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Search Results: 1 - 10 of 15 matches for " Asija Sanjeeta "
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FORMULATION AND EVALUATION OF MATRIX DIFFUSION CONTROLLED TRANSDERMAL DRUG DELIVERY SYSTEM OF GLIPIZIDE
Patel Chirag J,Mangukia Dhruv K,Asija Rajesh,Asija Sanjeeta
Journal of Drug Delivery and Therapeutics , 2012,
Abstract: There has been a tremendous increase in interest for transdermal drug delivery system for sustain release dosage form in chronic manageable diseased conditions like diabetes, hypertension etc to reduce the frequency of dosing. It reduces the risk of exposing the body to drug above maximum safe concentration in case of dosage form failure in comparison to oral sustained release drug delivery system. It also reduces the frequency of dosing and improves patient compliance. Transdermal patches of Glipizide were formulated to achieve sustain release pattern within the therapeutic range. HPMC 5cps, HPMC 15cps, HPMC K-100M, Ethyl cellulose (EC), Eudragit RS 100 (ERS-100) and Polyvinylpyrrolidone (PVP) K30 were used as matrix forming polymer. Propylene glycol was used as penetration enhancer. Polyethylene glycol (PEG) 400 and n-dibultyl phthalate (n-DB) were used as plasticizer. Methanol and chloroform were used as solvents. Patches were prepared by solvent casting method. Prepared patches were evaluated for physicochemical parameters like weight variation, thickness, folding endurance, drug content, % moisture absorption and % elongation break test. Patches prepared, from each batch, gave release profile for over 10 hours. Cumulative amount of drug release in 12 hours from all the prepared formulations were found to be in following order: F1 > F3 > F4 > F10 > F9 > F6 > F8 > F7 > F2 > F5 > F11 > F12. Prepared patch from HPMC 5 cps and ethyl cellulose (F1) exhibited good characteristics for sustained release action and other parameters evaluated
Sustained Released Drug Technology: A Review
Asija Rajesh,Rathi Harish,Asija Sangeeta
International Journal of Research in Pharmacy and Science , 2012,
Abstract: Very few drugs are coming out of research and development and already existing drugs are suffering the problem of resistance due to their irrational use specifically in case of drugs like antibiotics. Hence, change in the operation is a suitable and optimized way to make the some drug more effective by slight alteration in the drug delivery. By the sustained release method therapeutically effective concentration can be achieved in the systemic circulation over an extended period of time, thus achieving better compliance of patients and also providing promising way to decrease the side effect of drug by preventing the fluctuation of the therapeutic concentration of the drug in the body. Wide varieties of polymers are available for retarding the release rate of drugs hence sustains the action of drugs. This article contains the basic information regarding sustained-release formulation, its advantages, different types, and factors involved in oral sustained-release dosage form design
A NOVEL APPROCH: PULSATILE DRUG DELIVERY SYSTEM
Asija Rajesh,Patel Jaimin,Asija Sangeeta
International Research Journal of Pharmacy , 2012,
Abstract: Pulsatile drug delivery system (PDDS) is useful in the treatment of disease, in which drug availability is timed to match rhythms of disease, in order to optimize therapeutic effect and minimize side effects. PDDS have attracted attraction because of their multiple benefits over conventional dosage forms. The specific time that patients take their medication is very important as it has significant impact on success of treatment. If symptoms of a disease display circadian variation, drug release should also vary over time. Diseases wherein pulsatile drug delivery systems are promising include cardiovascular diseases, arthritis, asthma, cancer, hypercholesterolemia, duodenal ulcer, neurological disorders and diabetes. In pursuit of pulsatile release, various design strategies have been proposed, mainly including time controlling, stimuli induced, externally regulated and multiparticulate formulations. This review will cover methods that have been developed to control drug delivery profile with different polymeric systems like time controlling, internal stimuli induced (temperature induced and chemical stimuli-induced), and external induced (magnetic fields, ultrasound, electric fields and light stimulation) and multiparticulate system. Pulsatile drug delivery systems have the potential to bring new developments in the therapy of many diseases.
ENHANCED SOLUBILITY STUDY OF SULPHASALAZINE USING DIFFERENT SOLUBILIZATION TECHNIQUES
Asija Rajesh,Kalariya Nikunj,Asija Sangeeta
International Research Journal of Pharmacy , 2012,
Abstract: The aim of present work was to perform a comparative study on effect of solubility of suphasalazine by using different solubilization techniques such as solid dispersion, hydrotropy and micellar solubilization. Hydrotropic studies were carried out using different hydrotropic agents (sodium acetate, sodium benzoate and lignocaine hydrocholride) and Micellar solubilization was carried out using different surfactant solutions (sodium lauryl sulphate, tween 80 and tween 20). Solid dispersion of suphasalazine was prepared by fusion method. PEG (Polyethylene glycol) 4000, mannitol and urea were used as carriers. The solubility enhancement of sulphasalazine by different solubilization technique was observed in decreasing order as hydrotropic solubilization > solid dispersion > micellar solubilization. It was observed that the solubility increased with the increase in the concentration of hydrotropic agents and amongst the various hydrotropic agents used, the solubility of sulphasalazine was enhanced greatest to 40 folds with sodium benzoate. This increase may be attributed due to aggregation of the hydrotropic molecules and inclusion of one of these aggregates at high concentration probably by reacting to form an associated product as a result of hydrogen bonding.
ORAL COLON TARGETED DRUG DELIVERY SYSTEM: A REVIEW ON CURRENT AND NOVEL PERSPECTIVES
Asija Rajesh,Chaudhari Bharat,Asija Sangeeta
Journal of Pharmaceutical and Scientific Innovation , 2012,
Abstract: Small intestine is mostly the site for drug absorption but in some cases the drug needs to be targeted to colon due to some factors like local colonic disease, degradation related conditions, delayed release of drugs, systemic delivery of protein and peptide drugs etc. Colon targeted drug delivery is important and relatively new concept for the absorption of drugs because it offers almost neutral pH and long residence time, thereby increasing the drug absorption. Colon has proved to be a site for the absorption of poorly soluble drugs. For the successful targeting of drugs to colon the dosage form should be designed such that it prevents the drug release in upper GIT and releasing it in the colonic region. This review article discusses in brief about introduction of colon along with the novel and emerging technologies for colon targeting of drug molecule. Treatment of these diseases with colon-specific drug delivery system provides an interesting alternative over systemic drug administration because of lower dosing and fewer systemic side effects.
SUSTAIN OPHTHALMIC DELIVERY OF LEVOFLOXACIN FROM A pH -TRIGGERED IN SITU GELLING SYSTEM
Asija Rajesh,Patel Nikunj A.,Shah Smit,Asija Sangeeta
International Research Journal of Pharmacy , 2012,
Abstract: Most eye diseases are treated with topical application of eye drops. The poor bioavailability and therapeutic response exhibited by these conventional eye drops due to rapid precorneal elimination of the drug may be overcome by the use of in situ gelling systems that are instilled as drops into the eye and undergo a sol-to-gel transition in the cul-de-sac. Hence, the purpose of the present work was to develop Sustain Ophthalmic delivery of Levofloxacin from a pH-triggered in situ gelling system. Polyacrylic acid (Carbopol 934) was used as the gelling agent in combination with hydroxypropyl methylcellulose (Methocel K4M) and HPMC K100LV which acted as a viscosity enhancing agent. Compatibility studies of the drug excipients were carried out using FTIR. The prepared formulations were characterized for clarity, pH, drug content, Gelling capacity, Rheological studies, in vitro drug release study, sterility study and stability study.
EFFECT OF THE PREPARATION OF SOLID DISPERSION METHOD ON THE SOLUBILITY AND CRYSTALLINITY OF SULFASALAZINE
Asija Rajesh,Asija Sangeeta,Lamba H. S.,Kataria Sandeep
International Research Journal of Pharmacy , 2011,
Abstract: The solubility, dissolution and physicochemical properties of the sulfasalazine in the three solid dispersions were evaluated compared to drug powder using Scanning electron microscopy, differential scanning colorimetric and powder X-ray diffraction. Three solid dispersions containing poorly water-soluble sulfasalazine were prepared with hydroxypropyl-β-cyclodextrin (HP-β-CD) and dioctyl sulfosuccinate. The solubility and dissolution of the drug were significantly improved in the order of the sulfasalazine-loaded solid dispersion prepared by: solvent-evaporation method > solvent-wetting method > surface-attached method. The solid dispersions prepared by solvent evaporation appeared as an aggregated form with the amorphous form. In particular, the solid dispersion prepared by the solvent-evaporation method improved solubility about 900-fold. The solid dispersion prepared by the surface-attached method gave an unchanged crystalline form. In this solid dispersion, the carriers were attached to the surface of the undissolved drug. Thus, in the development of a solid-dispersion system containing poorly water-soluble drugs, the method of preparation plays an important role in the solubility and crystallinity of the drugs.
FORMULATION AND EVALUATION OF DICLOFENAC SODIUM SUSTAINED RELEASE TABLETS USING MELT GRANULATION TECHNIQUE
Asija Rajesh,Modi Jasmin,Kumawat Radheshyam,Asija Sangeeta
International Research Journal of Pharmacy , 2012,
Abstract: Hydrophilic polymers alone are not quite efficient in controlling the release of highly water soluble drugs. Hydrophobic Polymer and pore forming agent have been extensively investigated for sustaining the release of drug. They provide several advantages include good stability at varying pH ranges and effectively retards the water soluble drug. In the present study it was a novel approach where the water soluble drug is first incorporate in polymer matrix by melt granulation technique and this matrix is subsequently granulated with pore forming agent. Here it was considered that the combination of hydrophobic polymer and Pore forming agent to prepare the matrix tablets will result in desired slow release profile. Diclofenac sodium is selected as a model drug as it is water soluble and having short half life of 1-2 hours. Sustained release matrix tablets were developed by using hydrophobic polymer like Cetyl alcohol and pore forming agent like Pharmagrade sugar .Tablets containing 100 mg of drug were formulated. Flow properties of granules were studied by determining bulk density, tapped density, Carr’s index, Hausner ratio for all the formulations were obtained in satisfactory range. Drug content, Weight variation, Hardness, Percent Friability, and Thickness and are within acceptable limits of pharmacopoeial requirement. To know the drug release kinetics Zero order, First order, Higuchi plot, Korsmeyer Peppa’s plot were constructed 3, 10, 11.
FORMULATION AND EVALUATION OF SULPHASALAZINE INJECTION MADE BY MIXED SOLVENCY SOLUBILIZATION TECHNIQUE
Kalariya Nikunj,Asija Rajesh,Asija Sangeeta,Patel Chirag
International Research Journal of Pharmacy , 2012,
Abstract: Sulfasalazine, a sulfonamide derivative, is used as an antimicrobial agent by inhibiting bacterial growth and activity mainly in the treatment of ulcerative colitis and in the treatment of rheumatoid arthritis. It is practically insoluble in water. The aim of study was to prepare aqueous injection of sulphasalazine, using the mixed solvency solubilization technique. Several blends were prepared by co-solvents such as polyethylene glycol 200 (PEG200), PEG 400, PEG 600, PEG 4000, propylene glycol (PG), polyvinyl pyrrolidine (PVP) K 30, ethanol, glycerin, tween20, tween80, niacenamide, lignocain hydrochloride and sodium benzoate. The enhancement in the solubility of sulphasalazine in a mixed solvency was more than 50 folds (compared to its solubility in distilled water). This proved a synergistic enhancement in solubility of a poorly water soluble drug due to mixed solvency. Synergistic combination of mixed-solvency can minimize the amount of co-solvents employed, minimizing the chances of their toxicities. The developed formulation was studied for physical and chemical stability.
L-myo-InositoL-1- phosphate synthase from bryophytes: purification and characterization of the enzyme from Lunularia cruciata (L.) Dum
Chhetri, Dhani Raj;Yonzone, Sachina;Tamang, Sanjeeta;Mukherjee, Asok Kumar;
Brazilian Journal of Plant Physiology , 2009, DOI: 10.1590/S1677-04202009000300008
Abstract: l-myo-inositol-1-phosphate synthase (mips; ec: 5.5.1.4) catalyzes the conversion of d-glucose-6-phosphate to 1l-myo-inositol-1-phosphate, the rate limiting step in the biosynthesis of all inositol containing compounds. myo-inositol and its derivatives are implicated in membrane biogenesis, cell signaling, salinity stress tolerance and a number of other metabolic reactions in different organisms. this enzyme has been reported from a number of bacteria, fungi, plants and animals. in the present study some bryophytes available in the eastern himalaya have been screened for free myo-inositol content. it is seen that bryum corinatum, a bryopsid shows the highest content of free myo-inositol among the species screened. subsequently , the enzyme mips has been partially purified to the tune of about 70 fold with approximately 18% recovery form the reproductive part bearing gametophytes of lunularia cruciata. the l. cruciata synthase specifically utilized d-glucose-6-phosphate and nad+ as its substrate and co-factor respectively. the optimum ph shown was 7.0 while the temperature maximum was at 30oc. the enzyme activity was slightly stimulated by mg2+ and ca2+; remarkably stimulated by nh4+; slightly inhibited by mn2+; highly inhibited by cu2+, zn2+ and hg2+. the km values for d-glucose-6-phosphate and nad+ was found to be 0.80 and 0. 034 mm respectively while the vmax values were 2.8 and 1.21 mm for d-glucose-6-phosphate and nad+ respectively.
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