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Search Results: 1 - 10 of 1177 matches for " Aspergillus fumigatus "
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Pyopneumothorax Secondary to Aspergillus Infection: A Case Report
Surya Kant,S Saheer,Abhijjeet Singh,Ghulam Hassan
Oman Medical Journal , 2012,
Abstract: A 32 -year- old male presented with complaints of fever, dry cough, breathlessness and right sided chest pain of two months duration. Chest radiograph showed right sided hydropneumothorax which revealed frank pus on diagnostic thoracocentesis, for which tube thoracostomy was done. Despite vigorous broad spectrum antibiotic coverage, postural drainage and chest physiotherapy, there was no clinical improvement. Further work up included serology, pleural fluid culture, closed as well as thoracoscopic guided pleural biopsy revealed growth of Aspergillus fumigatus. Patient was prescribed antifungal medication (Voriconazole) and subsequent thoracotomy with right sided pneumonectomy showed good clinical recovery.
Purification and characterization of a low molecular weight xylanase from solid-state cultures of Aspergillus fumigatus Fresenius
Silva, Claudio Henrique Cerri e;Puls, Jurgen;Sousa, Marcelo Valle de;Ferreira Filho, Edivaldo Ximenes;
Revista de Microbiologia , 1999, DOI: 10.1590/S0001-37141999000200005
Abstract: a xylan-degrading enzyme (xylanase ii) was purified to apparent homogeneity from solid-state cultures of aspergillus fumigatus fresenius. the molecular weight of xylanase ii was found to be 19 and 8.5 kda, as estimated by sds-page and gel filtration on fplc, respectively. the purified enzyme was most active at 55 °c and ph 5.5. it was specific to xylan. the apparent km and vmax values on soluble and insoluble xylans from oat spelt and birchwood showed that xylanase ii was most active on soluble birchwood xylan. studies on hydrolysis products of various xylans and xylooligomers by xylanase ii on hplc showed that the enzyme released a range of products from xylobiose to xylohexaose, with a small amount of xylose from xylooligomers, and presented transferase activity.
Glucoamylase from the Isolate Aspergillus fumigatus
H.M. Cherry,Md. Towhid Hossain,M.N. Anwar
Pakistan Journal of Biological Sciences , 2004,
Abstract: Aspergillus fumigatus Fresenius was isolated from goat`s rumen and exhibited highest amylase production at temperature 37 C, medium pH 7.0 and 3 days of incubation period. Four percent starch as carbon source and 0.25% (NH4)2HPO4 as nitrogen source was found to induce amylase production by the isolate Aspergillus fumigatus. Maximum glucoamylase activity was achieved at 35 C temperature and pH 7.0 along with 4% starch as substrate concentration during enzyme-substrate reaction.
Purification and characterization of a low molecular weight xylanase from solid-state cultures of Aspergillus fumigatus Fresenius
Silva Claudio Henrique Cerri e,Puls Jurgen,Sousa Marcelo Valle de,Ferreira Filho Edivaldo Ximenes
Revista de Microbiologia , 1999,
Abstract: A xylan-degrading enzyme (xylanase II) was purified to apparent homogeneity from solid-state cultures of Aspergillus fumigatus Fresenius. The molecular weight of xylanase II was found to be 19 and 8.5 kDa, as estimated by SDS-PAGE and gel filtration on FPLC, respectively. The purified enzyme was most active at 55 °C and pH 5.5. It was specific to xylan. The apparent Km and Vmax values on soluble and insoluble xylans from oat spelt and birchwood showed that xylanase II was most active on soluble birchwood xylan. Studies on hydrolysis products of various xylans and xylooligomers by xylanase II on HPLC showed that the enzyme released a range of products from xylobiose to xylohexaose, with a small amount of xylose from xylooligomers, and presented transferase activity.
Proteomic Differences between Azole-Susceptible and -Resistant Aspergillus fumigatus Strains  [PDF]
Edith Vermeulen, Sebastien Carpentier, Olaf Kniemeyer, Machteld Sillen, Johan Maertens, Katrien Lagrou
Advances in Microbiology (AiM) , 2018, DOI: 10.4236/aim.2018.81007
Abstract: Background: Azole-resistance is increasingly reported in Aspergillus fumigatus infections. It remains challenging to rapidly assess antifungal susceptibility to initiate the appropriate therapy. The aim of this study was to map the proteomic differences of azole-susceptible and -resistant strains. Methods: Proteomic studies were performed with ultra-performance liquid chromatography tandem mass-spectrometry (UPLC-MS/MS). Results: UPLC-MS/MS detected 7899 peptides, of which 1792 peptides had a significantly different abundance (p < 0.05) between resistant and susceptible strains. The discriminating proteins were identified and provide an interesting tool for future research into A. fumigatus resistance. Conclusions: UPLC-MS/MS provided proof-of-concept that the proteome of azole-resistant A. fumigatus is diverse enough to serve as a diagnostic tool.
Diketopiperazines produced by an Aspergillus fumigatus Brazilian strain
Furtado, Niege A. J. C.;Pupo, M?nica T.;Carvalho, Ivone;Campo, Vanessa L.;Duarte, Marta Cristina T.;Bastos, Jairo K.;
Journal of the Brazilian Chemical Society , 2005, DOI: 10.1590/S0103-50532005000800026
Abstract: seven diketopiperazines, corresponding to the cyclos (l)-pro-(l)-phe, (l)-pro-gly, (l)-pro-(l)-pro, (l)-pro-(l)-val, (l)-4-oh-pro-(l)-leu, (l)-4-oh-pro-(l)-phe, and (l)-pro-(l)-leu, were isolated from the aspergillus fumigatus fermentation broth. the relative and absolute stereochemistries were determined on the basis of noesy experiments and by using a modified version of marfey's method using hplc, respectively.
Decolourization of textile dye effluent by non-viable biomass of Aspergillus fumigatus
Kalaiarasi, K.;Lavanya, A.;Amsamani, S.;Bagyalakshmi, G.;
Brazilian Archives of Biology and Technology , 2012, DOI: 10.1590/S1516-89132012000300019
Abstract: the aim of this work was to study the decolourization of textile dye effluent by non-viable biomass of aspergillus fumigates. the dried non-viable fungal biomass exhibited maximum dye removal at ph 7.0 with temperature of 30oc and 3 g/l (w/v) biomass concentration, after 24 h contact time. the results showed that the non-viable biomass possessed high efficiency for dye removal from textile effluent.
Obten??o e avalia??o de antígenos de Aspergillus fumigatus
Lirio, Vanda de Sá;Assis, Cezar Mendes de;Cano, Maria Isabel N.;Lacaz, Carlos da Silva;
Revista do Instituto de Medicina Tropical de S?o Paulo , 1992, DOI: 10.1590/S0036-46651992000400015
Abstract: antigens from three strains of aspergillus fumigatus (354, 356, and jig) and an antiserum against the mixing of these antigens have been produced, and evaluated immunochemically. the antigens were obtained through a modified coleman & kaufman technique (culture filtrate concentrated by acetone). analysis by the immunodiffusion test (id) against homologous serum has yielded 100% sensitivity (with the studied sera). concerning heterologous sera we found reactivity with a serum of a patient of candidiasis and another with histoplasmosis. the same result was obtained with a reference antigen in immunodiffusion, showing similar standards of response. titration of the antiserum by id and counterimmunoelectrophoresis showed a title of 1:32, and by complement fixation (micro-technique) a title of 1:128. using immunoelectrophoresis (ief), the produced antiserum yielded 8 lines of precipitation (5 in the anodic pole and 3 in the cathodic one). in sds-page at 12.5% the antigen has presented a rather complex electro-phoretic profile (26 proteic subunits with a molecular weight ranging from 18 a > 100 kda). immunogenicity of the antigen was observed in all fractions of sds-page when the immu-noblotting against the antiserum was carried out.
Aspergilose em avestruz (Struthio camelus) no Brasil
Paix?o Tatiane Alves da,Nascimento Ernane Fagundes do,Parra Paula Namie Shida,Santos Renato de Lima
Ciência Rural , 2004,
Abstract: Criatórios de avestruz têm se tornado comuns no Brasil, mas por se tratar de espécie exótica, as informa es sobre as doen as desses animais no nosso ambiente s o escassas. Um avestruz de cinco meses de idade apresentou tosse, anorexia, perda de peso, dispnéia discreta, temperatura corporal normal e morreu oito dias após o início dos sinais clínicos. Macroscopicamente foram observados nódulos múltiplos no pulm o e nos sacos aéreos. Histolopatogicamente, observou-se pneumonia granulomatosa e necrosante multifocal com hifas ramificadas e septadas intralesionais com características morfológicas de Aspergillus sp. Nos sacos aéreos, além das hifas e processo inflamatório adjacente haviam vários micélios com conidióforos na superfície interna. Foi isolado Aspergillus fumigatus dos tecidos afetados. De acordo com os achados histopatológicos e micológicos firmou-se o diagnóstico de pneumonia e aerossaculite micótica severa causada por Aspergillus fumigatus. Com base nas informa es disponíveis na literatura, esse é o primeiro caso de aspergilose em avestruz documentado no Brasil.
Receptor-mediated signaling in Aspergillus fumigatus
C. M. Grice,M. Bertuzzi,E. M. Bignell
Frontiers in Microbiology , 2013, DOI: 10.3389/fmicb.2013.00026
Abstract: Aspergillus fumigatus is the most pathogenic species among the Aspergilli, and the major fungal agent of human pulmonary infection. To prosper in diverse ecological niches, Aspergilli have evolved numerous mechanisms for adaptive gene regulation, some of which are also crucial for mammalian infection. Among the molecules which govern such responses, integral membrane receptors are thought to be the most amenable to therapeutic modulation. This is due to the localization of these molecular sensors at the periphery of the fungal cell, and to the prevalence of small molecules and licensed drugs which target receptor-mediated signaling in higher eukaryotic cells. In this review we highlight the progress made in characterizing receptor-mediated environmental adaptation in A. fumigatus and its relevance for pathogenicity in mammals. By presenting a first genomic survey of integral membrane proteins in this organism, we highlight an abundance of putative seven transmembrane domain (7TMD) receptors, the majority of which remain uncharacterized. Given the dependency of A. fumigatus upon stress adaptation for colonization and infection of mammalian hosts, and the merits of targeting receptor-mediated signaling as an antifungal strategy, a closer scrutiny of sensory perception and signal transduction in this organism is warranted.
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