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Search Results: 1 - 10 of 9880 matches for " Antony Pan "
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Intestinal absorbability of three Radix Puerariae isoflavones including daidzein, daidzin and puerarin
Li Zhang, Antony Pan Siu, Ge Lin, Zhong Zuo
Chinese Medicine , 2011, DOI: 10.1186/1749-8546-6-41
Abstract: The bi-directional transport of these three isoflavones in Caco-2 monolayer model was performed to evaluate their absorbability and involvement of transporters in Transwell. In vitro incubation of daidzin and puerarin with rat intestinal microvilli preparation was conducted to estimate their potential form of absorption in vivo.Daidzein demonstrated passive diffusion transport while puerarin did not. Daidzin showed basolateral-to-apical transport and the absorption extent could be reduced by 50% in the presence of MK571, a multidrug resistance-associated protein inhibitor (MRP). The in vitro incubation study of daidzin and puerarin indicated that daidzin was hydrolyzed to daidzein whereas puerarin remained unchanged.While daidzein was transported more efficiently, puerarin was resistant to intestinal hydrolysis and inefficiently transported across intestinal epithelium. Daidzin demonstrated a low intestinal absorbability due to a significant efflux transport mediated by MRPs. Daidzin was likely to be hydrolyzed by intestinal microvilli and subsequently released daidzein for intestinal absorption.Radix Puerariae, a Chinese medicinal plant, contains three major isoflavones, namely daidzein, daidzin and puerarin (Figure 1). Daidzin, which was reported to inhibit aldehyde dehydrogenase-2 (ALDH-2) in isolated mitochondria, may be useful as an anti-alcohol agent [1,2]. Puerarin is used to relieve thirst and treat common cold and neck stiffness due to hypertension [3].Despite various pharmacological activities reported for isoflavones, only a few pharmacokinetics studies on the soybean isoflavones were reported [4,5]. Izumi et al. found that the absorption rate of aglycones were higher than their corresponding glycosides due to their higher lipophilicities and smaller molecular sizes [5]. Setchell et al. indicated that isoflavone glycosides such as daidzin and genistin in the blood sample were barely detectable whereas a large amount of isoflavone aglycone and its conjugat
Unusual manifestation of Erdheim-Chester disease
Antony Pan, Terence Doyle, Martin Schlup, Ralf Lubcke, Michael Schultz
BMC Gastroenterology , 2011, DOI: 10.1186/1471-230x-11-77
Abstract: This case report describes the case of a 69-year-old man who presented otherwise well to the gastroenterology department with unspecific abdominal symptoms, nausea, vomiting and weight loss. ECD involving the gastrointestinal tract was confirmed clinically, radiologically and histologically.Gastroenterological manifestation of ECD is rare but should be considered in the differential diagnosis in patients presenting with evidence of multi-organ disease and typical radiological features of Erdheim-Chester disease elsewhere.Erdheim-Chester Disease (ECD) is a rare multisystem histiocytosis characterized by the xanthomatous or xanthogranulomatous infiltration of tissues with histiocytes, surrounded by fibrosis. The disease can affect multiple organs systems, but gastrointestinal involvement, is exceedingly rare. We describe here the case of a 69-year old man with ECD who presented to the gastroenterology department with unspecific abdominal symptoms, nausea, vomiting and weight loss.A previously fit and well 69-year-old man was admitted to the gastroenterology department with a short one month history of lethargy, decreased appetite, persistent vomiting, significant weight loss of six kilograms over 1 month and a dry cough. He denied abdominal pain, haematemesis, dysphagia and a change in bowel habit and described no cardiac, respiratory, neurological symptoms or bone pain. His past medical history includes appendectomy and total hip joint replacement. At the time of admission, he was not on any regular medication.Physical examination revealed that he was febrile (38.8C°) and appeared cachexic but with no peripheral stigmata of chronic liver disease. His abdominal examination revealed hepatomegaly but no other organomegaly, per rectal examination was unremarkable. His cardiopulmonary examinations were unremarkable apart from bilateral pitting edema up to his ankles. Peripheral blood analysis revealed an anaemia of chronic disease with hemoglobin of 108 g/L (norm - male 1
The role of aspirin in post-polypectomy bleeding – a retrospective survey
Pan Antony,Schlup Martin,Lubcke Ralf,Chou Annie
BMC Gastroenterology , 2012, DOI: 10.1186/1471-230x-12-138
Abstract: Background Bleeding following colonoscopic polypectomy is a common complication and has been reported to occur in up to 6.1% of patients. Several risk factors have been discussed but their overall contribution to post-polypectomy bleeding remains controversial. The aim of the study was to determine the rate of post polypectomy bleeding and to analyse the role of potential risk factors especially the role of aspirin. Methods We conducted a retrospective cohort study of all patients who underwent polypectomy at Dunedin Hospital, New Zealand between January 2007 and June 2009. Results During the study period, 514 patients underwent colonoscopy with polypectomy and a total of 1502 polyps were removed. From further analysis we excluded 21 patients; 15 patients had surgery immediately after colonoscopy for the diagnosis of colorectal carcinoma and 6 patients presented with symptoms of an acute lower gastrointestinal bleed prior to colonoscopy. Of the remaining 493 patients, 11 patients (2.2%) presented with post-polypectomy bleeding within 30 days of the investigation of which 8 were on aspirin. In total 145 patients were taking aspirin prior to colonoscopy and 348 patients were not taking aspirin. The use of aspirin was associated with an increased prevalence of post-polypectomy bleeding (OR=6.72, 95% C.I. 1.76 to 25.7). Interestingly, the use of non-steroidal anti-inflammatory drugs (NSAIDs) was not associated with risk of bleeding after polypectomy (OR=2.82, 95% C.I, 0.34 to 23.3). Conclusion Our study confirmed a significantly increased risk of lower gastrointestinal bleeding following polypectomy in patients taking aspirin. We would recommend approaching the patient on aspirin coming forward for a colonoscopy with potential polypectomy with caution.
Computation of Electron Impact Cross Sections from Molecules of Astrophysical Importance  [PDF]
Bobby Antony
Journal of Modern Physics (JMP) , 2011, DOI: 10.4236/jmp.2011.29133
Abstract: Computations were performed for calculating cross sections of electron impact scattering from astro-physical targets CaF, HCN and H2S at energies lower than their ionization potential. The results show that the use of highly accurate R-matrix method which includes all the relevant physics and chemistry of the molecule in its formalism generate features significantly different from the simple static exchange calculation. The data obtained shows interesting structures in the eigen-phase sums which may be attributed to the dissociation channel of the molecule.
An Exploration of the Predictors of Relationship Status with a Caveat on Interpretation  [PDF]
Antony Mastroniani
Open Journal of Applied Sciences (OJAppS) , 2017, DOI: 10.4236/ojapps.2017.78031
Abstract: Using the Puerto Rican Maternal and Infant Health Study dataset (PRMIHS), the predictors of relationship status were examined via probit regression. The strongest predictors of relationship status found were interactions between bi-nary variables for the age that a respondent first had sexual intercourse and for the age that a respondent first entered into a union (N = 1452). This paper con-cludes by arguing that the results provide support for viewing union status as being primarily dependent on the people involved in the union instead of being primarily dependent on factors external to the people themselves.
Comparison of Typhoon Locations over Ocean Surface Observed by Various Satellite Sensors
Yufang Pan,Antony K. Liu,Shuangyan He,Jingsong Yang,Ming-Xia He
Remote Sensing , 2013, DOI: 10.3390/rs5073172
Abstract: In this study, typhoon eyes have been delineated using wavelet analysis from the synthetic aperture radar (SAR) images of ocean surface roughness and from the warm area at the cloud top in the infrared (IR) images, respectively. Envisat SAR imagery, and multi-functional transport satellite (MTSAT) and Feng Yun (FY)-2 Chinese meteorological satellite IR imagery were used to examine the typhoons in the western North Pacific from 2005 to 2011. Three cases of various typhoons in different years, locations, and conditions have been used to compare the typhoon eyes derived from SAR (on the ocean surface) with IR (at the cloud-top level) images. Furthermore, the best track data from the Joint Typhoon Warning Center (JTWC), Chinese Meteorological Administration (CMA), and the Japan Meteorological Agency (JMA) are checked for the calibration. Because of the vertical wind shear, which acts as an upright tilt, the location of the typhoon eye on the ocean surface differs from that at the top of the clouds. Consequently, the large horizontal distance between typhoon eyes on the ocean surface and on the cloud top implies that the associated vertical wind shear profile is considerably more complex than generally expected. This result demonstrates that SAR can be a useful tool for typhoon monitoring study over the ocean surface.
A Wave Group for Entanglement, Linking Uncertainties in Time and Space  [PDF]
Antony J. Bourdillon
Journal of Modern Physics (JMP) , 2012, DOI: 10.4236/jmp.2012.33041
Abstract: A carrier wave in a 5-dimensional wave group is examined for information on electromagnetic waves and on particle probability amplitudes. Simulations by Maxwell’s equations show that the phase and group velocities in electromagnetic waves are equal, both in vacuo and in dielectric media. By contrast, particle probability amplitudes in wave packet motion are more complicated. A dependence of rest mass on relative phase and group velocities is derived by consistency. Occurrences that are simultaneous and connected on wave fronts in the rest frame, appear separated when observed in moving frames. Uncertainties in space and time are linked by the probability amplitude wave group.
A Travelling Wave Group II: Antiparticles in a Force Field  [PDF]
Antony J. Bourdillon
Journal of Modern Physics (JMP) , 2013, DOI: 10.4236/jmp.2013.46097
Abstract:

The travelling wave group is a solution to the wave equation. With a Gaussian envelope, this stable wave does not spread as it propagates. The group is derived for electromagnetic waves and converted with Planck’s law to quantized photons. The resulting wave is a probability amplitude, and this is adapted to particles subject to special relativity. By including mass and by inverting the wave group, a description for antiparticles is derived. The consequent explanation is consistent with Dirac’s relativistic equation and with his theory of the electron; while being more specific than his idea of the wave packet, and more stable. The travelling wave group is extended to describe the positron, either free or in an external field.

The Structure of Icosahedral Quasicrystals and Seven Blunders in Quasicrystallography  [PDF]
Antony J. Bourdillon
Journal of Modern Physics (JMP) , 2014, DOI: 10.4236/jmp.2014.56060
Abstract:

This structural study of quasicrystals is based on extremely dense icosahedral unit cells that are systematically and consistently measured for the first time. The structure and pattern indexation are 3-dimensional. A formula is given for scattering from atoms in hierarchic arrangement and geometric series. The Quasi-Bragg law is a new law in physics, with possible applications beyond crystallography. The structure is compared with previous, unsuccessful, and contradictory, attempts at analysis.

Analysis of the Metric in Quasicrystals—Linear Response in Logarithmically Periodic Solids  [PDF]
Antony J. Bourdillon
Journal of Modern Physics (JMP) , 2014, DOI: 10.4236/jmp.2014.512109
Abstract:

The metric, that enables measurement of structural data from diffraction in quasicrystals, is analyzed. A modified compromise spacing effect is the consequence of scattering of periodic electromagnetic or electron waves by atoms arranged on a geometric grid in an ideal hierarchic structure. This structure is infinitely extensive, uniquely aligned and uniquely icosahedral. The approximate analytic factor that converts the geometric terms base τ, into periodic terms modulo 2π, is \"\". It matches the simulated metric cs=0.947, consistently used in second (Bragg) order, over a wide scale from atomic dimensions to sixth order superclusters.

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