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Formulation and evaluation of domperidone pellets prepared by powder layering technology
Kibria Golam,Akhter Afsana,Ariful Islam K
Asian Journal of Pharmaceutics , 2010,
Abstract: The goal of the present study is to evaluate the influence of the formulation and operating conditions on pellet preparation by the pan technique. The effect of initial core weight on the physical parameters of pellets as well as to conduct stability study was also the goal of this study. For this domperidone maleate was selected as the model drug. Pellets were prepared by layering of powdered drug on sugar-based cores. Inert cores were intermittently treated with micronized drug powder and binding solution. This treatment led to the formation of multiple layers of drug particles around an inert core resulting in the production of pellets that can further be coated by different polymers to obtain modified release formulations. Scanning electron microscopy was employed to image the surface morphology of the prepared pellets. Drug loading efficiency, % yield, size, and shape uniformity of pellets were increased along with increasing the initial core weight. Drug content and dissolution study were performed by following HPLC and UV-Visible method. About 50% and 80% drug was released within 7.72 m and 13.66 m respectively in 0.1N HCl media (pH 1.2). Physical appearance of the prepared pellets, potency, moisture content, pellets size and shape, dissolution data, release rate constant, diffusion exponent (P< .05) over the stability period showed that the system is efficient for the production of highly stable formulations. This study also showed the good performance of the conventional coating pan system in obtaining instant release domperidone pellets prepared by the powder layering technique.
EVALUATION OF THROMBOLYTIC ACTIVITY AND BRINE SHRIMP LETHALITY BIOASSAY OF METHANOL EXTRACT OF STEMS OF TINOSPORA CRISPA
Md. Ariful Islam , Z. A. Mahmud*, S.M. Abdur Rahman , Md. Monirujjaman and Sajal K. Saha
International Journal of Pharmaceutical Sciences and Research , 2013,
Abstract: ABSTRACT: Tinospora crispa, a plant belonging to the family of Menispermaceae is a well-known traditional medicinal plant used in Bangladesh. The methanolic extracts of stems of the plant were evaluated for their thrombolytic and preliminary cytotoxic activities. The thrombolytic activity was evaluated using the in vitro clot lysis model while while the screening of cytotoxic activity was done using brine shrimp lethality bioassay. Different concentrations of stem extract were made in isotonic saline (2.5, 5, 10 and 20 mg/ml) and added to pre-clotted human blood (n=13) and the clot lysis activity was determined following 90 minute incubation at 37o C. The results showed that T. crispa stem extract induced mild to moderate (14.81- 25.73%) and significant (p <0.001) clot lysis activity whereas the standard Streptokinase (30,000 I.U.) evoked a significant (p < 0.001) clot lysis activity (50.1%). In Brine shrimp lethality bioassay, the LC50 values of methanolic crude extract and its pet ether, chloroform and aqueous fractions were found to be 6.43, 0.8. 4.58 and 7.46 g/ml respectively which were comparable to the standard vincristine sulphate (LC50: 0.107 μg/ml). The results of the study demonstrated that the stem of the plant possesses promising thrombolytic activity in vitro when tested on human blood as well as preliminary cytotoxic activity on Brine shrimp. However, further study is needed to see its potentiality as thrombolytic medicine.
Efficacy and Economics of Different Need Based Nitrogen Management Approaches in Winter Rice  [PDF]
Nilufar Akhtar Jahan, Sabina Yeasmin, Md. Parvez Anwar, Md. Ariful Islam, Hamidur Rahman, A. K. M. Mominul Islam
American Journal of Plant Sciences (AJPS) , 2018, DOI: 10.4236/ajps.2018.913189
Abstract: This experiment aimed to study the efficacy of different nitrogen (N) management approaches in winter rice. The experiment consisted of two rice varieties: 1) BRRI (Bangladesh Rice Research Institute) dhan29-an inbred and 2) Dhanigold-a hybrid, and eight N management approaches: 1) BRRI recommended N (control), 2) Soil analysis based N management, 3) N application based on Agro-ecological zone, 4) 20 kg·N·ha-1 at ≤35 SPAD (Silicon photon activate diode) value, 5) 30 kg·N·ha-1 at ≤35 SPAD value, 6) 20 kg·N·ha-1 at ≤3.0 LCC (leaf colour chart) value, 7) 30 kg·N·ha-1 at ≤3.0 LCC value and 8) Urea Super Granule. Between two varieties, hybrid Dhani gold produced higher grain yield (6.67 t·ha-1) than the inbred BRRI dhan29. Application of 20 kg·N·ha-1 at ≤3.0 LCC value gave the highest grain yield (7.10 t·ha-1), whereas the lowest grain yield (5.92 t·ha-1) was found from the SPAD approach with 20 kg·N·ha-1 at ≤35 SPAD value. In case of treatment interaction highest grain yield (7.34 t·ha-1) was found in BRRI dhan29 coupled with 20 kg·N·ha-1 at ≤3.0 LCC value with 18 kg·N·savings·ha-1 over control, maximum gross income (146,800 BDT·ha-1) and net benefit (142,120 BDT·ha-1), which was statistically identical with the grain yield from the interaction of Dhani gold and 30 kg·N·ha-1 at ≤3.0 LCC value but required 42 kg·extra·N·ha-1 (over control). The lowest grain yield (5.19 t·ha-1) was found when Dhanigold was coupled with 30 kg·N·ha-1 at ≤35 SPAD value, while the 20 kg·N·application·ha-1 at ≤35 SPAD value gave moderate yield (6.87 t·ha-1) with considerable higher gross (139,600 BDT·ha-1) and net (136,090 BDT·ha-1) incomes than the control (gross: 121,000 and net: 115,600 BDT·ha-1). The results reveal that 20 kg·N·ha-1 at ≤3.0 LCC value appeared as the promising practice for inbred BRRI dhan29, and 30 kg·N·ha-1 at ≤35 SPAD value for hybrid Dhanigold in terms of yield, N use efficiency and economic benefit of winter rice.
Survey of Feline Influenza and Feline Leukemia Virus Infection in Local Breed Cats of Bangladesh
Md. Aminul Islam,M.S. Rahman,S.A. Rony,M.J. Uddin,A.K.M.A. Rahman,M.T. Islam,M. Ariful Islam
International Journal of Tropical Medicine , 2012, DOI: 10.3923/ijtmed.2012.98.102
Abstract: Feline Influenza Virus (FInV) and Feline Leukemia Virus (FeLV) are two important viruses causing cat flu and neoplastic disease all over the world, respectively but to the knowledge, there is no epidemiological survey report available for these two killer diseases in cat in Bangladesh. Therefore, the present study was aimed to determine the prevalence of FInV and FeLV infection through an epidemiologic survey in selected areas of Bangladesh. For this purpose, a total 60 randomly selected cats consisting of 48 pet and 12 stray cats at Tangail district in Bangladesh during May to October, 2009 were used. Nasal swab and blood sample were collected from all cats and tested by commercial rapid RapiGEN Feline Influenza Virus (FInV) Ag Test kit and RapiGEN Feline Leukemia Virus (FeLV) Ag Test kit, respectively following the manufacturer s (RapiGEN Inc., Korea) instructions. Results revealed the overall prevalence of feline influenza and feline leukemia recorded 5.0 and 1.67%, respectively in cats. There was no significant relationship between the diseases (FInV and FeLV) and different variables. However, the knowledge of the status of FInV and FeLV in cats in the study area will be helpful to undertake preventive measures for FInV and FeLV infection.
Role of Routine Benzodiazepin in Eliciting Classical Electroencephalogram (EEG) Response in Suspected Sub-Acute Sclerosing Panencephalitis (SSPE) Cases  [PDF]
Yamin Shahriar Chowdhury, Narayan Chandra Saha, M. Abdullah Yusuf, Ariful Islam, S. K. Azimul Hoque, Rajib Nayan Chowdhury, M. Enayet Hussain
World Journal of Neuroscience (WJNS) , 2017, DOI: 10.4236/wjns.2017.71003
Abstract: Background: EEG could be normal or atypical in spite of suggestive clinical features and positive measles Ab of SSPE cases which could have typical EEG pattern after Benzodiazepine. Objectives: The purpose of the present study was to find out the necessity of administration of benzodiazepine during EEG recording of SSPE cases as well as to compare the efficacy of diazepam and midazolam in eliciting EEG pattern. Methodology: This double blind, parallel, single centered, non-randomized clinical trial was conducted in the Department of Pediatric Neurology at National Institute of Neurosciences, Dhaka, Bangladesh from July 2014 to June 2015 for a period of 1 (one) year. All the clinical and investigational suspected cases of sub-acute Sclerosing Panencephalitis (SSPE) children in both sexes were included as study population. Others neurodegenerative diseases including Wilson’s disease were excluded from this study. Patients were divided into two groups named as group A who were given diazepam and the other group B was given midazolam in IV during EEG recording. The clinical outcomes were measured and were recorded in a pre-designed data sheet. Result: The characteristic typical periodic slow wave complex (PSWC) was found only in 8 (30.8%) patients among the 26 (100.0%) before intervention with benzodiazepines. The remaining 18 (69.2%) had non-typical PSWC of which 10 (38.5%) were normal, 3 (11.5%) with atypical PSWC and 5 (19.2%) were with other EEG findings. After intervention with benzodiazepines, 23 (88.5%) had shown typical PSWC and only 3 (11.5%) had non-typical PSWC. Among the typical PSWC cases after intervention, 8 (30.8%) had normal EEG initially, 5 (19.2%) had other EEG finding, 2 (7.7%) had non-typical PSWC and 8 (30.8%) had typical PSWC from the beginning. Of the 3 (11.5%) of the non-typical PSWC of intervention group, 2 (7.7%) had shown no changes in EEG from the beginning and 1 (3.8%) had shown other EEG finding. The difference between before and after intervention was actually statistically extremely significant (p < 0.0001). Among the two study groups, 11 (84.6%) and 12 (92.3%) patients had shown typical PSWC respectively in Group A and Group B after intervention. The non-typical PSWC was seen in 2 (15.4%) of Group A and 1 (7.7%) of Group B patients. The statistical difference between the two groups was not significant (p > 0.05). Conclusion: The role of benzodiazepine is very obvious in eliciting the typical EEG pattern in SSPE patients which has
A Modified and Secured RSA Public Key Cryptosystem Based on “n” Prime Numbers  [PDF]
Muhammad Ariful Islam, Md. Ashraful Islam, Nazrul Islam, Boishakhi Shabnam
Journal of Computer and Communications (JCC) , 2018, DOI: 10.4236/jcc.2018.63006
Abstract: Cryptography is the study that provides security service. It concerns with confidentiality, integrity, and authentication. Public key cryptography provides an enormous revolution in the field of the cryptosystem. It uses two different keys where keys are related in such a way that, the public key can use to encrypt the message and private key can be used to decrypt the message. This paper proposed an enhanced and modified approach of RSA cryptosystem based on “n” distinct prime number. This existence of “n” prime number increases the difficulty of the factoring of the variable “N” which increases the complexity of the algorithm. In this approach, two different public key and private key generated from the large factor of the variable “N” and perform a double encryption-decryption operation which affords more security. Experiment on a set of a random number provided that the key generation time, analysis of variable “N”, encryption and decryption will take a long time compared to traditional RSA. Thus, this approach is more efficient, highly secured and not easily breakable.
MHD MICROPOLAR FLUID FLOW THROUGH VERTICAL PLATE WITH HEAT GENERATION
Prodyut Biswas,Amranul Hoque Jony,Ariful Islam
Academic Research International , 2012,
Abstract: The numerical studies are performed to examine the micropolar fluid flow past an infinite vertical heated generation in a magnetic field. Finite difference technique is used as a tool for the numericalapproach. The micropolar fluid behavior on two- dimensional unsteady flow has been considered and its non similar solution have been obtained. No similar equations of the corresponding momentum, angular momentum, energy and continuity equations are derived by employing the usual transformations. The dimensionless non similar equations for momentum, angular momentum, energy equation and continuity equations are solved numerically by finite difference technique. The effects onthe velocity, microrotation, the spin gradient viscosity, Prandtl number, Grashoff number and Eckert number of the various important parameters entering into the problem separately are discussed with the help of graphs.
Cutting a Cornered Convex Polygon Out of a Circle
Syed Ishtiaque Ahmed,Md. Ariful Islam,Masud Hasan
Journal of Computers , 2010, DOI: 10.4304/jcp.5.1.4-11
Abstract: The problem of cutting a convex polygon P out of a piece of planar material Q with minimum total cutting length is a well studied problem in computational geometry. Researchers studied several variations of the problem, such as P and Q are convex or non-convex polygons and the cuts are line cuts or ray cuts. In this paper we consider yet another variation of the problem where Q is a circle and P is a convex polygon such that P is bounded by a half circle of Q and all the cuts are line cuts. We give two algorithms for solving this problem. Our first algorithm is an O(log n)-approximation algorithm with O(n) running time, where n is the number of edges of P. The second algorithm is a constant factor approximation algorithm with approximation ratio 6.48 and running time O(n3).
Cutting a Convex Polyhedron Out of a Sphere
Syed Ishtiaque Ahmed,Masud Hasan,Md. Ariful Islam
Computer Science , 2009,
Abstract: Given a convex polyhedron $P$ of $n$ vertices inside a sphere $Q$, we give an $O(n^3)$-time algorithm that cuts $P$ out of $Q$ by using guillotine cuts and has cutting cost $O((\log n)^2)$ times the optimal.
MHD MICROPOLAR FLUID FLOW THROUGH VERTICAL POROUS MEDIUM
Ariful Islam,Md. Haider Ali Biswas,Md. Rizaul Islam,S.M Mohiuddin
Academic Research International , 2011,
Abstract: The numerical studies are performed to examine the MHD micro-polar fluid flow through a vertical porous plate. Finite difference technique is used as a tool for the numerical approach. Themicro-polar fluid behavior on two- dimensional unsteady flow has been considered and its nonsimilar solution have been obtained. Non-similar equations of the corresponding momentum, angular momentum and continuity equations are derived under MHD effect by employing theusual transformation. The dimensionless non-similar equations for momentum, angular momentum and continuity equations are solved numerically by finite difference technique. The effects on the velocity, micro rotation, the spin gradient viscosity, and vortex viscosity of the various important parameters entering into the problem separately are discussed with the help of graphs.
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