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Search Results: 1 - 10 of 474 matches for " Aslan Gonul "
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A comparative study on the different staining methods and number of specimens for the detection of acid fast bacilli
Ulukanligil, Mustafa;Aslan, Gonul;Tas?i, Sami;
Memórias do Instituto Oswaldo Cruz , 2000, DOI: 10.1590/S0074-02762000000600019
Abstract: the presence of acid fast bacilli in multiple specimens was investigated comparatively with ziehl-neelsen (zn) and fluorescence microscopy (fm) staining in order to determine sensitivity in detecting tuberculosis (tb). a total of 465 specimens obtained from 295 patients were analysed at harran university medical school hospital between march 1998 and march 2000. the culture was employed as the reference method. sixty-eight patients (23.1%) were diagnosed as having tb by culture. the zn and fm staining sensitivities were 67.6% (46/68) and 85.2% (58/68) respectively. two hundred and one patients (68.1%) submitted one specimen to the laboratory. tb positivity was detected in 42 (20.9%) of these patients by culture. the sensitivities of zn and fm stains were found to be 61% and 83% in these patients. however, in 18 patients (6.1%) who submitted two specimens to the laboratory, the tb was positive in six of them (33.3%) and zn and fm sensitivities were 66% and 83% respectively. when three specimens or more were collected from the patients (76 patients, 25.8%), tb positivity was determined in 20 of them (26.3%) and the sensitivities were 80% and 92% in the zn- and fm-stained smears, respectively. our data indicate that in the diagnosis of tb, fm has greater sensitivity than zn. in particular, in the case of a single specimen, the diagnostic value of fm is quite significant. it is, therefore, possible to conclude that both zn and fm staining can be used for the diagnosis of tb when there are more than two specimens. however, if only one or two specimens are available, fm staining is preferable.
Two Cases of Tuberculosis Complicating Treatment With Tumor Necrosis Factor- Inhibitors
Mukadder Calikoglu,Gunsah Sahin,Gonul Aslan
Turk Toraks Dergisi , 2008,
Abstract: TNF-a blocking agents have been increasingly used in the treatment of systemic inflammatory diseases. The main adverse effect of these drugs is susceptibility to infections, mainly reactivation of latent tuberculous infection (LTBI). In this paper we described two cases of TNF-a inhibitor-associated TB. Because LTBI and BCG vaccination are widespread in the Turkish population, a stringent pre-treatment screening protocol for LTBI should be used. In such patients, TB frequently presents as an extrapulmonary or disseminated and life-threatening disease. Physicians should be aware of the risk of the reactivation of TB, despite isoniazid chemoprophylaxis, with unusual clinical manifestations and a paradoxical response.
A comparative study on the different staining methods and number of specimens for the detection of acid fast bacilli
Ulukanligil Mustafa,Aslan Gonul,Tas?i Sami
Memórias do Instituto Oswaldo Cruz , 2000,
Abstract: The presence of acid fast bacilli in multiple specimens was investigated comparatively with Ziehl-Neelsen (ZN) and fluorescence microscopy (FM) staining in order to determine sensitivity in detecting tuberculosis (TB). A total of 465 specimens obtained from 295 patients were analysed at Harran University Medical School Hospital between March 1998 and March 2000. The culture was employed as the reference method. Sixty-eight patients (23.1%) were diagnosed as having TB by culture. The ZN and FM staining sensitivities were 67.6% (46/68) and 85.2% (58/68) respectively. Two hundred and one patients (68.1%) submitted one specimen to the laboratory. TB positivity was detected in 42 (20.9%) of these patients by culture. The sensitivities of ZN and FM stains were found to be 61% and 83% in these patients. However, in 18 patients (6.1%) who submitted two specimens to the laboratory, the TB was positive in six of them (33.3%) and ZN and FM sensitivities were 66% and 83% respectively. When three specimens or more were collected from the patients (76 patients, 25.8%), TB positivity was determined in 20 of them (26.3%) and the sensitivities were 80% and 92% in the ZN- and FM-stained smears, respectively. Our data indicate that in the diagnosis of TB, FM has greater sensitivity than ZN. In particular, in the case of a single specimen, the diagnostic value of FM is quite significant. It is, therefore, possible to conclude that both ZN and FM staining can be used for the diagnosis of TB when there are more than two specimens. However, if only one or two specimens are available, FM staining is preferable.
Environmental pollution with soil-transmitted helminths in Sanliurfa, Turkey
Ulukanligil, Mustafa;Seyrek, Adnan;Aslan, Gonul;Ozbilge, Hatice;Atay, Suleyman;
Memórias do Instituto Oswaldo Cruz , 2001, DOI: 10.1590/S0074-02762001000700004
Abstract: soil transmitted helminth (sth) infection are endemic in developing countries. a study was carried out of sewage farms, streams and vegetables to determine the sources and routes of sth infection in sanliurfa, turkey. stool samples from farmhouse inhabitants as well as soil and vegetable samples from the gardens were collected and examined. in addition, water samples from streams and vegetable samples from the city market were collected and examined. one hundred and eighty-seven (59.5%) of a total of 314 samples, including 88.4% of the stool samples, 60.8% of the water samples, 84.4% of the soil samples and 14% of the vegetable samples, were found to be positive for sth eggs. these results indicate that the water, soil and vegetables are heavily contaminated, and suggest a vicious circle between humans and the environment. improving environmental sanitation is imperative for the control of soil-transmitted helminthiasis in sanliurfa.
Diagnostic performance characteristics of rapid dipstick test for Plasmodium vivax malaria
Aslan, Gonul;Ulukanligil, Mustafa;Seyrek, Adnan;Erel, Ozcan;
Memórias do Instituto Oswaldo Cruz , 2001, DOI: 10.1590/S0074-02762001000500018
Abstract: we compared the diagnostic performance characteristics of newly developed method, the rapid dipstick test, which provides colorimetric determination by developing antibody to the lactate dehydrogenase enzyme of parasites, with conventional standard thick-blood film examination. for the rapid test, optimal commercial kits were used. the results were also evaluated with clinical findings from patients. the parasites were determined by microscopic examination of thick-blood films from 81 patients with vivax malaria from southeastern anatolia, turkey. the optimal test results were found to be negative in five patients who were diagnosed clinically and through thick-film testing as having vivax malaria. there was no false positivity observed with the optimal test. we concluded that this rapid malaria test has a lower level of sensitivity than the classical thick-blood-film test for malaria, but that these methods have equal specificity.
Diagnostic performance characteristics of rapid dipstick test for Plasmodium vivax malaria
Aslan Gonul,Ulukanligil Mustafa,Seyrek Adnan,Erel Ozcan
Memórias do Instituto Oswaldo Cruz , 2001,
Abstract: We compared the diagnostic performance characteristics of newly developed method, the rapid dipstick test, which provides colorimetric determination by developing antibody to the lactate dehydrogenase enzyme of parasites, with conventional standard thick-blood film examination. For the rapid test, OptiMAL commercial kits were used. The results were also evaluated with clinical findings from patients. The parasites were determined by microscopic examination of thick-blood films from 81 patients with vivax malaria from southeastern Anatolia, Turkey. The OptiMAL test results were found to be negative in five patients who were diagnosed clinically and through thick-film testing as having vivax malaria. There was no false positivity observed with the OptiMAL test. We concluded that this rapid malaria test has a lower level of sensitivity than the classical thick-blood-film test for malaria, but that these methods have equal specificity.
Environmental pollution with soil-transmitted helminths in Sanliurfa, Turkey
Ulukanligil Mustafa,Seyrek Adnan,Aslan Gonul,Ozbilge Hatice
Memórias do Instituto Oswaldo Cruz , 2001,
Abstract: Soil transmitted helminth (STH) infection are endemic in developing countries. A study was carried out of sewage farms, streams and vegetables to determine the sources and routes of STH infection in Sanliurfa, Turkey. Stool samples from farmhouse inhabitants as well as soil and vegetable samples from the gardens were collected and examined. In addition, water samples from streams and vegetable samples from the city market were collected and examined. One hundred and eighty-seven (59.5%) of a total of 314 samples, including 88.4% of the stool samples, 60.8% of the water samples, 84.4% of the soil samples and 14% of the vegetable samples, were found to be positive for STH eggs. These results indicate that the water, soil and vegetables are heavily contaminated, and suggest a vicious circle between humans and the environment. Improving environmental sanitation is imperative for the control of soil-transmitted helminthiasis in Sanliurfa.
Detection of Entamoeba histolytica/Entamoeba dispar in stool specimens by using enzyme-linked immunosorbent assay
Delialioglu, Nuran;Aslan, Gonul;Sozen, Mehmet;Babur, Cahit;Kanik, Arzu;Emekdas, Gurol;
Memórias do Instituto Oswaldo Cruz , 2004, DOI: 10.1590/S0074-02762004000700019
Abstract: entamoeba histolytica actually comprises two genetically distinct but morphologically indistinguishable species. e. histolytica can cause invasive intestinal and extra intestinal disease, while e. dispar cannot. identification and differentiation of e. dispar and e. histolytica in stool sample by microscopy is imprecise. several weeks of culture and isoenzyme analysis are required to differentiate e. histolytica from e. dispar. in this study, we have used an enzyme-linked immunosorbent assay (elisa) for detection of e. histolytica/e.dispar and compared it with microscopy. eighty-eight samples were evaluated, trichrome staining was positive in 20.4% (18) and elisa was positive in 29.5% (26). both tests were positive in 14 (15.9%) samples, 4 (4.5%) only with direct microscopy, and 12 (13.6%) only with elisa. both tests were negative in 58 (65.9%) samples. microscopy has low sensitivity and high specificity, low negative predictive value and high positive predictive value in comparison with elisa. e. histolytica/e. dispar antigen detection elisa tests are inexpensive compared to the specific tests, yield objective results and do not require experienced microscopists and can therefore be recommended for screening of stools worldwide and the results can be taken for treatment that are fitting with its clinic.
Modified Technique for Internal Ureteroileal Stenting in Orthotopic Neobladders  [PDF]
Guven Aslan
Open Journal of Urology (OJU) , 2011, DOI: 10.4236/oju.2011.12005
Abstract: We introduce a modified surgical technique for internal ureteroileal stenting to improve cosmesis in patients undergoing ileal neobladder. Internal ureteric stents are secured to the tip of the urethral catheter with nonabsorbable suture facilitating removal of the stents postoperatively 2-3 weeks along with the urethral catheter. This surgical modification was applied to 21 patients of whom no significant surgical or infectious complication due to single urethral catheter was observed. Internal ureteral stenting is simple, safe and inexpensive alternative to conventional methods to support ureteroileal anastomosis in patients undergoing orthotopic bladder substitution.
Comment on the Paper “Condom-Assisted Transurethral Resection: A New Surgical Technique for Urethral Tumor”, Surgical Science, Vol. 1, 2010, pp. 46-48  [PDF]
Guven Aslan
Surgical Science (SS) , 2011, DOI: 10.4236/ss.2011.24042
Abstract: The authors introduce a new technical modification which facilitates endoscopic resection of urethra tumors located at navicular fossa by using a tipcut condom that covers the resectoscope and the penis. This tech-nique can be used in the diagnosis and management of all kind male anterior urethral lesions at this location.
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