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Search Results: 1 - 10 of 8802 matches for " Barbosa JS "
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Multi-Layered Films Containing a Biomimetic Stimuli-Responsive Recombinant Protein
Barbosa JS,Costa RR,Testera AM,Alonso M
Nanoscale Research Letters , 2009,
Abstract: Electrostatic self-assembly was used to fabricate new smart multi-layer coatings, using a recombinant elastin-like polymer (ELP) and chitosan as the counterion macromolecule. The ELP was bioproduced, purified and its purity and expected molecular weight were assessed. Aggregate size measurements, obtained by light scattering of dissolved ELP, were performed as a function of temperature and pH to assess the smart properties of the polymer. The build-up of multi-layered films containing ELP and chitosan, using a layer-by-layer methodology, was followed by quartz-crystal microbalance with dissipation monitoring. Atomic force microscopy analysis permitted to demonstrate that the topography of the multi-layered films could respond to temperature. This work opens new possibilities for the use of ELPs in the fabrication of biodegradable smart coatings and films, offering new platforms in biotechnology and in the biomedical area.
Resistance of livestock to viruses: mechanisms and strategies for genetic engineering
JS Gavora
Genetics Selection Evolution , 1996, DOI: 10.1186/1297-9686-28-5-385
Menstrual disturbances
JS Bagratee
Continuing Medical Education , 2004,
risk factors for hypertension among urban males in mombasa kenya
JS Salehmohamed
Dar Es Salaam Medical Students' Journal , 2008,
Abstract: OBJECTIVE To assess socio-cultural factors associated with hypertension among adult males of Mombasa in Kenya. MATERIALS AND METHODS: A community based cross-sectional study was done in Mombasa Old Town area, whereby males aged 15 yrs and above attending mosque after prayers were randomly requested to participate in the study. Data was collected using structured English questionnaires. Hypertension (HT) risk factors were assessed, followed by physical examination for obesity anthropometric measurements and blood pressure measurements. Questionnaires were coded and data entered in a computer and analyzed by epi info 2002 statistical computer program. RESULTS: The Prevalence of Hypertension in the population was found to be 6.7%, increase in age and smoking were found to be a predisposing risk factor for HT. Smokers had significant risk ratio of 4 in acquiring HT. It was also noted that Chewing of Miraa and Drinking alcohol had no significant association as a risk predisposing to HT. Although many alcohol consumers had HT. Occupation was not significantly associated with HT. The study unveiled that physical exercise had protective effect there by decreasing the risk of having HT. High Body Mass index (BMI) and Weight to Hip ration (WHR) was a predisposing risk factor for having HT. CONCLUSION & RECOMMENDATIONS Doing physical exercise was found to have protective association towards HT. It has been also noted that those people who had hypertension and were on regular medication were relatively better, thus physicians should intervene as early as possible so as to block the natural history of this debilitating disease.
Bacteria associated with cultures of psathyrella atroumbonata (Pleger)and Schizophyllum commune (Fr.Ex.Fr)
JS Gbolagade
African Journal of Biomedical Research , 2004,
Abstract: Studies were carried out on bacteria, which usually infect spawns and culture plates of Psathyrella atroumbonata (Pegler) and Schizophyllum commune (Fr. Ex. Fr.), two Nigerian edible mushrooms. During the vegetative propagation of these higher fungi, six different bacteria species were isolated and characterized from 14 day old spawns and mycelial ramified PDA culture plates. These bacteria include Bacillus licheniformis, Bacillus subtilis, Leuconostoc mesenteroides, Pseudomonas aeruginosa, Bacillus cereus and Staphylococcus aureus. The average bacteria count was 1.0 x 106 cfu/ml and these bacteria grew within pH range of 5.0 and 9.0. the optimum temperature range of growth lied between 300C and 370C. The significance of these findings to the cultivation of P. atroumbonata and S. commune in Nigeria were discussed.
State of the art biotechnology and biosafety in Kenya
JS Wafula
African Crop Science Journal , 1995,
Role of institutional biosafety committees in Kenya
JS Wafula
African Crop Science Journal , 1995,
The effect of different nutrient sources on biomass production of Lepiota procera in submerged liquid cultures
JS Gbolagade
African Journal of Biotechnology , 2006,
Abstract: The effect of various organic, inorganic and complex compounds on the biomass production (mycelial dry weight) of Lepiota procera, a Nigerian edible higher fungus was investigated. Among the seventeen carbon compounds tested, mannose enhanced the best biomass yield. This was followed in order by glucose, raffinose and fructose (P>0.01) while Myo-inositol, sucrose and dextrin were the least stimulatory. Of all the twenty-one nitrogen sources used, D-alanine was the most utilizable. Moderate biomass yield was also supported by yeast extract and peptone while the least biomass production was recorded with D-cysteine and sodium nitrate. The carbon/nitrogen ratio that sustained the best biomass yield was 4:1 while the least utilized ratios were 2:5 and 3:5 respectively. Magnesium and calcium were the best macronutrients. Likewise, trace elements (Mn and Zn) stimulated very good mycelial growth
Disaffiliation in associations and the ποσυναγωγ of John
JS Kloppenborg
HTS Theological Studies/Teologiese Studies , 2011,
Abstract: This article tries to understand what might have been at stake for the synagogue from which the Johannine Jesus partisans had been expelled and what was at stake in the coinage of the term ποσυναγωγ . It we refuse to accept naively John’s overlexicalised and retrospective account of the grounds for expulsions and pay attention to the practices of other groups in articulating a disciplinary code, I suggest that what was at stake was deviant behaviour on the part of the Johannine Jesus-partisans: either failure to comply with the larger group’s practices concerning Sabbath observance, or more likely, clique formation.
The development and introduction of biosimilar anticoagulants – focus on enoxaparin
Ginsberg JS
Biosimilars , 2012, DOI: http://dx.doi.org/10.2147/BS.S17831
Abstract: evelopment and introduction of biosimilar anticoagulants – focus on enoxaparin Review (1780) Total Article Views Authors: Ginsberg JS Published Date September 2012 Volume 2012:2 Pages 27 - 31 DOI: http://dx.doi.org/10.2147/BS.S17831 Received: 12 July 2012 Accepted: 11 August 2012 Published: 13 September 2012 Jeffrey S Ginsberg Department of Medicine, McMaster University, Hamilton, Ontario, Canada Abstract: The aims of this paper are to discuss the: (1) pharmacology of low-molecular-weight heparins (LMWHs) emphasizing their synthesis, mechanism of action, and comparison with the parent compound, unfractionated heparin (UFH); and (2) recent controversial approval by the Food and Drug Administration (FDA) of a generic enoxaparin. Enoxaparin is one of several LMWHs that are currently available worldwide for clinical use. LMWHs are derived by chemical or enzymatic depolymerization of the “parent” molecule, UFH. Both UFH and LMWHs exert their primary antithrombotic effect by binding to and catalyzing the naturally-occurring anticoagulant, antithrombin. LMWHs are more effective at inhibiting factor Xa than factor IIa (thrombin). They also produce less heparin-induced thrombocytopenia and osteoporosis than UFH and are at least as effective and safe as UFH for each approved indication. They are safe and effective when given subcutaneously once or twice daily, without the need for anticoagulant monitoring, and are suitable for out-of-hospital treatment. The FDA first approved enoxaparin (Lovenox ) in March 1993. Despite its cost effectiveness, individual patients without drug insurance are often left paying for the cost of the drug. Uninsured pregnant subjects are particularly disadvantaged because they often require several months of therapy, costing several thousand dollars. To evaluate a less expensive, generic enoxaparin, the FDA chose to use the “abbreviated new drug application” because it considered enoxaparin to be a drug rather than a biologic medicine. This requires that the generic enoxaparin meets the following five criteria for “sameness”: equivalence of (1) UFH source material and method of depolymerization; (2) physicochemical properties; (3) disaccharide building blocks, fragment mapping, and sequence of oligosaccharide species; (4) biological and biochemical assays; and (5) in vivo pharmacokinetic profile. Based upon meeting these criteria, and despite protests from several outside expert groups, the generic enoxaparin was approved by the FDA in July 2010.
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