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Search Results: 1 - 10 of 723 matches for " Arijit Gandhi "
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Preparation and Characterization of Maleic Anhydride Cross-Linked Chitosan-Polyvinyl Alcohol Hydrogel Matrix Transdermal Patch
Parimal Maji *,Arijit Gandhi,Sougata Jana,Nirmal Maji
Journal of PharmaSciTech , 2013,
Abstract: Transdermal drug delivery systems are polymeric patches containing dissolved or dispersed drugs that deliver therapeutic agents at a constant rate to the human body. Matrix type transdermal patches were prepared using alprazolam as a model drug and employing the combinations of chitosan-polyvinyl alcohol (CS-PVA) cross linked with Maleic anhydride. The transdermal patches were evaluated for their physicochemical properties like thickness, tensile strength, folding endurance, drug content, swellability, surface pH, water vapour transmission, in vitro permeation and skin irritation studies. FTIR study indicated no interaction between drug and polymers. The permeability of alprazolam was increased with increase in PVA content. The in vitro drug permeation followed Higuchi kinetics as its coefficient of correlation value predominates over zero order and first order kinetics. Also the diffusion coefficient of release profiles had a value of nearly 0.5, which indicated Fickian transport diffusion. The patches were found to be free of any skin irritation.
Recent Trends of Phytosomes for Delivering Herbal Extract with Improved Bioavailability
Arijit Gandhi,Avik Dutta,Avijit Pal,Paromita Bakshi
Journal of Pharmacognosy and Phytochemistry , 2012,
Abstract: In the recent days, most of the prevailing diseases and nutritional disorders are treated with natural medicines. The effectiveness of any herbal medication is dependent on the delivery of effective level of the therapeutically active compound. But a severe limitation exists in their bioavailability when administered orally or by topical applications. Phytosomes are recently introduced herbal formulations that are better absorbed and as a result produced better bioavailability and actions than the conventional phyto molecules or botanical extracts. Phytosomes are produced by a process whereby the standardized plant extract or its constituents are bound to phospholipids, mainly phosphatidylcholine producing a lipid compatible molecular complex. Phytosome exhibit better pharmacokinetic and pharmacodynamic profile than conventional herbal extracts. The present review represents the recent advancesand applications of various standardized herbal extract phytosomes as a tool of drug delivery.
Simulation and Optimization of a Quarterwave Transformer for a W- Band Reducedheight Type IMPATT Oscillator
International Journal of Engineering Science and Technology , 2011,
Abstract: Millimeter-wave frequencies are gaining importance for applications in solid state transmitters for radar, radiometry, or short-range communication systems. The high-power pulsed IMPATT diode has beenproven to be best suitable for these applications. The most commonly used mm-wave IMPATT oscillator is a reduced-height waveguide circuit cross coupled with a coaxial line. The mounting parasitics at millimeter-waves usually limit output power and efficiency of these kinds of oscillators. In the current paper the author has carriedout modeling, simulation and optimization of a quarter-wave step transformer section for a W-band reduced height type IMPATT oscillator by using High Frequency Structure Simulator (HFSS). Also an easy method of designing and optimizing a tapered impedance transformer section has also been investigated using HFSS.
Case Based Reasoning with State Transition Mechanism for Problem-Solving in AI
Arijit Chatterjee
IAENG International Journal of Computer Science , 2006,
Obituary - Dr. B. C. Lahiri
Coondoo Arijit
Indian Journal of Dermatology, Venereology and Leprology , 2008,
Biologics in dermatologic therapy - An update
Coondoo Arijit
Indian Journal of Dermatology , 2009,
Abstract: Biologics are protein molecules which are used in various diseases to target the specific points in the immunopathogenesis of the diseases. The molecules are produced by recombinant DNA technology. The molecules bind to the specific targets without interfering wtih rest of the pathogenetic pathways. Therefore the so called ′immunosuppressives′ have, although, a broader broader spectrum of action on immune system, their side-effects are also equally more. The biologics, because of their spefic action on the immune system, have very little side effects. The biologics which have revolutionized the treatment of various dermatologic diseases have been discussed here.
Dr. Bhabesh Chandra Lahiri- (11.8.1932 to 5.8.2006)
Coondoo Arijit
Indian Journal of Dermatology , 2008,
Shri. Jhori Patra
Coondoo Arijit
Indian Journal of Dermatology , 2009,
29th National Conference Of IADVL Dermartech 2001
Coondoo Arijit
Indian Journal of Dermatology , 2001,
Arijit Das
International Journal of Pharmaceutical Research and Development , 2010,
Abstract: The aim of present research work was to prepare and evaluate transdermal drug delivery (TDDS) of metformin hydrochloride (MFH). MFH is an agonist at a2 -adrenergic receptor sites. The drug undergoes rapid first pass metabolism (approximately 95% of dose) which necessitates its frequent dosing by oral route. Transdermal drug delivery system of MFH was prepared using combinations of a hydrophobic polymer, ethyl cellulose and hydrophilic polymer, polyvinyl pyrrolidone in different ratios (1:2, 1:4, 1:6, 1:8, 2:1, 4:1, 6:1 and 8:1 w/w) by solvent evaporation technique. Polyvinyl alcohol was used to prepare the backing membrane and dibutyl phthalate as plasticizer. The prepared polymeric films were characterized for various physiochemical parameters like film thickness, tensile strength, moisture content, moisture uptake, water vapour transmission rate. Permeation studies were carried out for patches through commercial semi-permeable membrane as well as rat abdominal skin using Keshary-Chien diffusion cell. Formulation FC6 showed 96.92% drug release from the patch within 24 h in in vitro diffusion cell and was selected for ex vivo skin permeation and drug release data of selected patch showed good fit into Higuchi equation. The effect of storage on in vitro release and physiochemical parameters of selected patch was found within the acceptable limits. The drug polymer interaction study does not show any significant incompatibility among the drug and polymers.
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