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Adenoviral infectivity of exfoliated viable cells in urine: Implications for the detection of bladder cancer
Anuradha Murali, Laura Kasman, Christina Voelkel-Johnson
BMC Cancer , 2011, DOI: 10.1186/1471-2407-11-168
Abstract: Exfoliated cells from urine were obtained from 36 human subjects (> 40 years old). An adenovirus in which GFP expression is under control of the survivin promoter (Ad.Surv.GFP) was generated. An adenovirus in which GFP is expressed from the CMV promoter served as a control. GFP expression was analyzed by fluorescent microscopy and quantified by flow cytometry.Short-term cultures from exfoliated cells in urine could be established in 16 of 31 samples. These cultures were successfully transduced with Ad.CMV.GFP. Analysis of GFP expression following transduction with Ad.Surv.GFP, indicated that the survivin promoter was preferentially active in UM-UC-3 bladder cancer cells compared to non-malignant UROtsa cells. Interestingly, baseline levels of GFP expression in cultures from exfoliated cells in urine exhibited higher baseline levels than UROtsa following transduction with Ad.Surv.GFP.We demonstrated the feasibility of establishing and analysing short-term cultures isolated from exfoliated cells in voided urine by means of adenoviral transduction, thereby forming the foundation for future studies to determine the specificity and sensitivity of a non-invasive test based on survivin promoter activity.According to the American Cancer Society bladder cancer is the 5th highest in estimated new cases of cancers by site with 14,680 bladder cancer deaths and 70,530 new diagnoses in 2010 [1,2]. Bladder cancer can be categorized into non-muscle-invasive bladder cancer or muscle-invasive bladder cancer where 80% of the newly diagnosed cancers are non-muscle-invasive bladder cancer. Unfortunately, 70% of the patients will have recurrence of the disease and 10-30% will progress to muscle-invasive disease. Bladder cancer is detected as a result of incidental findings or by presenting hematuria. While hematuria is associated with benign conditions such as urinary tract infections and urolithiasis, 10% of the patients with gross hematuria are diagnosed with bladder cancer [3]. Contra
Mesolamellar composite of TiN and CTAB using fluoride ion bridge: synthesis, mechanism & characterization  [PDF]
Tumbavanam Venkateswaran Anuradha
Natural Science (NS) , 2010, DOI: 10.4236/ns.2010.25057
Abstract: In an attempt to synthesize hexagonal mesopo- rous titanium nitride, a mesolamellar composite based on titanium nitride and cetyltrimethylam- monium bromide (CTAB) is obtained by the sol-gel route involving templating at 80oC. The mechanism underlying the above synthesis is discussed for the first time in the literature and till date there are no reports on the synthesis of mesoporous nitrides. The above mesolamellar composite is found to form an oxide of titania (anatase) upon heat treatment at 335oC for 1h.
Synthesis, Kinetics and Mechanism of Terpolymerization of Styrene, Vinyl Acetate with Acrylonitrile Initiated by P-Nitrobenzyl Triphenyl Phosphonium Ylide  [PDF]
Kiran Prajapati, Anuradha Varshney
International Journal of Organic Chemistry (IJOC) , 2011, DOI: 10.4236/ijoc.2011.12010
Abstract: Synthesis of terpolymers consisting of two electron-donating monomers, viz. styrene and vinyl acetate with one electron-accepting monomer, i.e. acrylonitrile, initiated by p-nitrobenzyl triphenyl phosphonim ylide in dioxane as diluent at 65°C for 150 min has been studied. The kinetic expression is Rpα[I]0.8[Sty] 1.2[VA] 1.4 [AN]1.2. The terpolymer composition was determined by the Kelen-Tüdos method. The values of reactivity ratios using r1 (Sty + VA) = 0.1 and r2 (AN) = 0.005. The overall activation energy is 46 kJ●mol●L–1. The formation of terpolymer is confirmed by the FTIR spectra showing bands at 3030 cm–1, 1598 cm–1, and 2362 cm–1, confirming the presence of phenyl, acetoxy and nitrile group respectively. The terpolymer has been characterized by 1H-Nuclear Magnetic Resonance, 13C-Nuclear Magnetic Resonance. The Differential Scanning Calorimetric curve shows the Tg of the polymer as 149.5°C. A scanning electron microscope confirms the polymer to be phosphorus free. Electron.Spin.Resonance spectra confirms phenyl radical responsible for initiation.
Change in Mass of Spinning Black Holes w.r.t. the Angular Momentum  [PDF]
Dipo Mahto, Anuradha Kumari
Journal of Modern Physics (JMP) , 2018, DOI: 10.4236/jmp.2018.95065
Abstract: Mahto et al. have shown δS≥0 and M2=a*J by using the first law of the black hole mechanics in the vacuum and Einstein mass-energy equivalence relation specially for spinning black holes. In the present paper, this work is extended to propose a model for the change in mass of the spinning black holes due to corresponding change in the angular momentum for maximum & half spin parameter of black holes (a* = 1 & 1/2) and calculated their values for different test black holes in XRBs and AGN. We have also shown that the change in mass of the spinning black holes due to corresponding change in the angular momentum for maximum spinning rate of black holes (a* = 1) is double to that of the spinning black holes having spinning parameter (a* = 1/2).
Change in Entropy of Spinning Black Holes Due to Corresponding Change in Mass in XRBs  [PDF]
Dipo Mahto, Anuradha Kumari
International Journal of Astronomy and Astrophysics (IJAA) , 2018, DOI: 10.4236/ijaa.2018.82012
Abstract: The present paper gives a theoretical model for the change in entropy of spinning black holes due to change in mass to use the first law of black hole mechanics for unit spinning parameter and angular momentum in XRBs. This shows that the entropy change with respect to the mass of uncharged spinning black holes is essentially the function of mass and their surface gravity are lesser than to that of the non-spinning black holes.
Intuitionistic Fuzzy α-Generalized Closed Sets in Terms of Minimal Structure Spaces  [PDF]
Mani Parimala, Sivaraman Murali
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.78130
Abstract: In this paper, we introduce the notion of intuitionistic fuzzy α-generalized closed sets in intuitionistic fuzzy minimal structure spaces and investigate some of their properties. Further, we introduce and study the concept of intuitionistic fuzzy α-generalized minimal continuous functions.
Role of lncRNAs in GI Cancer  [PDF]
Murali Krishna, Anju Mullath
Journal of Cancer Therapy (JCT) , 2018, DOI: 10.4236/jct.2018.93026
Abstract: lncRNAs forms a part of the non coding part of human genome. This term denotes specific non coding RNAs with nucleotide length more than 200. They have been shown to affect various physiological and pathological processes within the human body. Of interest is their role in malignant transformation in several cancers. In this review, the role of lncRNAs in GI cancers namely pancreatic cancer, gastric cancer, hepatocellular cancer and colorectal cancer have been explained in brief. These lncRNAs have shown to be useful as a marker for detection and prognosis of various malignancies. They also have shown to have therapeutic potential. Various relevant lncRNAs in each section has also been mentioned.
Worm under the Skin—An Unusal Case of Filariasis  [PDF]
Murali Krishna, Jaya Manchanda
Surgical Science (SS) , 2018, DOI: 10.4236/ss.2018.94017
Abstract: Background: Filarial disease has a very high prevalence in South East Asian region especially India. It commonly presents as an affliction of the lymphatic system like acute lymphangitis and chronic lymphedema. Presentation of lymphatic filariasis as a subcutaneous nodule is a rare but previously reported scenario. Aim: We discuss a case with incidental detection of filaria in a subcutaneous nodule following excision biopsy. Case Presentation: 20-year-old male patient presented with subcutaneous swelling in left lower chest. Undergoing excision biopsy for same and on histopathological examination was found to be an encysted filarial worm. Conclusion: Such rare presentation of filariasis has been reported earlier also and should be kept in mind.
Impact of Water Resources Protection on Local Ground Water Market  [PDF]
Baskaran Anuradha, Neelakanda Kannaperumal Ambujam
Journal of Water Resource and Protection (JWARP) , 2010, DOI: 10.4236/jwarp.2010.28083
Abstract: Tanks are important means to conserve water resources in semi-arid areas. Tank irrigation in general, and in Tamil Nadu in particular, has a long history, and it can be traced to prehistoric times. Poor management of the integrated tank system including its structures and distribution system is one of the major reasons for decline of tank irrigated area. Rehabilitating tanks enhanced groundwater recharge leads to increased water table in the wells located in the command area. Hence well owning farmers can able to cultivate three times paddy crop in a year with the available ground water. Also they can provide water for adjacent non-well owning farmers for their second crop (during maturity stage) and third crop (whole season) cultivation by charging either cash or kind. This local ground water market helps villagers to cultivate more area and season, leads to efficient water use and increased income generation for the villagers. To prove the above statement a study was carried out in rural village of South India with an interview schedule and the data were analysed using SPSS (Statistical Package for Social Science). The result shows that the tank rehabilitation is highly correlated with local ground water market in post rehabilitation period.
Guillaine Barre Syndrome after OPCAB Surgery  [PDF]
Murali Vettath, A. V. Kannan
Surgical Science (SS) , 2014, DOI: 10.4236/ss.2014.512082
Abstract: We report a successful treatment of the first reported case of Guillaine-Barre Syndrome (GBS) detected post Off Pump Coronary Artery Bypass Surgery (OPCAB). A 70-year-old man underwent OPCAB surgery for Triple Vessel Disease. In the post-operative period he developed respiratory distress with unexplained weakness in the limbs. CSF study confirmed Guillaine-Barre Syndrome. He was administered immunoglobulin therapy. The patient fully recovered and was discharged in good health.
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