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Search Results: 1 - 10 of 1462 matches for " Ashley Wilkins "
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Quantum estimation via parametric amplification in circuit QED arrays
Ashley Wilkins,Carlos Sabín
Physics , 2015, DOI: 10.1103/PhysRevA.92.062102
Abstract: We propose a scheme for quantum estimation by means of parametric amplification in circuit Quantum Electrodynamics. The modulation of a SQUID interrupting a superconducting waveguide transforms an initial thermal two-mode squeezed state in such a way that the new state is sensitive to the features of the parametric amplifier. We find the optimal initial parameters which maximize the Quantum Fisher Information. In order to achieve a large number of independent measurements we propose to use an array of non-interacting resonators. We show that the combination of both large QFI and large number of measurements enables -in principle- the use of this setup for Quantum Metrology applications.
Organisational Creativity: Building a Business Ba-Haus?  [PDF]
Andy Wilkins, Clive Holtham
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.326110
Abstract: Our focus is on the systemic nature of creativity and the role of business schools in stimulating and enhancing organisational creativity, across all sectors of the economy, particularly those which are not conventionally regarded as ‘creative’ industries. After defining creativity and reviewing a number of frequently occurring ‘creativity clichés’ that are potentially keeping organisational creativity in a rut, we go on to explore some of the key challenges with creativity that need particular focus, including: taking a systemic approach, as well as more attention on ‘difficult’ aspects such as the climate for creativity or creativity ‘ba’. We propose a Systemic Innovation Maturity Framework as a way to conceptualise and organise a way forward in organisations and in business schools. We believe that in a similar way to the Bauhaus of the early 20th century, there needs to be a step change in the way creativity is researched, taught and applied that encompasses a more ecological approach. We believe a more comprehensive, inclusive and useful conception of creativity may result from the consideration of the four dimensions of the framework and their interactions. We wonder; is it time for a new Business Ba-Haus?
In Vivo Mitochondrial Function in HIV-Infected Persons Treated with Contemporary Anti-Retroviral Therapy: A Magnetic Resonance Spectroscopy Study
Brendan A. I. Payne, Kieren G. Hollingsworth, Joanne Baxter, Edmund Wilkins, Vincent Lee, D. Ashley Price, Michael Trenell, Patrick F. Chinnery
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0084678
Abstract: Modern anti-retroviral therapy is highly effective at suppressing viral replication and restoring immune function in HIV-infected persons. However, such individuals show reduced physiological performance and increased frailty compared with age-matched uninfected persons. Contemporary anti-retroviral therapy is thought to be largely free from neuromuscular complications, whereas several anti-retroviral drugs previously in common usage have been associated with mitochondrial toxicity. It has recently been established that patients with prior exposure to such drugs exhibit irreversible cellular and molecular mitochondrial defects. However the functional significance of such damage remains unknown. Here we use phosphorus magnetic resonance spectroscopy (31P-MRS) to measure in vivo muscle mitochondrial oxidative function, in patients treated with contemporary anti-retroviral therapy, and compare with biopsy findings (cytochrome c oxidase (COX) histochemistry). We show that dynamic oxidative function (post-exertional ATP (adenosine triphosphate) resynthesis) was largely maintained in the face of mild to moderate COX defects (affecting up to ~10% of fibers): τ? ADP (half-life of adenosine diphosphate clearance), HIV-infected 22.1±9.9 s, HIV-uninfected 18.8±4.4 s, p = 0.09. In contrast, HIV-infected patients had a significant derangement of resting state ATP metabolism compared with controls: ADP/ATP ratio, HIV-infected 1.24±0.08×10?3, HIV-uninfected 1.16±0.05×10?3, p = 0.001. These observations are broadly reassuring in that they suggest that in vivo mitochondrial function in patients on contemporary anti-retroviral therapy is largely maintained at the whole organ level, despite histochemical (COX) defects within individual cells. Basal energy requirements may nevertheless be increased.
El Federalismo en Australia: La cuestión de las transferencias de fondos.
Documentos y aportes en administraci?3n p?oblica y gesti?3n estatal , 2007,
Abstract: pointing out aspects of the australian federalism, the subject matter on fund transference between the federal government and the provincial ones is approached. differences among states and the vertical fiscal imbalance in australia are compensated, in part, with the implementation of the fiscal equalization criterion carried out by the commission of subsidies. by means of technical procedures and aiming to achieve equity in accessing public properties and services thorughout the territory, the state's capacities to collect and the state's welfare cost are considered while a fund distribution form is recommended. thereby, such federal fiscal system allows the coexistence among unequal state-members. lastly, it is mentioned that half of the transferences are made in accordance with such criterion and the rest by"conditioned funds" through which the central state defines politics in the provinces.
The strong WCD property for Banach spaces
Dave Wilkins
International Journal of Mathematics and Mathematical Sciences , 1995, DOI: 10.1155/s0161171295000081
Abstract: In this paper, we introduce weakly compact version of the weakly countably determined (WCD) property, the strong WCD (SWCD) property. A Banach space X is said to be SWCD if there s a sequence (An) of weak ¢ — compact subsets of X ¢ — ¢ — such that if K ¢ X is weakly compact, there is an (nm) ¢ N such that K ¢ ¢ m=1 ¢ Anm ¢ X. In this case, (An) is called a strongly determining sequence for X. We show that SWCG ¢ ’SWCD and that the converse does not hold in general. In fact, X is a separable SWCD space if and only if (X, weak) is an ¢ μ0-space. Using c0 for an example, we show how weakly compact structure theorems may be used to construct strongly determining sequences.
Massive Fields and the 2D String
Andy Wilkins
Physics , 1998, DOI: 10.1142/S0217732398001352
Abstract: The first massive level of closed bosonic string theory is studied. Free-field equations are derived by imposing Weyl invariance on the world sheet. A two-parameter solution to the equation of motion and constraints is found in two dimensions with a flat linear-dilaton background. One-to-one tachyon scattering is studied in this background. The results support Dhar, Mandal and Wadia's proposal that 2D critical string theory corresponds to the c=1 matrix model in which both sides of the Fermi sea are excited.
The Revised and Uniform Fundamental Groups and Universal Covers of Geodesic Spaces
Jay Wilkins
Mathematics , 2012,
Abstract: Sormani and Wei proved in 2004 that a compact geodesic space has a categorical universal cover if and only if its covering/critical spectrum is finite. We add to this several equivalent conditions pertaining to the geometry and topology of the revised and uniform fundamental groups. We show that a compact geodesic space X has a universal cover if and only if the following hold: 1) its revised and uniform fundamental groups are finitely presented, or, more generally, countable; 2) its revised fundamental group is discrete as a quotient of the topological fundamental group. In the process, we classify the topological singularities in X, and we show that the above conditions imply closed liftings of all sufficiently small path loops to all covers of X, generalizing the traditional semilocally simply connected property. A geodesic space with this new property is called semilocally r-simply connected, and X has a universal cover if and only if it satisfies this condition. We then introduce a topology on the fundamental group called the covering topology, with respect to which the fundamental group is always a topological group. We establish several connections between properties of the covering topology, the existence of simply connected and universal covers, and geometries on the fundamental group.
I like it but I don’t have time to tell patients’ families: Exploring barriers and facilitators of pain and dementia knowledge flow between healthcare providers and family caregivers  [PDF]
Cary A. Brown, Ashley Schmidt
Advances in Aging Research (AAR) , 2012, DOI: 10.4236/aar.2012.13008
Abstract: Pain in persons with dementia is prevalent, largely undetected, and undertreated within the care setting. Family members require resources to help them assume a more significant role in pain assessment and management. This report outlines a psycho-educational online resource developed to address these needs. The report explores the apparent disconnect between the positive evaluation healthcare providers gave the resource and their infrequent rate of referring family caregivers to the resource. We apply a Sticky Knowledge framework to examine these complex and incongruent findings and conclude that health literacy and knowledge translation strategies need to focus directly on family care- givers as opposed to adhering to a more traditional biomedical model in which healthcare professionals assumed the primary responsibility for gatekeeping and knowledge dissemination.
The Mapping and Characterization of Cruella (Cru), a Novel Allele of Capping Protein α (Cpa), Identified from a Conditional Screen for Negative Regulators of Cell Growth and Cell Division  [PDF]
Ashley Cosenza, Jacob D. Kagey
Advances in Bioscience and Biotechnology (ABB) , 2016, DOI: 10.4236/abb.2016.710036
Abstract: A Flp/FRT EMS mutagenesis screen was conducted in the eye of Drosophila melanogaster on chromosome 2R to identify negative regulators of cell growth and cell division. In addition to the EMS mutation in the mosaic eye, an ark loss of function allele (ark82) was utilized to block apoptosis in the homozygous mutant cells, setting up a screen for conditional regulators of cell growth and cell division. In the present study, we focus on the characterization and mapping of one mutant that resulted from this screen, Cruella (cru). A cross between flies with the flippase enzyme directed to the developing eye and flies with the mutations cru, ark82, revealed an unusual phenotype that resulted in the homozygous mutant tissue appearing black, in contrast to the expected red. To map the location of this mutation, complementation tests against the Bloomington deficiency kit were conducted. Cru failed to complement previously characterized alleles of capping protein α (cpa). Thus, cpacru is a novel allele of cpa and displays phenotypes similar to previously characterized alleles such as cpa 107E, cpa 69E, and cpascrd . The human homolog, Cap Z, is conserved in humans and serves a similar role in act in filament regulation.
Mean number of real zeros of a random hyperbolic polynomial
J. Ernest Wilkins Jr.
International Journal of Mathematics and Mathematical Sciences , 2000, DOI: 10.1155/s0161171200001848
Abstract: Consider the random hyperbolic polynomial, f(x)=1pa1coshx
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