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Search Results: 1 - 10 of 465068 matches for " Aurélie A. Albertini "
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Molecular and Cellular Aspects of Rhabdovirus Entry
Aurélie A. V. Albertini,Eduard Baquero,Anna Ferlin,Yves Gaudin
Viruses , 2012, DOI: 10.3390/v4010117
Abstract: Rhabdoviruses enter the cell via the endocytic pathway and subsequently fuse with a cellular membrane within the acidic environment of the endosome. Both receptor recognition and membrane fusion are mediated by a single transmembrane viral glycoprotein (G). Fusion is triggered via a low-pH induced structural rearrangement. G is an atypical fusion protein as there is a pH-dependent equilibrium between its pre- and post-fusion conformations. The elucidation of the atomic structures of these two conformations for the vesicular stomatitis virus (VSV) G has revealed that it is different from the previously characterized class I and class II fusion proteins. In this review, the pre- and post-fusion VSV G structures are presented in detail demonstrating that G combines the features of the class I and class II fusion proteins. In addition to these similarities, these G structures also reveal some particularities that expand our understanding of the working of fusion machineries. Combined with data from recent studies that revealed the cellular aspects of the initial stages of rhabdovirus infection, all these data give an integrated view of the entry pathway of rhabdoviruses into their host cell.
Characterization of Monomeric Intermediates during VSV Glycoprotein Structural Transition
Aurélie A. Albertini,Cécile Mérigoux,Sonia Libersou,Karine Madiona,Stéphane Bressanelli,Stéphane Roche,Jean Lepault,Ronald Melki,Patrice Vachette,Yves Gaudin
PLOS Pathogens , 2012, DOI: 10.1371/journal.ppat.1002556
Abstract: Entry of enveloped viruses requires fusion of viral and cellular membranes, driven by conformational changes of viral glycoproteins. Crystal structures provide static pictures of pre- and post-fusion conformations of these proteins but the transition pathway remains elusive. Here, using several biophysical techniques, including analytical ultracentrifugation, circular dichro?sm, electron microscopy and small angle X-ray scattering, we have characterized the low-pH-induced fusogenic structural transition of a soluble form of vesicular stomatitis virus (VSV) glycoprotein G ectodomain (Gth, aa residues 1–422, the fragment that was previously crystallized). While the post-fusion trimer is the major species detected at low pH, the pre-fusion trimer is not detected in solution. Rather, at high pH, Gth is a flexible monomer that explores a large conformational space. The monomeric population exhibits a marked pH-dependence and adopts more elongated conformations when pH decreases. Furthermore, large relative movements of domains are detected in absence of significant secondary structure modification. Solution studies are complemented by electron micrographs of negatively stained viral particles in which monomeric ectodomains of G are observed at the viral surface at both pH 7.5 and pH 6.7. We propose that the monomers are intermediates during the conformational change and thus that VSV G trimers dissociate at the viral surface during the structural transition.
RUNX3, EGR1 and SOX9B Form a Regulatory Cascade Required to Modulate BMP-Signaling during Cranial Cartilage Development in Zebrafish
Julia Dalcq, Vincent Pasque, Aurélie Ghaye, Arnaud Larbuisson, Patrick Motte, Joseph A. Martial, Marc Muller
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0050140
Abstract: The cartilaginous elements forming the pharyngeal arches of the zebrafish derive from cranial neural crest cells. Their proper differentiation and patterning are regulated by reciprocal interactions between neural crest cells and surrounding endodermal, ectodermal and mesodermal tissues. In this study, we show that the endodermal factors Runx3 and Sox9b form a regulatory cascade with Egr1 resulting in transcriptional repression of the fsta gene, encoding a BMP antagonist, in pharyngeal endoderm. Using a transgenic line expressing a dominant negative BMP receptor or a specific BMP inhibitor (dorsomorphin), we show that BMP signaling is indeed required around 30 hpf in the neural crest cells to allow cell differentiation and proper pharyngeal cartilage formation. Runx3, Egr1, Sox9b and BMP signaling are required for expression of runx2b, one of the key regulator of cranial cartilage maturation and bone formation. Finally, we show that egr1 depletion leads to increased expression of fsta and inhibition of BMP signaling in the pharyngeal region. In conclusion, we show that the successive induction of the transcription factors Runx3, Egr1 and Sox9b constitutes a regulatory cascade that controls expression of Follistatin A in pharyngeal endoderm, the latter modulating BMP signaling in developing cranial cartilage in zebrafish.
Enhanced Brain Disposition and Effects of Δ9-Tetrahydrocannabinol in P-Glycoprotein and Breast Cancer Resistance Protein Knockout Mice
Adena S. Spiro, Alexander Wong, Aurélie A. Boucher, Jonathon C. Arnold
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0035937
Abstract: The ABC transporters P-glycoprotein (P-gp, Abcb1) and breast cancer resistance protein (Bcrp, Abcg2) regulate the CNS disposition of many drugs. The main psychoactive constituent of cannabis Δ9-tetrahydrocannabinol (THC) has affinity for P-gp and Bcrp, however it is unknown whether these transporters modulate the brain accumulation of THC and its functional effects on the CNS. Here we aim to show that mice devoid of Abcb1 and Abcg2 retain higher brain THC levels and are more sensitive to cannabinoid-induced hypothermia than wild-type (WT) mice. Abcb1a/b (?/?), Abcg2 (?/?) and wild-type (WT) mice were injected with THC before brain and blood were collected and THC concentrations determined. Another cohort of mice was examined for THC-induced hypothermia by measuring rectal body temperature. Brain THC concentrations were higher in both Abcb1a/b (?/?) and Abcg2 (?/?) mice than WT mice. ABC transporter knockout mice exhibited delayed elimination of THC from the brain with the effect being more prominent in Abcg2 (?/?) mice. ABC transporter knockout mice were more sensitive to THC-induced hypothermia compared to WT mice. These results show P-gp and Bcrp prolong the brain disposition and hypothermic effects of THC and offer a novel mechanism for both genetic vulnerability to the psychoactive effects of cannabis and drug interactions between CNS therapies and cannabis.
Effects of deletion of the prolactin receptor on ovarian gene expression
Isabelle Grosdemouge, Anne Bachelot, Aurélie Lucas, Nathalie Baran, Paul A Kelly, Nadine Binart
Reproductive Biology and Endocrinology , 2003, DOI: 10.1186/1477-7827-1-12
Abstract: Prolactin (PRL) is a multifunctional hormone involved in diverse processes such as luteal function and thus maintenance of the pregnancy [1], and has long been known for its luteotropic actions in rodents [2-5]. Hormonal responsiveness in the mammalian ovary involves complex cellular processes that are essential for organ function and which can be deleterious if inappropriately orchestrated. After ovulation, subsequent luteinization leads to the formation of the corpus luteum, which is an endocrine gland of limited lifespan. This resulting corpus luteum is a highly vascularized endocrine organ producing progesterone, essential for uterine preparation and maintenance of pregnancy. The granulosa cells remaining in the postovulatory follicle undergo luteinization, which involves exit of the cells from the cell cycle, cellular hypertrophy, acquisition of steroidogenic morphology, and expression of cytochrome P450 cholesterol side chain cleavage.We previously demonstrated that female mice homozygous for a disruption of PRL receptor (PRLR) gene are infertile due to a failure of implantation [6]. PRL mediates its action via a single receptor, which is present in the corpus luteum during pregnancy and is also expressed in the uterus later in the pregnancy [7]. The PRL receptor is thus a key component regulating ovarian function and governing the regulation of progesterone secretion and, in fact PRL may trigger an early signal to induce the maintenance of the corpus luteum.In rodents, semi-circadian surges of PRL secretion are induced by cervical stimuli, which are believed to be responsible for the conversion of the corpus luteum of pregnancy (CLP) from the corpus luteum (CL) of the cycle. The CLP secretes a sufficient progesterone amount to maintain pregnancy [8,9].The factors affecting sterility of PRLR-/- mice were attributed to multiple causes, in particular to the absence of sufficient progesterone to support implantation and subsequent placental development and mainte
La Septième Porte. Réalités et représentations des conflits familiaux dans l’Athènes classique.
Aurélie Damet
Genre & Histoire , 2010,
Abstract: En étudiant la violence familiale dans l’Athènes classique des Ve et IVe siècles avant J. C, j’ai souhaité réconcilier des sources et des approches méthodologiques trop souvent cloisonnées. La dramaturgie, tragique et comique, les réflexions philosophiques platoniciennes et aristotéliciennes et les plaidoiries judiciaires méritent en effet d’être confrontées, afin de proposer une chronique intégrale de la parenté déchirée athénienne. Aux realia transmis par les traces juridiques du IVe siècle...
L’état du problème du logement à Quito
Aurélie Quentin
M@ppemonde , 2005,
Abstract: The housing problem in Quito take two different forms in the city, from the historical centre to the peripheral slums. Over the past ten years, the public response to these two sides of the problem has completely changed to comply with the rules of the good governance.
Günter Grass, peler l’oignon du souvenir
Aurélie Renault
m@gm@ , 2012,
Abstract: La publication en 2006 de l’autobiographie de Günter Grass, Pelures d’oignon, fait scandale : cet homme si engagé du c té des plus faibles s’est engagé volontairement dans la Waffen SS ! Cet aveu est difficile de la part de l’auteur. Il lui faut peler amèrement l’oignon du souvenir, multiplier les questions, cherchant alors des réponses pour comprendre son attitude d’alors, des réponses qui ne peuvent que le rendre coupable à ses yeux comme à celui de son lectorat. Aussi son pacte autobiographique tourne-t-il, pour l’essentiel, autour de la question du jugement. Il n’hésite pas à se dédoubler, faisant de son Moi passé un personnage que son Moi présent juge sévèrement. Les métaphores de la honte se multiplient, donnant lieu à un cache-cache entre les deux Moi de l’auteur qui ne va pas sans s’achever sur la victoire du Moi présent, lequel se dit coupable pour renforcer une thèse qui lui est chère, celle de la co-responsabilité : c’est l’ensemble du peuple allemand qui est co-responsable face au Mal nazi. Mémoire et Imagination se réconcilient au nom d’un engagement dont le présent prend acte.
Les réfugiés politiques espagnols en RDA
Aurélie Denoyer
Trajectoires , 2009,
Abstract: Les réfugiés politiques espagnols en RDA représentent le plus petit groupe de migrants que la RDA ait jamais accueilli. De sa constitution en 1951 à la mort de Franco en 1975, le collectif espagnol de Dresde compta entre 82 et 91 personnes. Cet exil espagnol dans le bloc de l'Est fut déclenché par l'opération Boléro-Paprika qui conduisit en septembre 1950 à l'expulsion vers la RDA de 33 Espagnols communistes résidant en France. La plupart n'en repartirent jamais. Dans cet article seront présentés l'accueil en RDA et la manière dont ce collectif se constitua. L'intégration de cette population en RDA sera elle aussi analysée. Dans un dernier temps, nous questionnerons la manière dont l'identité des enfants de ces exilés s'est constituée. Die politischen Flüchtlinge in der DDR sind die kleinste Migrantengruppe, die die DDR jemals aufgenommen hat. Das spanische Kollektiv in Dresden umfasste zwischen 82 und 91 Personen. Seinen Ursprung hatte dieses spanische Exil im Ostblock in der so genannten Operation Bolero-Paprika, die im Jahr 1950 zur Ausweisung von 33 spanischen Kommunisten aus Frankreich in die DDR führte. Die Mehrheit konnte dieses Land nie wieder verlassen. In diesem Beitrag wird die Aufnahme in der DDR und die Gründung dieses Kollektivs pr sentiert. Die Integration dieser Gruppe wird ebenfalls analysiert. Zudem wird der Frage der Identit tskonstruktion der Kinder nachgegangen.
Lucille Ball, the Queen of Show Business versus Lucy Ricardo, the Failed Actress
Aurélie Blot
Transatlantica : Revue d'études Américaines , 2011,
Abstract: Most American people, all generations taken into account, remember Lucille Ball as a great comic figure of the Fifties. Nonetheless, just a few people remember her as one of the most powerful women of her time. This might be because Lucille Ball refused to be considered as a businesswoman; she wanted to be seen as an actress above all. In this article, I will analyze how Lucille Ball became a businesswoman in spite of herself and how her success as an actress contributed to her success as a businesswoman.
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