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Immunohistochemical Expression Of Estrogen And Progesterone Receptors In Endometrial Hyperplasia And Endometrioid Carcinoma
S Sarmadi,N Izadi-Mood,B Rajabian
Tehran University Medical Journal , 2012,
Abstract: Background: Endometrial carcinoma (EC) is the most common gynecologic malignancy; however, mechanisms underlying its pathogenesis remain obscure.Endometrial carcinoma has been classified into two major categories: type I (related to estrogen or endometrioid adenocarcinoma)and type II (unrelated to estrogen).Estrogen is the main trigger for the abnormal proliferation in the endometrial epithelium but progesterone can inhibit this process. The aim of this study was to analyze the expression of estrogen and progesterone receptors in all types of endometrial hyperplasia in comparison to endometrioid adenocarcinoma of endometrium. Methods: Forty-seven specimens including 23 cases of histopathologically confirmed hyperplastic endometrium (12 simple hyperplasia, 5 complex hyperplasia without atypia, and 6 complex hyperplasia with atypia) and 24 cases of endometrial carcinoma were studied. Immunohistochemical staining of estrogen and progesterone receptors was performed in paraffin-embedded blocks and expression of estrogen and progesterone receptors were scored according to the proportion of positive staining cells. Results: Overexpression of progesterone receptors was seen in 18 (75%) out of 24 cases of endometrial carcinoma and 23 (100%) of all types of endometrial hyperplasia. The aforesaid differences were statistically significant (P=0.023). 70.8% of cases with endometrial carcinoma were 3+ for immunohistochemical staining of progesterone receptors as were 85.7% of the cases with endometrial hyperplasia; the difference being also statistically significant (P=0.02).Conclusion: Considering the increased proportion of progesterone receptor expression in all types of hyperplastic endometrium in comparison to endometrial carcinoma, hormonal therapy by progestinal agents is recommended as a treatment of choice.
Effects of Dietary Chromium-Methionin Supplementation on Blood Metabolites and Insulin Resistance Index in Fructose-Fed Diabetic Rats
S.E. Ghiasi,R. Valizadeh,R. Rajabian,R. Jalal,B. Azimian
Journal of Animal and Veterinary Advances , 2012, DOI: 10.3923/javaa.2010.2284.2289
Abstract: The aim of this study was to evaluate the effect of chromium-methionin supplementation in high dosage on blood parameters and Insulin Resistance (IR) index in fructose induced insulin resistant rats. At first stage of the experiment, ten wistar rats were assigned as the healthy control group and sixteen rats were given Fructose (Fr) for 5 weeks in order to inducing insulin resistance. In the 2nd stage the insulin resistant rats were divided into Cr-fed group that additionally fed 1000 μg day-1 chromium as Chromium-L-Mmethionin (Cr-Met) and insulin resistant rats with no chromium supplementation for 6 weeks. In the first stage, IR was significantly induced (p<0.05) in rats receiving Fr. Plasma Fasting glucose, insulin, IR index and triglyceride contents were significantly (p<0.05) increased in Fr-fed group in comparison with the control. According to the results of second stage, IR index significantly (p<0.05) decreased after Cr-Met supplementation. The fasting insulin, glucose and triglycerides concentrations in Cr-Met treated group were lower (p<0.05) than the Fr-fed insulin resistant group. The results of this study indicated that chromium supplementation as Cr-Met could be effective for lowering IR index, fasting insulin, glucose and triglyceride in insulin resistant rats.
Prevalence and extent of glycemic excursions in well-controlled patients with type 2 diabetes mellitus using continuous glucose-monitoring system
Bonakdaran Shokoufeh,Rajabian Reza
Indian Journal of Medical Sciences , 2009,
Abstract: Background : Continuous glucose-monitoring system (CGMS) is a tool for assessment of glycemic excursions. Glucose variability is a risk factor independent of glycosylated hemoglobin (HbA1c) for diabetic complications; hence CGMS may be a better method for management of diabetes. Aim: To evaluate the extent of glycemic excursions in well-controlled type 2 diabetic patients. Setting and Design :The study was carried out in 21 diabetic patients on oral agents. Materials and Methods: Patients underwent continuous glucose-monitoring by CGMS for 3 days. Number and duration of glycemic excursions, correlation coefficient (%) between CGMS and self-monitoring blood glucose (SMBG), mean absolute difference (%MAD) and complications of CGMS were analyzed. Statistical Analyses : The statistical analyses were performed with the use of mean ± SD, t-test and Mann-Whitney test. Results :The mean age of patients was 51.9 ± 9.7 years. The mean HbA1c was 6.7 ± 0.38%. The mean number of glycemic readings was 753.6 ± 203.5 times. The correlation coefficient was 0.83 and the MAD was 11.7 ± 8.0%, which were considerable. Three (14.2%) patients experienced, altogether, 9 hypoglycemic events with an average duration of 162 minutes. Twenty (94.7%) patients had hyperglycemic events. The mean duration of hyperglycemia was 19.4 ± 12.8 hours. All events were asymptomatic. Disconnection of device was the most common complication (3 patients). Conclusion : This study demonstrated that well-controlled type 2 diabetic patients have a considerable number of hypoglycemia and hyperglycemia events that may be missed by SMBG.
Cleft lip and palate in southwestern Iran : An epidemiologic study of live births.
Rajabian Mohammad,Aghaei Shahin
Annals of Saudi Medicine , 2005,
Abstract: Background: Cleft lip with or without cleft palate (CL/P), is the most common congenital anomaly in the head and neck worldwide. We stud-ied the prevalence of cleft lip (CL) and palate (CP) in Shiraz, which is located in southwestern Iran. Methods: Data was collected from the teaching hospitals of the Shiraz University of Medical Sciences. Records of 147 608 consecutive live births delivered in three hospitals during the 10 years from November 1993 to November 2003 were reviewed. Results: One hundred nineteen cases of CL/P or CP alone were reg-istered for a prevalence of 0.80 per thousand live births. The overall male/ female ratio was 1.25. The male/female ratio was 1.22 in the CL patients and 1.58 in the CL/P patients. A male predominance was obvi-ous in both groups. Conclusion: This study shows that the prevalence rate of CL and CP in southwestern Iran is closer to the low prevalence reported in African countries and is lower than the prevalence reported in previous reports in Caucasians.
Prevalence of Hypogonadotropic Hypogonadism in Type 2 Diabetes Male Patients  [PDF]
Mozhgan Afkhamizadeh, Seyed Bahman Ghaderian, Reza Rajabian, Armaghan Moravej Aleali
Open Journal of Endocrine and Metabolic Diseases (OJEMD) , 2015, DOI: 10.4236/ojemd.2015.53004
Abstract: Background: Erectile dysfunction is common in patients with diabetes mellitus. In addition, reduced testosterone itself is considered as a risk factor for diabetes; therefore hypogonadism was studied in diabetes. Objective: This study was done to determine the prevalence of hypo- and hypergonadotropic hypogonadism in the type 2 diabetes male patients in Mashhad in north-east of Iran. Methods: This study was done on type 2 diabetic men aged 40 - 60 years in the endocrine clinic, Endocrinology Research Center, Mashhad University of Medical Sciences, Iran. Fasting blood samples were collected at 8 am for measurement of fasting blood sugar (FBS), HbA1C, total serum testosterone, FSH, Sex Hormone Binding Globulin (SHBG), LH, prolactin, thyroxin-stimulating hormone (TSH), and immediately was sent to laboratory. Results: Out of total 96 type 2 diabetic males (mean age of 51.4 ± 11.26 years, range of 40 - 60 years), 11 (12.94%) patients were excluded because of inadequate samples, insufficient information and fulfillment of the exclusion criteria of the study. Hypogonadism based on Testosterone, Calculated free testosterone (CFT), and boiavailable testosterone (BT) were observed in 10 (11.8%), 31 (36.6%), and 30 (35.3%) of the patients, respectively. Libido was decreased in 55 (64.7%) of the patients. Based on the obtained SHBG values there were 7 (8.2%), 52 (61.2%), and 26 (30.6%) cases of low, normal and high values, respectively. According to TSH observed values there were 6 (7.1%) patients and 1 case of sub-clinical hypothyroidism and hyperthyroidism, respectively, and the rest 78 (91.8%) cases were euthyroid. Prolactin level was normal in all cases. Conclusion: Hypogonadotropic hypogonadism is common in type 2 diabetic men, and whether its treatment is useful for erectile dysfunction or not, needed additional investigation.
Severe facial dermatitis as a late complication of aesthetic rhinoplasty; a case report
Mohammad Rajabian, Manoochehr Sodaify, Shahin Aghaei
BMC Dermatology , 2004, DOI: 10.1186/1471-5945-4-1
Abstract: We are reporting an unexpected, severe allergic contact dermatitis of the face, in a young female, appearing one month following aesthetic rhinoplasty. She failed to respond to ordinary treatments for dermatitis. We did standard battery – including nitrofurazone, tincture of benzoin and hydrocortisone – patch test for the patient that showed sensitivity to benzoin and corticosteroid.In summary we report a case of a severe allergic contact dermatitis of the face, in a 21-year-old girl who underwent corrective aesthetic rhinoplasty, appearing one month following surgical operation. We were unable to find a similar report in the medical literature.Cutaneous problems after rhinoplasty are usually early, minor, and transient [1]. Most common being contact dermatitis, appearing as rashes or pustules with or without allergic reactions from the tape which might have been used with tincture of benzoin or a preparation containing gum mastic [2,3]. These substances are frequently used as a dressing support and to increase adhesive strength of the tape. The tape can cause necrosis, a major complication, if applied too tightly [1,4]. Patients with acne might find their condition temporarily worse just after rhinoplasty as a result of the local effect of the dressing or the systemic response to the operation [4].Late cutaneous complications are limited to permanent redness and telangiectasias of the nasal skin in some patients with a diathesis toward capillary telangiectasias [1,4].We report a severe dermatitis of the nose and adjacent skin areas starting one month after aesthetic rhinoplasty in an otherwise healthy young girl.A 21-year-old girl underwent corrective aesthetic rhinoplasty by endo-nasal technique in September 2000. She was healthy with an apparently normal skin and no evidence of acne was seen (figure 1). Facial preparation was made by povidone iodine scrub. Neither autologus or heterologus tissues nor foreign materials were used as a transplant. Chromic catgut, vi
Severe facial dermatitis as a late complication of aesthetic rhinoplasty; a case report
Rajabian Mohammad,Sodaify Manoochehr,Aghaei Shahin
BMC Dermatology , 2004,
Abstract: Background Contact dermatitis, as a cutaneous complication after rhinoplasty, is of early onset, limited and transient. The cause of this dermatitis is irritant or allergic. Late onset skin complications are rare and non-inflammatory. Case presentation We are reporting an unexpected, severe allergic contact dermatitis of the face, in a young female, appearing one month following aesthetic rhinoplasty. She failed to respond to ordinary treatments for dermatitis. We did standard battery – including nitrofurazone, tincture of benzoin and hydrocortisone – patch test for the patient that showed sensitivity to benzoin and corticosteroid. Conclusions In summary we report a case of a severe allergic contact dermatitis of the face, in a 21-year-old girl who underwent corrective aesthetic rhinoplasty, appearing one month following surgical operation. We were unable to find a similar report in the medical literature.
HYDATID CYST PRESENTING AS A THYROID NODULE:REPORT OF THREE CASES
Mohammad-Hassan Bastanhagh,Vahab Fatourechi,Reza Rajabian
Acta Medica Iranica , 1995,
Abstract: Hydatid cyst of the thyroid gland is rare, even in areas where echinococcosis is endemic. We report two cases of hydatid cyst of the thyroid gland and one case of a hydatid cyst in the soft tissues of the neck, in the latter, the cyst was superimposed on the thyroid gland and presented as a thyroid nodule. In one patient, fune needle aspiration biopsy produced severe anaphylaxis. In view of the rare occurrence of hydatid disease of the thyroid gland, fune needle aspiration biopsy of thyroid nodules can be performed routinely in areas enderric for echinococcosis but should be avoided if hydatid disease is strongly suspected.
Role of Physical Activity and Nutrition in Controlling Type 2 Diabetes Mellitus-2007
Mohsen Seyyednozadi,Mohammad Taghi Shakeri,Reza Rajabian,Ali Vafaee
Journal of Biological Sciences , 2008,
Abstract: This interventional study was designed to evaluate the role of recommended physical activity and diet in control of type 2 diabetes in order to choose an appropriate strategy for controlling diabetes according to condition of our community. This study carried out in a time-period between 2006-2007 and study`s community of this research was Persian Diabetes Clinic and Khorasan Diabetes Research Center: Mashhad, Khorasan Razavi. In this community based interventional study diabetic patients (type 2) with informed consent allocated randomized in one of the following groups, recommended physical activity, recommended both physical activity and diet, control group and laboratory test included: FBS, 2hpp, HbA1c and urinalysis before intervention and 2 months after intervention. Results were compared in four groups. Data were collected by a designed questionnaire and analyzed by SPSS 11.5 software. Comparison of 4 groups showed recommended physical activity has significant effect in decreasing FBS, 2hpp and HbA1c (p<0.030) Whereas the recommended diet led to merely significant decreasing in FBS (p = 0.032). Diabetic patients who were recommended for both physical activity and diet have improved variables but they are not significant although they have decreased the weight and drug (p<0.024). It is considerable that in controlling group variables a significant increase in the drug usage is recommended (p = 0.001). The result of the study show that simple and practical appropriate diet and physical activity is effective in control of diabetes. We suggest further consideration regarding this subject.
Diabetic ketoacidosis in a patient with acromegaly, a case report
O. Akha,R. Rajabian,R. Aboutorabi,S. Teymouri
Journal of Mazandaran University of Medical Sciences , 2007,
Abstract: Although impaired glucose tolerance affects 36% and overt diabetes mellitus can be seen in 30% of cases with acromegaly, diabetic ketoacidosis is rarely reported in patients with this disease. We present an unusual complication of acromegaly: a 22 year old woman with amenorrhea (6 month ago) and blurred vision of left eye (4 month ago) referred to Ghaem neurology clinic in Mashhad. With a growth hormone (GH) level of =100ng/ml, Insulin like growth factor-1 (IGF-1) =1560 ng/ml and pituitary macro adenoma in magnetic resonance imaging (MRI), she was candidated for surgery. A few hours before surgery she had dyspnea, loss of consciousness, fever and with blood sugar (BS) =500 mg/ml, Hco3=2.4, PH=7.06 and keton in urine. Diabetic ketoacidosis was diagnosed. The patient was treated with high dose of insulin (500 IU/day) and hydration. After octerotide administration the need for insulin decreased and after pituitary adenectomy, there was no need for insulin therapy and the patient was discharged on metformin (one tablet per day).
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