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Neural Tube Defects, Folic Acid and Methylation
Apolline Imbard,Jean-Fran?ois Benoist,Henk J. Blom
International Journal of Environmental Research and Public Health , 2013, DOI: 10.3390/ijerph10094352
Abstract: Neural tube defects (NTDs) are common complex congenital malformations resulting from failure of the neural tube closure during embryogenesis. It is established that folic acid supplementation decreases the prevalence of NTDs, which has led to national public health policies regarding folic acid. To date, animal studies have not provided sufficient information to establish the metabolic and/or genomic mechanism(s) underlying human folic acid responsiveness in NTDs. However, several lines of evidence suggest that not only folates but also choline, B12 and methylation metabolisms are involved in NTDs. Decreased B12 vitamin and increased total choline or homocysteine in maternal blood have been shown to be associated with increased NTDs risk. Several polymorphisms of genes involved in these pathways have also been implicated in risk of development of NTDs. This raises the question whether supplementation with B12 vitamin, betaine or other methylation donors in addition to folic acid periconceptional supplementation will further reduce NTD risk. The objective of this article is to review the role of methylation metabolism in the onset of neural tube defects.
Immaturités en acte
Apolline Caron,Dominique Ottavi
Criminocorpus, Revue Hypermédia , 2007, DOI: 10.4000/criminocorpus.216
Abstract: Un certain nombre de films noirs marqués par la psychanalyse manifestent ce que l’on peut appeler l’ immaturité en acte , c’est-à-dire, relatent des crimes commis par des personnages qui combinent une grande assurance et une fragilité, un inachèvement, internes. Cette fragilité peut être portée au compte de l’immaturité dans les cas où elle provient d’un rapport troublé à la parenté et à la succession des générations. L’intérêt de cette thématique dépasse le repérage d’un thème de fiction, ...
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