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Search Results: 1 - 10 of 540372 matches for " Arruzazabala M.L. "
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Protective effect of policosanol on atherosclerotic lesions in rabbits with exogenous hypercholesterolemia
Arruzazabala M.L.,Noa M.,Menéndez R.,Más R.
Brazilian Journal of Medical and Biological Research , 2000,
Abstract: Policosanol is a mixture of higher aliphatic alcohols purified from sugar cane wax, with cholesterol-lowering effects demonstrable in experimental models and in patients with type II hypercholesterolemia. The protective effects of policosanol on atherosclerotic lesions experimentally induced by lipofundin in rabbits and rats and spontaneously developed in stumptail monkeys have been described. The present study was conducted to determine whether policosanol administered orally to rabbits with exogenous hypercholesterolemia also protects against the development of atherosclerotic lesions. Male New Zealand rabbits weighing 1.5 to 2 kg were randomly divided into three experimental groups which received 25 or 200 mg/kg policosanol (N = 7) orally for 60 days with acacia gum as vehicle or acacia gum alone (control group, N = 9). All animals received a cholesterol-rich diet (0.5%) during the entire period. Control animals developed marked hypercholesterolemia, macroscopic lesions and arterial intimal thickening. Intima thickness was significantly less (32.5 ± 7 and 25.4 ± 4 μm) in hypercholesterolemic rabbits treated with policosanol than in controls (57.6 ± 9 μm). In most policosanol-treated animals, atherosclerotic lesions were not present, and in others, thickness of fatty streaks had less foam cell layers than in controls. We conclude that policosanol has a protective effect on the atherosclerotic lesions occurring in this experimental model.
Effect of policosanol on cerebral ischemia in Mongolian gerbils
Molina V.,Arruzazabala M.L.,Carbajal D.,Valdés S.
Brazilian Journal of Medical and Biological Research , 1999,
Abstract: Policosanol is a mixture of higher aliphatic primary alcohols isolated from sugar cane wax, whose main component is octacosanol. An inhibitory effect of policosanol on platelet aggregation and cerebral ischemia in animal models has been reported. Thus, the objective of the present study was to evaluate the effect of policosanol on cerebral ischemia induced by unilateral carotid ligation and bilateral clamping and recirculation in Mongolian gerbils. Policosanol (200 mg/kg) administered immediately after unilateral carotid ligation and at 12- or 24-h intervals for 48 h significantly inhibited mortality and clinical symptoms when compared with controls, whereas lower doses (100 mg/kg) were not effective. Control animals showed swelling (tissue vacuolization) and necrosis of neurons in all areas of the brain studied (frontal cortex, hippocampus, striatum and olfactory tubercle), showing a similar injury profile. In the group treated with 200 mg/kg policosanol swelling and necrosis were significantly reduced when compared with the control group. In another experimental model, comparison between groups showed that the brain water content of control gerbils (N = 15) was significantly higher after 15 min of clamping and 4 h of recirculation than in sham-operated animals (N = 13), whereas policosanol (200 mg/kg) (N = 19) significantly reduced the edema compared with the control group, with a cerebral water content identical to that of the sham-operated animals. cAMP levels in the brain of control-ligated Mongolian gerbils (N = 8) were significantly lower than those of sham-operated animals (N = 10). The policosanol-treated group (N = 10) showed significantly higher cAMP levels (2.68 pmol/g of tissue) than the positive control (1.91 pmol/g of tissue) and similar to those of non-ligated gerbils (2.97 pmol/g of tissue). In conclusion, our results show an anti-ischemic effect of policosanol administered after induction of cerebral ischemia, in two different experimental models in Mongolian gerbils, suggesting a possible therapeutic effect in cerebral vascular disorders.
Protective effect of policosanol on atherosclerotic lesions in rabbits with exogenous hypercholesterolemia
Arruzazabala, M.L.;Noa, M.;Menéndez, R.;Más, R.;Carbajal, D.;Valdés, S.;Molina, V.;
Brazilian Journal of Medical and Biological Research , 2000, DOI: 10.1590/S0100-879X2000000700015
Abstract: policosanol is a mixture of higher aliphatic alcohols purified from sugar cane wax, with cholesterol-lowering effects demonstrable in experimental models and in patients with type ii hypercholesterolemia. the protective effects of policosanol on atherosclerotic lesions experimentally induced by lipofundin in rabbits and rats and spontaneously developed in stumptail monkeys have been described. the present study was conducted to determine whether policosanol administered orally to rabbits with exogenous hypercholesterolemia also protects against the development of atherosclerotic lesions. male new zealand rabbits weighing 1.5 to 2 kg were randomly divided into three experimental groups which received 25 or 200 mg/kg policosanol (n = 7) orally for 60 days with acacia gum as vehicle or acacia gum alone (control group, n = 9). all animals received a cholesterol-rich diet (0.5%) during the entire period. control animals developed marked hypercholesterolemia, macroscopic lesions and arterial intimal thickening. intima thickness was significantly less (32.5 ± 7 and 25.4 ± 4 μm) in hypercholesterolemic rabbits treated with policosanol than in controls (57.6 ± 9 μm). in most policosanol-treated animals, atherosclerotic lesions were not present, and in others, thickness of fatty streaks had less foam cell layers than in controls. we conclude that policosanol has a protective effect on the atherosclerotic lesions occurring in this experimental model.
Effect of policosanol on cerebral ischemia in Mongolian gerbils
Molina, V.;Arruzazabala, M.L.;Carbajal, D.;Valdés, S.;Noa, M.;Más, R.;Fraga, V.;Menéndez, R.;
Brazilian Journal of Medical and Biological Research , 1999, DOI: 10.1590/S0100-879X1999001000014
Abstract: policosanol is a mixture of higher aliphatic primary alcohols isolated from sugar cane wax, whose main component is octacosanol. an inhibitory effect of policosanol on platelet aggregation and cerebral ischemia in animal models has been reported. thus, the objective of the present study was to evaluate the effect of policosanol on cerebral ischemia induced by unilateral carotid ligation and bilateral clamping and recirculation in mongolian gerbils. policosanol (200 mg/kg) administered immediately after unilateral carotid ligation and at 12- or 24-h intervals for 48 h significantly inhibited mortality and clinical symptoms when compared with controls, whereas lower doses (100 mg/kg) were not effective. control animals showed swelling (tissue vacuolization) and necrosis of neurons in all areas of the brain studied (frontal cortex, hippocampus, striatum and olfactory tubercle), showing a similar injury profile. in the group treated with 200 mg/kg policosanol swelling and necrosis were significantly reduced when compared with the control group. in another experimental model, comparison between groups showed that the brain water content of control gerbils (n = 15) was significantly higher after 15 min of clamping and 4 h of recirculation than in sham-operated animals (n = 13), whereas policosanol (200 mg/kg) (n = 19) significantly reduced the edema compared with the control group, with a cerebral water content identical to that of the sham-operated animals. camp levels in the brain of control-ligated mongolian gerbils (n = 8) were significantly lower than those of sham-operated animals (n = 10). the policosanol-treated group (n = 10) showed significantly higher camp levels (2.68 pmol/g of tissue) than the positive control (1.91 pmol/g of tissue) and similar to those of non-ligated gerbils (2.97 pmol/g of tissue). in conclusion, our results show an anti-ischemic effect of policosanol administered after induction of cerebral ischemia, in two different experimental models i
Modelo matemático predictivo del crecimiento de Escherichia coli O157 en carne vacuna
Signorini,M.L;
InVet , 2008,
Abstract: the aim of this study was modeled escherichia coli o157 growth in beef hamburger as part of a quantitative risk assessment. scientific articles that presented a complete pathogen growth model in meat depending on the temperature and two tertiary predictive models were selected. since they were generated data of lag phase (?) and growth rate (μ) in a range of temperatures (5 ° c to 34 ° c) and ph (5.6 - 6.5), and were obtained the linear relationship between each parameter and temperature. linear equations in probability distributions for each parameter were included and ran a model for analyzing the behavior of lag-exponential and gompertz equations in predicting e. coli o157 growth. the methodology exposed allows including different environmental conditions present in the meat throughout the process, taking into account the variability and uncertainty in the microbial growth parameters. gompertz microbiological model generated better results, because consider the bacteria concentration on the stationary growth phase, preventing obtain extremely high values.
Evaluation of the addition of ascorbic acid to the ration of cultivated Piaractus mesopotamicus (Characidae) on the infrapopulation of Anacanthorus penilabiatus (Monogenea)
Martins, M.L.;
Brazilian Journal of Medical and Biological Research , 1998, DOI: 10.1590/S0100-879X1998000500008
Abstract: sixty piaractus mesopotamicus holmberg, 1887 (pacu) fry fed a diet containing 0, 50, 100 and 200 mg ascorbic acid/kg dry feed were studied to evaluate the effect on parasitic infestation by the monogenean anacanthorus penilabiatus boeger, husak and martins, 1995 (monogenea: dactylogyridae) for a period of 24 weeks. the temperature of the aquaria was measured daily and remained between 28 and 31oc. at the beginning of the experiment, fish showed 6.15 ± 0.33 cm standard length and 8.64 ± 1.62 g average body weight. a sample of fish was examined and showed 43 ± 17 monogeneans per fish. at the end of the experiment, the gills of control and vitamin c-treated fish were collected for parasite counts. control fish had 42.5 parasites per fish, a significantly higher number (p<0.05) when compared with fish fed vitamin c, that showed 16.5 parasites per fish. ascorbic acid fortification in the food promoted an increase in fish resistance to parasites. it is suggested that an optimum level of 139 mg/kg vitamin c supplementation either elicited better nutritional conditions by stimulating the appetite of the fish or improved the immune response.
Bloqueos diagnóstico-terapéuticos de carillas articulares cervicales
Franco,M.L.;
Revista de la Sociedad Espa?ola del Dolor , 2009,
Abstract: cervical pain is experienced by 66% of adults during their lifetime and by 54% in the previous 6 months. only 5% will experience intense chronic pain with functional disability. eighty percent of cervical pain is produced by skeletal or muscular lesions as a result of disc and facet degeneration. external causative agents include trauma, overweight, occupational demands, stress, etc. diagnosis of cervical pain is mainly based on physical examination and clinical findings. in cervical pain radiating to the neck, scapulohumeral girdle and upper right arm without a radicular pattern and positive examination of the facet joints, diagnostic-therapeutic facet joint blocks are indicated. the present article describes the anatomy of the cervical region. knowledge of this region is essential to guarantee good results and to minimize risks. the indications and practical features of the technique are also discussed.
Causes and management of diarrhoea in children in a clinical setting
M.L Cooke
South African Journal of Clinical Nutrition , 2010,
Abstract: Diarrhoeal disease and its complications remain a major cause of morbidity and mortality in children, especially in developing countries. Diarrhoea is characterised by an increased frequency and volume, and decreased consistency of stool from the norm. Pathogens vary between developed and developing world settings. Rotavirus diarrhoea is the most important aetiological agent implicated in severe dehydrating diarrhoea. Although it is important to recognise the specific microbiological causation of diarrhoea in order to target appropriate treatment, the broader preventive aspects put forward by the World Health Organization (WHO) indicate the fundamental contributors to the massive burden of disease in developing countries. The management of a child presenting with acute diarrhoea must include a thorough history and examination with evaluation of hydration status, nutritional status and comprehensive clinical evaluation for any complications or associated illnesses. The most recent advances in the area of acute diarrhoeal disease include zinc supplementation, reduced osmolarity oral rehydration solution (ORS) and rotavirus vaccination.
Micromorphology of the springbok louse Damalinia (Tricholipeurus) antidorcus found at the Rietvlei Nature Reserve near Pretoria, South Africa
M.L. Turner
Koedoe : African Protected Area Conservation and Science , 2006, DOI: 10.4102/koedoe.v49i1.106
Abstract: This report provides additional information on the morphology of Damalinia (Tricholipeurus) antidorcus, previously described only by light microscopy. Live lice were collected and prepared for viewing by SEM. Micromorphological features investigated included aspects of the forehead, mandibles and spiracles. The average length of the males was 2.0 mm and females 2.04 mm. The anterior hyalin region of the head was notably emarginated. Awell-developed medial groove on the ventral surface of the head between the mandibles was noted. The surface of the epipharynx was smooth. The labrum with its typical scale-like appearance gradually changed into the pulvinal area of the clypeus. Both genders had notched left mandibles. The mandibles were highly serrated on the oral surfaces. Situated ventrally below and caudal to the mandibles were a pair of labial palpi. The immediate area between, and surrounding the labial palpi was littered with numerous spiked setae and two well developed larger setae raised at their bases. The tips of the palpi bore three larger and longer sensory setae. Palpi of this nature are described here for the first time in D. antidorcus.
The micromorphology of the blesbuck louse Damalinia (Damalinia) crenelata as observed under the scanning electron microscope
M.L. Turner
Koedoe : African Protected Area Conservation and Science , 2003, DOI: 10.4102/koedoe.v46i1.45
Abstract: The blesbuck is an important game animal on many game farms and reserves in South Africa. Damalinia crenelata, a biting louse, host-specific to the blesbuck, feed upon epidermal debris of this antelope, leading to severe skin irritation and dermatitis. Symptomatic scratching by the host aggravates these conditions. High infestations may lead to decreased population numbers. Live lice were collected from a blesbuck in the Rietvlei Nature Reserve and prepared for selectron microscopic investigation. Micrographs were recorded. The SEM investigation revealed several micromorphological features not previously described in D. crenelata. Besides the obvious anatomical differences in the reproductive organs of the male and female, several other differences were noted. The antennal flagellae showed morphological differences as well as certain features on the ventral surfaces of the head. Dorsally the forehead was markedly emarginated and showed an acute invagination (clypeo labral suture) in the pulvinal area. The ventral surface of the head clearly demonstrated the structures of the preantennal regions such as ventral carina, pulvinus, labrum, mandibles and clypeus. The epipharynx appeared as an underlying extension of the labrum. The rims of the clypeus were more raised and thickened in the female than in that of the male. The mandibles were not notched and were noted to be angular in shape. The three segments of each of the antennae of the male were thicker and more robust than than those of the female. This could suggest sexual dimorphism in this species. The sensilla basoconica comprised 10 pegs. Pit organs were seen within the pore organs. The prothorax and mesothorax were clearly distinguished. The abdominal segments showed six pairs of spiracles. The male andfemale terminalia were confirmed to be strongly sexually dimorphic. The three pairs oflegs each terminated in a single, long and slender, claw.
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