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Search Results: 1 - 10 of 56043 matches for " Audrey Y. Jung "
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No Effect of Folic Acid Supplementation on Global DNA Methylation in Men and Women with Moderately Elevated Homocysteine
Audrey Y. Jung, Yvo Smulders, Petra Verhoef, Frans J. Kok, Henk Blom, Robert M. Kok, Ellen Kampman, Jane Durga
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0024976
Abstract: A global loss of cytosine methylation in DNA has been implicated in a wide range of diseases. There is growing evidence that modifications in DNA methylation can be brought about by altering the intake of methyl donors such as folate. We examined whether long-term daily supplementation with 0.8 mg of folic acid would increase global DNA methylation compared with placebo in individuals with elevated plasma homocysteine. We also investigated if these effects were modified by MTHFR C677T genotype. Two hundred sixteen participants out of 818 subjects who had participated in a randomized double-blind placebo-controlled trial were selected, pre-stratified on MTHFR C677T genotype and matched on age and smoking status. They were allocated to receive either folic acid (0.8 mg/d; n = 105) or placebo treatment (n = 111) for three years. Peripheral blood leukocyte DNA methylation and serum and erythrocyte folate were assessed. Global DNA methylation was measured using liquid chromatography-tandem mass spectrometry and expressed as a percentage of 5-methylcytosines versus the total number of cytosine. There was no difference in global DNA methylation between those randomized to folic acid and those in the placebo group (difference = 0.008, 95%CI = ?0.05,0.07, P = 0.79). There was also no difference between treatment groups when we stratified for MTHFR C677T genotype (CC, n = 76; CT, n = 70; TT, n = 70), baseline erythrocyte folate status or baseline DNA methylation levels. In moderately hyperhomocysteinemic men and women, long-term folic acid supplementation does not increase global DNA methylation in peripheral blood leukocytes. ClinicalTrials.gov NCT00110604
Dietary Supplement Use and Colorectal Adenoma Risk in Individuals with Lynch Syndrome: The GEOLynch Cohort Study
Renate C. Heine-Br?ring, Renate M. Winkels, Akke Botma, Fr?nzel J. B. van Duijnhoven, Audrey Y. Jung, Jan H. Kleibeuker, Fokko M. Nagengast, Hans F. A. Vasen, Ellen Kampman
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0066819
Abstract: Background and Aims Individuals with Lynch syndrome have a high lifetime risk of developing colorectal tumors. In this prospective cohort study of individuals with Lynch syndrome, we examined associations between use of dietary supplements and occurrence of colorectal adenomas. Materials and Methods Using data of 470 individuals with Lynch syndrome in a prospective cohort study, associations between dietary supplement use and colorectal adenoma risk were evaluated by calculating hazard ratios (HR) and 95% confidence intervals (CI) using cox regression models adjusted for age, sex, and number of colonoscopies during person time. Robust sandwich covariance estimation was used to account for dependency within families. Results Of the 470 mismatch repair gene mutation carriers, 122 (26.0%) developed a colorectal adenoma during an overall median person time of 39.1 months. 40% of the study population used a dietary supplement. Use of any dietary supplement was not statistically significantly associated with colorectal adenoma risk (HR = 1.18; 95%CI 0.80–1.73). Multivitamin supplement use (HR = 1.15; 95%CI 0.72–1.84), vitamin C supplement use (HR = 1.57; 95%CI 0.93–2.63), calcium supplement use (HR = 0.69; 95%CI 0.25–1.92), and supplements containing fish oil (HR = 1.60; 95%CI 0.79–3.23) were also not associated with occurrence of colorectal adenomas. Conclusion This prospective cohort study does not show inverse associations between dietary supplement use and occurrence of colorectal adenomas among individuals with Lynch syndrome. Further research is warranted to determine whether or not dietary supplement use is associated to colorectal adenoma and colorectal cancer risk in MMR gene mutation carriers.
Fluid Permeabilities of Triply Periodic Minimal Surfaces
Y. Jung,S. Torquato
Physics , 2006,
Abstract: It has recently been shown that triply periodic two-phase bicontinuous composites with interfaces that are the Schwartz primitive (P) and diamond (D) minimal surfaces are not only geometrically extremal but extremal for simultaneous transport of heat and electricity. The multifunctionality of such two-phase systems has been further established by demonstrating that they are also extremal when a competition is set up between the effective bulk modulus and electrical (or thermal) conductivity of the bicontinuous composite. Here we compute the fluid permeabilities of these and other triply periodic bicontinuous structures at a porosity $\phi=1/2$ using the immersed boundary finite volume method. The other triply periodic porous media that we study include the Schoen gyroid (G) minimal surface, two different pore-channel models, and an array of spherical obstacles arranged on the sites of a simple cubic lattice. We find that the Schwartz P porous medium has the largest fluid permeability among all of the six triply periodic porous media considered in this paper. The fluid permeabilities are shown to be inversely proportional to the corresponding specific surfaces for these structures. This leads to the conjecture that the maximal fluid permeability for a triply periodic porous medium with a simply connected pore space at a porosity $\phi=1/2$ is achieved by the structure that globally minimizes the specific surface.
Information Security Issues in a Digital Library Environment: A Literature Review = Dijital Kütüphane Ortam nda Bilgi Güvenli i Sorunlar : Literatür De erlendirmesi
Anday, Audrey,Francese, Enrico,Huurdeman, Hugo C.,Y?lmaz, Muharrem
Bilgi Dünyas? , 2012,
Abstract: This paper aimed to explore the literature on security issues that digital libraries should consider in managing digital resources. Books on information security and network security were consulted as well as several databases such as ERIC, Ebrary, LISA, Science Direct, EbscoHost, ISI, Google Scholar, ProQuest, Emerald Insight, ACM were searched to understand what particular aspect of information security and privacy in digital libraries exist from 2000 - 2010. Security in digital libraries is an issue of the most important, and should be considered carefully in creating policies and strategic plans of institutions wanting to set up a digital library. This paper focused on the four main streams that concerns security in the digital environment, namely: infrastructure, digital content, users and standards and legal issues. This literature review also built upon previous literature reviews, and is one of the few of its kind in the topic. / Bu al ma dijital kütüphanelerin kaynaklar n y netiminde g z nünde bulundurmas gereken güvenlik sorunlar na ili kin literatürü ortaya koymay ama lamaktad r. Bilgi Güvenli i, A Güvenli i, Ki isel Gizlilik konular üzerine 2000 - 2010 y l aral n kapsayan kitaplar ve makaleler ERIC, Ebrary, LISA, Science Direct, EbscoHost, ISI, Google Akademik, ProQuest, Emerald Insight ve ACM gibi e itli veri tabanlar ndan taranm t r. ncelenen literatürden elde edilen sonu lara g re,bilgi güvenli i dijital kütüphaneler i in son derece nemli bir konudur ve dijitalle me sürecinde bir kütüphane, güvenlik politikalar n ve stratejik planlar n dikkatle g z nünde bulundurmal d r. Bu ara t rmada dijital ortamda güvenli i ilgilendiren Altyap , Dijital erik, Kullan c lar, Standartlar ve Hukuki Konular olmak üzere d rt ana madde üzerinde durulmu tur. Bu al ma ayr ca daha nceki literatür taramalar n da kapsamaktad r.
Seeking a Balance: Helping Pre-Service Teachers Develop Positive Attitudes towards Mathematics as They Develop Competency  [PDF]
Chris Hurst, Audrey Cooke
Open Journal of Social Sciences (JSS) , 2014, DOI: 10.4236/jss.2014.24022
Abstract: Mathematical competence of teachers continues to be an issue of great interest to mathematics educators within tertiary institutions and it is often thought of simultaneously with the notion of mathematics anxiety. While there has been considerable recent research into the latter, no clear conclusions have been able to be drawn about many aspects of the phenomenon and how it is linked to mathematical competence. Most recently, international studies have highlighted notable differences in the standards of teacher preparation in different countries and in Australia new standards for accreditation of teacher education programs have been drafted. This paper reports on a part of on-going research into mathematics anxiety and competence of pre-service teachers. It uses two small samples of pre-service teachers from different cohorts of a Bachelor of Education course and attempts to identify factors that may help develop positive attitudes towards mathematics as they seek to develop their competency in mathematics. In addition, as a response to greater reported levels of anxiety regarding cognitive and knowledge traits, the paper identifies targeted professional learning and social constructivist teaching as key factors as well as the need to identify personal knowledge of mathematics as a prelude to seeking to become more competent.
Different characteristics of new particle formation between urban and deciduous forest sites in Northern Japan during the summers of 2010–2011
J. Jung, Y. Miyazaki,K. Kawamura
Atmospheric Chemistry and Physics (ACP) & Discussions (ACPD) , 2013,
Abstract: To investigate new particle formation (NPF) events in urban and forest environments, number size distributions of ultrafine particles were measured at an urban site and a deciduous forest site in Sapporo, Northern Japan, during the summers of 2011 and 2010, respectively. The burst of nucleation mode particles at the urban site typically started in the morning (07:00–11:30 local time, LT) with simultaneous increases in SO2 and O3 concentrations and the UV index under clear (sunny) weather conditions. The growth rates of nucleated particles at the urban site ranged from 5.0 to 7.8 nm h 1 with an average of 6.3 ± 1.1 nm h 1. NPF events at the urban site were separated into events with or without subsequent particle growth after the burst of nucleation mode particles. This division was found to relate to prevailing wind direction because the subsequent growth of freshly nucleated particles typically occurred when wind direction shifted to northwesterly (from residential and public park areas), whereas it did not occur under southeasterly winds (from the downtown area). During the periods with NPF events, elevated concentrations of non-methane hydrocarbons (NMHC) were obtained under conditions of northwesterly winds when compared to southeasterly winds, whereas no difference in SO2 levels was recorded. These results suggest that variations in NMHC concentration may play an important role in the growth of freshly nucleated particles at the urban site. The burst of nucleation mode particles at the forest site typically started around noon (10:30–14:30 LT), which was 3–4 h later than that at the urban site. Interestingly, at the forest site the burst of nucleation mode particles usually started when air masses originating from urban Sapporo arrived at the forest site. The present study indicates that the inflow of these urban air masses acted as a trigger for the initiation of the burst of nucleation mode particles in the deciduous forest.
Constructing Cost-effective Anomaly Detection Systems for User Identification
Charlie Y. Shim,Jung Yeop Kim
Lecture Notes in Engineering and Computer Science , 2008,
Quiet and Noisy Metastable Voltage States in High-Tc Superconductors
G. Jung,B. Savo,Y. Yuzhelevski
Physics , 2000, DOI: 10.1103/PhysRevB.62.6674
Abstract: The interaction between the telegraph noise and background voltage fluctuations in the current induced dissipative state of high-Tc BiSrCaCuO thin films has been investigated. Experimental time records of the voltage drop across current biased thin film strips show markedly different background noise traces in the up and down telegraph states. Detailed analysis demonstrates that fluctuations around the telegraph voltage levels are due to a unique background noise process. The apparent quiet and noisy voltage states are due only to differences in the effective frequency bandwidth at which background noise is seen at distinct telegraph levels. Changes of the background noise variance ratio with changing bias current follow changes of the statistical average lifetimes of the random telegraph process.
Electronic coherence in mixed-valence systems: Spectral analysis
Y. Jung,R. J. Silbey,J. Cao
Physics , 2000,
Abstract: The electron transfer kinetics of mixed-valence systems is studied via solving the eigen-structure of the two-state non-adiabatic diffusion operator for a wide range of electronic coupling constants and energy bias constants. The calculated spectral structure consists of three branches in the eigen-diagram, a real branch corresponding to exponential or multi-exponential decay and two symmetric branches corresponding to population oscillations between donor and acceptor states. The observed electronic coherence is shown as a result of underdamped Rabi oscillations in an overdamped solvent environment. The time-evolution of electron population is calculated by applying the propagator constructed from the eigen-solution to the non-equilibrium initial preparation, and it agrees perfectly with the result of a direct numerical propagation of the density matrix. The resulting population dynamics confirms that increasing the energy bias destroys electronic coherence.
Some Relations of the Twisted q-Genocchi Numbers and Polynomials with Weight α and Weak Weight β
J. Y. Kang,H. Y. Lee,N. S. Jung
Abstract and Applied Analysis , 2012, DOI: 10.1155/2012/860921
Abstract: Recently many mathematicians are working on Genocchi polynomials andGenocchi numbers. We define a new type of twisted q-Genocchi numbers and polynomialswith weight and weak weight and give some interesting relations of the twistedq-Genocchi numbers and polynomials with weight and weak weight . Finally, we findrelations between twisted q-Genocchi zeta function and twisted Hurwitz q-Genocchi zetafunction.
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