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Search Results: 1 - 10 of 2222 matches for " Apostolovi? Milan "
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TENECTEPLASE AS A NEW MEDICATION IN MANAGING NO-REFLOW
Milan ?ivkovi?,Svetlana Apostolovi,Milan Pavlovi?,Sonja ?alinger Martinovi?
Acta Medica Medianae , 2012,
Abstract: No-reflow has been defined as “inadequate myocardial perfusion through a given segment of coronary circulation without angiographic evidence of a mechanical obstruction”. Important components of the process are thought to include endothelial ischemic injury producing “blebs” of tissue that directly obstruct the microvasculature, leukocyte plugging of capillaries, and the vascular effects of reactive oxygen species. No-reflow can complicate any percutaneous intervention (PCI), though it is more common following acute myocardial infarctions (MI), particularly with prolonged occlusion times. A 59-year-old woman presented to the hospital after two hours of continuous chest pain. Because of acute myocardial infarction of the inferior and lateral wall, she underwent direct stenting to an occlusion in the right coronary artery. Despite successful implantation of stents revascularization failed. In absence of aspiration devices and other pharmacological agent we decide to apply 30 mg (6000 IU) tenecteplase intracoronary. Three min after administration TIMI flow grade improved from TIMI 0 to TIMI 3. Managing no-reflow can be approached in a number of different ways and needs to be tailored to the type of intervention being performed. As confirmed in practice, prevention is better than cure and both mechanical and pharmacological approaches can be employed in high risk cases. In the setting of acute myocardial infarction the most effective preventative measure is the rapid opening of the vessel and as such the development of a robust and efficient primary PCI service is integral to the avoidance of this complication. Managing no-reflow will become increasingly important with the wider development of primary PCI. Within the setting of acute myocardial infarctions with no reflow as primary percutaneous intervention complication, there are potential important future pharmacological regimens that may become established and one of them can be tenecteplase.
USEFULNESS OF FUNCTIONAL LESION ASSESSMENT BY CORONARY PRESSURE MEASUREMENT IN CLINICAL CONDITIONS
Miloje Toma?evi?,Branko Beleslin,Svetlana Apostolovi,Milan Pavlovi?
Acta Facultatis Medicae Naissensis , 2005,
Abstract: The shortcomings of coronary arteriography to assess the physiological significance of coronary stenosis have been recognised for decades. Noninvasive test can be inconclusive in some patients. In patients with moderate coronary stenosis, fractional flow reserve (FFR) provide important information and appears to be a useful index of the functional severity of the stenosis and need for coronary revascularization. FFR is invasive index of stenosis severity that is a substitute for noninvasive stress testing. A patient with long stenosis of the mid and distal right coronary artery and inconclusive noninvasive test was presented. FFR was significantly improved, from 0,45 to 0,92, after the coronary intervention. It predicts low restenosis rate.
ACUTE MYOCARDIAL INFARCTIONTHERAPY IN WOMEN
Ru?ica Jankovi?,Milan Pavlovi?,Svetlana Apostolovi,Danijela Djordjevi?-Radojkovi?
Acta Medica Medianae , 2004,
Abstract: Although after the AHA/ACC recommendations there should be no sex differences regarding the diagnostic and therapeutic procedures in acute coronary syndrome and secondary prevention of coronary disease (CD), they still persist not only in our country but also in other, much more developed and equipped hospitals of the West. It has been demonstrated that the discrepancy is primarily conditioned by the advanced age of women and consequently advanced cardiac status at CD presentation, as well as a greater burden of comorbidity in this patient population. Aim of this paper was to assess the sex differences in therapeutic approach in our patients with their first acute myocardial infarction.The investigation enrolled 320 patients (94 women and 226 men) treated in the Coronary Unit, Clinic for Cardiovascular diseases, Clinical Center Nis in the acute phase of the first myocardial infarction. In the experimental sample women were significantly older than men (62,95 ± 8,16 vs 57,73 ± 10,24; p<0,0001). Based on the stratification of both sexes into the age groups, it was demonstrated that there were significantly less women with acute myocardial infarction (AIM) below 55 years of age, and significantly more in more advanced age groups (between 65 and 74 years of life). Compared to men, it was observed that women with AIM significantly less often received fibrinolytic therapy (40% vs 58%; p<0,05). Average age of women receiving fibrinolytic agents was 65,67±8,69 years and men 56,09±10,7, which was of statistical significance (p<0,05). There were no significant differences regarding other groups of drugs. Medicamentous treatment of AIM in our country follows the up-to-date recommendations of European and worldwide associations of cardiologists. The only difference observed was infrequent use of fibrinolytic therapy in women due to sex-conditioned reasons, including different AIM presentation, patient age and complication proneness.
THE FREQUENCY OF LEFT VENTRICULAR HYPERTROPHY IN PATIENTS WITH ARTERIAL HYPERTENSION AND OBESE PATIENTS WITH ARTERIAL HYPERTENSION
Suzana Milutinovi?,Milan Pavlovi?,Miloje Toma?evi?,Svetlana Apostolovi
Acta Medica Medianae , 2005,
Abstract: The aim of this research was to investigate the potential relationship between the longterm exposure to air pollution, as a risk factor, and the development of allergic reactions in the population. The observed sample consisted of Nis citizens of different age groups who lived in areas with high concentrations of air pollutants (investigated group) such as the Square of the October Revolution and Sindjelic’s Square (investigated group), as well as the citizens of Niska Banja (control group) which is the zone with the lowest concentration of air pollution. The investigation was carried out in the Public Health Institute in the period between 1996 and 2000. A significance test was performed using a Mantel-Haenszel chi square test. This test was used to check for a statistically significant difference between the incidence of the obstructive lung disease between the investigated group and the control group across all age groups. The cross-risk and relative risk were determined. The highest value of the chi square test was determined in the age group 26-50 (RR=3.50), in the group up to 25, RR=2.25, and in the group above 51, RR=1.89. The obtained results prove that the incidence of the obstructive lung disease is significantly higher in the exposed population than in the non-exposed.
Assessment of health-related quality of life in patients after acute myocardial infarction
Ran?i? Nata?a,Petrovi? Branislav,Apostolovi? Svetlana,Mandi? Milan
Medicinski Pregled , 2011, DOI: 10.2298/mpns1110453r
Abstract: Introduction. Acute myocardial infarction has negative influence on patient’s quality of life. The objective of the paper was to assess the healthrelated quality of life in the patients one month and twelve months after acute myocardial infarction and to compare it with the healthy controls. Material and Methods. A prospective cohort study involved 160 patients aged from 30 to 79 and 240 healthy controls. The health-related quality of life was assessed with the Serbian version of these questionnaires: Euro- Quol-5-Dimension and EuroQuolVAS. Angina pectoris was ranked according to the classification of Canadian Cardiovascular Society. Multivariate logistic regression analysis was used. Results. The healthy controls had significantly higher average scores in EuroQuolVAS compared with the patients one month after acute myocardial infarction (74.35±9.42 vs 60.50±12.03, p<0.001), as well as twelve months after acute myocardial infarction (74.35±9.42 vs 69.83±12.06, p<0.001). Significantly lower average ranges in EuroQuol-5-Dimension questionnaire and higher quality of life were found twelve months after acute myocardial infarction than one month after acute myocardial infarction (1.41±0.26 vs 1.53±0.26, p<0.001). The average ranges of angina pectoris were significantly lower in all the patients twelve months after acute myocardial infarction compared with the first month (0.78±0.51 vs 0.91±0.44, p<0.001). The multivariate regression analysis confirmed thrombolytic therapy, percutaneous transluminal angioplasty and age to be important factors influencing health-related quality of life. Conclusion. The patients assessed their health condition to be significantly higher twelve months after acute myocardial infarction than one month after it. The health-related quality of life was significantly higher in patients who had undergone the percutaneous intervention than in those who had been treated with the thrombolytic therapy.
Review of thirty patients with bone chondroblastoma
Slavkovi? Slobodan,Tomi? Slavko,Slavkovi? Nemanja,ApostoloviMilan
Vojnosanitetski Pregled , 2005, DOI: 10.2298/vsp0510705s
Abstract: Background/Aim. To analyse the results of the treatment of the patients with the diagnosis of chondroblastoma, to confirm the possible malignancy and to recommend the best and the safest method of the treatment. Methods. We reviewed the cases of 30 patients with chondroblastoma who were treated between 1975 and 2004. Data were obtained using complete medical documentation, physical examinations, radiographic findings, and the available additional diagnostic procedures. Results. We found that the proximal part of the tibia, proximal part of the humerus, and distal part of the femur were the most common sites of the tumor in 63% of the cases. The higher prevalence of chondroblastoma in male patients was found, especially in the second decade of life. The patients were treated with different surgical procedures after histologically confirmed chondroblastoma. In 1 of the patients, radiation therapy was performed because the lesion recurred, after which the malignant transformation of chondroblastoma occurred. We found two more malignant chondroblastomas, one of which had been diagnosed as a primary tumor. Seven patients had a local recurrence, one of them had a second recurrence and the malignant transformation of chondroblastoma. The only solution was a below knee amputation. Conclusion. Chondroblastoma of bone is a rare lesion with the high local recurrence rate. We emphasized the need for an adequate and rapid diagnosis, including histological verification. The treatment was strictly surgical. The basic goal of the treatment was to avoid tumor penetration into articular cavity and/or local soft tissues. Malignant chondroblastoma of bone should be treated with radical surgical resection, avoiding any adjuvant therapy.
Model of an Atom by Analogy with the Transmission Line  [PDF]
Milan Perkovac
Journal of Modern Physics (JMP) , 2013, DOI: 10.4236/jmp.2013.47121
Abstract:

Model of an atom by analogy with the transmission line is derived using Maxwells equations and Lorentz theory of electrons. To be realistic such a model requires that the product of the structural coefficient of Lechers transmission lines σ and atomic number Z is constant. It was calculated that this electromechanical constant is 8.27756, and we call it structural constant. This constant builds the fine-structure constant 1/α = 137.036, and with permeability μ, permittivity ε and elementary charge e builds Plank’s constant h. This suggests the electromagnetic character of Planck’s constant. The relations of energy, frequency, wavelength and momentum of electromagnetic wave in an atom are also derived. Finally, an equation, similar to Schrodinger’s equation, was derived, with a clear meaning of the wave function, which represents the electric or magnetic field strength of the observed electromagnetic wave.

Determination of the Structural Constant of the Atom  [PDF]
Milan Perkovac
Journal of Applied Mathematics and Physics (JAMP) , 2014, DOI: 10.4236/jamp.2014.23002
Abstract:

The equations for energy, momentum, frequency, wavelength and also Schr?dinger equation of the electromagnetic wave in the atom are derived using the model of atom by analogy with the transmission line. The action constant A0 = (μ0/ε0)1/2s02e2 is a key term in the above mentioned equations. Besides the other well-known quantities, the only one unknown quantity in the last expression is a structural constant s0. Therefore, this article is dedicated to the calculation of the structural constant of the atoms on the basis of the above mentioned model. The structural constant of the atoms s0 = 8.277 56 shows up as a link between macroscopic and atomic world. After calculating this constant we get the theory of atoms based on Maxwells and Lorentz equations only. This theory does not require Planck constant h, which once was introduced empirically. Replacement for h is the action constant A0, which is here theoretically derived, while the replacement for fine structure constant α is 1/(2s02). In this way, the structural constant s0 replaces both constants, h and α. This paper also defines the stationary states of atoms and shows that the maximal atomic number is equal to 2s02 = 137.036, i.e., as integer should be Zmax=137. The presented model of the atoms covers three of the four fundamental interactions, namely the electromagnetic, weak and strong interactions.

Maxwell’s Equations as the Basis for Model of Atoms  [PDF]
Milan Perkovac
Journal of Applied Mathematics and Physics (JAMP) , 2014, DOI: 10.4236/jamp.2014.25029
Abstract: A century ago the classical physics couldn’t explain many atomic physical phenomena. Now the situation has changed. It’s because within the framework of classical physics with the help of Maxwell’s equations we can derive Schrödinger’s equation, which is the foundation of quantum physics. The equations for energy, momentum, frequency and wavelength of the electromagnetic wave in the atom are derived using the model of atom by analogy with the transmission line. The action constant A0 = (μ0/ε0)1/2s02e2 is a key term in the above mentioned equations. Besides the other well-known constants, the only unknown constant in the last expression is a structural constant of the atom s0. We have found that the value of this constant is 8.277 56 and that it shows up as a link between macroscopic and atomic world. After calculating this constant we get the theory of atoms based on Maxwell’s and Lorentz equations only. This theory does not require knowledge of Planck’s constant h, which is replaced with theoretically derived action constant A0, while the replacement for the fine structure constant α-1 is theoretically derived expression 2s02 = 137.036. So, the structural constant s0 replaces both constants h and α. This paper also defines the stationary states of atoms and shows that the maximal atomic number is equal to Zmax = 137. The presented model of the atoms covers three of the four fundamental interactions, namely the electromagnetic, weak and strong interactions.
Stochastic Resonance Synergetics—Quantum Information Theory for Multidimensional Scaling  [PDF]
Milan Jovovic
Journal of Quantum Information Science (JQIS) , 2015, DOI: 10.4236/jqis.2015.52007
Abstract: A quantum information theory is derived for multidimensional signals scaling. Dynamical data modeling methodology is described for decomposing a signal in a coupled structure of binding synergies, in scale-space. Mass conservation principle, along with a generalized uncertainty relation, and the scale-space wave propagation lead to a polynomial decomposition of information. Statistical map of data, through dynamical cascades, gives an effective way of coding and assessing its control structure. Using a multi-scale approach, the scale-space wave information propagation is utilized in computing stochastic resonance synergies (SRS), and a data ensemble is conceptualized within an atomic structure. In this paper, we show the analysis of multidimensional data scatter, exhibiting a point scaling property. We discuss applications in image processing, as well as, in neuroimaging. Functional neuro-cortical mapping by multidimensional scaling is explained for two behaviorally correlated auditory experiments, whose BOLD signals are recorded by fMRI. The point scaling property of the information flow between the signals recorded in those two experiments is analyzed in conjunction with the cortical feature detector findings and the auditory tonotopic map. The brain wave nucleons from an EEG scan, along with a distance measure of synchronicity of the brain wave patterns, are also explained.
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