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Search Results: 1 - 10 of 2209 matches for " Ashley Lloyd "
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Pedagogy vs. Competition in Higher Education Distance Learning
Ashley D. Lloyd
Educational Technology & Society , 2000,
Abstract: Convergence of computing and communications technology, growth of the Web and modularisation of curricula have increased the potential for courses developed in one institution to be delivered to the students of others. This is now a global, growing, and increasingly competitive market with room for, potentially, few suppliers. Given a static budget, any loss of income to this distance learning market will have a negative impact on existing educational institutions ability to support the needs of all the communities they serve. This paper explores recent infrastructure developments in the U.K. Higher Education sector that enable increased bandwidth to be used to improve the flexibility and quality of education. It concludes that bandwidth may also be used as a barrier to global competition for resources, without sacrificing opportunities for achieving scale efficiencies.
V-BOINC: The Virtualization of BOINC
Gary A. McGilvary,Adam Barker,Ashley Lloyd,Malcolm Atkinson
Computer Science , 2013,
Abstract: The Berkeley Open Infrastructure for Network Computing (BOINC) is an open source client-server middleware system created to allow projects with large computational requirements, usually set in the scientific domain, to utilize a technically unlimited number of volunteer machines distributed over large physical distances. However various problems exist deploying applications over these heterogeneous machines using BOINC: applications must be ported to each machine architecture type, the project server must be trusted to supply authentic applications, applications that do not regularly checkpoint may lose execution progress upon volunteer machine termination and applications that have dependencies may find it difficult to run under BOINC. To solve such problems we introduce virtual BOINC, or V-BOINC, where virtual machines are used to run computations on volunteer machines. Application developers can then compile their applications on a single architecture, checkpointing issues are solved through virtualization API's and many security concerns are addressed via the virtual machine's sandbox environment. In this paper we focus on outlining a unique approach on how virtualization can be introduced into BOINC and demonstrate that V-BOINC offers acceptable computational performance when compared to regular BOINC. Finally we show that applications with dependencies can easily run under V-BOINC in turn increasing the computational potential volunteer computing offers to the general public and project developers.
Mapping the Self with Units of Culture  [PDF]
Lloyd H. Robertson
Psychology (PSYCH) , 2010, DOI: 10.4236/psych.2010.13025
Abstract: This study explored a method of representing the self graphically using elemental units of culture called memes. A diverse sample of eleven volunteers participated in the co-construction of individual “self-maps” during a series of interviews over a nine month period. Two of the resultant maps are presented as exemplars. Commonalities found in all eleven maps lend support to the notion that there are certain structures to the self that are cross-cultural. The use of memes in mapping those structures was considered useful but insufficient because emotive elements to the self emerged from the research that could not be represented in memetic form. Suggestions are made for future research.
Encouraging Creativity with Scientific Inquiry  [PDF]
Lloyd H. Barrow
Creative Education (CE) , 2010, DOI: 10.4236/ce.2010.11001
Abstract: Creativity facilitates scientists in their investigations of new problems or with a new orientation. However, K-12 science education typically does not acknowledge this aspect of creativity. Science/Technology/Society provides an avenue for creativity when addressing inquiry. The use of Cothron et al.’s [1] four question strategy allows for a planning approach for inquiry.
Hepatic Haemangioma Masquerading as the Gallbladder in a Case of Gallbladder Agenesis: A Case Report and Literature Review
James A. Stephenson,Michael Norwood,Dhya Al-Leswas,Omer Al-Taan,Richard Beable,David M. Lloyd,Ashley R. Dennison
HPB Surgery , 2010, DOI: 10.1155/2010/971609
Abstract: Gallbladder agenesis is uncommon. In contrast, liver haemangiomas are the most common type of benign liver lesions. We describe the first documented case of gallbladder agenesis where the clinical presentation was consistent with biliary colic, and radiological investigation suggested the presence of gallstones. Subsequent operative findings revealed a solitary haemangioma of the liver sited in the normal position of the gallbladder fossa but with absence of the gallbladder. It is important that clinicians should keep gallbladder agenesis in mind when the gallbladder appears abnormal on preoperative imaging studies and cannot be found at laparoscopy. As symptoms will improve in 98% of cases, it is very important to avoid unnecessary intervention in patients who have a negative laparoscopy. The clinical presentation, investigations, and operative findings are discussed with a review of other relevant reported cases in the literature. 1. Introduction Gallbladder agenesis has been reported in the medical literature but is uncommon. It is thought to occur in approximately 1 in 6,000 live births [1]. In contrast, liver haemangiomas are the most common type of benign liver lesions. We describe the first documented case of gallbladder agenesis where the clinical presentation was consistent with biliary colic, and radiological investigation suggested the presence of gallstones within a collapsed, fibrosed gallbladder. Subsequent operative findings revealed a solitary haemangioma of the liver sited in the normal position of the gallbladder fossa but with absence of the gallbladder. 2. Case Presentation A 23-year-old female presented with intermittent episodes of nausea, vomiting, right upper quadrant abdominal pain, and occasional diarrhoea. Clinical examination was unremarkable. Routine haematological and biochemical investigations including full blood count profile, c-reactive protein, liver function tests (including alanine aminotransferase, total bilirubin, -glutamyltransferase, and alkaline phosphatase), and amylase were unremarkable. Stool culture demonstrated no abnormality, and faecal elastase was within the normal range. Abdominal ultrasonography suggested a contracted gallbladder containing gallstones. On clinical review following the ultrasound examination, the patient’s pain had improved but the vomiting persisted. Due to the continued vomiting, nonclassic symptoms of gallstones disease, and absence of dyspeptic symptoms, magnetic resonance cholangiopancreatography (MRCP) was performed. The MRCP report commented that the gallbladder was difficult to
Possible Race and Gender Divergence in Association of Genetic Variations with Plasma von Willebrand Factor: A Study of ARIC and 1000 Genome Cohorts
Zhou Zhou, Fuli Yu, Ashley Buchanan, Yuanyuan Fu, Marco Campos, Kenneth K. Wu, Lloyd E. Chambless, Aaron R. Folsom, Eric Boerwinkle, Jing-fei Dong
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0084810
Abstract: The synthesis, secretion and clearance of von Willebrand factor (VWF) are regulated by genetic variations in coding and promoter regions of the VWF gene. We have previously identified 19 single nucleotide polymorphisms (SNPs), primarily in introns that are associated with VWF antigen levels in subjects of European descent. In this study, we conducted race by gender analyses to compare the association of VWF SNPs with VWF antigen among 10,434 healthy Americans of European (EA) or African (AA) descent from the Atherosclerosis Risk in Communities (ARIC) study. Among 75 SNPs analyzed, 13 and 10 SNPs were associated with VWF antigen levels in EA male and EA female subjects, respectively. However, only one SNP (RS1063857) was significantly associated with VWF antigen in AA females and none was in AA males. Haplotype analysis of the ARIC samples and studying racial diversities in the VWF gene from the 1000 genomes database suggest a greater degree of variations in the VWF gene in AA subjects as compared to EA subjects. Together, these data suggest potential race and gender divergence in regulating VWF expression by genetic variations.
Architectural design for a topological cluster state quantum computer
Simon J. Devitt,Austin G. Fowler,Ashley M. Stephens,Andrew D. Greentree,Lloyd C. L. Hollenberg,William J. Munro,Kae Nemoto
Physics , 2008, DOI: 10.1088/1367-2630/11/8/083032
Abstract: The development of a large scale quantum computer is a highly sought after goal of fundamental research and consequently a highly non-trivial problem. Scalability in quantum information processing is not just a problem of qubit manufacturing and control but it crucially depends on the ability to adapt advanced techniques in quantum information theory, such as error correction, to the experimental restrictions of assembling qubit arrays into the millions. In this paper we introduce a feasible architectural design for large scale quantum computation in optical systems. We combine the recent developments in topological cluster state computation with the photonic module, a simple chip based device which can be used as a fundamental building block for a large scale computer. The integration of the topological cluster model with this comparatively simple operational element addresses many significant issues in scalable computing and leads to a promising modular architecture with complete integration of active error correction exhibiting high fault-tolerant thresholds.
I like it but I don’t have time to tell patients’ families: Exploring barriers and facilitators of pain and dementia knowledge flow between healthcare providers and family caregivers  [PDF]
Cary A. Brown, Ashley Schmidt
Advances in Aging Research (AAR) , 2012, DOI: 10.4236/aar.2012.13008
Abstract: Pain in persons with dementia is prevalent, largely undetected, and undertreated within the care setting. Family members require resources to help them assume a more significant role in pain assessment and management. This report outlines a psycho-educational online resource developed to address these needs. The report explores the apparent disconnect between the positive evaluation healthcare providers gave the resource and their infrequent rate of referring family caregivers to the resource. We apply a Sticky Knowledge framework to examine these complex and incongruent findings and conclude that health literacy and knowledge translation strategies need to focus directly on family care- givers as opposed to adhering to a more traditional biomedical model in which healthcare professionals assumed the primary responsibility for gatekeeping and knowledge dissemination.
The Mapping and Characterization of Cruella (Cru), a Novel Allele of Capping Protein α (Cpa), Identified from a Conditional Screen for Negative Regulators of Cell Growth and Cell Division  [PDF]
Ashley Cosenza, Jacob D. Kagey
Advances in Bioscience and Biotechnology (ABB) , 2016, DOI: 10.4236/abb.2016.710036
Abstract: A Flp/FRT EMS mutagenesis screen was conducted in the eye of Drosophila melanogaster on chromosome 2R to identify negative regulators of cell growth and cell division. In addition to the EMS mutation in the mosaic eye, an ark loss of function allele (ark82) was utilized to block apoptosis in the homozygous mutant cells, setting up a screen for conditional regulators of cell growth and cell division. In the present study, we focus on the characterization and mapping of one mutant that resulted from this screen, Cruella (cru). A cross between flies with the flippase enzyme directed to the developing eye and flies with the mutations cru, ark82, revealed an unusual phenotype that resulted in the homozygous mutant tissue appearing black, in contrast to the expected red. To map the location of this mutation, complementation tests against the Bloomington deficiency kit were conducted. Cru failed to complement previously characterized alleles of capping protein α (cpa). Thus, cpacru is a novel allele of cpa and displays phenotypes similar to previously characterized alleles such as cpa 107E, cpa 69E, and cpascrd . The human homolog, Cap Z, is conserved in humans and serves a similar role in act in filament regulation.
The Growth Delusion
Bob Lloyd
Sustainability , 2009, DOI: 10.3390/su1030516
Abstract: Concern for the environment and a move towards “sustainable development” has assisted progress in a wide range of renewable energy technologies in recent years. The science suggests that a transition from fossil fuels to sustainable sources of energy in a time frame commensurate with the demise of the fossil fuels and prevention of runaway climate change is needed. However, while the movement towards sustainable energy technologies is underway, the World does not want to give up the idea of continuing economic growth. In recent times the financial collapse of October 2008 has given rise to yet another set of pleas from corporations and politicians alike to restart the growth machine. The transition to renewable energy technologies will be difficult to achieve as nowhere within existing economic and political frameworks are the limits to when growth will be curtailed being set. It is possible that the irrational insistence on endless growth as a non negotiable axiom, by a large proportion of the world’s population, may in fact be akin to the similarly irrational belief, by a similarly large proportion of the world’s population, that a supernatural being controls our existence and destiny. The irrationality of religion has recently been examined by Richard Dawkins in “The God Delusion”. Dawkins’ book is used as a starting point to investigate similarities between a belief in God and a belief in continuous growth.
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