Interviewen von Eliten ist, enth lt vielf ltige praktische Hinweise für das Interviewen von Eliten, die nach wie vor gültig sind. Sie betreffen sowohl die gegenw rtig prim r englischsprachige Literatur über Eliteinterviews als auch das vergleichbare deutschsprachige Interviewen von ExpertInnen. Insofern kann das Buch zurecht als Klassiker bezeichnet werden, auch wenn die methodologischen und methodischen überlegungen qualitativer Sozialforschung inzwischen differenzierter und methodenkritischer sind. URN: urn:nbn:de:0114-fqs080151 The European Consortium for Political Research (ECPR) republished in 2006 the book of the political scientist L.A. DEXTER on "Elite and Specialized Interviewing." According to DEXTER the main characteristic of this type of interviews is non-standardized treatment. Through this the interviewee is given the chance to present his or her own relevance with regard to the topic and situation at stake. What seems to be self-evident in the context of qualitative social research today—the importance of the interviewee's definition of the situation and the topic at stake—can be regarded as an innovation in the 1970ies considering the predominance of quantitative social research. DEXTER's essay gives a broad variety of hints of how to approach and practically interview elites, which are still up-to-date. Thus the book can be labeled as a classic, despite the fact that the methodological reflections about qualitative social research, including elite interviewing or as in the German-speaking context expert interviews have become much more detailed and divers. URN: urn:nbn:de:0114-fqs080151 El Consorcio Europeo para la Investigación Política (ECPR, por sus siglas en inglés) reeditó en 2006 el libro del politólogo L.A. DEXTER sobre "Elite and Specialized Interviewing". De acuer
Interviews mit Eliten – Interviews mit ExpertInnen: Gibt es Unterschiede? Interviews with the Elite and with Experts. Are There Any Differences? Entrevistas con élites y con expertos. Existen diferencias?
Beate Littig
Forum : Qualitative Social Research , 2008,
Abstract: Vergleicht man die überwiegend deutschsprachige Literatur zu Experteninterviews mit den internationalen Beitr gen zu Eliteninterviews, fallen mehr Gemeinsamkeiten als Unterschiede auf. Thematisiert werden hier wie dort die gro en Zugangsprobleme und Spezifika der Interaktionssituation und der Gespr chsführung. Auch bei der jeweiligen Definition der Zielgruppen der Interviews (ExpertInnen und Eliten) gibt es überschneidungen, wenn auch nicht Deckungsgleichheit. Der Beitrag diskutiert die Gemeinsamkeiten und Unterschiede von beiden methodischen Ans tzen und will so zu einer Pr zisierung der Methodologie des Experteninterviews beitragen. Er endet mit einem wissenssoziologisch begründeten Pl doyer dafür, (professionelle) Funktionseliten aufgrund ihrer Machtpositionen als eine spezifische Gruppe von ExpertInnen zu betrachten. Methodologisch betrachtet sind ExpertInnen (und somit auch Eliten) aufgrund ihres spezifischen Deutungs- und Handlungswissens für die sozial- und politikwissenschaftlich orientierte Forschung bedeutsam. Konsequenterweise sind dann Interviews mit Eliten, die auf die Generierung expliziten wie impliziten, professionellen oder berufsbezogenen Wissens abzielen, als Experteninterviews anzusehen. URN: urn:nbn:de:0114-fqs0803161 A comparison of the predominantly German-language literature on expert interviews in international articles on interviewing the elite reveals more commonalities than differences. Similar issues are discussed in both, such as the problems of gaining access to these groups, and the specifics of interaction and interviewing. Although not identical, the respective target group definitions (experts and the elite) for such interviews overlap. This article discusses the commonalities and differences in these two methodological approaches, thereby contributing to a more detailed specification of the methodology of expert interviews. It concludes with an appeal based on the sociology of knowledge that the (professional) functional elite—given their positions of power—be considered as a specific group of experts. From a methodological perspective and as a result of their specific background knowledge ("know why") and know-how, experts (and thus also the elite) are of relevance to social and political science research. Consequently, interviews with the elite aimed at generating explicit, tacit, professional or occupational knowledge should be seen as expert interviews. URN: urn:nbn:de:0114-fqs0803161 Una comparación de la literatura preferentemente en alemán sobre entrevistas a expertos y de artículos internacionales sobre la entr
New Measures for Combatting Discrimination in the European Union
Beate Winkler
Revista CIDOB d'Afers Internacionals , 2001,
Abstract: The European Commission on November 25, 1999 adopted two Directives related to racial discrimination and equality respectively and a Community Action Plan for combatting discrimination in the period 2001-2006. Between June and November 2000, the Council of the EU moved ahead with determination and speed in adopting said proposals.This paper analyzes and describes the two Directives and the Action Plan as well as the role the European Monitoring Centre for Racism and Xenophobia.
Die Entdeckung der Differenz: Zur Besonderheit des Vaters für das Kind The Discovery of Difference: On the Noteworthiness of the Father for his Child
Beate Kortendiek
querelles-net , 2003,
Abstract: In dem Sammelband wird in zehn Beitr gen aus psychoanalytischer und -therapeutischer sowie bindungs- und systemtheoretischer Perspektive nach der Bedeutung des Vaters für S ugling und Kleinkind gefragt. Hierbei geht es u.a. um die Analyse von Vaterlosigkeit, Bindungsentwicklungen, Spielsituationen und Schlafst rungen unter besonderer Berücksichtung der Entwicklung dyadischer und triadischer Beziehungen zwischen Vater, Mutter und Kind. Die Berichte sind von Wissenschaftler/-innen und Therapeut/-innen aus sterreich, Deutschland und der Schweiz verfasst und gehen zurück auf die Jahrestagung (2001) der Deutschen Gesellschaft für die seelische Gesundheit in der frühen Kindheit“ (Germanspeeking Association für Infant Mental Health/GAIMH). Die Ver ffentlichung erm glicht einen überblick über die aktuelle psychologisch orientierte Forschung und Debatte der frühen Beziehung zwischen Vater und Kind. The ten contributions to this anthology all address the relevance of the father for the baby and infant, employing psychoanalytical and therapeutic perspectives, as well as attachment theory and systemic theory. Among other things, the texts analyse growing up without a father, developing attachment, child play, and sleep disorders with a special focus on the development of dyadic and triadic relations between father, mother, and child. The individual reports were written by scientists and therapists in Austria, Germany, and Switzerland, and were inspired by the 2001 annual Meeting of the “German Speaking Association for Infant Mental Health (GAIMH).” This publication offers an overview of current psychological research and debates about early father-child relationships.
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