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In vitro cytotoxicity of extracts and fractions of Calotropis procera (Ait.) roots against human cancer cell lines
Bhagat Madhulika,Arora Jatinder,Saxena Ajit
International Journal of Green Pharmacy , 2010,
Abstract: This study was designed to determine the antiproliferative activity of three extracts (alcoholic, hydro-aqueous and aqueous) and their fractions from the root part of Calotropis procera using human oral (KB) and central nervous system (SNB-78) cancer cell lines as a model system. KB and SNB-78 cells were cultured in the presence of extracts and fractions at various concentrations (10, 30 and100 μg/ml) for 48 h, and the percentage of cell viability was evaluated by the sulforhodamine-B (SRB) assay. Our result indicates that out of the three extracts of C. procera (root), alcoholic extract had shown greater potential for growth inhibition followed by hydro-aqueous extract at three different concentration of 10 μg/ml, 30 μg/ml and 100 μg/ml in a dose-dependent manner, whereas aqueous extract was found to be least active against both oral and CNS human cancer lines. On evaluation of the fractions prepared from alcoholic and hydro-aqueous extracts, it was observed that chloroform fraction from alcoholic extract was antiproliferative for oral (KB) cancer cell line and n-butanol fraction from alcoholic extract was antiproliferative for CNS cancer cell line than remaining fractions at three different concentration of 10 μg/ml, 30 μg/ml, 100 μg/ml in a dose-dependent manner. Thus, our result indicates that the root part of C. procera possess in vitro cytotoxicity against oral and CNS human cancer cell lines. Further investigations are required to obtain the clinically important lead molecules for the drug development.
Antioxidant Capacities, Phenolic Profile and Cytotoxic Effects of Saxicolous Lichens from Trans-Himalayan Cold Desert of Ladakh
Jatinder Kumar, Priyanka Dhar, Amol B. Tayade, Damodar Gupta, Om P. Chaurasia, Dalip K. Upreti, Rajesh Arora, Ravi B. Srivastava
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0098696
Abstract: Fourteen saxicolous lichens from trans-Himalayan Ladakh region were identified by morpho-anatomical and chemical characteristics. The n-hexane, methanol and water extracts of the lichens were evaluated for their antioxidant capacities. The lichen extracts showing high antioxidant capacities and rich phenolic content were further investigated to determine their cytotoxic activity on human HepG2 and RKO carcinoma cell lines. The ferric reducing antioxidant power (FRAP), 2,2′-azinobis-(3-ethylbenzothiazoline-6-?sulfonicacid) diammonium salt (ABTS), 1,1-diphenyl-2-picrylhydrazyl (DPPH) and nitric oxide (NO) radical scavenging capacities and β-carotene-linoleic acid bleaching property exhibited analogous results where the lichen extracts showed high antioxidant action. The lichen extracts were also found to possess good amount of total proanthocyanidin, flavonoid and polyphenol. The methanolic extract of Lobothallia alphoplaca exhibited highest FRAP value. Methanolic extract of Xanthoparmelia stenophylla showed the highest ABTS radical scavenging capacity. The n-hexane extract of Rhizoplaca chrysoleuca exhibited highest DPPH radical scavenging capacity. Highest antioxidant capacity in terms of β-carotene linoleic acid bleaching property was observed in the water extract of Xanthoria elegans. Similarly, Melanelia disjuncta water extract showed highest NO scavenging capacity. Among n-hexane, methanol and water extracts of all lichens, the methanolic extract of Xanthoparmelia mexicana showed highest total proanthocyanidin, flavonoid and polyphenol content. From cytotoxic assay, it was observed that the methanolic extracts of L. alphoplaca and M. disjuncta were exhibiting high cytotoxic effects against cancer cell growth. Similarly, the water extract of Dermatocarpon vellereum, Umbilicaria vellea, X. elegans and M. disjuncta and the methanolic extract of M. disjuncta and X. stenophylla were found to possess high antioxidant capacities and were non-toxic and may be used as natural antioxidants for stress related problems. Our studies go on to prove that the unique trans-Himalayan lichens are a hitherto untapped bioresource with immense potential for discovery of new chemical entities, and this biodiversity needs to be tapped sustainably.
COMPARATIVE ANALYSIS FOR CONTRAST ENHANCEMENT USING HISTOGRAM EQUALIZATION TECHNIQUES
Jatinder Kaur
Journal of Global Research in Computer Science , 2012,
Abstract: Contrast enhancement is basically improving the quality of images for better perception. They are widely used for image and video processing to achieve wider dynamic range. There are two major goals: contrast enhancement and preserving the brightness of the image. This paper presents the parameters comparison and simulation results of various histogram equalization techniques like GHE, BBHE, Novel, BPDHE in terms of Correlation, Peak Signal to Noise Ratio (PSNR), Normalized Absolute Error (NAE) due to which visual quality of the image becomes better.
Comparison of Alberta Industrial and Pipeline Projects and US Projects Performance  [PDF]
Elias Ikpe, Jatinder Kumar, George Jergeas
American Journal of Industrial and Business Management (AJIBM) , 2014, DOI: 10.4236/ajibm.2014.49053
Abstract: Project performance issues are major concerns in Alberta. This paper compares the projects executed in Alberta and US projects. The paper analyses the projects performance in Alberta and compares it with US projects with a view to improve project performance in Alberta. 17 participating companies in Alberta provided the previous projects data and COAA/CII database provided the US data for the analysis. A qualitative research methodology was also employed in investigating the Alberta project performance. Interviews were conducted with industry practitioners, which contained open-ended questions. The research found that in comparison, the Alberta projects showed higher average cost and schedule growth than the US projects and the US based projects were more productive in erecting structural steel than Alberta projects. This method has the potential to contribute to a reduction in cost and schedule overruns, and improves project performance. It is concluded that comparison of projects executed in Alberta and US projects can provide a guide to companies to improve performance in Alberta.
Kinetics of Jatropha Curcas Transesterification in Batch Reactor
Vipan Kumar,Jatinder Kumar
Lecture Notes in Engineering and Computer Science , 2008,
Abstract:
Photocatalytic Degradation of Amaranth Dye in Aqueous Solution Using Sol-gel Coated Cotton Fabric
Jatinder Kumar,Ajay Bansal
Lecture Notes in Engineering and Computer Science , 2010,
Abstract:
Cutaneous drug reaction with intravenous ceftriaxone
Kaur Inderpal,Singh Jatinder
Indian Journal of Pharmacology , 2009,
Abstract:
Performance Evaluation and Optimization of TCP Parameters over Frame Relay Network
Gursimran Singh,Jatinder Singh
International Journal on Computer Science and Engineering , 2011,
Abstract: The TCP window size value, which is contained in the window size field of the TCP segment is a very important TCP Parameter. The window size value determines the number of bytes of data that canbe sent before an acknowledgement from the reciever is necessary. If the window size field value is made too small, the performance deteriorates. This will slow throughput considerably. On the other hand, if the window size field is made too large, the sender may transmit so many segments that reciever will be overloaded. The window size field provides flow control, regulating the rate at which the transport processes on the two hosts may transmit. In this paper we have proposed modifications in TCP Window Size, wherein the performance in the network is improved by changing the TCP parameters. Simulations done on Opnet Simulator shows significant improvement in throughput, reduction in upload response time and delay.
Risk of high gestational weight gain on adverse pregnancy outcomes  [PDF]
Rajin Arora, Darin Arora, Jayanton Patumanond
Open Journal of Obstetrics and Gynecology (OJOG) , 2013, DOI: 10.4236/ojog.2013.31A027
Abstract:

Background/Aims: Excessive gestational weight gain was known to be associated with adverse pregnancy outcomes. It increased the complications during pregnancy, delivery and postpartum period. Nevertheless, there are studies reporting the incompliance of pregnant women with recommendations of weight gain. The objectives of this study were to estimate the prevalence of high gestational weight gain and to identify the increased adverse pregnancy outcomes in these women. Methods: This was a cross sectional study. Data were collected retrospectively from hospital electronic database of Lampang Regional Hospital (LPH) along with manual retrieval from medical charts and labor records. Data of all pregnant women who delivered at labor room of LPH were collected from 1st February 2011 to 31st August 2012. After preterm and multifetal pregnancies were excluded, 4747 cases were brought to the study. This study used the new weight gain recommendation from the Institute of Medicine and National Research Council to classify pregnant women by pre-pregnancy body mass index. Data were analyzed by univariate and multivariate analysis. Results: The proportions of pregnant women with different level of weight gain were 28.4%, 38.5% and 33.1% for low, normal and high weight gain. After multivariate analysis was done to control the confounders, women with high weight gain were significantly correlated with having preeclampsia, higher birth weight group, cesarean section and long neonatal length with relative risk (RR) and 95% confidence interval (95% CI) of 4.84 (2.31 - 10.16), 3.94 (3.24 - 4.79), 2.12 (1.82 - 2.47) and 2.33 (1.90 - 2.86). Conclusions: There were more than half of pregnant women that were prone to have inappropriate weight gain. Many complications from high weight gain that have been reported from aboard also occurred in Thai pregnant women. This should alert corresponding health institute to establish a new guideline to avoid high gestational weight gain.

Adverse pregnancy outcomes in women with high pre-pregnancy body mass index  [PDF]
Rajin Arora, Darin Arora, Jayanton Patumanond
Open Journal of Obstetrics and Gynecology (OJOG) , 2013, DOI: 10.4236/ojog.2013.32053
Abstract:

Background/Aims: Obesity along with high prepregnancy body mass index (PP-BMI) is known to cause many adverse pregnancy outcomes. In Thailand, there is not much study showing both the prevalence and complications of these conditions. The objectives of this study were to estimate the prevalence of prepregnancy overweight and obesity and their impacts on adverse pregnancy outcomes. Methods: This study was a cross sectional study. Data were collected retrospectively from hospital electronic database along with manual retrieval from medical charts and labor records. Data of all delivery women from 1st February 2011 to 31st August 2012 were collected. When excluded cases with incomplete data and those without PP-BMI, 5420 cases were into analysis. Descriptive and inferential data analyses were used with both univariate and multivariate methods. Results: The proportion of pregnant women with overweight and obesity were 11.1% and 3.9%. After multiple logistic regression analysis was done, women in obesity group were correlated with having 1, 2 and 3 complications. They were also correlated with preeclampsia, gestational diabetes, cesarean section, higher birth weight group and long neonatal length. Conclusions: This Thai prevalence of obesity in pregnancyshould alarm health care providers to be more prepared, for a future health problem of the country. Many complications that come with obese pregnant women that were reported in western countries also happen in Thai population. Decreasing body weight before conception, giving correct health education, well planned pregnancy; antenatal lifestyle intervention and even gestational weight gain restricttion could help avoiding these uneventful morbidities.

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