OALib Journal期刊

ISSN: 2333-9721



匹配条件: “Ascolani” ,找到相关结果约13条。
Libros de lectura en la escuela primaria argentina: civilizando al ni?o urbano y urbanizando al ni?o campesino (1900-1946)
Ascolani, Adrián;
Educa??o em Revista , 2010, DOI: 10.1590/S0102-46982010000100015
Abstract: textbooks used in the primary argentine education were a very important instrument for the transmission of the ideas of modernization and "civilization" of the society. they were a fundamental support in the diffusion of the moral, aesthetic and patriotic values, though they were not militaristic and tended to moderate the incorporation of hygienists rules, as the population was assimilating them. the consolidation of the spiritualist pedagogy, with elements of the new school, are found also in the contents of these books, which put the emphasis in the self-control of the student, appealing to the persuasion and the feelings of emulation and fault. written for urban children, they were not functional for the rural area, though they contributed to an early urbanization of the agrarian mentality.
Estratégias del banco mundial para el financiamiento de la educación en los países latinoamericanos
Ascolani, Adrián
Educa??o , 2008,
Abstract: N o possui resumo em português
Actores, instituciones e ideas en la historiografía de la educación Argentina =Actors, institutions and ideas in the historiography of education in Argentina
Ascolani, Adrián
Educa??o , 2012,
Abstract: N o possui resumo em português La comprensión de una disciplina científica, en este caso de la Historia de la Educación, requiere el conocimiento no sólo del corpus acumulado sino también de la historia intelectual del mismo, es decir de las instituciones, sujetos e ideas que han intervenido en su elaboración, debate, circulación y recepción. Nuestro propósito ha sido desnaturalizar ciertos puntos de partida habitualmente presentes en los estados del arte de las investigaciones recientes sobre historia de la educación argentina, a través de la reconstrucción de algunos lineamientos centrales del desarrollo de la disciplina desde su origen hasta el presente, en varios registros distintos – curricular, ideológico, institucional y político-. Particularmente interesante es constatar la existencia de continuidades metodológicas o de valoraciones en coyunturas y en grupos de investigación distanciados en el tiempo o diferentes en cuanto a los factores que los legitimaron, aunque no en sus prácticas de pensamiento y de escritura, siendo este un efecto de herencias y causalidades, y no de la simple coincidencia. $$bspa
La pampa pródiga. Una imagen del mundo rural para escolares (1920/1945)
Adrián Ascolani
Mundo agrario , 2000,
Modeling TGF-β in Early Stages of Cancer Tissue Dynamics
Gianluca Ascolani, Pietro Liò
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0088533
Abstract: Recent works have highlighted a double role for the Transforming Growth Factor (-): it inhibits cancer in healthy cells and potentiates tumor progression during late stage of tumorigenicity, respectively; therefore it has been termed the “Jekyll and Hyde” of cancer or, alternatively, an “excellent servant but a bad master”. It remains unclear how this molecule could have the two opposite behaviours. In this work, we propose a - multi scale mathematical model at molecular, cellular and tissue scales. The multi scalar behaviours of the - are described by three coupled models built up together which can approximatively be related to distinct microscopic, mesoscopic, and macroscopic scales, respectively. We first model the dynamics of - at the single-cell level by taking into account the intracellular and extracellular balance and the autocrine and paracrine behaviour of -. Then we use the average estimates of the - from the first model to understand its dynamics in a model of duct breast tissue. Although the cellular model and the tissue model describe phenomena at different time scales, their cumulative dynamics explain the changes in the role of - in the progression from healthy to pre-tumoral to cancer. We estimate various parameters by using available gene expression datasets. Despite the fact that our model does not describe an explicit tissue geometry, it provides quantitative inference on the stage and progression of breast cancer tissue invasion that could be compared with epidemiological data in literature. Finally in the last model, we investigated the invasion of breast cancer cells in the bone niches and the subsequent disregulation of bone remodeling processes. The bone model provides an effective description of the bone dynamics in healthy and early stages cancer conditions and offers an evolutionary ecological perspective of the dynamics of the competition between cancer and healthy cells.
Modelling Circulating Tumour Cells for Personalised Survival Prediction in Metastatic Breast Cancer
Gianluca Ascolani,Annalisa Occhipinti?,Pietro Liò
PLOS Computational Biology , 2015, DOI: 10.1371/journal.pcbi.1004199
Abstract: Ductal carcinoma is one of the most common cancers among women, and the main cause of death is the formation of metastases. The development of metastases is caused by cancer cells that migrate from the primary tumour site (the mammary duct) through the blood vessels and extravasating they initiate metastasis. Here, we propose a multi-compartment model which mimics the dynamics of tumoural cells in the mammary duct, in the circulatory system and in the bone. Through a branching process model, we describe the relation between the survival times and the four markers mainly involved in metastatic breast cancer (EPCAM, CD47, CD44 and MET). In particular, the model takes into account the gene expression profile of circulating tumour cells to predict personalised survival probability. We also include the administration of drugs as bisphosphonates, which reduce the formation of circulating tumour cells and their survival in the blood vessels, in order to analyse the dynamic changes induced by the therapy. We analyse the effects of circulating tumour cells on the progression of the disease providing a quantitative measure of the cell driver mutations needed for invading the bone tissue. Our model allows to design intervention scenarios that alter the patient-specific survival probability by modifying the populations of circulating tumour cells and it could be extended to other cancer metastasis dynamics.
Exclusion processes: short range correlations induced by adhesion and contact interactions
Gianluca Ascolani,Mathilde Badoual,Christophe Deroulers
Quantitative Biology , 2012, DOI: 10.1103/PhysRevE.87.012702
Abstract: We analyze the out-of-equilibrium behavior of exclusion processes where agents interact with their nearest neighbors, and we study the short-range correlations which develop because of the exclusion and other contact interactions. The form of interactions we focus on, including adhesion and contact-preserving interactions, is especially relevant for migration processes of living cells. We show the local agent density and nearest-neighbor two-point correlations resulting from simulations on two dimensional lattices in the transient regime where agents invade an initially empty space from a source and in the stationary regime between a source and a sink. We compare the results of simulations with the corresponding quantities derived from the master equation of the exclusion processes, and in both cases, we show that, during the invasion of space by agents, a wave of correlations travels with velocity v(t) ~ t^(-1/2). The relative placement of this wave to the agent density front and the time dependence of its height may be used to discriminate between different forms of contact interactions or to quantitatively estimate the intensity of interactions. We discuss, in the stationary density profile between a full and an empty reservoir of agents, the presence of a discontinuity close to the empty reservoir. Then, we develop a method for deriving approximate hydrodynamic limits of the processes. From the resulting systems of partial differential equations, we recover the self-similar behavior of the agent density and correlations during space invasion.
Renewal aging and linear response
Paolo Allegrini,Gianluca Ascolani,Mauro Bologna,Paolo Grigolini
Physics , 2006,
Abstract: We study the linear response to an external perturbation of a renewal process, in an aging condition that, with no perturbation, would yield super-diffusion. We use the phenomenological approach to the linear response adopted in earlier work of other groups, and we find that aging may have the effect of annihilating any sign of coherent response to harmonic perturbation. We also derive the linear response using dynamic arguments and we find a coherent response, although with an intensity dying out very slowly. In the case of a step-like perturbation the dynamic arguments yield in the long-time limit a steady signal whose intensity may be significantly smaller than the phenomenological approach prediction.
Susceptibility of Primary HTLV-1 Isolates from Patients with HTLV-1-Associated Myelopathy to Reverse Transcriptase Inhibitors
Beatrice Macchi,Emanuela Balestrieri,Arianna Ascolani,Silva Hilburn,Fabiola Martin,Antonio Mastino,Graham P Taylor
Viruses , 2011, DOI: 10.3390/v3050469
Abstract: Since human T-lymphotropic virus type 1 (HTLV-1)-associated diseases are associated with a high HTLV-1 load, reducing this load may treat or prevent disease. However, despite in vitro evidence that certain nucleoside/nucleotide analogue reverse transcriptase inhibitors (NRTIs) are active against HTLV-1, in vivo results have been disappointing. We therefore assayed the sensitivity of HTLV-1 primary isolates to a panel of RT inhibitors. HTLV-1 primary isolates were obtained, pre- and post- NRTI treatment, from patients with HTLV-1-associated myelopathy. Sensitivity to azidothymidine (AZT), lamivudine (3TC), tenofovir (TDF) and three phosphonated carbocyclic 2’-oxa-3’aza nucleosides (PCOANs) was assessed in a RT inhibitor assay. With the exception of 3TC, HTLV RT from primary isolates was less sensitive to all tested inhibitors than HTLV-1 RT from MT-2 cells. HTLV-1 RT from primary isolates and from chronically infected, transformed MT-2 cells was insensitive to 3TC. Sensitivity of primary isolates to RT inhibitors was not reduced following up to 12 months of patient treatment with AZT plus 3TC. The sensitivity of HTLV-1 primary isolates to NRTIs differs from that of cell lines and may vary among patients. Failure of NRTIs to reduce HTLV-1 viral load in vivo was not due to the development of phenotypic NRTI resistance. AZT and the three PCOANs assayed all consistently inhibited primary isolate HTLV-1 RT.
Resistencia a la corrosión de recubrimientos electroquímicos de cromo y zinc mediante EIE
Torres Luque,Magda Marcela; Olaya Flórez,Jhon Jairo; del Luján Ascolani,Hugo;
Ingeniería y Desarrollo , 2011,
Abstract: the corrosion behavior of chromium and zinc industrial coatings was investigated in 3%wt nacl solution using electrochemical impedances pectroscopy technique. in order to determine the mechanisms of proresistance in time function, with the morphology and chemical composition. to do this, we characterized the microstructure of the coatings by scanning electron microscopy, the crystalline phases with x-ray diffrac-tion and chemical composition, before and after exposure to a corrosive environment, by x-ray photoelectron spectroscopy and auger electron spectroscopy. overall, both coatings (cr and zn) showed degradation with the immersion time, due to microstructure defects, however, the protective and failure mechanisms are different for each system. these details are discussed in this research.

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