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Reconstruction of the infected war defects of the tibia: A fragment elongation according to the Ilizarov technique
Tomi? Slavko,Bajin Zoran,Slavkovi? Nemanja
Vojnosanitetski Pregled , 2005, DOI: 10.2298/vsp0512895t
Abstract: Introduction/Aim. The treatment of tibia defects complicated with chronic osteomyelitis is difficult, often requiring one or more surgical interventions with prolonged periods of functional incapacity. Methods. We treated 20 patients with tibia defects, who had been wounded during the war operations in the former Yugoslavia, complicated with chronic osteomyelitis by applying the Ilizarov apparatus. In 10 patients with the average defect of 4.7 cm, interfragmentary diastasis of 1.5 cm, and 3.1 cm of shortening we applied the bilocal synchronous compressive - distractive method (BSCD). In the remaining 10 patients with average defect of 6.4 cm, interfragmentary diastasis of 5.5 cm, and 1.6 cm of shortening we applied bilocal alternating distractive - compressive osteosynthesis (BADC). Results. The average followup was 93 months. In the group A, the average distraction index was 10.6, maturation index 39.8, and external fixation index 52.5. In the group B, the average distraction index was 11.7, maturation index 47.1, and external fixation index 60.1. The average time from the application to the apparatus removing was in the group A 6.5 months, and in the group B 11.9 months. There were 27 complications: 11 problems, 8 disturbs, and 8 true complications. Pin-track inflammation of the soft tissue was noted most frequently (6 patients). Conclusions. One stage of repairing inflamation and the restitution of defect in lower leg tissue was the advantage of this type of treatment. All of the patients recovered. There was not any bad result, either in osteal or in functional outcome.
Medial rotation deformity of the hip in cerebral palsy: Surgical treatment by transposition of gluteal muscles
?obelji? Goran,Bajin Zoran,Vuka?inovi? Zoran,Le?i? Aleksandar
Srpski Arhiv za Celokupno Lekarstvo , 2005, DOI: 10.2298/sarh0502036c
Abstract: INTRODUCTION Medial rotation deformity of the hip is a problem to patients who are handicapped by cerebral palsy but able to walk, because the knees point inward during gait ( kissing patellae") and cause falls and frequent injuries. Knees and ankles are subject to stress and, therefore, they assume compensating positions. Lower legs assume position of valgus and external rotation, whereas feet rotate either inwards or outwards. Secondary deformities make gait more difficult and cause rapid tear of footwear. AIM The purpose of the paper was to retrospectively analyze the effects of transposition of the gluteus medius and minimus muscles, a procedure introduced for the first time in our country in order to correct the deformity. A new method of binding the muscles by wire was described. There had been no previous experience with this method. METHOD This operation was indicated in patients with spastic form of cerebral palsy, who were able to walk, who had difficulties in gait and whose lateral rotation was less than 10° along with the medial rotation of over 70° of the hip on the side of the deformity. Additional prerequisite for the operation was the absence of flexion contracture of more than 15° of either the hip or the knee on the side of deformity, as there is possibility of aggravation of the flexion hip deformity due to transposed gluteal muscles (now in front of the hip joint). Fifteen hips of 10 patients were operated on. Five patients were operated on bilaterally at one time. The average age was 8 (6-12) years. The majority of patients, 8 (80%) were aged between 6 and 8. The average follow-up was 5 years (3-8). The assessment of the results was based on the comparison of rotational abilities of both hips before and after the operation (in unilateral and bilateral deformities), as well as on individual complaints before and after the operation. In patients with unilateral deformity, their healthy" hips were the control hips. The analysis of the femoral neck anteversion before and after operation was performed. RESULTS Average values of medial and lateral rotation of the deformed hips before operation exhibited significant statistical difference when compared to control hips. The difference of average values of rotatory movements of control and operated hips was not statistically significant after operation. The difference of average preoperative values of the femoral neck anteversion in hips with deformity was statistically significant (49.40±4.63° compared to 32.8±3.1G). Postoperative average values of anteversion in operated and control hips w
Medial rotation deformity of the hip in cerebral palsy: Surgical treatment by derotation femoral osteotomy
?obelji? Goran,?or?i? I.,Bajin Zoran,Vuka?inovi? Zoran
Acta Chirurgica Iugoslavica , 2004, DOI: 10.2298/aci0403029c
Abstract: Medial rotation deformity of the hip is a problem to patients handicapped by cerebral palsy who are able to walk, because the knees point inward during gait ("kissing patellae") and cause falls and frequent injuries, knee and ankle distorsions. The deformity is a result of an increased femoral neck anteversion. The purpose of the paper is to present the results of an original method of precise determination of the degree of rotation for derotation femoral osteotomy. Indications for this operation were set in pa- tients with spastic form of cerebral palsy over 10 years of age, able to walk, who had difficulties in gait and whose lateral rotation was less than 15 along with the medial rotation of over 70 in the hip on the side of the deformity. Twenty hips in 17 patients able to walk were operated on. The average age was 21 (11 - 42), the average follow-up was 11 years (3-17). The assessment of the results was based on the comparison of the rotational abilities of the hip and individual problems before and after the operation. Excellent result was achieved in 12 (70.6%) patients i.e. 15 (75%) hips; good result was achieved in 3 (17.6%) patients i.e. 3 (15%) hips; unsuccessful result in 2 (11.8%) patients i.e. 2 (10%) hips. Complications aroused in 6 patients i.e. 6 (30%) hips. The conclusion is that derotation osteotomy of the femur is a successful procedure for the treatment of the medial rotation deformity of the hip in patients with the spastic form of cerebral palsy who are able to walk. The above mentioned indications must be respected and the original method of determining the degree of derotation applied. Due to a relatively high percentage of complications, e.g. osteitis, the operation is suggested to patients aged 10 to 15 when possible complications can more easily be cured.
Changes of biochemical parameters in rat intestinal mucosa induced by methotrexate and effects of enteral administration of glutamine
Bajin-Kati? Katica,Stankov Karmen,Kova?evi? Zoran
Archive of Oncology , 2004, DOI: 10.2298/aoo0401035b
Abstract: BACKGROUND: Rapidly proliferating crypt cells of the intestinal epithelium, the precursors of the mature enterocytes, are extremely sensitive to the effects of cytostatic agents. We investigated the effects of the methotrexate on rat intestinal mucosa in order to get the information on biochemical indicators of intestinal damage. METHODS: Biochemical parameters were investigated in isolated intestinal mucosa of Sprague-Dawley rats, previously treated with methotrexate by intraperitoneal administration. Glutamine was dissolved in water and administered orally. RESULTS: The activity of glutaminase and alkaline phosphatase showed the enzymatic response to different doses of methotrexate. The activity of both enzymes was significantly lower in the mucosa of treated animals, compared to control group. CONCLUSION: Minimal mucosal damage and regeneration time is dose dependent and influenced by the dosage schedule of antitumor therapy.
Intestinal alkaline phosphatase activity as a molecular marker of enterotoxicity induced by single dose of 5-fluorouracil and protective role of orally administered glutamine
Bajin-Kati? Katica,Stankov Karmen,?olai Matilda,Kova?evi? Zoran
Archive of Oncology , 2006, DOI: 10.2298/aoo0604101b
Abstract: Background. One of the critical limitations for the administration of the chemotherapy is the toxicity affecting normal tissue. The main target organs for 5-fluorouracil (5-FU) toxicity in humans and experimental animals are the gastrointestinal tract, bone marrow, and skin. The cytotoxic effects of antimetabolite chemotherapy are based on their role as substrates for the same transport processes and enzymes involved in anabolism and catabolism as the natural substrates. The main goal of our study was to analyze the dose-dependent antiproliferative effects of 5-FU on intestinal mucosa, enterotoxic potential of 5-FU in experimental animals and to test possible protective role of glutamine. Methods. In our study, we used Sprague Dawley rats. The control group of rats included 50 animals, while the groups where either 5-fluorouracil (5-FU) alone or 5-FU and glutamine were administered included 200 animals. All experimental animals were further stratified according to the experimental model (25 animals in each of 8 experimental subgroups of animals). The 5-FU was administered by intraperitoneal application in single dose of 0, 100, 200, 300, and 400 mg of 5-FU per kg of body weight. Water solution of 1% glutamine was prepared daily and administered orally, in volume of 200 ml, for 7 days continuously, after the 7th day of 5-FU administration. Experimental animals were sacrificed 7 days after the administration of 5-FU. The isolation of enterocytes was performed according to the method of Kralovansky et al. In cell homogenate obtained by described method, we determined the protein content using the Biuret method and the DNA content using the Burton reagent. The activities of enzymes alkaline phosphatase (ALP), glutathione S-transferase (GST), glutathione reductase (GR), and glutathione peroxidase (GPX) were determined by kinetic method. All paraffin samples of the small intestine were stained by haematoxiline and eosine(HE method). All the experiments were done in duplicate and analyzed by standard statistical methods. All the experiments were done in duplicate and analyzed by standard statistical methods. Results: Our results of enterotoxicity induced by intraperitonealy administered 5-FU showed statistically significant decrease of DNA content in small intestine samples of experimental animals, decrease in activity of intestinal alkaline phosphatase enzyme and the increase in glutathione-dependent enzymes. The glutamine supplementation reduced 5-FU intestinal toxicity. Conclusion: Intestinal alkaline phosphatase is a good marker of the dose-dependent enter
Comparison of glycolytic enzyme and isoenzyme activity in breast cancers and dysplasia
Bajin-Kati? Katica
Medicinski Pregled , 2012, DOI: 10.2298/mpns1206200b
Abstract: The study was aimed at assessing the total enzyme activity and the profile of breast cancer and dysplasia on the human material. In addition, the validity of data was evaluated from the aspect of improving diagnostics. Lactate dehydrogenase activity, as well as the profile of its isoenzymes, pyruvate kinase and hexokinase, were measured. The study included 60 samples of breast cancer, out of which 20 were benign breast tumours and 40 were 1st and 2nd degree dysplasia of the breast. The samples were collected from the patients operated at the Institute for Oncology of Faculty of Medicine in Sremska Kamenica. Lactate dehydrogenase isoenzymes were separated by the vertical polyacrylamide gel disc electrophoresis according to the slightly modified Brewer and Ashworth’s method. The activity of all the tested enzymes was measured under the conditions of linear kinetics in the function of time and enzyme concentration. Lactate dehydrogenase-5 was found in 88% of the analyzed breast cancer samples, whereas it was not detected in breast dysplasia. Pyruvate kinase (4.-isoenzyme) was about 50 times higher and the activity of hexokinase was 3 times higher in breast cancer than in breast dysplasia. Lactate dehydrogenase-5 and pyruvate kinase (4.-isoenzyme) are particularly important and reliable markers of malignity. The results obtained for quantitative and qualitative changes in the enzyme activity can be used to improve diagnostics and early diagnostics of malignant breast neoplasm.
Colour as an Element of the Creativity in Education of Design  [PDF]
Zoran Markovic
Open Journal of Social Sciences (JSS) , 2014, DOI: 10.4236/jss.2014.25015
Abstract: Education of Design is creativity based process. From Kansei Engineering to Emotional Design, there are several different approaches in involving feelings and emotions in designing process. Analysing all tools and techniques used by designers, colour has one of the biggest psychological impacts on the final users. Colour has the power not only to change the existing architectural language, but also to be a language on its own. Within architectural semiology, colour has a very important role. The paper presents the preliminary results of the research on cultural background and its influence on the psychological impact of the colour in design (architectural, interior, etc.). The research started in the beginning of 2012 and it has been conducted in Serbia, Botswana, Kenya (fully finalized), India, Slovenia, Brazil (ongoing), Singapore, South Africa and Malaysia (in the preparation stage), Japan, China, Russia, South Korea and Mexico (organization started). The Research objective is to describe, analyse and present importance of the emotional creativity in education, the current status of the role cultural background plays in colour choices in design, as well as to analyse psychological (personal) and social (group) impact and influence of colour. Moreover, the experiments planned are intended not only to outline contemporary cultural influence on colour preferences but also to revisit, revive and expand on the existing research in this field (e.g. [1] Kaya/Epps research at University of Georgia, USA, etc.) by adding the notion of multi-cultural background.
Maxwell-Proca Fields in Relativistic Astrophysical Compact Objects  [PDF]
Zoran Pazameta
Journal of Modern Physics (JMP) , 2013, DOI: 10.4236/jmp.2013.48A023

A general-relativistic model is formulated for hypothetical ultra-compact astrophysical objects composed of fluid infused with charges carrying a generalized massless Maxwell-Proca field. The chosen interior metric has the algebraic property that \"\"; the fluid consequently possesses a negative pressure which halts gravitational collapse and establishes hydrostatic equilibrium. For an object containing a global distribution of non-interacting Maxwell-Proca charges, it is shown that physical considerations define the relationship between the charge density and the metric function uniquely, corroborating an earlier finding (for an electrostatic distribution of charge) that the interior field must increase with radial distance and the exterior field necessarily follows an inverse-square law. For the case of a charged fluid envelope surrounding a core of uncharged fluid, numerous solutions are possible. Assuming the interior field to vary as rn and requiring its strength to increase with radial distance while the charge density decreases, the range of values for n is found to be 0 < n ≤ 1 (where n is not necessarily an integer) with n = 1 denoting the special case of a continuous distribution of charge. For both continuous and stratified charge distributions, the exterior field is found to decrease as 1/r2 regardless of the interior field’s dependence on

Effect of Myostatin Depletion on Weight Gain, Hyperglycemia, and Hepatic Steatosis during Five Months of High-Fat Feeding in Mice
Kerri Burgess,Tianshun Xu,Roger Brown,Bajin Han,Stephen Welle
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0017090
Abstract: The marked hypermuscularity in mice with constitutive myostatin deficiency reduces fat accumulation and hyperglycemia induced by high-fat feeding, but it is unclear whether the smaller increase in muscle mass caused by postdevelopmental loss of myostatin activity has beneficial metabolic effects during high-fat feeding. We therefore examined how postdevelopmental myostatin knockout influenced effects of high-fat feeding. Male mice with ubiquitous expression of tamoxifen-inducible Cre recombinase were fed tamoxifen for 2 weeks at 4 months of age. This depleted myostatin in mice with floxed myostatin genes, but not in control mice with normal myostatin genes. Some mice were fed a high-fat diet (60% of energy) for 22 weeks, starting 2 weeks after cessation of tamoxifen feeding. Myostatin depletion increased skeletal muscle mass ~30%. Hypermuscular mice had ~50% less weight gain than control mice over the first 8 weeks of high-fat feeding. During the subsequent 3 months of high-fat feeding, additional weight gain was similar in control and myostatin-deficient mice. After 5 months of high-fat feeding, the mass of epididymal and retroperitoneal fat pads was similar in control and myostatin-deficient mice even though myostatin depletion reduced the weight gain attributable to the high-fat diet (mean weight with high-fat diet minus mean weight with low-fat diet: 19.9 g in control mice, 14.1 g in myostatin-deficient mice). Myostatin depletion did not alter fasting blood glucose levels after 3 or 5 months of high-fat feeding, but reduced glucose levels measured 90 min after intraperitoneal glucose injection. Myostatin depletion also attenuated hepatic steatosis and accumulation of fat in muscle tissue. We conclude that blocking myostatin signaling after maturity can attenuate some of the adverse effects of a high-fat diet.
Choice of operative procedures to correct equinus deformity in patients with cerebral palsy
?obelji? G.,Vuka?inovi? Z.,Apostolovi? M.,Bajin Z.
Acta Chirurgica Iugoslavica , 2006, DOI: 10.2298/aci0604021c
Abstract: Equinus deformity of the foot presents a great number of difficulties to ambulant patients with cerebral palsy. Non-operative treatment of the incorrectible - fixed equinus is not successful. Many procedures are applied to treat it operatively, so its not clear which procedure at what age is the most successful. The purpose of this manuscript is to clarify the issue. The results of four procedures are analyzed: aponeurectomy of m. gastrocnemius, Achilles tendon lengthening by z-plasty, a combination of these two procedures and sliding elongation of m. triceps surae. The analysis was based on 417 operations in 291 patients of the average age of 9 years (1-64). The average follow-up was 7 years. The assessment of the results was based on the visual evaluation of the gait, on pedoscope prints and on comparison of ankle movements before and after operation. The analysis shows that the best results were achieved by sliding elongation of m. triceps surae after the age of 7.
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