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Fish are rising
David Bassett
Genome Biology , 2001, DOI: 10.1186/gb-2001-2-7-reports4016
Abstract: Several major factors that are bringing the zebrafish to the fore as a genomic resource and genetic model system were showcased at this meeting. The small, cheap, tropical, freshwater zebrafish is an important vertebrate developmental model organism that is widely used for random mutagenesis projects and is well suited to embryological manipulation because of its externally developing transparent embryos. More recently, new techniques including insertional mutagenesis, imaging and ablation of cells in live embryos, using easy-to-make transgenics carrying green fluorescent protein derivatives under a host of promoters, and the GAL4-UAS system of targeted expression have been added to the zebrafish repertoire, revealing its sheer elegance as a model organism. Some people would say that the mouse has the advantage of reverse genetics (gene knockout technology), but the advent of translation-blocking morpholino oligonucleotides in the zebrafish (and Xenopus) communities provides similar results for a fraction of the cost and time of mouse gene knockouts without positional effects.If this all sounds too good to be true, then there is more: the zebrafish genome will be fully sequenced by way of an annotated physical map by 2003. Funding from the Wellcome Trust is allowing the Sanger Centre (represented at the meeting by Jane Rogers) to shotgun-sequence the genome, with daily release of data to the Sanger's own FTP site and repositories of raw sequence traces at the European Bioinformatics Institute (Hinxton, UK) and the National Center for Biotechnology Information (National Institutes of Health, Bethesda, USA). Coverage of the genome is predicted to reach threefold by December 2001, and the Sanger Centre is already providing a high-stringency search engine for the zebrafish community to use in accessing the sequence. This will be followed by increased efforts to sequence a minimal overlapping set of bacterial artificial chromosomes (BACs) covering the whole genome (being
New Maps for Old?: The Cultural Stakes of '2.0'
Caroline Bassett
Fibreculture Journal , 2008,
Abstract: Convergence theorists explore/predict the fusion of a series of previously discrete forms, a process that might be viewed as un-problematically centripetal. This is the longstanding view of the information industry. It produces a particular outcome - there may be local difficulties, but the perceived ontology of information is towards total convergence. Focussing on the socio-cultural diffusion of information cultural theorists have offered a different account of technical convergence where the stress has been on the centrifugal as much as the centripetal, so that not only what is pushed together through information but also what is forced apart, becomes significant. Jameson’s 1980s account of schizophrenia as the cultural logic of information capitalism is an example of this – and is written about the same time Negroponte set about founding/defining future media at MIT. Forcing these different accounts into relation with each other is productive, revealing lacunae not only in technical accounts of convergence but in critical accounts of informational culture, and exposing a naturalized set of alignments which might be questioned; to read the centrifugal moment of convergence as the technological moment and as the enlargement of a form of social control, and the centripetal moment as the cultural moment and as a form of evasion of control, can be problematic. In this context this article (i) explores the contemporary relationship between ‘2.0’ (read as essentially industrial account of convergence) and Henry Jenkins’ account of convergence culture as post-resistance culture and (ii) explores the potential for understanding contemporary convergence processes and the forms of participation they entail across a series of axes which together might provide a different and more multi-dimensional form of mapping.
Clinical applications of schizophrenia genetics: genetic diagnosis, risk, and counseling in the molecular era
Costain G, Bassett AS
The Application of Clinical Genetics , 2012, DOI: http://dx.doi.org/10.2147/TACG.S21953
Abstract: ical applications of schizophrenia genetics: genetic diagnosis, risk, and counseling in the molecular era Review (5123) Total Article Views Authors: Costain G, Bassett AS Published Date February 2012 Volume 2012:5 Pages 1 - 18 DOI: http://dx.doi.org/10.2147/TACG.S21953 Received: 26 November 2011 Accepted: 20 December 2011 Published: 21 February 2012 Gregory Costain1,2, Anne S Bassett1–4 1Clinical Genetics Research Program, Centre for Addiction and Mental Health, 2Institute of Medical Science, University of Toronto, 3Division of Cardiology, Department of Medicine and Department of Psychiatry, University Health Network, 4Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada Abstract: Schizophrenia is a complex neuropsychiatric disease with documented clinical and genetic heterogeneity, and evidence for neurodevelopmental origins. Driven by new genetic technologies and advances in molecular medicine, there has recently been concrete progress in understanding some of the specific genetic causes of this serious psychiatric illness. In particular, several large rare structural variants have been convincingly associated with schizophrenia, in targeted studies over two decades with respect to 22q11.2 microdeletions, and more recently in large-scale, genome-wide case-control studies. These advances promise to help many families afflicted with this disease. In this review, we critically appraise recent developments in the field of schizophrenia genetics through the lens of immediate clinical applicability. Much work remains in translating the recent surge of genetic research discoveries into the clinic. The epidemiology and basic genetic parameters (such as penetrance and expression) of most genomic disorders associated with schizophrenia are not yet well characterized. To date, 22q11.2 deletion syndrome is the only established genetic subtype of schizophrenia of proven clinical relevance. We use this well-established association as a model to chart the pathway for translating emerging genetic discoveries into clinical practice. We also propose new directions for research involving general genetic risk prediction and counseling in schizophrenia.
British trade and policy in Indonesia 1760-1772. (Met 3 kaarten)
D.K. Bassett
Bijdragen tot de Taal-, Land- en Volkenkunde , 1964,
Abstract:
The surrender of Dutch Malacca, 1795
D.K. Bassett
Bijdragen tot de Taal-, Land- en Volkenkunde , 1961,
Abstract:
A Short Chapter in the History of the CynipidousGall-Flies
Homer Franklin Bassett
Psyche , 1889, DOI: 10.1155/1889/10789
Abstract:
Clinical applications of schizophrenia genetics: genetic diagnosis, risk, and counseling in the molecular era
Costain G,Bassett AS
The Application of Clinical Genetics , 2012,
Abstract: Gregory Costain1,2, Anne S Bassett1–41Clinical Genetics Research Program, Centre for Addiction and Mental Health, 2Institute of Medical Science, University of Toronto, 3Division of Cardiology, Department of Medicine and Department of Psychiatry, University Health Network, 4Department of Psychiatry, University of Toronto, Toronto, Ontario, CanadaAbstract: Schizophrenia is a complex neuropsychiatric disease with documented clinical and genetic heterogeneity, and evidence for neurodevelopmental origins. Driven by new genetic technologies and advances in molecular medicine, there has recently been concrete progress in understanding some of the specific genetic causes of this serious psychiatric illness. In particular, several large rare structural variants have been convincingly associated with schizophrenia, in targeted studies over two decades with respect to 22q11.2 microdeletions, and more recently in large-scale, genome-wide case-control studies. These advances promise to help many families afflicted with this disease. In this review, we critically appraise recent developments in the field of schizophrenia genetics through the lens of immediate clinical applicability. Much work remains in translating the recent surge of genetic research discoveries into the clinic. The epidemiology and basic genetic parameters (such as penetrance and expression) of most genomic disorders associated with schizophrenia are not yet well characterized. To date, 22q11.2 deletion syndrome is the only established genetic subtype of schizophrenia of proven clinical relevance. We use this well-established association as a model to chart the pathway for translating emerging genetic discoveries into clinical practice. We also propose new directions for research involving general genetic risk prediction and counseling in schizophrenia.Keywords: schizophrenia, genetics, 22q11 deletion syndrome, copy number variation, genetic counseling, genetic predisposition to disease
Modern garden delphiniums
Bassett, Shirley E.
Collectanea Botanica , 1990,
Abstract: The characteristic features or modern English garden hybrid delphiniums are described. The development by Reinelt of the Pacific seed strain in America, and the successful introduction or red colours by Legro in Holland are discussed. The evolution of the tetraploid garden hybrid is considered in the light of species available to early breeders. The role of the Delphinium Society in the promotion of the flower and the encouragement or breeding programs is reviewed. [ca] Es descriuen les característiques dels delphiniums híbrids de jardí anglesos moderns. Es discuteix el desenvolupament de la ra a de granes Pacific a Amèrica per Reinelt i l'èxit de la introducció de colors vermells a Holanda per Legro. L'evolució dels híbrids de jardineria tetraploides és considerada a la llum de les espècies que eren disponibles per als primers milloradors. Es revisa el paper de la Delphinium Society en la promoció de la flor i en la promoció dels programes de millora.
Gender and Blindness: Eye Disease and the Use of Eye Care Services
Paul Courtright,Ken Bassett
Community Eye Health Journal , 2003,
Abstract: Summary and Recommendations from a meeting at the Kilimanjaro Centre for Community Ophthalmology, Moshi, Tanzania, June 17-21, 2002
Gender Differences in the Social Pathways Linking Neighborhood Disadvantage to Depressive Symptoms in Adults
Emma Bassett, Spencer Moore
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0076554
Abstract: Depression debilitates the lives of millions and is projected to be the second leading disease burden worldwide by 2020. At the population level, the causes of depression are found in the everyday social and physical environments in which people live. Research has shown that men and women often experience neighbourhood environments differently and that these variations are often reflected in health outcomes. The current study examines whether social and environmental correlates of depression are similar in men and women. This study examines whether (i) there are gender differences in the association between neighbourhood disadvantage and depressive symptoms, and (ii) dimensions of social capital and cohesion mediate these associations. Data come from the Montreal Neighbourhood Networks and Healthy Aging Study, which consists of a cluster stratified sample of Montreal census tracts (nct = 300) and individuals within those tracts (ni = 2707). Depressive symptoms and social capital were measured with a questionnaire. Neighbourhood disadvantage was measured at the census tract level using data from the 2006 Canada Census. Multilevel logistic regression stratified by gender and a three-step mediation analysis procedure were used. Final sample size for these analyses was 2574 adults. Depressive symptoms had a prevalence of 17.3% in the overall sample. Disadvantage was associated with depressive symptoms in women only (OR = 1.25, 95% CI = 1.01–1.55). Perceived neighbourhood cohesion was shown to mediate the association of disadvantage and depressive symptoms in women (ab = 0.02; 95% CI = 0.003–0.04, p<0.05). Other socio-relational variables, specifically generalized trust and trust in neighbours were associated with depression in women but did not act as mediating variables. Health promotion initiatives meant to combat depression may wish to consider gender differences in the design and implementation of neighbourhood or peer-based programs.
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