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Search Results: 1 - 10 of 22 matches for " Artigiani "
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History, Narrative, and Meaning
Roberto Artigiani
Cosmos and History : the Journal of Natural and Social Philosophy , 2007,
Abstract: Recent developments in the natural sciences make a renewed dialogue with the humanities possible. Previously, humanists resisted transferring scientific paradigms into fields like history, fearing materialism and determinism would deprive experience of its meaning and people of their freedom. At the same time, scientists were realizing that deterministic materialism made understanding phenomena like life virtually impossible. Scientists escaped the irony of describing a nature to which they did not belong by also discovering that their knowledge can never be complete and that descriptions of nature at the subatomic level were essentially random. These developments, as Monod said, weakened the “Modern” paradigm sufficiently to make life scientifically possible. To understand how life might actually exist, however, scientists had to move beyond laments about observations losing information and concentrate on how nature creates information. Nature creates information in the process of reducing thermodynamic gradients and stores created information in self-organized systems. Nature thus becomes historical, for it is defined by qualitative changes accumulating over time because of unpredictable contingencies. This paper will explore the possibility that the patterned processes by which nature changes apply in the human realm, where interactions can change people and created information can be stored in self-organized societies. Values, Ethics and Morals (VEMs) are the qualitatively new information stored in social systems. VEMs script the actions structuring societies, demonstrating there is meaning in history and solving the problem of how sequences of events –“chronicles”–become narratives. Moreover, when societies compete, their system-structuring information is tested in the same way natural selection tests DNA. Thus, the succession of social systems suggests there is a meaning of history. The meaning of history need be no more transcendental or intended than Darwinian evolution. But if organs and traits can have biological value without implying design, socially constructed attributes like morality, consciousness, and freedom can be valued without supposing history has an ultimate or eternal purpose. Aspiring to show how the cacophony of historical events becomes a cosmos, a “well-ordered” context in which changes become meaningful, this sketch suggests a new understanding of nature may provide a basis for ethics.
Exceptional ergodic directions in Eaton lenses
Mauro Artigiani
Mathematics , 2015,
Abstract: We construct examples of ergodic vertical flows in periodic configurations of Eaton lenses of fixed radius. We achieve this by studying a family of infinite translation surfaces that are $\mathbb{Z}^2$-covers of slit tori. We show that the Hausdorff dimension of lattices for which the vertical flow is ergodic is bigger than 3/2. Moreover, the lattices are explicitly constructed.
The Lagrange spectrum of a Veech surface has a Hall ray
Mauro Artigiani,Luca Marchese,Corinna Ulcigrai
Mathematics , 2014,
Abstract: We study Lagrange spectra of Veech translation surfaces, which are a generalization of the classical Lagrange spectrum. We show that any such Lagrange spectrum contains a Hall ray. As a main tool, we use the boundary expansion developed by Bowen and Series to code geodesics in the corresponding Teichm\"uller disk and prove a formula which allows to express large values in the Lagrange spectrum as sums of Cantor sets.
Patogenicidade de Helminthosporium oryzae a algumas espécies de gramíneas
Artigiani Filho, V.H.;Bedendo, I.P.;
Scientia Agricola , 1995, DOI: 10.1590/S0103-90161995000100021
Abstract: helminthosporium oryzae is a rice pathogen. due to its variability in pathogenicity, the possibility of this fungus infecting other grasses was investigated. the capacity of this pathogen was demonstrated to be able to infect oat, sugar-cane, rye, sorghum, wheat, brachiaria decumbens and panicum maximum through artificial inoculations. therefore, those plant species can be considered potencial hosts for the fungus in nature.
Assessment of angiogenesis expression and its relationship with prognosis of colorectal cancer by conventional and computer-assisted histopathological image analysis
Leme, Marcelo Betim Paes;Waitzberg, ?ngela Flavia Logullo;Artigiani Neto, Ricardo;Linhares, Marcelo Moura;Matos, Delcio;
Acta Cirurgica Brasileira , 2006, DOI: 10.1590/S0102-86502006000600007
Abstract: purpose: to quantify the degree of angiogenesis by conventional method (microvessel density, mvd) and computerized method (endothelial area, ea), and to evaluate their relationships with the prognosis of patients operated on for colorectal adenocarcinoma. methods: tumoral angiogenesis was studied by means of an immunohistochemical technique, using cd 34, on 126 patients; to quantify the angiogenesis, mvd (defined as number of microvessels per mm2) and ea measurement (defined as the area occupied by ea in the microscope field). a computerized method, imagelab software was utilized to quantify endothelial area. results: the mean number of microvessels was 128.6 mv/mm2 (sd = 44.5) and the mean ea was 4.3% (sd = 2.1). the pearson method demonstrated a low correlation coefficient between mvd and ea (r = 0.429). no relationship between mvd and ea was observed with regard to relapse-free interval and overall survival. conclusion: the histological analysis of angiogenesis expression in patients with colorectal adenocarcinoma can be performed either by computer-assisted image analysis of endothelial area or by conventional microvessels counting. both methods did not show any significant relationship between these angiogenesis parameters with relapse-free interval and overall survival.
Analysis of the correlation between p53 and bcl-2 expression with staging and prognosis of the colorectal adenocarcinoma
Lustosa, Suzana Angelica Silva;Logullo, Angela;Artigiani, Ricardo;Saad, Sarhan Sydney;Goldenberg, Alberto;Matos, Delcio;
Acta Cirurgica Brasileira , 2005, DOI: 10.1590/S0102-86502005000500003
Abstract: purpose: to analyze the correlation between p53 and bcl-2 expression and colorectal adenocarcinoma staging and prognosis. methods: this was a retrospective series of 125 colorectal adenocarcinoma patients (67 women and 58 men; ages 30-87 years) who underwent surgery with curative intent. the mean follow-up was 28.5 months (range: 2-96 months). tnm staging, tumor recurrence, survival and cancer-related mortality were analyzed. immunoreactivity was evaluated using do7 (dako) for p53 and k492 (dako) for bcl-2. tumors with accumulation of staining for cytoplasmic bcl-2 or nuclear p53 in more than 10% of cells were considered positive. statistical analysis utilized pearson chi-squared, log-rank and wilcoxon tests, and kaplan-meier survival estimation (significance level: p<0.05). results: p53+ was found in 11.8% (14/118), bcl-2+ in 50% (58/116) and associated p53+/bcl-2+ in 6.4% (7/109) of the tumors. there was no significant correlation between expression of these biomarkers and tnm i, ii, iii and iv staging (p=0.385 for p53; p=0.461 for bcl-2). for tumor recurrence, p53+ was found in 9.5% (2/21), bcl-2+ in 50% (11/22), and associated p53+/bcl-2+ in 5.2% (1/19) of the tumors (p=0.714, p=1.000 and p=0.960, respectively). for survival analysis, p53+: 57 months (45.0-68.0), bcl-2+: 78 (37.0-89.0), and p53+/bcl-2+: 62 (56.0-68.0) (p=0.319). for cancer-related mortality, p53+: 8.3% (3/36), bcl-2+: 47.2% (17/36), and p53+/bcl-2+: 5.9% (2/36) of the patients (p=0.432, p=0.688 and p=0.907, respectively). conclusion: no correlation was found between tumor expression of p53 and bcl-2 and the tnm staging, recurrence, survival and cancer-related mortality in colorectal adenocarcinoma.
Ki-67 expression score correlates to survival rate in gastrointestinal stromal tumors (GIST)
Artigiani Neto, Ricardo;Logullo, Angela Flavia;Stávale, Jo?o Norberto;Louren?o, Laércio Gomes;
Acta Cirurgica Brasileira , 2012, DOI: 10.1590/S0102-86502012000500007
Abstract: purpose: to evaluate the immunohistochemical expression of p16, ki-67, p53 and bcl-2 proteins in gastrointestinal stromal tumors (gist); to assess the possible association between these variables and clinical and histopathological factors of cancer; and to check for prognostic value of these variables (survival and recurrence). methods: a sample of 55 patients treated surgically for gist in three hospitals was studied. the surgically excised tumors were confirmed as gist by kit, vimentin, desmin s100 protein, cd117, 1a4 and cd34 assessment in paraffin blocks. results: only 9 (16%) cases of gist were positive for p53, p16 was positive among 43.6%; 80% of gists showed staining for bcl-2. the proliferative index (expressed as the proportion of positive cells) assessed by immunohistochemical expression of ki-67 was high in 49% of cases. elevated ki-67 scores were associated to high histological grade (p=0.0026) and mitosis index, mi (p=0.0001). high ki-67 index was associated to death. expression of p53, p16 and bcl-2 did not correlate to morphological or clinical variables. conclusions: ki-67 immunohistochemical evaluation should be included in preoperative evaluation of gist biopsies or surgical specimens as a prognostic tool for clinical staging; and all other proteins studied (bcl-2, p53 and p16) did not play a role in gist metabolic or carcinogenic process, remaining without prognostic value.
Evaluation of the immunoexpression of COX-1, COX-2 and p53 in Crohn's disease
Romero, M?nica;Artigiani, Ricardo;Costa, Henrique;Oshima, Celina Tizuko Fujiyama;Miszputen, Sender;Franco, Marcello;
Arquivos de Gastroenterologia , 2008, DOI: 10.1590/S0004-28032008000400007
Abstract: background: crohn's disease accompanied by nonspecific or idiopathic ulcerative proctocolitis corresponds to a condition called intestinal inflammatory disease. the immunoexpression of cyclooxygenase 2 (cox-2) in crohn's disease becomes more marked with progression of the disease and the presence of wild-type p53 suppresses the transcription of cox-2. aims: to investigate the immunoexpression of cyclooxygenase 1 (cox-1), cox-2 and p53 in crohn's ileocolitis and to correlated this expression with clinical and histopathological parameters. methods: forty-five cases of crohn's disease, 16 cases of actinic colitis (diseased-control group) and 11 cases without a history of intestinal disease (normal control group) were studied. hematoxylin-eosin-stained sections were submitted to histopathological analysis and the immunohistochemical expression of cox-1, cox-2 and p53 was evaluated by the streptavidin-biotin-peroxidase method. results: sixty percent of the crohn's disease patients were women and 40% were men, with 75.5% whites and 25.5% non-whites. the disease involved the terminal ileum in 44.5% of cases, ileum in 33.3%, colon in 20% and duodenum-ileum in 2.2%. a significant association was observed between cox-2 immunoreactivity and age <40 years. histopathological analysis of crohn's disease samples showed mild or moderate crypt distortion (57.8% and 35.6% of cases), atrophy (6.6%), mild, moderate and marked chronic inflammation (46.7%, 26.7% and 20%), acute inflammatory activity (93.3%), ulceration (24.4%), mucin depletion (37.8%), paneth's cells (24.4%), intraepithelial lymphocytes (93.3%), and subepithelial collagen (6.7%). in the cd group, cox-1 immunoreactivity in epithelial and inflammatory cells was observed in 26.7% and 22.2% of cases, respectively. cox-2 immunoreactivity was detected in epithelial cells in 68.9% of cases and in inflammatory cells in 46.7%. a marginal difference in cox-2 reactivity was observed between epithelial and inflammatory cells in asso
A rela??o da caderina-E com o prognóstico do adenocarcinoma colorretal
Leme, Marcelo Betim Paes;Waitzberg, ?ngela F L;Artigiani, Ricardo;Matos, Delcio;
Revista do Colégio Brasileiro de Cirurgi?es , 2005, DOI: 10.1590/S0100-69912005000400009
Abstract: background: to evaluate the relationship between e-cadherin and recurrence, relapse free survival, overall survival and tnm system in patients operated on for colorectal adenocarcinoma. methods: this study included 89 patients (41 men and 48 women, mean age 62.3 years) who underwent colorectal ressection for adenocarcinoma. of these patients, 13 (14.6%) had tnm stage i disease, 29 (32.6%) stage ii, 23 (25.8%) stage iii and 24 (27.0%) stage iv. sixty-seven patients had been treated by curative resection and their mean follow-up was 37.9 months. paraffin-embedded tumor specimens were immunohistochemically stained to cadherin-e and assessed as positive and negative. results: e-cadherin was positive in 49.4% of the patients and negative for the remaining 50.6%. the disease recurred in 22.4% of the patients and there was no relation with e-cadherin expression. likewise, there was no relationship between e-cadherin and relapse free survival or overall survival. no significant association has been show between e-cadherin (p = 0.958) and tnm system. conclusion: these results do not allow us to associate ecadherin with the tnm system and prognosis of patients with colorectal adenocarcinoma.
Analysis of the correlation between p53 and bcl-2 expression with staging and prognosis of the colorectal adenocarcinoma
Lustosa Suzana Angelica Silva,Logullo Angela,Artigiani Ricardo,Saad Sarhan Sydney
Acta Cirurgica Brasileira , 2005,
Abstract: PURPOSE: To analyze the correlation between p53 and bcl-2 expression and colorectal adenocarcinoma staging and prognosis. METHODS: This was a retrospective series of 125 colorectal adenocarcinoma patients (67 women and 58 men; ages 30-87 years) who underwent surgery with curative intent. The mean follow-up was 28.5 months (range: 2-96 months). TNM staging, tumor recurrence, survival and cancer-related mortality were analyzed. Immunoreactivity was evaluated using DO7 (Dako) for p53 and K492 (Dako) for bcl-2. Tumors with accumulation of staining for cytoplasmic bcl-2 or nuclear p53 in more than 10% of cells were considered positive. Statistical analysis utilized Pearson chi-squared, log-rank and Wilcoxon tests, and Kaplan-Meier survival estimation (significance level: p<0.05). RESULTS: p53+ was found in 11.8% (14/118), bcl-2+ in 50% (58/116) and associated p53+/bcl-2+ in 6.4% (7/109) of the tumors. There was no significant correlation between expression of these biomarkers and TNM I, II, III and IV staging (p=0.385 for p53; p=0.461 for bcl-2). For tumor recurrence, p53+ was found in 9.5% (2/21), bcl-2+ in 50% (11/22), and associated p53+/bcl-2+ in 5.2% (1/19) of the tumors (p=0.714, p=1.000 and p=0.960, respectively). For survival analysis, p53+: 57 months (45.0-68.0), bcl-2+: 78 (37.0-89.0), and p53+/bcl-2+: 62 (56.0-68.0) (p=0.319). For cancer-related mortality, p53+: 8.3% (3/36), bcl-2+: 47.2% (17/36), and p53+/bcl-2+: 5.9% (2/36) of the patients (p=0.432, p=0.688 and p=0.907, respectively). CONCLUSION: No correlation was found between tumor expression of p53 and bcl-2 and the TNM staging, recurrence, survival and cancer-related mortality in colorectal adenocarcinoma.
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