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Search Results: 1 - 10 of 401304 matches for " Apostolovi? M. "
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Differences in the rehabilitation period following two methods of anterior cruciate ligament replacement: Semitendinosus / gracilis tendon vs. Ligamentum patellae
Blagojevi? Z.,Stevanovi? V.,ApostoloviM.,Lalo?evi? V.
Acta Chirurgica Iugoslavica , 2006, DOI: 10.2298/aci0604033b
Abstract: In this study we have analyzed outcome during the early rehabilitation period phase following two different methods of anterior cruciate ligament (ACL) reconstruction: ligamentum patellae (LP) and semitendonosus/gracilis tendon (SG) based reconstruction. This study included 40 patients treated by each method, examined 6 weeks and 3, 6 and 12 months after surgery. Patients in the SG group showed significantly better Lysholm scores at 6 and 12 months, Tegner Activity Scale scores at 3 months, and pain profile assessments at 6 weeks and 3 months than those in the LP group. Significant differences were observed in LP group in range-of-motion at 6 weeks and 3 and 6 months post-surgery. Stability tests revealed no significant differences between patients in the two groups. SG-based reconstruction of the ACL thus demonstrated advantages over LP-based reconstruction regarding pain and function, while LP-based reconstruction was associated with an earlier return of motion.
The treatment of infected diaphyseal femoral defects by lengthening one of the bone fragments by Ilizarov
Tomi? S.,Kraj?inovi? O.,Blagojevi? Z.,ApostoloviM.
Acta Chirurgica Iugoslavica , 2006, DOI: 10.2298/aci0604027t
Abstract: We analyzed 30 patients with infected diaphyseal defect of femur, which have been treated by lengthening one of the bone fragments with Ilizarov apparatus. The mean length of the bone defect was 6 cm. Substitution of the defect, bone healing and elimination of the infection was achieved in 27 patients. The mean time of apparatus fixation was 10 months. According to Palley scoring system, 10 patients had excellent functional results.
Choice of operative procedures to correct equinus deformity in patients with cerebral palsy
?obelji? G.,Vuka?inovi? Z.,ApostoloviM.,Bajin Z.
Acta Chirurgica Iugoslavica , 2006, DOI: 10.2298/aci0604021c
Abstract: Equinus deformity of the foot presents a great number of difficulties to ambulant patients with cerebral palsy. Non-operative treatment of the incorrectible - fixed equinus is not successful. Many procedures are applied to treat it operatively, so its not clear which procedure at what age is the most successful. The purpose of this manuscript is to clarify the issue. The results of four procedures are analyzed: aponeurectomy of m. gastrocnemius, Achilles tendon lengthening by z-plasty, a combination of these two procedures and sliding elongation of m. triceps surae. The analysis was based on 417 operations in 291 patients of the average age of 9 years (1-64). The average follow-up was 7 years. The assessment of the results was based on the visual evaluation of the gait, on pedoscope prints and on comparison of ankle movements before and after operation. The analysis shows that the best results were achieved by sliding elongation of m. triceps surae after the age of 7.
Chondrofibrosis of adolescent hip
Slavkovi? S.,Vuka?inovi? Z.,Slavkovi? N.,ApostoloviM.
Acta Chirurgica Iugoslavica , 2006, DOI: 10.2298/aci0604011s
Abstract: Authors present 420 hips with slipped capital epiphysis treated in the IOHB "Banjica", during the period between 1970 and 2005. Research includes the analysis of incidence, diagnostics and causes which contribute to the genesis of hip chondrofibrosis. Risk factors are shown, as well as the approach to eliminate them. 39 hips in which this complication occurred were individually analyzed. Every hip was separately studied with intent to determine the cause of the condition’s genesis, it’s evolution, treatment and it’s final functionality result. Synovia biopsy was performed in 7 cases, as well as the biopsy of the capsule, articular hyaline cartilage and subchondral bone of the femoral head, which enabled detailed description of both microscopic and macroscopic changes that follow this condition. Regardless of still hypothetical comprehension of the inception of chondrofibrosis, authors clearly state all the risky procedures during treatment that can contribute to the development of chondrofibrosis. The importance of early diagnostics and well-timed treatment are highlighted in this article, for they are crucial. Results of treated hip chondrofibrosis presented here give hope for the destiny of the ill joint, which was considered highly uncertain for a long time.
Left atrial size in patients with arterial hypertension
Milutinovi? Suzana,Apostolovi? Svetlana,Tasi? Ivan
Srpski Arhiv za Celokupno Lekarstvo , 2006, DOI: 10.2298/sarh0604100m
Abstract: INTRODUCTION Left atrial size is increased in patients with arterial hypertension. Left atrial enlargement represents a risk factor of atrial fibrillation and stroke. Left atrial size depends on the effect of many other etiological factors, predominantly by body mass and the left ventricular mass. OBJECTIVE The objective of the study was to investigate the frequency of the left atrial enlargement in patients with arterial hypertension, in obese patients with arterial hypertension and in patients with arterial hypertension and left ventricular hypertrophy. In addition, the aim was to investigate the influence of diastolic function parameters on the left atrial dimension. METHOD The study included 93 patients with arterial hypertension (mean age of 46.9 ± 9.7 years, 50.5% of males) and 33 healthy subjects (mean age 45.6 ±10.6 yrs., 40% of males) who consisted the control group. There was no statistical difference of the age and sex between patients and healthy persons. All patients were examined by the echocardiographic ultrasound device HP Sonos 2500 by three echosonographers. RESULTS The patients with arterial hypertension compared to the control group had significantly higher: body mass index (27.8 ± 4.1 versus 24.3 ± 3.0) (p<0.001), the left ventricular mass (249.7 ± 79.1 versus 174.6 ± 47.7) (p<0,001), the left ventricular mass index (122.2 ± 34.3 versus 96.7 + 20.9)(p<0.001) and the left atrium (3.8 ± 0.7 versus 3.3 ± 0.5) (p<0.001). The frequency of the left atrial enlargement in patients with arterial hypertension was 44.1%. The frequency of the left atrial enlargement In patients with arterial hypertension and the left ventricular hypertrophy was 53.3%, and in obese patients with arterial hypertension was 58.3%. Left ventricular diastolic function parameters in patients with arterial hypertension in relation to control exhibited statistically significant differences: isovolumetric relaxation time (IVRT) was longer (193.2 ± 37.8 versus 175,8 ± 23,6) (p<0.001), deceleration time (DT) was longer (193.2 ±37,8 versus 175.8 ±23.6) (p<0.01) and peak early diastolic filling wave velocity /peak atrial diastolic filling wave velocity ratio (E/A ratio) was lower (1.0 ± 0.3 versus 1.2 ± 0.3) (p<0.01). The quotient of linear correlation of the left ventricular diastolic function parameters in patients with arterial hypertension with left atrial volume did not show any significant correlation. CONCLUSION The left atrial size was statistically bigger in patients with arterial hypertension in relation to healthy subjects. The biggest left atrial enlargement was
Caries risk estimation in children regarding values of saliva buffer system components and carboanhydrase activity
?urdilovi? Du?an,Stojanovi? Ivana,Apostolovi? Mirjana
Vojnosanitetski Pregled , 2008, DOI: 10.2298/vsp0809676s
Abstract: Background/Aim. One of the preconditions for efficacious systematic reduction of caries prevalence and prophylaxis is the determination of risks of this disease appearance. The aim of this study was to prove the significance of salivary carboanhydrase activity determination in estimation of caries risk in children. Methods. The study included 123 children of average age of 13.4±0.3 years and permanent dentition. The children were divided into two groups according to caries risk (low and high caries risk groups). Two samples of saliva - unstimulated and stimulated one were taken from each child. Salivary carboanhydrase activity, as well as pH value, bicarbonate and phosphate buffer levels were estimated in both group of saliva samples. Results. The investigation showed significantly higher carboanhydrase activity (p < 0.001) in both saliva samples in low caries risk group compared to high caries risk one. In children with low caries risk, both unstimulated and stimulated saliva show significantly higher bicarbonate and phosphate buffer concentrations (p < 0.001), as well as pH values. Conclusion. The lower caries incidence could be expected in children with high carboanhydrase activity and higher salivary buffer system parameters levels. The presented results suggest that salivary carboanhydrase activity represents the important marker of individual susceptibility for caries appearance in children.
Presence and role of noncollagenous proteins in dentin: Dentin siaolproten, bone sialoprotein and osteopontin
?urdilovi? Du?an,Apostolovi? Mirjana,Tri?kovi?-Janji? Olivera
Stomatolo?ki Glasnik Srbije , 2004, DOI: 10.2298/sgs0402071s
Abstract: Dentin, as a specific hard tooth tissue is very rich in organic materials, representing approximately 20% of its weight and 33% of its volume. The basic organic component of dentin is collagen. However, the noncollagenous organic content of dentin has not been sufficiently studied. Dentin and its complex ultrastructure, molecular content and biochemical process, playing the main role in dentinogenesis, still haven’t been fully explained, which presents a real scientific challenge. Protein separation was done with sodium dodecil sulfate poliacrilamid gel electrophoresis (SDS PAGE) technique in which polipeptides are separated by the differences in their molecular masses.Electrophoretic analysis of proteins is very important in basic research of proteins family which are organic constituents of the dentin tissue. Research results revealed significant presence of dentin sialoprotein, bone sialo protein and osteopontin in analized samples of dentin. Dentin sialoptotein (DSP) is one of the specific proteins in dentin, and its produced by secretory activity of mature odontoblasts. It also represents a reliable phenotype marker of odontoblasts. The fact that dentin sialoprotein is specific for dentin and cannot be found in any other tissue implicate sits unique, critical and key-roll in dentinogenesis. Bone sialoprotein (BSP) and osteopontin, revealed in this research, are not specific for dentin. They are produced both by odontoblasts and osteoblasts. Bone sialoprotein may have a function in the initiation of the crystal hydroxiapatite growth in mineralized tissues. Osteopontin and alkaline phosphatase could be the markers of the odontoblast differentiation. Upon analyzing the characteristics of the presented nonspecific proteins, the necessity of their presence during the process of dentinogenesis can be stated as a conclusion to this research.
Late thrombosis of coronary bare-metal stent: Case report
Apostolovi? Svetlana,Peri?i? Zoran,Toma?evi? Miloje,Stankovi? Goran
Srpski Arhiv za Celokupno Lekarstvo , 2006, DOI: 10.2298/sarh0604155a
Abstract: Stent thrombosis remains the primary cause of death after percutaneous coronary interventions (PCI). Despite modern concepts of PCI, stent thrombosis occurs in 0.5% -2% of elective procedures and even 6% of patients with the acute coronary syndrome (ACS). Stent thrombosis most often develops within the first 48 hours after the PCI, and rarely after a week of stent implantation. Angiographically documented late (>6 months) thrombosis of coronary bare-metal stent (BMS) is rare, because the stent endothelialization is considered to be completed after four weeks of the intervention. Our patient is a 41 year old male and he had BMS thrombosis 345 days after the implantation, which was clinically manifested as an acute myocardial infarction in the inferoposterolateral localization. Stent Clinical Centre of Serbia, Belgrade thrombosis occurred despite a long term dual antiplatelet therapy and control of known risk factors. Thrombolytic therapy (Streptokinase in a dose of 1 500 000 IU) was not successful in reopening the occluded vessel, so the flow through the coronary artery was achieved by rescue balloon angioplasty, followed by implantation of drug eluting stent in order to prevent restenosis.
Comparative effect of streptokinase and alteplase on electrocardiogram and angiogram signs of myocardial reperfusion in ST segment elevation acute myocardial infarction
Toma?evi? Miloje,Kosti? Tomislav,Apostolovi? Svetlana,Peri?i? Zoran
Srpski Arhiv za Celokupno Lekarstvo , 2008, DOI: 10.2298/sarh0810481t
Abstract: INTRODUCTION Modern pharmacological reperfusion in ST segment elevation acute myocardial infarction means the application of fibrin specific thrombolytics combined with modern antiplatelets therapy dual antiplateles therapy, acetylsalicylic acid and clopidogrel, and enoxaparin. The contribution of each agent has been widely examined in large clinical studies, but not sufficiently has been known about the effects of a combined approach, where the early angiography and percutaneous coronary intervention is added during hospitalization, if necessary. OBJECTIVE The aim of the paper is to compare the effects of streptokinase and alteplase, together with the standard modern adjuvant antiplatelets and anticoagulation therapy (aspirin, clopidogrel, enoxaparin) in patients with ST segment elevation acute myocardial infarction, on electrocardiographic and angiographic signs of the achieved myocardial reperfusion. METHOD The prospective study included 127 patients with the first ST segment elevation acute myocardial infarction who were treated with a fibrinolytic agent in the first 6 hours from the chest pain onset. The examined group included 40 patients on the alteplase reperfusion therapy, while the control 87 patients were on the streptokinase therapy. All the patients received the same adjuvant therapy and all were examined by coronary angiography on the 3rd to 10th day of hospitalization. Reperfusion effects were estimated on the basis of the following: ST segment resolution at 60, 90 and 120 minutes, the appearance of reperfusion arrhythmias at the electrocardiogram, percentage of residual stenosis at the 'culprit' artery, TIMI coronary flow at the 'culprit' artery and the appearance of new major adverse coronary events in the 6-month-follow-up period. RESULTS By analysing the resolution of the sum of ST segment elevation in infarction leading 60 minutes after the beginning of the medication application, we received a statistically significantly higher resolution of ST segment in the group of patients who received alteplase (p<0.05). 60 minutes after the application of thrombolytics, 64% of patients at streptokinase showed the absence of ST segment resolution (<30%), and 32% of patients at alteplase (p<0.0001). Reperfusion arrhythmias as the sign of successful myocardial reperfusion were present in 62.5% of patients at alteplase and in 57.4% of patients at streptokinase, but the difference is not statistically significant. There was no statistically significant difference in the degree of residual stenosis at the 'culprit' artery in the compared groups of p
Miloje Toma?evi?,Branko Beleslin,Svetlana Apostolovi,Milan Pavlovi?
Acta Facultatis Medicae Naissensis , 2005,
Abstract: The shortcomings of coronary arteriography to assess the physiological significance of coronary stenosis have been recognised for decades. Noninvasive test can be inconclusive in some patients. In patients with moderate coronary stenosis, fractional flow reserve (FFR) provide important information and appears to be a useful index of the functional severity of the stenosis and need for coronary revascularization. FFR is invasive index of stenosis severity that is a substitute for noninvasive stress testing. A patient with long stenosis of the mid and distal right coronary artery and inconclusive noninvasive test was presented. FFR was significantly improved, from 0,45 to 0,92, after the coronary intervention. It predicts low restenosis rate.
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