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Search Results: 1 - 10 of 1221 matches for " Asad Ullah "
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Analysis of PB2 protein from H9N2 and H5N1 avian flu virus
Danishuddin,Asad Ullah Khan
Bioinformation , 2008,
Abstract: Influenza A viruses of subtype H9N2 are wide spread among poultry and other mammalian species. Crossing the species barrier from poultry to human occurred in recent years creating a pandemic of H9N2 virus. It is known that the pathogenicity of H9N2 is lower than H5N1. Nonetheless, it is important to establish the molecular functions of H9N2 viral proteins. We studied mutations in the polymerase protein PB2 of H9N2 from different strains and compared it with the highly pathogenic H5N1. The mutation M294T was found to be important in the N-myristoylation domain of Ck/UP/2573/India/04(H9N2) isolate. Prediction of secondary structures and PROSITE motif assignments were performed for PB2 to gain functional insight. Subsequently, the effect of mutations in secondary structures among strains is discussed.
Analysis of 1246 Cases of Orbital Lesions: A Study of 17 Years  [PDF]
Asad Aslam Khan, Suhail Sarwar, M. Ali Ayaz Sadiq, Munib Ur Rehman, Asad Ullah, Imran Ahmad
Natural Science (NS) , 2015, DOI: 10.4236/ns.2015.76036
Abstract: Purpose: The aim of this study is to present an analysis of orbital lesions by classifying them according to the site of origin in patients of all ages presenting at a tertiary care eye hospital from 1996 till 2012. Methods: 1637 patients were initially enrolled in this descriptive case series. Clinical data of 1246 patients who completed the study during 17 years were analyzed. Orbital lesions of the patients were examined and managed medically or surgically as per requirement. The histopathological reports of these patients were used to classify the lesions. Results: Out of all cases 54.57% (n = 680) were neoplastic and 45.42% (n = 566) were nonneoplastic lesions. Amongst the neoplastic lesions 86.17% (n = 586) were malignant and 13.82% (n = 94) were benign. Primary orbital lesions were the most common orbital lesions being 963 (77.29%) followed by secondary orbital lesions being 232 (18.62%), hematopoietic reticuloendothelial being 47 (3.77%) and metastatic lesions being 04 (0.32%). Conclusion: Orbital lesions are more common in adults as compared to children. Neoplastic lesions are more common than nonneoplastic lesions, and amongst the neoplastic lesions malignant lesions are more common than benign ones. Primary orbital lesions are the most common orbital lesions followed by secondary orbital lesions, lesions of the hematopoietic reticuloendothelial system and metastatic lesions.
Asad Ullah Hyder and Samee Ullah1
Pakistan Veterinary Journal , 2002,
Abstract: Data on production performance of 90 imported Dutch Holstein-Friesian cattle and their 127 Pakistani- born progeny from 1982 to 1991 were analyzed. The mean first lactation 305-day milk yield for imported and Pakistani-born cows was 3196.7 ± 66.36 and 2418.3 ± 104.65 litres respectively (P<0.05). The overall 305-milk yield for the two groups was 3356.53 ± 244.25 and 2493.51 ± 106.89 litres, respectively. The effect of year of calving was non-significant on first lactation (305-day) milk yield, while it was significant (P<0.05) for 305-day overall average milk yield. For all lactations the cows calved in 1988 gave maximum (3370.0 ± 306.9 litres) average 305-day milk yield and 1984-calvers gave the minimum (2713.0 ± 67.35 litres) overall lactation milk yield. Month of calving had significant effect on first lactation 305-day milk yield and overall 305-day milk yield. Maximum first lactation milk yield was obtained from cows calved in April (4073.0 ± 181.31 litres) and minimum for cows calved in February (2259.9 ± 126.69 litres) in first lactation. An overall basis, cows calved in October yielded maximum (3397.4 ± 37.17 litres) milk and those calved in .June gave the minimum (2472.2 ± 61.35 litres) milk yield
Interaction of CTX-M-15 enzyme with cefotaxime: a molecular modelling and docking study
Shazi Shakil,Asad Ullah Khan
Bioinformation , 2010,
Abstract: Extended-spectrum β-lactamases (ESBLs) are the bacterial enzymes that make them resistant to advanced-generation cephalosporins. CTXM enzymes (the most prevalent ESBL-type) target cefotaxime. Aims of the study were: (i) Modelling of CTX-M enzyme from blaCTX-M sequences of clinical Escherichia coli isolates (ii) Docking of cefotaxime with modelled CTX-M enzymes to identify amino acid residues crucial to their interaction (iii) To hypothesize a possible relationship between ‘interaction energy of the docked enzyme-antibiotic complex’ and ‘minimum inhibitory concentration (MIC) of the antibiotic against the bacteria producing that enzyme’. Seven E. coli strains of clinical origin which were confirmed as PCR-positive for blaCTX-M were selected for the study. C600 cells harboring cloned blaCTX-M were tested for ESBL-production by double-disk-synergy test. BLAST analysis confirmed all the blaCTX-M genes as blaCTX-M-15. Four of the 7 strains were found to be clonally related. Modelling was performed using Swiss Model Server. Discovery Studio 2.0 (Accelrys) was used to prepare Ramachandran plots for the modelled structures. Ramachandran Z-scores for modelled CTX-M enzymes from E. coli strains D8, D183, D253, D281, D282, D295 and D296 were found to be -0.449, 0.096, 0.027, 0.043, 0.032, -1.249 and -1.107, respectively. Docking was performed using Hex 5.1 and the results were further confirmed by Autodock 4.0. The amino acid residues Asn 104, Asn132, Gly 227, Thr 235, Gly 236, and Ser237 were found to be responsible for positioning cefotaxime into the active site of the CTX-M-15 enzyme. It was found that cefotaxime MICs for the CTX-M-15-producers increased with the increasing negative interaction energy of the enzyme-antibiotic complex.
An in silico approach to map the binding site of doxorubicin on hemoglobin
Shahper Nazeer Khan,Asad Ullah Khan
Bioinformation , 2008,
Abstract: Binding modalities of doxorubicin (DOX), a widely used antineoplastic anthracyline antibiotic with hemoglobin (Hb) have been studied. The protein and the ligand were prepared using CORINA and protonated with insight II. The best conformation was sought by employing GOLDV. Molecular modeling calculations showed that DOX binds Hb to a non-classical drug binding site. The alpha subunit of Hb has been assigned to posses the binding site for DOX with a binding affinity (Ka) = 16.98 x103 mol-1. The interaction was found to be thermodynamically favorable (ΔG° = -66.23 KJmol-1). The analysis of DOX binding site to Hb suggested that the types of interactions that contribute in this binding are hydrophobic contacts, hydrogen bonding and electrostatic interactions.
Insha’s Redescending M-estimator for Robust Regression: A Comparative Study
Insha Ullah,Muhammad F. Qadir,Asad Ali
Pakistan Journal of Statistics and Operation Research , 2006, DOI: 10.1234/pjsor.v2i2.97
Abstract: In this paper we present a new redescending M-estimator “Insha’s estimator” for robust regression and outliers detection that overcomes some drawbacks of other M-estimators for robust regression and outliers detection, such as destruction of the good observations and lack of simplicity in applications. The Ψ-function associated with the proposed estimator attains more linearity in the central section before it redescends, resulting in enhanced efficiency. Moreover the estimator is continuous everywhere and can be written in closed form without the use of an indictor function. The estimator is also applied to a real world example taken from the literature. For the purpose of comparison with other well-known redescending M-estimators extensive simulation study has been carried out. The example and simulation study show that using this estimator all the outliers can be successfully detected and is not affected by outliers.
Fenugreek (Trigonella foenum-graecum L.) effect on muscle growth of broiler chicks
Farman Ullah Khan,,Asad Ullah,,Sajid Rahman,,Shabana Naz
Research Opinions in Animal & Veterinary Sciences , 2011,
Abstract: The purpose of this research work was to evaluate the aqueous seed extract of Trigonella foenum-graecum L. (Fenugreek) on the weight of breast, thigh and leg of broiler chicks. One hundred and sixty, day old male broiler chicks were randomly assigned to four treatments i.e., A, B, C and D. Each treatment was replicated four times with 10 chicks per replicate. Groups B, C and D received the aqueous extract of fenugreek @ 10, 20 and 30 ml/L, respectively while group A served as a control. Chicks were reared in cages in an open sided house. The data showed that weight of breast, thigh and leg were significantly (P<0.05) heavier in group C compared to control. It was concluded from this study that Trigonella foenum-graecum at the rate of 30 ml/L aqueous extract has a beneficial impact on the growth of these muscle tissues.
Rheological studies of aqueous stabilised nano-zirconia particle suspensions
Khan, Asad Ullah;Haq, Anwar Ul;Mahmood, Nasir;Ali, Zulfiqar;
Materials Research , 2012, DOI: 10.1590/S1516-14392011005000097
Abstract: in the present investigation aqueous suspensions of nano- and colloidal range particles are stabilised by changing the ambient ph. rheology is used to establish the stability of the suspensions and it is found that the rheology of the suspensions is strongly dependent on the ph values. the viscosity is highest close to the iso-electric point of the powders. at the iso-electric point the net surface charge on the powder particles is zero and is the cause of the high viscosity. away from the iso-electric point, the particles are charged, giving rise to a double layer phenomenon and causing the reduction in viscosity. it is also found that increasing the solid contents of the suspensions reduces the ph region of low viscosity.
Direct comparison between rotational and extrusion rheometers
Khan, Asad Ullah;Mahmood, Nasir;Bazmi, Aqeel Ahemd;
Materials Research , 2009, DOI: 10.1590/S1516-14392009000400017
Abstract: the use of cone and plate rotational rheology to characterize the flow properties of concentrated dispersion and extrusion methods to determine the rheological properties of pastes have become established rheometric techniques. direct comparison between the results obtained from the two techniques has not previously been demonstrated. in this article the results of such a comparison using established experimental methods and associated analysis are reported. it is found that for most samples investigated the difference in the calculated values of shear stress at a shear rate of 5/s is <10%. data for a series of slurries, composed of various solid fractions of lime waste, are reported over a shear rate of 0-10/s. the computed results for two techniques are shown to be, within the experimental error, identical over this shear rate range.
Electrochemical investigations of unexplored anthraquinones and their DNA binding
Journal of Electrochemical Science and Engineering , 2013, DOI: 10.5599/jese.2012.0026
Abstract: The redox behaviour of two potential anticancer anthraquinones, 9,10-anthraquinone and 2-chloromethyl-9,10-anthraquinone was investigated in a wide pH range. Cyclic voltammetry based assay was developed for the assessment of the effect of medium, substituents, potential scan rate and number of scans on the voltammetric response of anthraquinones. The electrode reaction mechanism was suggested on the basis of cyclic and differential pulse voltammetric results. The effect of DNA on anthraquinones was also probed at physiological pH which could lead to further investigation of possible citotoxic activity in vitro. The results revealed that anthraquinones interact with DNA more strongly than the clinically used anticancer drug, epirubicin.
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