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Search Results: 1 - 10 of 32141 matches for " Arsenijevi? Sne?ana "
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Nasal septum extramedullary plasmacytoma
Beli? Branislav,Mitrovi? Slobodanka,ArsenijeviSneana,Erdevi?ki Ljiljana
Vojnosanitetski Pregled , 2013, DOI: 10.2298/vsp1302221b
Abstract: Introduction. Plasmacytomas are malignant tumors characterized by abnormal monoclonal proliferation of plasma cells. They originate in either bone - solitary osseous plasmacytoma, or in soft tissue - extramedullary plasmacytoma (EMP). EMP represents less than 1% of all head and neck malignancies. Case report. We presented a case of EMP of the nasal septum in a 44-year-old male who had progressive difficulty in breathing through the nose and frequent heavy epistaxis on the right side. Nasal endoscopy showed dark red, soft, polypoid tumor in the last third of the right nasal cavity arising from the nasal septum. The biopsy showed that it was plasmacytoma. Bence Jones protein in the urine, serum electrophoresis, bone marrow biopsy, skeletal survey and other screening tests failed to detect multiple myeloma. This confirmed the diagnosis of EMP. The mass was completely removed via an endoscopic approach, and then, 4 week later, radiotherapy was conducted with a radiation dose of 50 Gray. No recurrence was noted in a 3-year follow- up period. Conclusion. EMP of the nasal cavity, being rare and having long natural history, represents a diagnostic and therapeutic challenge for any ear, nose and throat surgeon. Depending on the resectability of the lesion, a combined therapy is the accepted treatment.
Subdural empyema, retropharyngeal and parapharyngeal space abscess: Unusual complications of chronic otitis media
Erdevi?ki Ljiljana,Beli? Branislav,ArsenijeviSneana,Milojevi? Ivan
Vojnosanitetski Pregled , 2012, DOI: 10.2298/vsp1205449e
Abstract: Introduction. Otitic complications arise from expansion of the middle ear infection. Subdural empyema is a rare otitic complication, and both retropharyngeal and parapharyngeal abscesses have been described in just a few cases. Case report. A 30-year-old male was, admitted as an emergency case because of breathing difficulties, secretion from the ear, and fever. Clinical examination had shown a purulent, fetid secretion from the ear, swelling on the roof of epipharynx, left tonsil pushed medialy, immobile epiglottis, reduced breathing space. Computed tomography revealed thick hypodense content filling cavity, mastoid entering the posterior cranial fossa, descending down throw the parapharyngeal space to the mesopharynx. On the roof and posterior wall of the epipharynx hypodense collection was also present. Tracheotomy was conducted, and incision of the parapharyngeal and retropharyngeal abscess and radical tympanomastoidectomy were performed. The patient’s state deteriorated on the tenth postoperative day with hemiparesis and consciousness disorder. Magnetic resonance imaging was done. It showed subdural empyema of the left frontoparietal region and next to the falx, so craniotomy and abscess drainage were conducted. Conclusion. Parapharyngeal, retropharyngeal abscess and subdural empyema are rare otitic complications. Adequate antibiotic therapy and radical surgical treatment make possible an outcome with survival.
Risk factors for the appearance of minimal pathologic lesions on vocal folds in vocal professionals
Stojanovi? Jasmina,Ili? Nevenka,Stankovi? Predrag,ArsenijeviSneana
Vojnosanitetski Pregled , 2012, DOI: 10.2298/vsp1211973s
Abstract: Background/Aim. An excessive use or misuse of voice by vocal professionals may result in symptoms such are husky voice, hoarse voice, total loss of voice, or even organic changes taking place on vocal folds - minimal pathological lesions - MAPLs. The purpose of this study was to identify the type of MAPLs which affects vocal professionals, as well as to identify the risk factors that bring about these changes. Methods. There were 94 vocal professionals who were examined altogether, out of whom 46 were affected by MAPLs, whereas 48 of them were diagnosed with no MAPLs, so that they served as the control group. All these patients were clinically examined (anamnesis, clinical examination, bacteoriological examination of nose and pharynx, radiography of paranasal cavities, allergological processing, phoniatric examination, endo-video-stroboscopic examination, as well as gastroenterologic examination, and finally endocrinological and pulmological analyses). Results. The changes that occurred most often were identified as nodules (50%; n = 23/46) and polyps (24%; n = 11/46). Risk factors causing MAPLs in vocal professionals were as follows: age, which reduced the risk by 23.9% [OR 0.861 (0.786-0.942)] whereas the years of career increase the risk [OR 1.114 (1.000-1.241)], as well as the presence of a chronic respiratory disease [OR 7.310 (1.712- 31.218)], and the presence of gastro-oesophageal reflux disease [OR 4.542 (1.263-16.334)]. The following factors did not contribute to development of MAPLs in vocal professionals: sex, a place of residence, irritation, smoking, endocrinologic disease and the presence of poly-sinusitis. Conclusion. It is necessary to introduce comprehensive procedures for prevention of MAPLs, particularly in high-risk groups. Identification of the risk factors for MAPLs and prevention of their influence on vocal professionals (given that their income depends on their vocal ability) is of the highest importance.
The effect of propylthiouracil on function of phagocytic peripheral blood cells in persons with thyroid hyperfunction
?uki? Aleksandar,?ivan?evi?-Simonovi? Sneana,?ur?evi? Predrag,Arsenijevi? Neboj?a
Srpski Arhiv za Celokupno Lekarstvo , 2006, DOI: 10.2298/sarh0608290d
Abstract: Introduction. It is known that hyperthyroidism as well as thyrosuppressive therapy can influence the cells of immunological system. Objective. To examine the function of phagocyte cells in persons with hyperthyroidism and to examine if propylthiouracil (PTU) influences this function. Method. The study included 15 patients with hyperthyroidism and 10 healthy persons. The parameters of phagocytic activity of mononuclear and polymorphonuclear leucocytes were tested by method of ingestion of particles of inactivated yeast labeled with neutral-red. Results. It was demonstrated that patients with hyperthyroidism, before the onset of therapy as well as 14 days after introduction of PTU, had decreased number of leucocytes (before PTU: 6.7±3.2Ч109/l, after PTU: 6.1±2.0Ч109/l and control: 8.0±1.6Ч109/l; p=0.039), PMN leucocytes (before PTU: 3.9±2,4 Ч109/l, after PTU: 3.5±1.6Ч109/l and control: 4.8±0.9Ч109/l; p=0.037) and number of phagocyte PMN cells (before PTU: 0.9±0.9Ч109/l, after PTU: 0.9±0.7Ч109/l and control: 1.3±0.6 Ч109/l; p<0,05), but they had increased index of phagocytosis (before PTU: 2.0±0.2, after PTU: 1.9±0.2 and control: 1.7±0.2; p=0.029), while capacity of phagocytosis remained unchanged (before PTU: 1.9±1.7Ч109/l, after PTU: 1.6±1.9Ч109/l and control: 2.4±1.4Ч109/l; p>0.05). The number of mononuclear leucocytes and parameters of phagocytic activity of mononuclear phagocytes in persons with hyperthyroidism did not change significantly in comparison with the control group. Conclusion. Patients with hyperthyroidism had decreased number of leucocytes, PMN leucocytes and number of phagocyte PMN cells, and increased index of phagocytosis, while capacity of phagocytosis remained unchanged. The number and parameters of phagocytic activity of mononuclear leucocytes did not change. PTU therapy had no effect on the examined parameters.
Investment Activity in Small Open Economies  [PDF]
Vera Karadjova, Sneana Di?evska
Technology and Investment (TI) , 2014, DOI: 10.4236/ti.2014.52008
Abstract:


The paper gives a brief elaboration of the basic macroeconomic aspects of investments with emphasis on the specificities of small open economies in the process, theoretically elaborates the need for openness of small economies (especially the economies that need the acceleration of their development), then highlights the risks and opportunities arising from the investment activity both on the micro and macro level. Further distinguishes between investments in financial instruments and in real investment projects, emphasize the need for creation of an optimal diversified portfolio. Finally, the paper underlines the need for various forms of foreign direct investment for all economies, particularly the opportunities and threats arising in small open economies, to complete the wholeness with empirical data of the previously elaborated matters on the example of the Republic of Macedonia as a small open economy.


MARP Protein Family: A Possible Role in Molecular Mechanisms of Tumorigenesis
Sne ana Koji
Journal of Medical Biochemistry , 2010, DOI: 10.2478/v10011-010-0024-9
Abstract: The MARP (muscle ankyrin repeat protein) family comprises three structurally similar proteins: CARP/Ankrd1, Ankrd2/Arpp and DARP/Ankrd23. They share four conserved copies of 33-residue ankyrin repeats and contain a nuclear localization signal, allowing the sorting of MARPs to the nucleus. They are found both in the nucleus and in the cytoplasm of skeletal and cardiac muscle cells, suggesting that MARPs shuttle within the cell enabling them to play a role in signal transduction in striated muscle. Expression of MARPs is altered under different pathological conditions. In skeletal muscle, CARP/Ankrd1 and Ankrd2/Arpp are up-regulated in muscle in patients suffering from Duchene muscular dystrophy, congenital myopathy and spinal muscular atrophy. Mutations in Ankrd1 gene (coding CARP/Ankrd1) were identified in dilated and hypertrophic cardiomyopathies. Altered expression of MARPs is also observed in rhabdomyosarcoma, renal oncocytoma and ovarian cancer. In order to functionally characterize MARP family members CARP/Ankrd1 and Ankrd2/Arpp, we have found that both proteins interact with the tumor suppressor p53 both in vivo and in vitro and that p53 up-regulates their expression. Our results implicate the potential role of MARPs in molecular mechanisms relevant to tumor response and progression.
Biohemijski Aspekti, Laboratorijska Dijagnoza I Pra enje Povi ene Koncentracije Holesterola: Preporuke NCEP ATP III
Sne ana Jovi i
Journal of Medical Biochemistry , 2008, DOI: 10.2478/v10011-007-0044-2
Abstract: The Third Report of the expert panel on detection, evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel III, ATP III) constitutes the National Cholesterol Education Program's (NCEP's) updated clinical guidelines for cholesterol testing and clinical management of patients with high blood cholesterol. While ATP III maintains attention to intensive treatment of patients with coronary heart disease (CHD), its major new feature is a focus on primary prevention in persons with multiple risk factors. ATP III continues to identify elevated LDL cholesterol as the primary target of cholesterol lowering therapy. A basic principle of prevention is that the intensity of risk reduction therapy should be adjusted to a person's absolute risk. Risk assessment requires measurement of LDL cholesterol as part of lipoprotein analysis and identification of accompanying risk determinants (presence or absence of CHD, other clinical forms of atherosclerotic disease, diabetes, cigarette smoking, hypertension, low HDL cholesterol, family history of premature CHD, age). The category of highest risk consists of CHD and CHD risk equivalents - persons with absolute 10-year risk for major coronary events (death and myocardial infarction) >20%. The second category consists of persons with multiple (2+) risk factors in whom 10-year risk for CHD is ≥20%. Absolute risk is estimated from Framingham risk scores. The third category consists of persons having 0-1 risk factor. The LDL cholesterol goal for each category is defined and it can be achieved with dietary changes and/or drug therapy. European guidelines on cardiovascular disease (CVD) prevention in clinical practice recommend using the SCORE (Systematic COronary Risk Evaluation) Risk Charts in order to assess the risk for development of CVD, which is defined in terms of the absolute 10 year probability of developing a fatal cardiovascular event. The aim of this paper is to introduce parts of the NCEP's ATP III and European guidelines important for their implementation in laboratory practice.
Conservation biogeography: The modern scientific contribution of biogeography to the improvement of nature conservation
?ur?i? Sneana
Glasnik Srpskog Geografskog Dru?tva , 2009, DOI: 10.2298/gsgd0904311d
Abstract: In present times, there is a clear and growing need for applying theoretical biogeographic achievements in improving the state of biodiversity and conservation. Conceptual principles of conservation biogeography take the research into the relationship between fundamental biogeographic principles and the need for their appliance in nature conservation as the basic theory model, based upon biogeographic studies of isolated ranges. This paper is meant to point out the differences between spatial and functional isolation and the effects these have on the stability of populations and species. In light of this need to apply theories in biodiversity and nature conservation, it is important to research not only the processes that depend solely upon natural factors, but also those that are caused by a number of human-induced changes, e.g. habitat fragmentation, climate change or biotic homogenization.
Forests as the factor of the economy development of the Ra ka region
Vujadinovi? Sneana M.
Glasnik Srpskog Geografskog Dru?tva , 2003, DOI: 10.2298/gsgd0302061v
Abstract: Forests represent the significant natural resource of the Ra ka region. The preservation of forests ecosystems, and space potential offer, a favourable basis for their many-functional usage. For the time being, the productive, i.e., economic function, is dominant. The forests on the territory of the Prijepolje Forest Organization present the main raw material basis. In the whole cut wood volume of Serbia (state forests), the above mentioned organization participates with 37,1%. Opposite to that fact, the economic effects that the region economy has from the forest utilization, are far less than the potentials. Forest resources are neither enough nor adequately used. That greatly complicates the development of wood industry, as well as the other activities whose prosperity is connected with forests. Making and realization of plans for protection, fending forests and utilization, constructing infrastructure, tending and preservation of wild life, rational exploitation of forest resources, are the trends of the future usage of the Ra ka region forest natural wealth.
Structure and aims of land utilization the municipality of Knic
Vujadinovi? Sneana
Glasnik Srpskog Geografskog Dru?tva , 2008, DOI: 10.2298/gsgd0802079v
Abstract: Among developmental potentials of the municipality of Knic land is of primary significance. A survey of types and fertility land classes was presented in the paper. The structure of surfaces was analyzed according the way of utilization as well as changes that occurred due to construction of the river Gruza accumulation. Spatial differentiation of structural aims for the utilization of the whole land and agricultural one was carried out, which confirmed the physical-geographic and socio-economic heterogeneity of the area. It was pointed to numerous limiting factors of optimal exploitation of land fund (with a special review on shortening the properties). Appropriate measures and activities were also suggested.
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