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Search Results: 1 - 10 of 480893 matches for " Arruda L.V.R. "
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Identifica??o genética de modelos por pólos e zeros baseada no compromisso entre os erros de polariza??o e variancia
Arruda, L.V.R.;Fávaro, Sílvio;Neves-Jr., F.;
Sba: Controle & Automa??o Sociedade Brasileira de Automatica , 2003, DOI: 10.1590/S0103-17592003000200001
Abstract: this work proposes a genetic algorithm (ga) to solve process estimation problems when the real process presents high orders polynomials (complexity model) or non-linearities, non-minimum phase behavior, etc. the algorithm finds the best linear model in the pole and zero form to represent the real plant using its input and output signals. a new chromosome representation was introduced and a new ''fitness'' function based on the tradeoff bias x variance was developed. to validate this genetic estimator, simulations studies were done and the ga performance was compared with one obtained by use of the traditional least square estimation method.
Identifica o genética de modelos por pólos e zeros baseada no compromisso entre os erros de polariza o e variancia
Arruda L.V.R.,Fávaro Sílvio,Neves-Jr. F.
Sba: Controle & Automa??o Sociedade Brasileira de Automatica , 2003,
Abstract: Este trabalho prop em um algoritmo genético aplicado ao problema de identifica o de plantas n o-lineares, de fase n o-mínima ou plantas lineares de ordem superior. O algoritmo proposto tem como objetivo encontrar um modelo linear na forma de pólos e zeros e de ordem reduzida, que melhor represente a planta real, a partir dos sinais de entrada e saída. Uma proposta inovadora para a representa o dos indivíduos e fun o de ''fitness'' foi desenvolvida neste trabalho. Esta fun o de fitness representa o compromisso entre os erros de polariza o e variancia do modelo estimado. Já a representa o proposta divide o espa o de busca em dois subespa os: um destinado à busca de pólos e zeros de natureza real e outro com a finalidade de se encontrar os pólos e zeros complexos. Resultados de simula o s o utilizados para ilustrar o desempenho do estimador genético desenvolvido.
Effect of a submaxillary gland extract on Ehrlich tumor growth in mice
Weill, P.;Frussa-Filho, R.;Bonamin, L.V.;
Brazilian Journal of Medical and Biological Research , 1999, DOI: 10.1590/S0100-879X1999001000005
Abstract: ablation of host submaxillary glands modifies ehrlich tumor growth and tumor-infiltrating leukocytes, possibly by modifications in the serum level of growth factors produced by this gland. to extend this research, 7-month-old male epm-1 mice (n = 30) were divided into two groups: 1) inoculated with tumor cells previously incubated with submaxillary salivary gland extract (sge) in pbs for 30 min at 37%; 2) inoculated with tumor cells previously incubated with pbs, under the same conditions. animals were inoculated into the footpad with 40 μl of a suspension containing 4.5 x 107 tumor cells/ml, and footpad thickness was measured daily for 10 days. sections and smears of tumor cells were prepared from the tumor mass to determine mitosis frequency, percent of tumor cells immunopositive to nerve (ngf) and epidermal (egf) growth factors and percent of tumor-infiltrating leukocytes. the incubation of tumor cells with sge produced a tumor reduction of about 30% in size (p<0.01). this effect was not related to loss of cell viability during incubation, but a 33% increase (p<0.05) in the percentage of dead or dying tumor cells and a 15% increase in the percent of ngf/egf-positive tumor cells (p<0.01) were observed in vivo at the end of experiment. tumor-infiltrating lymphocytes and mitosis frequency did not differ between groups. these data suggest a direct effect of factors present in sge on tumor cells, which induce degeneration of tumor cells.
Effect of a submaxillary gland extract on Ehrlich tumor growth in mice
Weill P.,Frussa-Filho R.,Bonamin L.V.
Brazilian Journal of Medical and Biological Research , 1999,
Abstract: Ablation of host submaxillary glands modifies Ehrlich tumor growth and tumor-infiltrating leukocytes, possibly by modifications in the serum level of growth factors produced by this gland. To extend this research, 7-month-old male EPM-1 mice (N = 30) were divided into two groups: 1) inoculated with tumor cells previously incubated with submaxillary salivary gland extract (SGE) in PBS for 30 min at 37%; 2) inoculated with tumor cells previously incubated with PBS, under the same conditions. Animals were inoculated into the footpad with 40 μl of a suspension containing 4.5 x 107 tumor cells/ml, and footpad thickness was measured daily for 10 days. Sections and smears of tumor cells were prepared from the tumor mass to determine mitosis frequency, percent of tumor cells immunopositive to nerve (NGF) and epidermal (EGF) growth factors and percent of tumor-infiltrating leukocytes. The incubation of tumor cells with SGE produced a tumor reduction of about 30% in size (P<0.01). This effect was not related to loss of cell viability during incubation, but a 33% increase (P<0.05) in the percentage of dead or dying tumor cells and a 15% increase in the percent of NGF/EGF-positive tumor cells (P<0.01) were observed in vivo at the end of experiment. Tumor-infiltrating lymphocytes and mitosis frequency did not differ between groups. These data suggest a direct effect of factors present in SGE on tumor cells, which induce degeneration of tumor cells.
Cultured myoblasts from patients affected by myotonic dystrophy type 2 exhibit senescence-related features: ultrastructural evidence
M. Malatesta,M. Giagnacovo,L.V. Renna,R. Cardani
European Journal of Histochemistry , 2011, DOI: 10.4081/ejh.2011.e26
Abstract: Myotonic dystrophy type 2 (DM2) is an autosomal dominant disorder caused by the expansion of the tetranucleotidic repeat (CCTG)n in the first intron of the Zinc Finger Protein-9 gene. In DM2 tissues, the expanded mutant transcripts accumulate in nuclear focal aggregates where splicing factors are sequestered, thus impairing the whole mRNA processing. Interestingly, the ultrastructural alterations in the splicing machinery observed in the myonuclei of DM2 skeletal muscles are reminiscent of the nuclear changes occurring in age-related muscle atrophy. Here, we investigated structural and functional features of satellite cell-derived myoblasts from biceps brachii, in the attempt to investigate cell senescence indices in DM2 patients by ultrastructural cytochemistry. We observed that in satellite cell-derived DM2 myoblasts, cell-senescence alterations and impairment of the pre-mRNA maturation pathways occur earlier than in myoblasts from healthy patients. This suggests that also in vivo the regeneration capability of satellite cells could be reduced in dystrophic muscles.
Indicadores biológicos en México, Distrito Federal, el caso de la corteza arbórea
V.G. Calva,V.C. Flores,R. Germán,L.V. Ruz
Revista internacional de contaminación ambiental , 1991,
Abstract:
Efectos en salud y misceláneos/ health affects and miscelaneous
V.G. Calva,V.C. Flores,R. Germán,L.V. Ruz
Revista internacional de contaminación ambiental , 1991,
Abstract:
Syndrome of a Systemic Inflammatory Reaction at the Acute Pancreatitis: Peculiarities of a Molecular Pathophysiology and Possible Ways of Correction
V.A. Gorsky,M.A. Agapov,L.V. Kovalchuk,E.R. Ovanesyan
Sovremennye Tehnologii v Medicine , 2010,
Abstract: Aim of the given work is a study of the lornoxycam-cyclooxygenase inhibitor influence on the proinflammatory and antiinflammatory cytokine output, stipulated by ligands of the 1st and 2nd type Toll-like receptors (TLR1/2) and the 4th type Toll-like receptors (TLR4), the mononuclear cells of the healthy donor peripheral blood in vitro and in patients with the AP.Materials and methods. Influence of a nonsteroid antiinflammatory preparation on a synthesis of the pro-and and antiinflammatory cytokines was assessed in 10 healthy donors and 11 patients with the acute pancreatitis.Results. A release of the endogenous ligand significant concentrations takes place at the acute pancreatitis as a result of the organism proper cell large number death, which leads to activation of the TLR signal ways, activation of the immune system cell and starts the pro-inflammatory cytokine output. That fact necessitates the preparation with a cytokine-inhibiting activity inclusion into a complex therapy of AP.
Cardiological management of pregnant women in the Udmurt Republic
I.R. Gaisin,R.M. Valeeva,L.V. Shilina,N.Yu. Chernisheva
Rational Pharmacotherapy in Cardiology , 2009,
Abstract: Aim. To assess the efficacy of specialized management of pregnant women with cardiovascular diseases (CVD) in the Udmurt Republic (UR) of Russia.Material and methods. In prospective and retrospective study we investigated pregnancy outcomes in all 17948 women in management system created for pregnant patients with CVD in the UR from 2000 to 2007. The system comprises specialized outpatient and inpatient departments and an obstetric hospital within the regional cardiological centre.Pregnant women had different CVD including hypertension, congenital and rheumatic heart disease, cardiac arrhythmias, noncoronary myocardial disease, disorders and autoimmune diseases of connective tissue, etc.Results. Perinatal mortality decreased by 41,1% from 11,2‰in 2000 to 6,6‰in 2007. During 8 years, no one woman died.Conclusion. The management system for pregnant women with CVD within the regional cardiological clinic makes it possible to reduce of maternal and perinatal mortality rates significantly.
Experimental study and simulation of mass distribution of the covering layer of soybean seeds coated in a spouted bed
Duarte C. R.,Neto J. L.V.,Lisboa M. H.,Santana R. C.
Brazilian Journal of Chemical Engineering , 2004,
Abstract: In previous work, it was observed that the covering of soybean seeds with bacteria and micronutrients enhances vigorous growth of the plant thereby avoiding use of ammoniacal fertilizers. In the spouted bed covering can be done by pulverization of the coater slurry on the soybean seeds using a pneumatic atomizer. The optimum thickness of the cover allows the fundamental gaseous interchanges for germination and provides the ideal conditions for bacterium activity. The objective of this work was to study the influence of the process variables on thickness of the cover. A simulation of the mass distribution of seeds was obtained using a population balance model. Through the results obtained the operational conditions under which the coating layer distribution were determined has the greatest uniformity.
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