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Search Results: 1 - 10 of 144331 matches for " B. Mount "
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Quantification of multiple infections of Plasmodium falciparum in vitro
Mark A Wacker, Lindsey B Turnbull, Leah A Walker, Michael C Mount, Michael T Ferdig
Malaria Journal , 2012, DOI: 10.1186/1475-2875-11-180
Abstract: A quantitative PCR (qPCR) method was developed to track the dynamic interaction of P. falciparum infections containing genetically distinct parasite clones in cultured red blood cells. Allele-specific primers were used to generate a standard curve and to quantify the absolute concentration of parasite DNA within multi-clonal infections. Effects on dynamic growth relationships between parasites under drug pressure were examined by treating mixed cultures of drug sensitive and drug resistant parasites with the anti-malarial drug chloroquine at different dosing schedules.An absolute quantification method was developed to monitor the dynamics of P. falciparum cultures in vitro. This method allowed for the observation of competitive suppression, the reduction of parasites numbers due to the presence of another parasite, and competitive release, the improved performance of a parasite after the removal of a competitor. These studies demonstrated that the presence of two parasites led to the reduction in density of at least one parasite. The introduction of drug to a mixed culture containing both a drug resistant and drug sensitive parasites resulted in an increased proportion of the drug resistant parasite. Moreover, following drug treatment, the resistant parasite experienced competitive release by exhibiting a fitness benefit greater than simply surviving drug treatment, due to the removal of competitive suppression by the sensitive parasite.The newly developed assay allowed for the examination of the dynamics of two distinct clones in vitro; both competitive suppression and release were observed. A deeper understanding of the dynamic growth responses of multiple strain P. falciparum infections, with and without drug pressure, can improve the understanding of the role of parasite interactions in the spread of drug resistant parasites, perhaps suggesting different treatment strategies.
Evaluation of a regional air quality forecast model for tropospheric NO2 columns using the OMI/Aura satellite tropospheric NO2 product
F. L. Herron-Thorpe, B. K. Lamb, G. H. Mount,J. K. Vaughan
Atmospheric Chemistry and Physics (ACP) & Discussions (ACPD) , 2010,
Abstract: Results from a regional air quality forecast model, AIRPACT-3, are compared to OMI tropospheric NO2 integrated column densities for an 18 month period over the Pacific Northwest. AIRPACT column densities are well correlated (r=0.75) to cloud-free (<35%) retrievals of tropospheric NO2 for monthly averages without wildfires, but are poorly correlated (r=0.21) with significant model over-predictions for months with wildfires when OMI and AIRPACT are compared over the entire domain. AIRPACT predicts higher NO2 in some northwestern US urban areas, and lower NO2 in the Vancouver, BC urban area, when compared to OMI. Model results are spatially averaged to the daily OMI swath. The Dutch KNMI (DOMINO) and NASA (Standard Product) retrievals of tropospheric NO2 from OMI (Collection-3) are compared. The NASA product is shown to be significantly different than the KNMI tropospheric NO2 product. The average difference in tropospheric columns, after applying the averaging kernels of the respective products to the model results, is shown to be larger in the summer (±50%) than winter (±20%).
Evaluation of a regional air quality forecast model for tropospheric NO2 columns using the OM/AURA satellite tropospheric NO2 product
F. L. Herron-Thorpe,J. K. Vaughan,B. K. Lamb,G. H. Mount
Atmospheric Chemistry and Physics Discussions , 2009,
Abstract: Results from a regional air quality forecast model, AIRPACT-3, are compared to OMI tropospheric NO2 integrated column densities for an 18 month period over the Pacific Northwest. AIRPACT column densities were well correlated with cloud-free monthly averages of tropospheric NO2 (R=0.75) to NASA retrievals for months without wildfires, but were poorly correlated with significant model overpredictions (R=0.21) for months with wildfires when OMI and AIRPACT were compared over the entire domain. AIRPACT forecasted higher NO2 in some US urban areas, and lower NO2 in many Canadian urban areas, when compared to OMI. There are significant changes in results after spatially averaging model results to the daily OMI swath. Also, it is shown that applying the averaging kernel to model results in cloudy conditions has a large effect, but applying the averaging kernel in cloud free conditions has little effect. The KNMI and NASA retrievals of tropospheric NO2 from OMI (collection 3) are compared. The NASA product is shown to be significantly different than the KNMI tropospheric NO2 product, i.e. July 2007 (R=0.60) and January 2008 (R=0.69).
Frequency of Rare Allelic Variation in Candidate Genes among Individuals with Low and High Urinary Calcium Excretion
Hakan R. Toka, Giulio Genovese, David B. Mount, Martin R. Pollak, Gary C. Curhan
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0071885
Abstract: Our study investigated the association of rare allelic variants with extremes of 24-hour urinary calcium excretion because higher urinary calcium excretion is a dominant risk factor for calcium-based kidney stone formation. We resequenced 40 candidate genes potentially related to urinary calcium excretion in individuals from the Nurses' Health Studies I & II and the Health Professionals Follow-up Study. A total of 960 participants were selected based on availability of 24-hour urine collection data and level of urinary calcium excretion (low vs. high). We utilized DNA sample pooling, droplet-based target gene enrichment, multiplexing, and high-throughput sequencing. Approximately 64% of samples (n = 615) showed both successful target enrichment and sequencing data with >20-fold deep coverage. A total of 259 novel allelic variants were identified. None of the rare gene variants (allele frequencies <2%) were found with increased frequency in the low vs. high urinary calcium groups; most of these variants were only observed in single individuals. Unadjusted analysis of variants with allele frequencies ≥2% suggested an association of the Claudin14 SNP rs113831133 with lower urinary calcium excretion (6/520 versus 29/710 haplotypes, P value = 0.003). Our data, together with previous human and animal studies, suggest a possible role for Claudin14 in urinary calcium excretion. Genetic validation studies in larger sample sets will be necessary to confirm our findings for rs113831133. In the tested set of candidate genes, rare allelic variants do not appear to contribute significantly to differences in urinary calcium excretion between individuals.
Minimal intervention dentistry: Site #1 lesions
Mount Graham J.
Stomatolo?ki Glasnik Srbije , 2005, DOI: 10.2298/sgs0504217m
Abstract:
Minimal intervention dentistry: site #2 lesions
Mount Graham J.
Stomatolo?ki Glasnik Srbije , 2006, DOI: 10.2298/sgs0601054m
Abstract:
Minimal intervention dentistry progress of the carious lesion
Mount Graham J.
Stomatolo?ki Glasnik Srbije , 2005, DOI: 10.2298/sgs0501055m
Abstract:
Minimal intervention dentistry: Cavity classification
Mount Graham J.
Stomatolo?ki Glasnik Srbije , 2005, DOI: 10.2298/sgs0502120m
Abstract:
Minimal intervention dentistry: Site #3 lesions
Mount Graham J.
Stomatolo?ki Glasnik Srbije , 2006, DOI: 10.2298/sgs0602124m
Abstract:
Minimal intervention dentistry: Cavity preparation
Mount Graham J.
Stomatolo?ki Glasnik Srbije , 2005, DOI: 10.2298/sgs0503165m
Abstract:
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