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Metabolic and Endocrine Side Effects of Atypical Antipsychotic Drugs in Children and Adolescents
Gonca Gul Celik,Aysegul Tahiroglu,Ayse Avci
Psikiyatride Guncel Yaklasimlar , 2011,
Abstract: omorbid psychiatric disorders, frequent hospitalization, multiple outpatient treatment, prior history of hypertension, obesity and lipid dysregulation are associated with higher risk of metabolic syndrome in children. Side effects of antipsychotic drugs and their management have recently become a major subject of research due to enhanced antipsychotic drug usage in child and adolescents. Prevention strategies are usually preferred to secondary or tertiary strategies in the management of metabolic syndrome associated with antipsychotic drugs. Clinicians should present multidisciplinary approach to endocrine and metabolic side effects due to antipsychotic use in pediatric patient groups and avoid multiple drug use in such patients. In this paper, we briefly reviewed metabolic side effects of second generation antipsychotic drugs in child and adolescent population, possible mechanisms of susceptibility to metabolic syndrome and pharmacological and non pharmacological treatment approach to prevention of weight gain.
Atomoxetine Induced Seperation Anxiety: A Case Report
Gonca Gul Celik,Aysegul Tahiroglu,Ayse Avci
Cukurova Medical Journal , 2013,
Abstract: Atomoxetine, a selective norepinephrine (NE) inhibitor, is introduced as a safe non-stimulant alternative treatment of children and adolescents with attention deficit hyperactivity disorder (ADHD), especially co-morbid ADHD and anxiety disorder and/or Tourette syndrome. Generally known side effects were including weight loss, decrease appetite, nausea and somnolence, exacerbation of tics. In this paper, we want to present an adolescent case with ADHD-inattention type who developed separation anxiety during Atomoxetine treatment. It will be discussed in light of current knowledge about possible neurotransmitter systems associated with side effects of Atomoxetine. Consequently, atomoxetine treatment may trigger anxiety or obsessional thoughts although without any premorbid psychopathology. However, it is unclear whether effects of genetic, gender or adolescence period are associated with this. [Cukurova Med J 2013; 38(3.000): 503-505]
Corpus Callosum Agenesis Presented With Attention Deficit Hyperactivity Disorder: Two Case Reports
Musa Sahpolat,gonca celik,ayse avci,aysegul tahiroglu
Cukurova Medical Journal , 2013,
Abstract: ADHD is a treatable neuropsychiatric disorder which can continue till adulthood. There have been three subtypes including attention deficiency, hyperactivity and impulsivity. Its etiology remains unclear yet. It is hypothesized that there is an impairment of neurodevelopment in early developmental periods through the interactions between genetic and environmental processes. Corpus callosum provides an integration of cognitive, sensorial and motor functions of brain as a response to the impulses originating from the cortex. The damage of this region may result in deterioration of some cerebral functions such as cognitive functions, speaking, learning ability and impulse control. In this paper, we report two pediatric cases who had comorbid attention deficiency and corpus callosum agenesis without mental retardation. [Cukurova Med J 2013; 38(4.000): 759-764]
The influence of pericentric inversion in 10th chromosome on aggressive behavior and hyperactivity
Nilgun Tanriverdi,Ayfer Pazarbasi,Dilara Karahan,Ayse Avci
Cukurova Medical Journal , 2013,
Abstract: Aggressive behavior and hyperactivity are neurodevelopmental diseases with unknown pathogenesis. Pericentric inv(10)(p11.2;q21.2) mutation is frequently encountered in cytogenetic laboratories. This mutation is accepted as a polymorphic variant and is phenotypically silent, but in some cases it has been associated with neurodevelopmental diseases like autism. After blood culturing, standard chromosome obtaining procedure was applied to patients. In this study, clinical and cytogenetical findings of a boy with developmental delay, mental and motor retardation, attention deficit and hyperactivity have been reported. As a result of chromosome analysis, on chromosome 10, a large pericentric inversion between p11.1 and q22.q bands has been found. Karyotype analysis was also performed to mother, father and siblings of the patient and they have been found to have normal karyotype. It is plausible to consider a relation between inv(10) and some behavioral problems. Additionally, molecular studies targeting 10p-q critical region will be more informative for the true identification of this disease. [Cukurova Med J 2013; 38(1.000): 108-113]
Effect of Tilmicosin on Serum Cytokine Levels in the Endotoxemia
Kamil Uney,Ayse Er,Gulcan Erbil Avci,Aziz Bulbul,Muammer Elmas,Enver Yazar
Journal of Animal and Veterinary Advances , 2012,
Abstract: The effect of tilmicosin on serum cytokine concentrations were investigated in healthy and lipopolysaccharide-treated mice. The mice were divided into 3 groups. Lipopolysaccharide (250 μg, Escherichia coli 0111:B4, intraperitoneally) was injected into the positive control group. The other 2 groups received tilmicosin (20 mg kg-1, subcutaneously) concurrently without or with lipopolysaccharide. After treatment, serum samples were collected at 0, 1.5, 3, 6, 12 and 24 h. Serum tumor necrosis factor, interleukin-1 and interleukin-10 levels were determined by enzyme-linked immunosorbent assay. Lipopolysaccharide increased all cytokine levels in the healthy mice. Tilmicosin slightly induced interleukin-1 production in the healthy mice, while it had no effect on tumor necrosis factor or interleukin-10 productions. However, tilmicosin elevated (p<0.05) tumor necrosis factor, interleukin-1 and interleukin-10 levels in lipopolysaccharide-treated mice. In conclusion, these data suggest that tilmicosin stimulates both proinflammatory and antiinflammatory cytokines at the dose recommended for infection.
Factors of Acceptance for Mobile Learning in Corporate Settings: An Empirical Investigation in Banking Industry  [PDF]
Ayse Kok
Intelligent Information Management (IIM) , 2013, DOI: 10.4236/iim.2013.55015
Abstract: Due to the proliferation of mobile technology and devices like smartphones and tablet PCs into our daily lives, m-learning attracts also more attention in professional training in enterprises. Derived from these statements, this research paper is focused on the following question: what are acceptance factors for m-learning (mobile learning) in the organizational setting? The paper analyzes a real experience in m-learning for training the banking personnel in an international banking institution in Turkey. For this purpose, a mobile virtual learning environment called as mFOR@ was developed and implemented, which was designed to support the training and development process for employees using Pocket PCs. The participants of the training activity (13 professionals) evaluated the m-learning experience via a semi-structured interview; all the content and interactions within mFOR@ were analyzed via content analysis. As a basis for a successful implementation in professional training in enterprises, the acceptance by decision makers and the learners is critical. That is the reason why I present a qualitative analysis of acceptance and the perceived value of m-learning in a corporate setting.
Behind the Scenes with a Video Training Platform: The Challenges of Researching the Provision of Open Educational Resources  [PDF]
Ayse Kok
Advances in Internet of Things (AIT) , 2013, DOI: 10.4236/ait.2013.34009

Video training platforms are now being implemented on a large scale in organizations. In this paper, I look at a video training platform including open educational resources available for many employees with varying patterns and motivations for use. This has provided me with a research challenge to find methods that help other practitioners in the field understand and explain such initiatives. I describe ways to model the research and identify where pressures and contradictions can be found, drawing on a reflective view of my own practice in performing the research. Open educational resources are defined as technology-enabled educational resources that are openly available for consultation, use and adaptation by users for non-commercial purposes [1]. The bank subject to this case study has been the first organisation in Turkey that provided open educational resources for all its employees. The video platform (called “For @ Tube”) provides users with over 100 video lectures drawn from reputable universities around the world including Yale and Harvard. Other learning tools such as discussion forums, blogs and traditional e-learning courses have been made available to the users on the e-learning platform called “For @” since 2006. In this paper, I aim to introduce the new video training platform (“For @ Tube”) and outline some of the main research issues surrounding such an

Uric Acid and GGT Have Causal Relations with Abdominal Obesity: A Real-Life Research in Turkish Population with 1214 Diabetics  [PDF]
Deniz Avci, Ali ?etinkaya
Journal of Biosciences and Medicines (JBM) , 2019, DOI: 10.4236/jbm.2019.72001
Abstract: Aim: We compared the waist circumferences (WC) of 1214 diabetics with various parameters in real-life conditions. Patients and Method: The study was carried out by reviewing the anthropometric measurements and biochemical analyzes of diabetics and they were analyzed due to WC status of the patients. Results: Mean total cholesterol level was 204.6 ± 47.1 mg/dL in patients with normal WC and 211.6 ± 45.6 mg/dL in patients with increased WC (p = 0.015). Total cholesterol was found to be a risk factor for WC enlargement (OR: 1.003, 95% CI: 1.001 - 1.006, p = 0.015). HDL-cholesterol appeared to be a risk factor for the increase in WC (OR: 1.005, CI: 1.001 - 1.010, p = 0.029). Median triglyceride level was 158 (41 - 975) mg/dL in the normal WC group, while it was 176 (22 - 1379) mg/dL in the patients with increased WC (p < 0.001). Triglyceride was observed as a risk factor for WC increase (OR: 1.002, 95% CI: 1.001 - 1.003, p = 0.004). The serum uric acid level was 4.75 ± 1.6 mg/dL in the normal WC group, while it was 5.09 ± 1.5 mg/dL in the increased WC group (p = 0.002). Serum uric acid level was appeared as a risk factor for increased WC (OR: 1.162, 95% CI: 1.057 - 1.276, p = 0.002). The median serum GGT level was 27 (7 - 174) mg/dL in WC normal group and 28 (8 - 730) mg/dL in increased WC diabetics (p = 0.029). Serum GGT level was a risk factor for increased WC (OR: 1.162, 95% CI: 1.001 - 1.010, p = 0.029). Conclusion: We have demonstrated that the measurement of WC has an important role in diabetes management and is related with inflammatory parameters such as uric acid and GGT.
Sleep Apnea Detection Using Adaptive Neuro Fuzzy Inference System  [PDF]
Cafer Avci, G?khan Bilgin
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.510B054

This paper presents an efficient and easy implemented method for detecting minute based analysis of sleep apnea. The nasal, chest and abdominal based respiratory signals extracted from polysomnography recordings are obtained from PhysioNet apnea-ECG database. Wavelet transforms are applied on the 1-minute and 3-minute length recordings. According to the preliminary tests, the variances of 10th and 11th detail components can be used as discriminative features for apneas. The features obtained from total 8 recordings are used for training and testing of an adaptive neuro fuzzy inference system (ANFIS). Training and testing process have been repeated by using the randomly obtained five different sequences of whole data for generalization of the ANFIS. According to results, ANFIS based classification has sufficient accuracy for apnea detection considering of each type of respiratory. However, the best result is obtained by analyzing the 3-minute length nasal based respiratory signal. In this study, classification accuracies have been obtained greater than 95.2% for each of the five sequences of entire data.

Parasitoid Complex and New Host Plants of the Gypsy Moth, Lymantria dispar L. in the Lakes District, Turkey
Mustafa Avci
Journal of Animal and Veterinary Advances , 2012,
Abstract: The present study determined egg, larval and pupal parasitoids of the gypsy moth Lymantria dispar L. (Lepidoptera: Lymantriidae), which is an important forest pest in Turkey. High populations of the gypsy moth have been observed recently in oak forests and coniferous forests in the Lakes District of Turkey. Pinus brutia Ten and Cedrus libani A. Rich are reported for the 1st time in the world as host plants of L. dispar. Its parasitoid complex and impact were analyzed in a 2-years study. In larval and pupal stages of the pest, the tachinids Exorista segregata (Rond.), Compsilura concinnata Meigen, Drino inconspicua Meigen and Pales pavida Meigen, the chalcid Brachymeria intermedia (Nees), the torymid Monodontomerus aereus Walk. The braconid Apanteles xanthostigma (Haliday) and the egg parasitoids Ooencrytus kuvanae (Howard) (Hym. Encyrtidae), Anastatus disparis Rusch and Anastatus bifasciatus (Fonsc.) (Hym: Eupelmidae) were recorded. O. kuvanae had the greatest impact on L. dispar populations. A. xanthostigma is a new record for Turkey and also a new record for the world as a parasitoid of L. dispar.
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