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Search Results: 1 - 10 of 139231 matches for " Bansal K "
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Primer on pediatric intracranial ependymomas
Bansal K
Journal of Pediatric Neurosciences , 2006,
Abstract: Aims and Objectives: To review the clinical features and current understanding of the biology and management of pediatric ependymoma, critically analysing the different treatment modalities. Materials and Methods: The MEDLINE database, bibliographies of selected articles, and current English-language texts on the subject were reviewed. A Pubmed search was made with keywords pediatric, intracranial, ependymoma, surgery, chemotherapy, and radiotherapy. Most recent articles and also significant older articles having all above said words were selected and their results were compared in detail. Results: Almost all articles stress the complete or near total resection of the tumor at first surgery followed by radiotherapy in patients older than 3 years of age and chemotherapy in younger children. Conformal radiation therapy (CRT) is a technique which has promising results. Conclusion: Local tumor control is single most important prognostic factor. This is best achieved through gross total tumor resection wherever possible. Radiotherapy should be offered to all patients (>3-years age) with focused dose (CRT) to tumor bed. Chemotherapy with the current agents does not appear to hold much promise. However, it may be useful in the context of providing the surgeon with an opportunity to do further surgery on a tumor that is less vascularized.
Bioinformatics in microbial biotechnology – a mini review
Arvind K Bansal
Microbial Cell Factories , 2005, DOI: 10.1186/1475-2859-4-19
Abstract: In the last decade, the revolution in computer technology and memory storage capability has made it possible to model grand challenge problems such as large scale sequencing of genomes and management of large integrated databases over the Internet. This vastly improved computational capability integrated with large-scale miniaturization of biochemical techniques such as PCR, BAC, gel electrophoresis and microarray chips has delivered enormous amount of genomic and proteomic data to the researchers all over the world. This availability of data has led to an explosion of genome and proteome analysis leading to many new discoveries and tools that are not possible in wet-lab experiments.The availability of genomic and proteomics data and improved bioinformatics and biochemical tools has raised the expectation of the humanity to be able to control the genetics by manipulating the existing microbes. The advantages are enormous such as better diagnosis of the diseases through the use of protein biomarkers, protection against diseases using cost effective vaccines [56,73] and rational drug design, improvement in agricultural quality and quantity, and the development of techniques that help us visualize and understand the detailed microbial machine at the systemic level.Since the sequencing of the first complete microbial genome of Haemophilus influenzae in 1995 [29], hundreds of microbial genomes have been sequenced and archived for public research in GenBank ftp://ftp.ncbi.nih.gov/genbank/ webcite through the concerted effort of federal health agencies such as NIH and DOE in USA, EMBL and EBI in Europe, DNA databank of Japan, national laboratories, academic universities, multiple drug development companies such as Celera and non-profit organizations such as TIGR, and companies involved in agricultural industry and bioremediation. The sequencing of human genome [68] and other relevant eukaryotic genomes has raised the expectation of understanding host pathogen interaction f
Truck Drivers And Risk Of STDs Including HIV
Bansal R.K
Indian Journal of Community Medicine , 1995,
Abstract: Research Question: Whether long distance truck drivers are at a higher risk of contracting and transmitting STDs including HIV? Objectives: i) To study the degree of knowledge of HIV and AIDS among long- distance truck drivers. ii) Assess their sexual behaviour including condom use. iii) Explore their prevailing social influences and substance abuse patterns. iv) Explore their treatment seeking bahaviour as regards STDs. v) Deduce their risk of contracting and transmitting STDs including HIV. Study Design: Cross- sectional interview. Setting: Transport Nagar, Indore (M.P) Participants: 210 senior drivers (First drivers) and 210 junior drivers (Second drivers). Study Variables: Extra-Marital sexual intercourse, condom usage, past and present history of STDs, treatment and counseling, substance abuse, social a€" cultural milieu. Outcome Variables: Risk of contraction of STDs. Statistical Analysis: Univariate analysis. Results: 94% of the drivers were totally ignorant about AIDS. 82.9% and 43.8 % of the senior and junior drivers had a history of extra- marital sex and of these only 2 regularly used condoms. 13.8% and 3.3 % of the senior and junior drivers had a past or present history suggestive of STD infection. Alcohol and Opium were regularly used by them. Conclusion: The studied drivers are at a high risk of contracting and transmitting STDs including HIV.
Atypical teratoid/rhabdoid tumors of central nervous system
Bansal K,Goel Deepak
Journal of Pediatric Neurosciences , 2007,
Abstract: Aims and Objectives: To review the clinical features and current understanding of the epidemiology, biology and management of pediatric atypical teratoid/rhabdoid tumors and analyzing the different treatment modalities. Materials and Methods: The MEDLINE database, bibliographies of selected articles and current English-language texts on the subject were reviewed. A Pubmed search was made with keywords pediatric atypical teratoid/rhabdoid tumors, intracranial, surgery, chemotherapy and radiotherapy. Most recent articles and also significant older articles having all above said words were selected and their results were reviewed in detail. Results: Atypical teratoid/rhabdoid tumors (AT/RT) of the central nervous system (CNS) most frequently diagnosed in smaller than 3 years of age and incidence is 1-2% of all brain tumors in children. 63% of the AT/RT of the CNS is seen in infra-tentorial compartment, there are no precise imaging features that differentiate AT/RT from the other posterior fossa tumor. The "rhabdoid" cells are characteristic on cytopathology. It has been established now that CNS, AT/RT often show deletion of the long arm of chromosome 22q11.2. The initial treatment for most children with AT/RT is surgical with and without cerebrospinal fluid diversionary procedure. Children with less than 3 years of age offered chemotherapy but in older children radiotherapy is given in addition.
Effect of flunixin meglumine alone and in combination on haemodynamics during bovine endotoxic shock and after treatment  [PDF]
D. V. Singh, S. K. Bansal, G. S. Ghumman
Journal of Biomedical Science and Engineering (JBiSE) , 2011, DOI: 10.4236/jbise.2011.41004
Abstract: To investigate the effect of Flunixin meglumine- a NSAID; alone and in combination with hypertonic saline on endotoxemic buffalo calves, two groups of five apparently healthy male buffalo calves aged be-tween 6-8 months were subjected to I.V. infusion of E.coli endotoxin at the rate of 5μg/kg BW per hour for 3 hours. A highly significant (P < 0.01) fall in mean systolic,diastolic, pulse, mean arterial pressure (M.A.P), central venous pressure (C.V.P) and haemo-globin was observed till the end of endotoxin infusion while respiratory rate was significantly elevated along with a non-significant alteration in rectal tem-perature and hematocrit during the infusion of en-dotoxin. Immediately at the end of endotoxin infusion, flunixin meglumine at the rate of 1.1 mg/kg B.W was infused i.v. in group-I animals and group-II animals were infused with hypertonic saline solution (H.S.S.) at the rate of 4 ml/Kg BW as one time infusion fol-lowed by flunixin meglumine at the rate of 1.1 mg/kg B.W which resulted in increase of various parameters either to normal or very close to normal value while the rectal temperature and haematocrit decreased non-significantly throughout the observation period of 7 hours. No improvement in Hb and respiration was observed consequent to FM administration. Both treatments successfully raised systolic, diastolic, pulse pressure, C.V.P & M.A.P to normal pre-infusion val-ues. From the results of the present investigation, it can be concluded that i.v. infusion of FM alone and in combination with hypertonic saline solution in en-dotoxemic buffalo calves effectively restores the various hemodynamic parameters close to normal pre-infusion values and it can be used as immediate resuscitation measure to provide the clinician valu-able time to plan further long term treatment.
Coefficient estimates and subordination properties associated with certain classes of functions
R. K. Raina,Deepak Bansal
International Journal of Mathematics and Mathematical Sciences , 2005, DOI: 10.1155/ijmms.2005.3685
Abstract: This note investigates coefficient estimates and subordination properties for certain classes of normalized functions (which are essentially defined by means of a Hadamard product of two analytic functions). We exhibit several interesting consequences of our main results, and in the process, we are also led to the corrected forms of the results given by Owa and Nishiwaki (2002).
Improved dissolution of a poorly water soluble drug in solid dispersions with polymeric and non-polymeric hydrophilic additives
Garima Chawla, Arvind K. Bansal
Acta Pharmaceutica , 2008, DOI: 10.2478/v10007-008-0016-1
Abstract: Irbesartan (IBS) is a hydrophobic drug with poor aqueous solubility and dissolution rate. Solid dispersions (SDs) of IBS were prepared with both small molecules (tartaric acid and mannitol) and polymeric additives (polyvinyl-pyrrolidone, PVP, and hydroxypropyl methylcellulose, HPMC). A 9.5 and 7 folds enhancement in solubility over the crystalline form (14.6 μg mL-1) was observed for tartaric acid (138 μg mL-1) and PVP (103 μg mL-1), respectively. Powder X-ray diffraction confirmed that IBS existed in the glassy state in all cases, even with excipients having low glass transition temperature. Thermal methods (differential scanning calorimetry and hot stage microscopy) were used to evaluate the miscibility of the drug and additives. These techniques suggested that tartaric acid led to generation of amorphous solutions in contrast to amorphous suspensions in other three cases. The in vitro dissolution of IBS depended on the additive load and increased with increasing concentration in the case of tartaric acid, an acidifying excipient. The results indicate the suitability of even small molecules for providing solubility benefits, which can be attributed to the good glass forming ability and reasonable ability of IBS to remain in the glassy state.
Some subordination theorems associated with a new operator
Deepak Bansal,Ravindar K. Raina
Le Matematiche , 2010,
Abstract: In this paper we introduce a linear operator and obtain certain differential subordination properties associated with this linear operator. Some relevant consequences of the main results including new variations of earlier known results are also pointed out.
Phylogenetic Analysis and Molecular Dating Suggest That Hemidactylus anamallensis Is Not a Member of the Hemidactylus Radiation and Has an Ancient Late Cretaceous Origin
Rohini Bansal, K. Praveen Karanth
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0060615
Abstract: Background of the Work The phylogenetic position and evolution of Hemidactylus anamallensis (family Gekkonidae) has been much debated in recent times. In the past it has been variously assigned to genus Hoplodactylus (Diplodactylidae) as well as a monotypic genus ‘Dravidogecko’ (Gekkonidae). Since 1995, this species has been assigned to Hemidactylus, but there is much disagreement between authors regarding its phylogenetic position within this genus. In a recent molecular study H. anamallensis was sister to Hemidactylus but appeared distinct from it in both mitochondrial and nuclear markers. However, this study did not include genera closely allied to Hemidactylus, thus a robust evaluation of this hypothesis was not undertaken. Methods The objective of this study was to investigate the phylogenetic position of H. anamallensis within the gekkonid radiation. To this end, several nuclear and mitochondrial markers were sequenced from H. anamallensis, selected members of the Hemidactylus radiation and genera closely allied to Hemidactylus. These sequences in conjunction with published sequences were subjected to multiple phylogenetic analyses. Furthermore the nuclear dataset was also subjected to molecular dating analysis to ascertain the divergence between H. anamallensis and related genera. Results and Conclusion Results showed that H. anamallensis lineage was indeed sister to Hemidactylus group but was separated from the rest of the Hemidactylus by a long branch. The divergence estimates supported a scenario wherein H. anamallensis dispersed across a marine barrier to the drifting peninsular Indian plate in the late Cretaceous whereas Hemidactylus arrived on the peninsular India after the Indian plate collided with the Eurasian plate. Based on these molecular evidence and biogeographical scenario we suggest that the genus Dravidogecko should be resurrected.
Role of non-coplanarity in nuclear reactions using the Wong formula based on the proximity potential
Manie Bansal,Raj K. Gupta
Physics , 2010,
Abstract: we assessed Wong's formula for its angular momentum $\ell$-summation and "barrier modification" effects at sub-barrier energies in the dominant fusion-evaporation and capture (equivalently, quasi-fission) reaction cross-sections. For use of the multipole deformations (up to $\beta_4$) and (in-plane, $\Phi$=0$^0$) orientations-dependent proximity potential in fusion-evaporation cross-sections of $^{58}$Ni+$^{58}$Ni, $^{64}$Ni+$^{64}$Ni and $^{100}$Mo, known for fusion hindrance phenomenon in coupled-channels calculations, and the capture cross-sections of $^{48}$Ca+$^{238}$U, $^{244}$Pu and $^{248}$Cm reactions, forming superheavy nuclei, though the simple $\ell$=0 barrier-based Wong formula is found inadequate, its extended version, the $\ell$-summed Wong expression fits very well the above noted capture cross-sections at all center-of-mass energies $E_{c.m.}$'s, but require (additional) modifications of the barriers to fit the fusion-evaporation cross-sections in the Ni-based reactions at below-barrier energies. Some barrier modification effects are shown \cite{kumar09} to be already present in Wong expression due to its inbuilt $\ell$-dependence via $\ell$-summation.
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