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Search Results: 1 - 10 of 942 matches for " Atizado Valerie "
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Elevated expression of the toll like receptors 2 and 4 in obese individuals: its significance for obesity-induced inflammation
Ahmad Rasheed,Al-Mass Anfal,Atizado Valerie,Al-Hubail Asma
Journal of Inflammation , 2012, DOI: 10.1186/1476-9255-9-48
Abstract: Background Expression profile of the toll like receptors (TLRs) on PBMCs is central to the regulation of proinflammatory markers. An imbalance in the TLRs expression may lead to several types of inflammatory disorders. Furthermore, the dynamic regulation of inflammatory activity and associated impaired production of cytokines by peripheral blood mononuclear cells (PBMCs) in obese individulas remain poorly understood. Therefore, we determined the perturbation in TLRs (TLR2 and TLR4), their adaptor proteins (MyD88, IRAK1 and TRAF6) expression in PBMCs/subcutaneous adipose tissue (AT) as well as inflammatory cytokines changes in obese individuals. Methods mRNA expression levels of TLR2, TLR4, IL-6, TNF-α and adaptor proteins were determined by RT-PCR. TLR2, TLR4 and adaptor proteins expression in AT was determined by immunohistochemistry. Results Obese and overweight individuals showed significantly increased expression of TLR2, TLR4 and MyD88 in both PBMCs and AT as compared with lean individuals (P < 0.05). Interestingly, we found a remarkably higher expression of TLRs in obese and overweight individuals with type 2 diabetes (P < 0.05). Increased expression of TLR2, TLR4, MyD88 and IRAK1 correlated with body mass index (BMI) (TLR2: r = 0.91; TLR4: r = 0.88, P <0.0001; MyD88: r = 0.95, P < 0.0001; IRAK1 r = 0.78, P < 0.002). TLRs’ expression was also correlated with fasting blood glucose (FBG) (TLR2: r = 0.61, P < 0.002; TLR4: r = 0.52, P < 0.01) and glycated haemoglobin (HbA1c) ( TLR2: r = 0.44, P <0.03; TLR4: r = 0.48, P < 0.03). Transcript levels of IL-6 and TNF-α were highly elevated in obese subjects compared to lean subjects. There was a strong association of TLRs’ expression in PBMCs with TNF-α (TLR2: r = 0.92; TLR4: r = 0.92; P < 0.0001) and IL-6 (TLR2: r = 0.91, P < 0.0001; TLR4: r = 0.81; P < 0.001). Similarly adaptor proteins were significantly correlated with TNF-α (MyD88: r = 0.9, P < 0.0001; IRAK1: r = 0.86; P < 0.0002) and IL-6 (MyD88: r = 0.91, P < 0.0001; IRAK1: 0.77; P < 0.002). Conclusions TLRs and adapter proteins were overexpressed in PBMCs from obese subjects, which correlated with increased expression of TNF-α and IL-6. This association may explain a potential pathophysiological link between obesity and inflammation leading to insulin resistance.
An exploratory study on perceived relationship of alcohol, caffeine, and physical activity on hot flashes in menopausal women  [PDF]
Jay Kandiah, Valerie Amend
Health (Health) , 2010, DOI: 10.4236/health.2010.29146
Abstract: This study examined the effects of caffeine, alcohol, and physical activity (PA) on the perceived frequency and severity of hot flashes in menopausal women. Female employees at a Mid-Western university were invited to participate in an on-line survey. The 26-itemized Wo- men’s Health Survey (WHS) included questions regarding demographics, menopausal stage, experience of hot flashes, consumption of caffeinated beverages and alcohol, and participation in PA. One-hundred and ninety-six women completed the study. Ordinary Least Squares regressions revealed PA, caffeine, and alcohol intake were significant in predicting the severity of hot flashes (R2 = 0.068, F(6,180) = 2.195, p = 0.046), though they did not predict frequency of hot flashes (R2 = 0.043, F(6,184) = 1.39, p = 0.221). Participation in aerobic PA increased frequency of hot flashes (p = 0.031); while higher intensity of aerobic PA had an inverse relationship on both frequency and severity of hot flashes (p = 0.011, p = 0.003, respectively). Spearman correlations demonstrated a positive relationship between caffeinated soda intake and frequency (r = 0.17, p = 0.06) and severity (r = 0.19, p = 0.04) of hot flashes. Beverage consumption and PA may predict severity of hot flashes in women. Less frequent, higher intensity aerobic PA may lead to fewer, less severe hot flashes.
International Public Opinion on China’s Climate Change Policies  [PDF]
Valerie Victoria Benguiat y Gomez
Chinese Studies (ChnStd) , 2013, DOI: 10.4236/chnstd.2013.24027
Abstract: With the emergence of a global public sphere and the revolution of global media, international public opinion has gained an intrinsic importance for effective multilateral cooperation. Global governance initiatives are subject to international public opinion, and climate change is the single most important global governance issue of our time. Tackling climate change requires a fundamental transformation of the global economy, with an emphasis on sustainable development. Due to its political and economic weight, China can push forward UN climate change negotiations, and can do so without compromising its national development goals (China’s National Climate Change Programme, 2007). China’s national policies are beyond what is required from developing nations, but international public opinion often perceives a different message. This paper holds that a national branding strategy will help convey China’s current efforts, allowing a better understanding among nations in order to break the climate change negotiations deadlock. This research merged perception analysis and public opinion surveys with mass media qualitative and quantitative analysis to gain a full insight into what the international climate change decision-makers, opinion-leaders and general public think about China’s position at the UNFCCC negotiations. As seen in the findings of the present research, the climate of opinion is unfavorable to China. Overall, the results show that China is perceived as a negative influence in the negotiations. China’s climate change efforts are being overlooked by international public opinion. But the reason lies in China’s current discourse, where climate change and the environment are always downplayed by the right to develop (D’Hooghe, 2011). According to China’s 12th Five Year Plan, the new path for the country is marked by its commitment to achieve growth through low carbon development, with a strong focus on addressing climate change and energy challenges (Shealy & Dorian, 2007). The results of this study show that the positive intentions and actions of the Chinese government aren’t being accurately perceived by public opinion. The empirical findings in this study provide a new understanding of one specific part of the overall image that the world has about China. Whilst this study did not confirm unequivocally that international public opinion directly determines the outcomes of international negotiations and foreign policy, it did partially substantiate the concept that there’s a correlation between China’s public declarations and actions, the
Relationship between Quality and Editorial Leadership of Biomedical Research Journals: A Comparative Study of Italian and UK Journals
Valerie Matarese
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0002512
Abstract: Background The quality of biomedical reporting is guided by statements of several organizations. Although not all journals adhere to these guidelines, those that do demonstrate “editorial leadership” in their author community. To investigate a possible relationship between editorial leadership and journal quality, research journals from two European countries, one Anglophone and one non-Anglophone, were studied and compared. Quality was measured on a panel of bibliometric parameters while editorial leadership was evaluated from journals' instructions to authors. Methodology/Principal Findings The study considered all 76 Italian journals indexed in Medline and 76 randomly chosen UK journals; only journals both edited and published in these countries were studied. Compared to UK journals, Italian journals published fewer papers (median, 60 vs. 93; p = 0.006), less often had online archives (43 vs. 74; p<0.001) and had lower median values of impact factor (1.2 vs. 2.7, p<0.001) and SCImago journal rank (0.09 vs. 0.25, p<0.001). Regarding editorial leadership, Italian journals less frequently required manuscripts to specify competing interests (p<0.001), authors' contributions (p = 0.005), funding (p<0.001), informed consent (p<0.001), ethics committee review (p<0.001). No Italian journal adhered to COPE or the CONSORT and QUOROM statements nor required clinical trial registration, while these characteristics were observed in 15%–43% of UK journals (p<0.001). At multiple regression, editorial leadership predicted 37.1%–49.9% of the variance in journal quality defined by citation statistics (p<0.0001); confounding variables inherent to a cross-cultural comparison had a relatively small contribution, explaining an additional 6.2%–13.8% of the variance. Conclusions/Significance Journals from Italy scored worse for quality and editorial leadership than did their UK counterparts. Editorial leadership predicted quality for the entire set of journals. Greater appreciation of international initiatives to improve biomedical reporting may help low-quality journals achieve higher status.
Articles selected in February 2004
Valerie Speirs
Breast Cancer Research , 2004, DOI: 10.1186/bcr769
Articles selected in September 2004
Valerie Speirs
Breast Cancer Research , 2004, DOI: 10.1186/bcr955
Articles selected in July 2004
Valerie Speirs
Breast Cancer Research , 2004, DOI: 10.1186/bcr925
Articles selected in May 2004
Valerie Speirs
Breast Cancer Research , 2004, DOI: 10.1186/bcr817
The evolving role of oestrogen receptor beta in clinical breast cancer
Valerie Speirs
Breast Cancer Research , 2008, DOI: 10.1186/bcr2140
Abstract: Oestrogen receptor (ER)α remains the most important biomarker in breast cancer as it indicates the likelihood of patients to benefit from endocrine therapy. The discovery of ERβ over a decade ago was initially greeted with interest by the breast cancer community. Its presence indicated that ER signalling was no longer restricted to ERα, with a real possibility of using ERβ as an additional prognostic or predictive marker in breast cancer, complementing ERα. A number of studies were subsequently published, examining ERβ mRNA, protein or a combination of both – but many of these studies suffered from small sample numbers, use of poorly validated primary antibodies and failure to consider the potential importance of known ERβ isoforms. This led to conflicting results, holding back anticipated progress. As a result, a great deal of scepticism began to surround the potential importance of ERβ in breast cancer.ERβ has recently emerged from the shadows with the concurrent publication of three papers [1-3]. These articles stand out from previous studies because they examined large numbers of breast cancers using well validated, readily available antibodies.In the present journal, Novelli and colleagues conducted a prospective immunohistochemical study of ERβ1 in 936 breast cancers [1]. Rather than relying solely on conventional statistics to define ERβ association with clinicopathological factors, the authors used two additional statistical approaches: multiple correspondence analysis, and classification and regression tree analysis. The former approach analyses patterns of relationships of several categorical dependent variables, while the latter is a tree-building technique developed to reveal complex interactions between predictors that may be difficult to find using traditional multivariate techniques. Multiple correspondence analysis showed ERβ1 positivity was associated with more aggressive breast cancer phenotypes, namely HER2-positive tumours and triple negative/bas
Emerging concepts in high-impact publishing: insights from the First Brazilian Colloquium on High Impact Research and Publishing
Annali dell'Istituto Superiore di Sanità , 2010, DOI: 10.4415/ANN_10_04_14
Abstract: reports of scientific research are published by selective journals only when they meet stringent criteria, first and foremost of which are the quality and importance of the research. even when the research is excellent, other elements come into play to determine if the manuscript will be accepted for publication. many of these factors are under direct control of the researcher-author, but not all authors are aware of the elements of high-impact scientific writing. at the first brazilian colloquium on high impact research and publishing, editors of leading biomedical journals provided insight on the aspects of scientific reporting that favor acceptance (or immediate rejection). this commentary summarizes the editors' advice and uses the debate that followed as the basis for analyzing emerging concepts in high-impact publishing. lessons learned from this meeting are relevant to researcher-authors in other non-anglophone countries as well as to their educators and administrators who wish to improve the impact of the research that they support and finance.
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