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Search Results: 1 - 10 of 263090 matches for " Avellaneda i Díaz-Grande "
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Medio ambiente, comportamiento y durabilidad del cerramiento
Avellaneda i Díaz-Grande, Jaume
Informes de la Construccion , 1983,
Abstract:
Genetic diagnosis of X-linked dominant hypophosphatemic rickets in a cohort study: Tubular reabsorption of phosphate and 1,25(OH)2D serum levels are associated with PHEX mutation type
Marcos Morey, Lidia Castro-Feijóo, Jesús Barreiro, Paloma Cabanas, Manuel Pombo, Marta Gil, Ignacio Bernabeu, José M Díaz-Grande, Lourdes Rey-Cordo, Gema Ariceta, Itxaso Rica, José Nieto, Ramón Vilalta, Loreto Martorell, Jaime Vila-Cots, Fernando Aleixandre, Ana Fontalba, Leandro Soriano-Guillén, José M García-Sagredo, Sixto García-Mi?aur, Berta Rodríguez, Saioa Juaristi, Carmen García-Pardos, Antonio Martínez-Peinado, José M Millán, Ana Medeira, Oana Moldovan, Angeles Fernandez, Lourdes Loidi
BMC Medical Genetics , 2011, DOI: 10.1186/1471-2350-12-116
Abstract: Forty three affected individuals from 36 non related families were analyzed. For the genetic analysis, the PHEX gene was sequenced in all of the patients and in 13 cases the study was complemented by mRNA sequencing and Multiple Ligation Probe Assay. For the genotype-phenotype correlation study, the clinical and biochemical phenotype of the patients was compared with the type of mutation, which was grouped into clearly deleterious or likely causative, using the Mann-Whitney and Fisher's exact test.Mutations in the PHEX gene were identified in all the patients thus confirming an XLHR. Thirty four different mutations were found distributed throughout the gene with higher density at the 3' end. The majority of the mutations were novel (69.4%), most of them resulted in a truncated PHEX protein (83.3%) and were family specific (88.9%). Tubular reabsorption of phosphate (TRP) and 1,25(OH)2D serum levels were significantly lower in patients carrying clearly deleterious mutations than in patients carrying likely causative ones (61.39 ± 19.76 vs. 80.14 ± 8.80%, p = 0.028 and 40.93 ± 30.73 vs. 78.46 ± 36.27 pg/ml, p = 0.013).PHEX gene mutations were found in all the HR cases analyzed, which was in contrast with other cohort studies. Patients with clearly deleterious PHEX mutations had lower TRP and 1,25(OH)2D levels suggesting that the PHEX type of mutation might predict the XLHR phenotype severity.Genetic Hypophosphatemic Rickets (HR) is a group of diseases characterized by renal phosphate wasting, with inappropriately low or normal serum 1,25-dihydroxyvitamin D3 (1,25(OH)2D) levels, causing growth retardation, rickets and osteomalacia. The most common form is X-linked dominant hypophosphatemic rickets (XLHR, OMIM 307800) with an incidence of 1/20,000 [1]. XLHR is caused by inactivating mutations in the PHEX gene (Phosphate Regulating Gene with Homologies to Endopeptidases on the × chromosome) which is located in Xp22.1-22.2 [2]. Singular cases are autosomal forms with a muc
Black Truffle Production, Soils and Mediterranean Woods: Spanish Research Contributions (1962-2006)
L.G. García-Montero, P. Díaz, I. Valverde, M.A. Grande and J. VelázquezTuberBoletusLactariusTuberTuber
The Open Forest Science Journal , 2008, DOI: 10.2174/1874398600801010016]
Abstract: The production of mycorrhizal fungi provides higher economic returns than any other forest product in many Mediterranean woods. In these areas, truffles (Tuber spp.) and mushrooms of Boletus and Lactarius genus are the fungi that yield the highest economic benefits. However, there are still evident gaps in the understanding of the truffle's biological cycles, ecology and interactions with host plants and other fungi. In the last 12 years, Spanish research has begun to respond to the requirements of truffle research. Most of Spanish Tuber references deal with the areas of agronomy, forestry, ecology and soil science. In this respect, Spain is one of the main truffle-producing countries in the world and its varied climate, topography and lithology make it a useful geographic area for increasing knowledge on Tuber ecology and truffle production. This work describes the content of Spanish research and its impact on the knowledge of truffles.
Cadmio en sangre y su relación con el consumo de tabaco en una población laboral hospitalaria Blood cadmium and its relationship with smoking in a hospital employee population Cádmio presente no sangue e a sua rela o com o consumo de tabaco numa popula o de trabalhadores de um hospital
Avellaneda Díaz Díaz,Montserrat González-Estecha,Elena M. Trasobares Iglesias,César Morales Bayle
Revista de Salud Ambiental , 2012,
Abstract: La exposición de la población general al cadmio es un problema de salud pública, siendo las principales fuentes tanto el consumo de tabaco como la exposición al humo del mismo. El objetivo de este trabajo fue determinar la concentración de cadmio en sangre en una población laboral hospitalaria y su asociación con el consumo de tabaco. Se administró el cuestionario PESA a 395 sujetos. El cadmio en sangre se midió por espectrometría de absorción atómica con atomización electrotérmica. La mediana de cadmio en sangre fue 0,29 μg/L. La mediana de cadmio de los fumadores (0,83 μg/L) fue la más elevada y la de los exfumadores (0,31 μg/L) fue a su vez más elevada que la de aquellos que nunca habían fumado (0,21 μg/L). Dentro del grupo de fumadores, se observó una asociación entre la concentración de cadmio y el número de cigarrillos inhalados. En el grupo de exfumadores se observó una asociación con el número de cigarrillos que habían consumido y una correlación negativa entre el tiempo transcurrido desde el abandono del hábito tabáquico y la concentración de cadmio en sangre. Dentro del grupo de los que nunca habían fumado, se observó una diferencia entre la concentración de cadmio de los fumadores pasivos (0,24 μg/L) y los que no lo eran (0,20 μg/L). La concentración de cadmio en sangre se relacionó con el consumo de tabaco. Son necesarios más estudios para confirmar el hallazgo de concentraciones de cadmio más elevadas en los fumadores pasivos. Exposure to cadmium is a public health problem due to the broad exposure to this toxic substance among the general population. The main sources of exposure are both tobacco consumption and tobacco smoke. The aim of this study was to determine the blood cadmium concentration in an employee population drawn from our hospital and its association with tobacco consumption. The exposure questionnaire PESA was administered to 395 employees. Blood cadmium was measured by electrothermal atomization atomic absorption spectrometry. The median blood cadmium concentration was 0.29 μg/L. The median cadmium of current smokers (0.83 μg/L) was the highest, while that for ex-smokers (0.31 μg/L) was also higher than that for those who had never smoked. Among the smokers, an association was observed between the concentration of blood cadmium and the number of cigarettes inhaled. The group of ex-smokers showed an association with the number of cigarettes they had consumed and a negative correlation between the elapsed time between quitting smoking and the concentration of blood cadmium. In never smokers, there was a difference between th
Colestasis postinfección por virus de Epstein-Barr sin elevación de gamma glutamil transpeptidasa Post-infection cholestasis due to Epstein-Barr virus infection without elevation of gamma glutamyl transpeptidase
B. Gorozarri Gallo,A. Grande Benito,R. Torres Peral,L. Ramos Díaz
Boletín de Pediatría , 2010,
Abstract: El virus de Epstein-Barr es el agente responsable de la mayoría de los casos de mononucleosis infecciosa, síndrome linfoproliferativo que suele ser benigno y autolimitado, aunque puede acompa arse en ocasiones de complicaciones neurológicas, respiratorias o hematológicas. A la sintomatología clínica habitual, caracterizada por fiebre, malestar general, odinofagia y adenopatías generalizadas, es frecuente que se asocie una hepatopatía subclínica, caracterizada en el ni o por un leve y transitorio aumento de las transaminasas. A diferencia del adulto, en el ni o, la existencia de un síndrome colestásico es excepcional. Presentamos el caso clínico de una ni a de 6 a os que presenta una colestasis clínico-bioquímica en el curso de una infección aguda por el virus de Epstein-Barr, en la que destaca la normalidad de las cifras de gamma glutamil transpeptidasa durante toda la evolución de su proceso. The Epstein-Barr virus is the responsible agent for most of the cases of infectious mononucleosis, a lymphoproliferative syndrome that is generally benign and self-limited, although it may sometimes be accompanied by neurological, respiratory or hematological complications. Frequently, it is frequent to find that subclinical liver disease, characterized in the child by mild and transitory increase of transaminases is associated to the usual clinical symptoms, characterized by fever, general malaise, odinophagia and generalized abnormal lymph nodes. On the contrary to the adult, the existence of a cholestatic syndrome in the child is rare. We present the case of a 6-year old girl who presented a clinical-biochemical cholestasis during an acute infection due to Epstein-Barr virus in which the normality of the gamma glutamyl transpeptidase values during the entire course stands outs.
Malvinas-slope water intrusions on the northern Patagonia continental shelf
A. R. Piola, N. Martínez Avellaneda, R. A. Guerrero, F. P. Jardón, E. D. Palma,S. I. Romero
Ocean Science (OS) & Discussions (OSD) , 2010, DOI: 10.5194/os-6-345-2010
Abstract: The Patagonia continental shelf located off southeastern South America is bounded offshore by the Malvinas Current, which extends northward from northern Drake Passage (~55° S) to nearly 38° S. The transition between relatively warm-fresh shelf waters and Subantarctic Waters from the western boundary current is characterized by a thermohaline front extending nearly 2500 km. We use satellite derived sea surface temperature, and chlorophyll-a data combined with hydrographic and surface drifter data to document the intrusions of slope waters onto the continental shelf near 41° S. These intrusions create vertically coherent localized negative temperature and positive salinity anomalies extending onshore about 150 km from the shelf break. The region is associated with a center of action of the first mode of non-seasonal sea surface temperature variability and also relatively high chlorophyll-a variability, suggesting that the intrusions are important in promoting the local development of phytoplankton. The generation of slope water penetrations at this location may be triggered by the inshore excursion of the 100 m isobath, which appears to steer the Malvinas Current waters over the outer shelf.
Spatial interpolation techniques for stimating levels of pollutant concentrations in the atmosphere
Rojas-Avellaneda, D.;
Revista mexicana de física , 2007,
Abstract: the inverse distance-weighting method (idw) and kriging techniques are the most commonly used spatial interpolation techniques for estimating levels of pollutant concentrations in regions that contain a number of monitoring stations. the measured ozone pollution peaks in a period, in the atmosphere of the méxico city region, are considered to be a sampled data set with a non-stationary mean. in order to study the effect of a non-stationary mean in the performance of interpolation methods idw and kriging, the data set is transformed by removing the data trend of the sampled data set. the residuals obtained are considered to be a set of stationary random variables. this work initially considers the residuals obtained from measured ozone concentration data at 20 stations at 15:00 hours for a set of 21 days in december, 2001. this set of 420 data is considered to be the training set. to determine the parameter values that define the statistical weights for each of the idw and kriging methods that are analyzed in this work, a cross-validation method is considered. this method assumes initial parameter values, which are fitted by minimizing the root mean squared error, rmse, between the observed and estimated values in each of the stations. this process takes the training set in consideration for calculation. once the parameter values that define the statistical weights for each idw and kriging methods are obtained, by the process described above, these methods are used to interpolate its corresponding values at the stations at 15:00 hours for the days (3rd, 6th, 9th , ...27th, 30th) of december, 2001, which are considered to be the testing sets. the rmse between interpolated and measured values at monitoring stations is also evaluated for these testing values and is shown as a percentage in table i. these values and the defined generalization parameter g can be used to evaluate the performance and the ability of the models to predict and reproduce the peak of ozone conce
Peperitas del Paleozoico superior en la margen norte del río Mendoza, borde oriental de la Cordillera Frontal Upper Paleozoic peperites at the northern margin of the Mendoza River, eastern border of the Cordillera Frontal
M. Koukharsky,D. Avellaneda
Revista de la Asociación Geológica Argentina , 2006,
Abstract: Se describe un afloramiento perteneciente a la Formación Tambillos del Grupo Choiyoi compuesto dominantemente por peperitas, reconociéndose los tipos ameboidales, globulíticos, blocosos (blocky) y de morfologías mixtas. Las lavas que dieron origen a estas rocas tenían composición intermedia o ácida con escasos fenocristales de oligoclasa y de biotita y los sedimentos con los que interaccionaron eran de origen volcánico. También se describen sectores con lavas y retazos de areniscas laminadas, conformando un complejo que se habría originado por la irrupción de lava en el fondo de un lago de unos 130 km2. Las rocas están afectadas por alteración arcillosa y silicificación. El conjunto está atravesado por diques basálticos pertenecientes a otro ciclo magmático. Se propone la zona como sitio de interés geológico por su accesibilidad, magnitud y calidad de los afloramientos que ilustran un fenómeno paleovolcánico poco común ocurrido durante el Paleozoico superior. An outcrop of Tambillos Formation of the Choiyoi Group is described. It is composed mostly by peperites, being recognized the types amoeboid, globular, blocky and of mixed morphologies. The lavas that gave origin to these rocks had intermediate or acid compositions with scarce oligoclase and biotite phenocrysts, and the sediments which they had interacted were of volcanic origin. In the outcrop, sectors of lavas and laminated sandstones are also described, and constitute a complex that would have originated by the irruption of lava in the bottom of a lake of about 130 km2. The rocks were affected by argillic alteration and silicification. The complex was intruded by basaltic dikes that belong to another magmatic cycle. The area is proposed as a site of geologic interest based on its accessibility, magnitude and quality of the outcrops, which illustrate an uncommon paleovolcanic process, occurred during the Late Paleozoic.
Spatial interpolation techniques for stimating levels of pollutant concentrations in the atmosphere
D. Rojas-Avellaneda
Revista mexicana de física , 2007,
Abstract: Las t′ecnicas de interpolaci′on espacial, peso inverso con la distancia (IDW) y kriging, son las m′as com′unmente usadas para la estimaci′on de niveles de contaminante en regiones que tienen un limitado n′umero de estaciones de monitoreo. Los valores del pico de contaminaci′on por ozono, medidos en la atm′osfera de la regi′on de la Ciudad deM′exico, se consideran como un conjunto de datos muestreados cuya media no es estacionaria. Con el fin de estudiar el efecto de una media no estacionaria sobre el desempe no de los m′etodos de interpolaci′on IDWy kriging, se transforma el conjunto de datos al remover de cada uno de ellos el valor de su tendencia. El conjunto residual obtenido se considera como un conjunto de variables aleatorias estacionarias. Para este caso se considera inicialmente el conjunto residual obtenido de los datos medidos en las 20 estaciones para concentraci′on de ozono a las 15 horas por un periodo de 21 d′ as del mes de Diciembre del 2001. Este conjunto de 420 datos constituye el conjunto de entrenamiento. Para determinar el valor de los par′ametros que definen los pesos en cada uno de los m′etodos IDW y kriging que se analizan en este trabajo, se considera un m′etodo de validaci′on cruzada mediante el cual se suponen para los par′ametros valores iniciales, que se van ajustando iterativamente hasta obtener el valor que produce el m′ nimo error cuadr′atico medio entre los datos medidos y los estimados en cada una de las estaciones, para lo cual hacemos uso de los datos que constituyen el conjunto de entrenamiento. Una vez determinados, por el procedimiento anterior, los valores de los par′ametros que definen los pesos de cada uno de los m′etodos IDW o kriging, se usan estos m′etodos para hacer estimaciones de los valores de las concentraciones de ozono, a las 15 horas en las estaciones para los 10 d′ as de Diciembre de 2001 no considerados en el conjunto de entrenamiento. El error cuadr′atico medio entre datos medidos y estimados es calculado para este conjunto de prueba y se muestra en porcentaje en la Tabla I. Estos valores y el par′ametro de generalizaci′on G pueden ser usados para medir el desempe no y habilidad de los modelos para predecir y reproducir el pico de ozono tanto para los residuales como para los datos originalmente muestreados sin ninguna transformaci′on. Se muestran gr′aficas de dispersi′on de los datos de prueba para cada m′etodo de interpolaci′on. Se da una interpretaci′on de los niveles de contaminaci′on de ozono obtenidos para Diciembre 21 de 2001 a las 15 horas usando el campo de vientos preexistente en la regi ′
Operadores diferenciales en el análisis de se ales en geofísica
Díaz Campos Ramiro I.
Earth Sciences Research Journal , 2000,
Abstract: EI objetivo de este artículo es mostrar la utilidad que tienen los operadores vectoriales en el análisis e interpretación de información en Geofísica. Con éste propósito, se plantean algunos filtros digitales y se sugiere una metodología para su implementación mediante el análisis de un muestreo de campo magnético total. The objective of this paper is show the utility that have the vectorial operators in the analysis and interpretation of information in Geophysics. With this purpose, they come some digital filters and suggested a methodology for their application by means of the analysis of a map of magnetic total field.
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