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Search Results: 1 - 10 of 1257 matches for " Arne Nysted "
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Predictive and Prognostic Impact of TP53 Mutations and MDM2 Promoter Genotype in Primary Breast Cancer Patients Treated with Epirubicin or Paclitaxel
Ranjan Chrisanthar,Stian Knappskog,Erik L?kkevik,Gun Anker,Bj?rn ?stenstad,Steinar Lundgren,Terje Risberg,Ingvil Mjaaland,Gudbrand Skj?nsberg,Turid Aas,Ellen Schlichting,Hans E. Fj?sne,Arne Nysted,Johan Richard Lillehaug,Per Eystein L?nning
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0019249
Abstract: TP53 mutations have been associated with resistance to anthracyclines but not to taxanes in breast cancer patients. The MDM2 promoter single nucleotide polymorphism (SNP) T309G increases MDM2 activity and may reduce wild-type p53 protein activity. Here, we explored the predictive and prognostic value of TP53 and CHEK2 mutation status together with MDM2 SNP309 genotype in stage III breast cancer patients receiving paclitaxel or epirubicin monotherapy.
The Effects of European Austerity Programmes on Social Security Systems  [PDF]
Arne Heise, Hanna Lierse
Modern Economy (ME) , 2011, DOI: 10.4236/me.2011.24055
Abstract: The recent financial and economic crisis is intensifying the pressure for budget consolidation,increasing the likelihood of cuts in social services throughout Europe. One government after another is bringing forward a budget consolidation programme. Cuts are envisaged above all in social services and so the question arises of what effects this will have on welfare states in EU member countries and on Social Europe in general. In this study cuts in social systems are analysed and compared, both planned and already undertaken. Regardless of the different magnitudes of the austerity efforts and the policy fields concerned there can be no doubt that all austerity programmes are regressive in nature and that the option of raising incomes is being exercised far less frequently than spending cuts and this applies especially in the social realm.
A Normative Model for Regional University Network Collaboration in Education  [PDF]
Arne Jensen, Rickard Bergqvist
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.326156
Abstract: Increasing demand for more specialized courses and programme increases the need for universities to differentiate their educational offer and portfolio. Increasing the course portfolio combined with small student populations at the same time ensuring high quality is a difficult challenge for most universities given their budget limitation and the access they have to educators in the specialized disciplines within their own organization. Pooling, coordination and utilization of resources through the creation of network creation and university collaborations is one option for coping with this challenge. This paper develops a normative model for intraregional university network collaboration in education aiming at preparing students for work in a particular industry. The paper deals with network organization, principles of operation, course structure, course delivery, and supporting activities.
Prediction and Verification of Resistance Spot Welding Results of Ultra-High Strength Steels through FE Simulations  [PDF]
Oscar Andersson, Arne Melander
Modeling and Numerical Simulation of Material Science (MNSMS) , 2015, DOI: 10.4236/mnsms.2015.51003
Abstract: Resistance spot welding (RSW) is the most common welding method in automotive engineering due to its low cost and high ability of automation. However, physical weldability testing is costly, time consuming and dependent of supplies of material and equipment. Finite Element (FE) simulations have been utilized to understand, verify and optimize manufacturing processes more efficiently. The present work aims to verify the capability of FE models for the RSW process by comparing simulation results to physical experiments for materials used in automotive production, with yield strengths from approximately 280 MPa to more than 1500 MPa. Previous research has mainly focused on lower strength materials. The physical weld results were assessed using destructive testing and an analysis of expulsion limits was also carried out. Extensive new determination of material data was carried out. The material data analysis was based on physical testing of material specimens, material simulation and comparison to data from literature. The study showed good agreement between simulations and physical testing. The mean absolute error of weld nugget size was 0.68 mm and the mean absolute error of expulsion limit was 1.10 kA.
The Exchange Rate Response of Credit-Constrained Exporters: The Role of Location  [PDF]
Trond-Arne Borgersen
Theoretical Economics Letters (TEL) , 2016, DOI: 10.4236/tel.2016.65096
Abstract: This paper analyses the exchange rate response of credit-constrained exporters and highlights location-driven balance sheet effects residing both on the real side and on the financial side of the economy. A model focusing the location of production relative to both credit markets and to the first and the second hand market for capital inputs introduces a number of balance-sheet driven exchange rate effects. When it comes to location, we consider four regimes, referred to as a developed, a developing and two transition economies that differ with respect to production technology and credit market structure, respectively. The export supply response differs both across countries at different stages of development as well as between countries with different strategies to globalisation.
Reproductive performance of Norwegian cattle from 1985 to 2005: trends and seasonality
Arne Refsdal
Acta Veterinaria Scandinavica , 2007, DOI: 10.1186/1751-0147-49-5
Abstract: In many countries there has been a decline in reproductive performance in dairy cattle. Several studies show increasing number of days from calving to first service and decreasing pregnancy rates, e.g. [1-5]. As a result, the number of inseminations per inseminated cow, days from calving to conception and calving intervals have increased. To improve fertility and save labour, various pharmaceuticals to control the oestrous cycle and to treat reproductive disorders are extensively used in many herds, e.g. [6,7]. During the last decades the productivity of dairy cattle has increased considerably in many countries, not least because of progress due to genetic improvement. However, a serious breeding concern is that estimates from a number of studies present unfavourable genetic correlations, on average near 0.3, between various fertility measures and production [8]. In contrast to many other countries, Norway has a long tradition of including fertility in the Total Merit Index (TMI). Viewed against this background, the primary objective of the present study was to describe the trends in some reproductive measures in Norway the last two decades. Seasonal variations in reproductive performance are also revealed.The results obtained in the present study are based on insemination reports and herd recording files in Norway comprising 66.8% of the herds in 1985 increasing to 94.2% in 2005 [9]. AI-technicians and veterinarians report all inseminations into the AI-database, and they are only paid when the inseminations are registered. From 1985 to 2005, the part of inseminations performed by veterinarians has increased from 45.8% to 59.7%. The rest of the inseminations was performed by technicians, but from 2002 also a small part by herdsmen, increasing from 0.3% to 0.7% in 2005. After attending an AI-course the herdsmen have to sign an agreement to report inseminations to the AI-database. Sixty days non return rates after single inseminations (NR60), return rates 0–3 days pos
Urban Densification and Recreational Quality of Public Urban Green Spaces—A Viennese Case Study
Arne Arnberger
Sustainability , 2012, DOI: 10.3390/su4040703
Abstract: Public urban green spaces play an important role in urban sustainability. These places should provide high-quality recreation experiences for the urban residents. However, they are often overused. The Wienerberg area in the south of Vienna, Austria, was transformed from a waste disposal site into a natural recreation area. During the past years, intensive settlement densification processes have taken place, resulting in a doubling of the local population living within a few minutes walking distance. An on-site survey among green space visitors (N = 231) revealed that the majority of them considered the area to be overcrowded on Sundays/holidays and reported a perceived increase in visitor numbers during the past years. Visitors with more past experience, as well as those who have perceived an increase in visitor numbers during recent years, reported higher crowding perceptions. A significant proportion of them try to avoid these crowds, relying on behavioral coping strategies, such as inter-area displacement. While urban regeneration has provided an attractive recreation area, urban densification around the green space appears to have reduced its recreational quality. Monitoring recreation quality indicators, such as crowding perceptions, seems to be useful for sustainable urban green space management and city planning.
Arne Oshaug
African Journal of Food, Agriculture, Nutrition and Development , 2002,
Abstract: What can be called `modern' food aid has changed considerably in the 1990's. It has strong political, agricultural, economic and trade features. Two publications[1,2], have assessed the nature of food aid, indicated future challenges and possible role, and provided recommendations for food aid policy measures. Also highlighted is the chain of events in the last 15-20 years, pointing to the transformation of the international system as a result of political events at national and global level are addressed. Issues discussed are for example food aid in relation to human insecurity and humanitarian crisis, poverty, need for institutional reform, World Trade Organization (WTO) and mounting globalization, World Food Program, Food Aid Convention, humanitarian law, human rights and codes of conduct with emphasis on humanitarian assistance. Food aid as a development tool is questioned, and what will happen when food aid is drying out. The books provide a comprehensive analysis and are highly recommended.
Pragma-semantische Analysen zur Erforschung interkultureller Kommunikation Pragma-semantic Analysis for Researching Intercultural Communication Análisis semántico-pragmático para investigar la comunicación intercultural
Arne Weidemann
Forum : Qualitative Social Research , 2008,
Abstract: Auf Basis von Ernst E. BOESCHs "Symbolic Action Theory" (1991), und der relationalen Hermeneutik von STRAUB und SHIMADA (1999) sowie der Grounded-Theory-Methodologie (GLASER & STRAUSS 1967; STRAUSS & CORBIN 1990) wird ein integrativer Ansatz zur Analyse (inter-) kultureller Handlungs- und Bedeutungszusammenh nge vorgestellt. Das Ziel einer solchen pragma-semantischen Analyse ist die Bestimmung, Differenzierung und Kontextualisierung des interessierenden Ph nomens durch die Untersuchung vollzogener wie potenziell m glicher Handlungen und Objektivationen. Die pragma-semantische Analyse verdeutlicht, aus welchen Quellen bzw. welchen Symbolbest nden individuell wie kollektiv verfügbare denotative und konnotative Aspekte von Handlungen stammen und wie dies in (durch die Analyse erst als interkulturell auszuweisende) Interaktionen zum Tragen kommt. Am konkreten empirischen Beispiel des Umgangs einer deutschen Touristin mit Bettler/innen in Indien soll die Vorgehensweise verdeutlicht sowie gezeigt werden, dass das pragma-semantische Netz es im Hinblick auf konkrete Handlungen und Interaktionen auch erlaubt, Handlungsm glichkeiten und potenzielle Bedeutungszusammenh nge auszuweisen, d.h. den subjektiven wie objektiven M glichkeitsraum zu bestimmen. Darüber hinaus werden die Implikationen des Ansatzes für die Erforschung interkultureller Kommunikation sowie die Forschungspraxis diskutiert. URN: urn:nbn:de:0114-fqs0901373 Based on Ernst E. BOESCH's symbolic action theory (1991), the concept of relational hermeneutics (STRAUB & SHIMADA, 1999; STRAUB, 2006) and within the framework of grounded theory methodology (GLASER & STRAUSS, 1967; STRAUSS & CORBIN, 1990) this paper presents an integrative approach to the analysis of complex (inter)cultural action and meaning relations. The objective of pragma-semantic analysis is the identification, differentiation and contextualization of phenomena by analyzing performed as well as potentially possible actions and objectivations. Pragma-semantic analysis tries to reveal from which sources resp. pools of symbols individually as well as collectively available denotative and connotative aspects of actions derived. Further it can be utilized to show how these meanings come to bear in interactions that—through the analysis—have to be identified as intercultural in the first place. Using the empirical example of a German tourist's narrative of her interaction with beggars in India, the paper will outline the approach and show to what extent the pragma-semantic web also allows conclusions on action-possiblities and potential meaning
Time Models in Estonian Traditional and Literary Ballads
Arne Merilai
Folklore : Electronic Journal of Folklore , 1997,
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