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Search Results: 1 - 10 of 271 matches for " Anuj Khattar "
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SRA-Domain Proteins Required for DRM2-Mediated De Novo DNA Methylation
Lianna M. Johnson,Julie A. Law,Anuj Khattar,Ian R. Henderson,Steven E. Jacobsen
PLOS Genetics , 2008, DOI: 10.1371/journal.pgen.1000280
Abstract: De novo DNA methylation and the maintenance of DNA methylation in asymmetrical sequence contexts is catalyzed by homologous proteins in plants (DRM2) and animals (DNMT3a/b). In plants, targeting of DRM2 depends on small interfering RNAs (siRNAs), although the molecular details are still unclear. Here, we show that two SRA-domain proteins (SUVH9 and SUVH2) are also essential for DRM2-mediated de novo and maintenance DNA methylation in Arabidopsis thaliana. At some loci, SUVH9 and SUVH2 act redundantly, while at other loci only SUVH2 is required, and this locus specificity correlates with the differing DNA-binding affinity of the SRA domains within SUVH9 and SUVH2. Specifically, SUVH9 preferentially binds methylated asymmetric sites, while SUVH2 preferentially binds methylated CG sites. The suvh9 and suvh2 mutations do not eliminate siRNAs, suggesting a role for SUVH9 and SUVH2 late in the RNA-directed DNA methylation pathway. With these new results, it is clear that SRA-domain proteins are involved in each of the three pathways leading to DNA methylation in Arabidopsis.
On З-Reconstruction Property  [PDF]
Lalit Kumar Vashisht, Geetika Khattar
Advances in Pure Mathematics (APM) , 2013, DOI: 10.4236/apm.2013.33046
Abstract: Reconstruction property in Banach spaces introduced and studied by Casazza and Christensen in [1]. In this paper we introduce reconstruction property in Banach spaces which satisfy \"\"-property. A characterization of reconstruction property in Banach spaces which satisfy \"\"-property in terms of frames in Banach spaces is obtained. Banach frames associated with reconstruction property are discussed.
Cks1: Structure, Emerging Roles and Implications in Multiple Cancers  [PDF]
Vinayak Khattar, Jaideep V. Thottassery
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.48159

Deregulation of the cell cycle results in loss of normal control mechanisms that prevent aberrant cell proliferation and cancer progression. Regulation of the cell cycle is a highly complex process with many layers of control. One of these mechanisms involves timely degradation of CDK inhibitors (CKIs) like p27Kip1 by the ubiquitin proteasomal system (UPS). Cks1 is a 9 kDa protein which is frequently overexpressed in different tumor subtypes, and has pleiotropic roles in cell cycle progression, many of which remain to be fully characterized. One well characterized molecular role of Cks1 is that of an essential adaptor that regulates p27Kip1 abundance by facilitating its interaction with the SCF-Skp2 E3 ligase which appends ubiquitin to p27Kip1 and targets it for degradation through the UPS. In addition, emerging research has uncovered p27Kip1-independent roles of Cks1 which have provided crucial insights into how it may be involved in cancer progression. We review here the structural features of Cks1 and their functional implications, and also some recently identified Cks1 roles and their involvement in breast and other cancers.

On $\mathfrak{I}$-reconstruction Property
L. K. Vashisht,Geetika Khattar
Mathematics , 2013,
Abstract: Reconstruction property in Banach spaces introduced and studied by Casazza and Christensen in [1]. In this paper we introduce reconstruction property in Banach spaces which satisfy $\mathfrak{I}$-property. A characterization of reconstruction property in Banach spaces which satisfy $\mathfrak{I}$-property in terms of frames in Banach spaces is obtained. Banach frames associated with reconstruction property are discussed.
Theoretical Study of Specific Heat and Density of States of MgB2 Superconductor in Two Band Model  [PDF]
Anuj Nuwal, Shyam Lal Kakani
World Journal of Condensed Matter Physics (WJCMP) , 2013, DOI: 10.4236/wjcmp.2013.31006

MgB2 with Tc 40 K, is a record-breaking compound among the s-p metals and alloys. It appears that this material is a rare example of the two band electronic structures, which are weakly connected with each other. Experimental results clearly reveal that boron sub-lattice conduction band is mainly responsible for superconductivity in this simple compound. Experiments such as tunneling spectroscopy, specific heat measurements, and high resolution spectroscopy show that there are two superconducting gaps. Considering a canonical two band BCS Hamiltonian containing a Fermi Surface of π- and σ-bands and following Green’s function technique and equation of motion method, we have shown that MgB2 possess two superconducting gaps. It is also pointed out that the system admits a precursor phase of Cooper pair droplets that undergoes a phase locking transition at a critical temperature below the mean field solution. Study of specific heat and density of states is also presented. The agreement between theory and experimental results for specific heat is quite convincing. The paper is organized in five sections: Introduction, Model Hamiltonian, Physical properties, Numerical calculations, Discussion and conclusions.


Crian?as muito más: "tortura indiana" e o relatório da comiss?o sobre Tortura de Madras de 1855
Bhuwania, Anuj;
Sur. Revista Internacional de Direitos Humanos , 2009, DOI: 10.1590/S1806-64452009000100002
Abstract: while it is often argued that police torture is institutionalised in india, the only authoritative government-backed study of the practice in the history of modern india is the madras torture commission report of 1855. in the context of the silence that surrounds present-day police violence in india, the rather curious phenomenon of an investigative commission, instituted by a colonial state, over a hundred and fifty years ago, is particularly interesting. in this article, i attempt a textual analysis of this report, and an investigation of its ideological and historical context i argue that the report primarily served to discursively "manage" the issue of torture, by erasing the complicity of the colonial state in its practice, and that the reforms it suggested resulted in the institutionalisation of a specifically colonial model in the restructuring of the indian police, a structure that substantially survives to this day.
Golden Research Thoughts , 2013, DOI: 10.9780/22315063
Abstract: A single examination does not fulfill all the functions of assessment, such as assessing knowledge, comprehension, skills, motivation, and feedback [1,2,3]. A good test must be acceptable to those using it, feasible, valid and reliable [4]. The present study was undertaken to determine the reliability and student satisfaction regarding the objective structured practical examination (OSPE) as a method of practical examination. The present study was undertaken in the Department of Anatomy of UPRural Institute of Medical Sciences and Research, Saifai. During the OSPE, students were made to rotate through 11 stations, of which 8 stations were composed of questions that tested their knowledge and critical thinking, 1 station tested their skills to carry out surface marking, and 1 station composed of skills that students had to perform before the examiner. One station was kept as the rest station. Performance of the students was assessed by comparing the students scores in the traditional practical examination (TPE) and OSPE.Student perspectives regarding the OSPE were obtained by asking them to a questionnaire. Overall a better scoring was reached by all the students. Not only this, the number students failing in the practical examination was also reduced in OSPE.Feedback indicated that students were in favour of the OSPE compared with the TPE. Feedback from the students provided scope for improvement of ongoing practical examinations by inducting OSPE.
Golden Research Thoughts , 2013, DOI: 10.9780/22315063
Abstract: The anatomy course offers important opportunities to develop professionalism at an early stage in medical education. Dissection in anatomy can be the beginning of a physician's training in how to isolate and restrict their emotional responses to difficult or disturbing clinical situations, or conversely how to deal appropriately with emotions engendered by such exposure.Study of regional anatomy through cadaveric dissection is considered to be a unique feature of medical courses in India. The benefits of meticulous dissection mostly fall into three domains: knowledge acquisition and integration, skills, and attitudes. Anatomical dissection is a time-honoured part of medical education. Bodies donated by patients themselves, for students to learn anatomy by dissection, is the ultimate gift, which needs continued appreciation by educators.Because of current arguments on balancing learning outcomes, problems related to the use of human cadaver, teaching methods and resources, many recent curricula in anatomy have introduced a shift towards greater use of alternative modalities of teaching involving cadaveric plastination, non-cadaveric models and computer-based imaging . Moreover, the use of cadavers for dissection in anatomy learning has been identified by some scholars as expensive, time consuming and potentially hazardous. Although there is no consensus on its effect, working with cadavers, whether through active dissection or by examination of prosected specimens constitute a potential stress. In medical colleges, where cadaveric dissection mainly constitutes preclinical teaching of anatomy, students are exposed to cadavers in the early stages of their training but this exposure induces both positive and unintended negative experiences in these students. The emotional impact of such exposure on students is the main subject of present study.
Indian Streams Research Journal , 2013,
Abstract: Children are the most precious gift of God, the human kind has ever recieved. The pleasure, a father or mother gets, in embracing a child is unparallel to anything. It is a common experience that whenever our children gets even a small scratch, we are worried and it brings pain to us. But unfortunately, every day in India, dozens of children die from an injury that was not intended. Such tragedy often leaves families broken apart and changes the lives of parents left behind. Injury deaths, however, are only part of the picture. Each year, millions of children in India are injured and live with the consequences of those injuries. These children may face disability and chronic pain that limit their ability to perform age-appropriate everyday activities over their lifetime.These deaths and injuries need not occur because they often result from predictable events, which could have been avoided if the parents are educated about the role of supervision and modifying the environment of children and other measures to prevent injuries. This paper explores some of the remedial interventions that needs to be undertaken to safeguard the rights of the children.
Indian Streams Research Journal , 2013,
Abstract: Paranasal sinuses are prone to a great diversity of anomalies. It is important for surgeons to be aware of variations that may predispose patients to increased risk of intraoperative complications and help avoid possible complications and improve success of management strategies. Plane x-rays can be widely used to map sinus anatomy prior to surgical intervention to limit morbidity.The frontal sinus has been used for personal identification since the early part of the 20th century as a result of its tremendous interindividual variation. The frontal sinus is present in approximately 90% of adults. However, some populations have a higher proportion of people without a frontal sinus. This study investigated the frequency of the absence of frontal sinus in Karnataka region of India. The present study was performed retrospectively on radiographs from a series of 238 cases. Abilateral absence and a unilateral absence of sinuses were found in 6(2.5 %) and 2(0.84 %) of cases, respectively. The clinical significance of the frontal sinuses and their absence are also discussed.
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