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Search Results: 1 - 10 of 39111 matches for " Antonio; Miranda-Murua "
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Current management of gastric cancer Situación actual en el tratamiento del cáncer gástrico
Antonio Viúdez-Berral,Coro Miranda-Murua,Fernando Arias-de-la-Vega,Irene Hernández-García
Revista Espa?ola de Enfermedades Digestivas , 2012,
Abstract: Gastric cancer is a disease with high incidence and mortality in our population. The prognosis of patients with this disease is closely related to the neoplasm stage at diagnosis, including the following characteristics of the tumor: extension into the gastric wall thickness, spread to locoregional lymph nodes and the ability to generate distant metastases, as described by the TNM classification. For localized tumors characterized only by invasion of mucosa or submucosa at diagnosis, survival at 5 years is between 70 and 95% with exclusive surgical management; however, when extension into the gastric wall is higher and/or there is locoregional nodal involvement, survival decreases to 20-30% at 5 years. Currently, at high-volume centers, the extent of gastrectomy is individualized based on several parameters, which in an increasing number of cases allows a total gastrectomy with D2 lymphadenectomy and preservation of the spleen and pancreas. This improved procedure increases the chance of R0 surgery and improves the relationship between resected and affected lymph nodes, resulting in a decreased risk of the long-term locoregional recurrence. To improve these results, different therapeutic strategies combining chemotherapy or chemoradiotherapy with surgery have been tested. Previously, the Intergroup 0116 clinical trial, published in 2001, which changed clinical practice in the United States, showed that adjuvant chemoradiotherapy improved survival (from 26 to 37 months overall survival) of these patients. In Europe, perioperative chemotherapy has been considered the standard treatment, since the publication of two randomized phase III trials showed an increase at 5 years survival in the group treated with chemotherapy. El cáncer gástrico es un tumor de alta incidencia y mortalidad en nuestro medio, y su pronóstico está íntimamente relacionado con la situación neoplásica al diagnóstico, que incluye su extensión en el grosor de la pared gástrica, sobre los ganglios linfáticos locorregionales y su capacidad de generar metástasis a distancia, extensión basada en la clasificación TNM. En aquellos tumores localizados al diagnóstico, caracterizados por la invasión únicamente de mucosa-submucosa, la supervivencia a 5 a os se establece entre el 70 y el 95% con manejo quirúrgico exclusivo, sin embargo, cuando la extensión en la pared es mayor y/o existe afectación ganglionar locorregional, la supervivencia disminuye al 20-30% a 5 a os. Actualmente en centros con alto volumen de pacientes, la extensión de la gastrectomía se individualiza en función de varios parámet
Current management of gastric cancer
Viúdez-Berral,Antonio; Miranda-Murua,Coro; Arias-de-la-Vega,Fernando; Hernández-García,Irene; Artajona-Rosino,Alicia; Díaz-de-Lia?o,álvaro; Vera-García,Ruth;
Revista Espa?ola de Enfermedades Digestivas , 2012, DOI: 10.4321/S1130-01082012000300006
Abstract: gastric cancer is a disease with high incidence and mortality in our population. the prognosis of patients with this disease is closely related to the neoplasm stage at diagnosis, including the following characteristics of the tumor: extension into the gastric wall thickness, spread to locoregional lymph nodes and the ability to generate distant metastases, as described by the tnm classification. for localized tumors characterized only by invasion of mucosa or submucosa at diagnosis, survival at 5 years is between 70 and 95% with exclusive surgical management; however, when extension into the gastric wall is higher and/or there is locoregional nodal involvement, survival decreases to 20-30% at 5 years. currently, at high-volume centers, the extent of gastrectomy is individualized based on several parameters, which in an increasing number of cases allows a total gastrectomy with d2 lymphadenectomy and preservation of the spleen and pancreas. this improved procedure increases the chance of r0 surgery and improves the relationship between resected and affected lymph nodes, resulting in a decreased risk of the long-term locoregional recurrence. to improve these results, different therapeutic strategies combining chemotherapy or chemoradiotherapy with surgery have been tested. previously, the intergroup 0116 clinical trial, published in 2001, which changed clinical practice in the united states, showed that adjuvant chemoradiotherapy improved survival (from 26 to 37 months overall survival) of these patients. in europe, perioperative chemotherapy has been considered the standard treatment, since the publication of two randomized phase iii trials showed an increase at 5 years survival in the group treated with chemotherapy.
Sociedade da informa??o: globaliza??o, identidade cultural e conteúdos
Miranda, Antonio;
Ciência da Informa??o , 2000, DOI: 10.1590/S0100-19652000000200010
Abstract: the informational contents in the electronic networks are analyzed from the point of view of its social impact and promotion of cultural identity. penetration and capilarity of information technologies are considered as the main indicators of development of the information society and it argues on behalf of installing points of access to internet in public and school libraries. it is also in favor of implementing production of contents, their records and diffusion within the government, of the society by individuals, in order to reflect the cultural and regional, urban, peripherical and rural diversities, as well as the retrieval of the memory already registered in the portuguese language, but not yet accessible. the document was written with the participation of experts from all parts of the country and is used as a basis for the elaboration of chapter 5 of the green book of the program information society in brazil - socinfo.
Lo retro siempre está de moda
Antonio Miranda
Cuadernos de Proyectos Arquitectónicos , 2011,
Abstract: Reality exhibits a rational and objective structure, hard to uncover. Few are willing to study, distinguish and analyze it. "Modernism or a common cause" embodies the critical objectivity that finds true criteria within the object itself. Modernism is a historic tension that thinks and acts with a sense of emancipation and happiness for humanity. As opposed to local cultures, Modernism is a single and international civilization: "Neither the old nor the new; just what is necessary" (V.Y. Tatlin.). Architecture has always been associated to Power; serving the "Sitting Power" and subjugating to it. Architecture liberated from that power made Form adjust to its own Identity: its method of construction. This liberated it as territorial infrastructure, as an economic structure, and as an ideological superstructure. At the end of the twentieth century, Postmodernism became yet another phase within the immortal Modernism. It was architecture dressed to the fashion of the times. What is new can be described as Contemporary, when we are unable to sense its quality. We must distinguish between Civilization and Modernism, which the true and higher architecture serves. Being contemporary is not what is most important for a work of architecture; what is difficult is for it to become "modern". Only a few hundred projects can be considered "modern", free from the systems of power, and fighting these with truth, kindness and beauty; because being modern is a question of quality, a question of genuine authenticity. The scarce valuable tradition in existence supports itself on Civilization.
An Importance-Performance Analysis of Primary Health Care Services: Managers vs. Patients Perceptions  [PDF]
Francisco J. Miranda, Antonio Chamorro, Luis R. Murillo, Juan Vega
Journal of Service Science and Management (JSSM) , 2010, DOI: 10.4236/jssm.2010.32028
Abstract: Using importance-performance analysis (IPA), this paper examines the perceptions of patients and managers of health centres of several health care quality services attributes. IPA is an approach to the measurement of customer/user satisfaction which allows for a simple and functional identification of both the strong and the weak aspects, or improvement areas, of a given service. Taking both the importance assigned by users to all relevant aspects of a given service and the perceived performance of the establishment in providing the service, the result is an IPA grid with four quadrants. To the best of our knowledge, this is the first time this methodology has been used to compare the perceptions of health centre patients and managers. The results showed patients and managers to have very different perceptions of all the quality service attributes. Implications for researchers and health centre managers are discussed. The study illustrates the usefulness of the IPA model as a managerial tool in identifying areas to which marketing resources should be allocated in order to improve and enhance the quality of the health centre services provided.
Ecología y evolución de hantavirus en el Cono Sur de América
Murua,R; Padula,P;
Archivos de medicina veterinaria , 2004, DOI: 10.4067/S0301-732X2004000100001
Abstract: hantavirus are associated with a single primary rodent host of the familiy muridae in three sub families, two of them murinae and arvicolinae distributed in the paleartic region (europa, asia, china) and the sub family sigmodontinae in north, central and south america besides an arvicolinae genus (microtus) in north america. studies on the host and virus phylogeny show close similarities when are compared which implies that hantavirus are very ancient infectious agents which have coevolved with the rodent host. the history of earth, tectonic movements and climatic changes which affected the continents in the past are relevant to understand the host reservoir and its micro parasites current geographic distribution. this review provides historical biogeography of the sigmodontine rodents, phylogentic analyses of hantavirus, its molecular epidemiology and its geographical distribution in south america in order to sustain the proposal that the virus- rodent interaction has coevolved in the neartic before the family muridae was detached in subfamilies and before the sigmodontines rodents spread into the south american continent. it is described the existence of a large number of hantavirus lineages with small differences which make difficult to establish so far, well define species of hantavirus. an analisis between similarities and differences in the ecology and pathogenesis of two virus which have produced an important number of human cases in north america (sin nombre) and in the southern cone of america (virus andes) is discussed.
El Uso de la Eritropoyetina en el Manejo de la Insuficiencia Cardíaca
Pablo Ryan Murua
Medicrit : Revista de Medicina Crítica , 2004, DOI: 10.5413/mrmc.2004.16.23
Abstract: Casi el 64% de los pacientes que acuden al nefrólogo por insuficiencia renal (IR), presentan además insuficiencia cardiaca (IC), y la mayoría de estos presentan también anemia. A esta conjunción de anemia, insuficiencia cardiaca e insuficiencia renal se le ha llamado síndrome anemia cardiorrenal (SACR), cuyos componentes cierran un circulo vicioso. Cada uno de ellos es capaz de producir o empeorar los otros dos. La anemia se encuentra de un tercio de la mitad de los pacientes con insuficiencia cardiaca y puede producir y/o empeorar a esta, aumentar la mortalidad, hospitalización, y la malnutrición. Además la anemia se asocia con un deterioro de la función renal e insuficiencia renal, causando una progresión más rápida hacia la diálisis en los pacientes con anemia que en los pacientes sin anemia. El control subóptimo de la insuficiencia cardiaca puede llevar a un deterioro de la función renal y a anemia. La insuficiencia renal cronica puede causar anemia y empeorar la insuficiencia cardiaca...
Ecología y evolución de hantavirus en el Cono Sur de América Ecology and evolution of hantavirus in the Southern Cone of America
R Murua,P Padula
Archivos de medicina veterinaria , 2004,
Abstract: Los hantavirus tienen huéspedes especie específicos pertenecientes a una familia común Muridae con tres sub familias, dos de ellas Murinae y Arvicolinae que se distribuyen en áreas geográficas de Europa Asia y Oceanía con un género Arvicolinae en América del Norte y la Sub familia Sigmodontinae en Centro América y Sudamérica. Estudios de la filogenia del huésped y el virus muestran fuertes similitudes al ser comparados, lo que sugiere una asociación de mucha más larga data con un proceso de coevolución entre el agente infeccioso y sus huéspedes roedores. La historia de la tierra y los procesos tectónicos y climáticos que afectaron al continente en épocas pretéritas son relevantes para comprender la actual distribución de los reservorios huéspedes y sus parásitos. Se entregan antecedentes biogeográficos de los roedores con la distribución geográfica de los hantavirus en Sudamérica, análisis filogenético de los virus, epidemiología molecular que sustentan la propuesta que el virus y el roedor han coevolucionado antes del momento de separarse la Familia Muridae en subfamilias (Murinae, Arvicolinae y Sigmodontinae) y anterior al ingreso de los roedores sigmodontinos al continente sudamericano. Se discute la dificultad en demarcar especie nueva de hantavirus y la existencia de varios linajes con diferencias peque as entre si para ser consideradas como especies virales. Se describen diferencias y similitudes entre las dos especies de hantavirus que más casos han producido en América del Norte (virus Sin Nombre) y en el Cono Sur de de América (Virus Andes). Hantavirus are associated with a single primary rodent host of the familiy Muridae in three sub families, two of them Murinae and Arvicolinae distributed in the Paleartic Region (Europa, Asia, China) and the sub family Sigmodontinae in North, Central and South America besides an Arvicolinae genus (Microtus) in North America. Studies on the host and virus phylogeny show close similarities when are compared which implies that hantavirus are very ancient infectious agents which have coevolved with the rodent host. The history of earth, tectonic movements and climatic changes which affected the continents in the past are relevant to understand the host reservoir and its micro parasites current geographic distribution. This review provides historical biogeography of the sigmodontine rodents, phylogentic analyses of hantavirus, its molecular epidemiology and its geographical distribution in South America in order to sustain the proposal that the virus- rodent interaction has coevolved in the Neartic before the Fa
An efficient algorithm for computing the Baker-Campbell-Hausdorff series and some of its applications
Fernando Casas,Ander Murua
Physics , 2008, DOI: 10.1063/1.3078418
Abstract: We provide a new algorithm for generating the Baker--Campbell--Hausdorff (BCH) series $Z = \log(\e^X \e^Y)$ in an arbitrary generalized Hall basis of the free Lie algebra $\mathcal{L}(X,Y)$ generated by $X$ and $Y$. It is based on the close relationship of $\mathcal{L}(X,Y)$ with a Lie algebraic structure of labeled rooted trees. With this algorithm, the computation of the BCH series up to degree 20 (111013 independent elements in $\mathcal{L}(X,Y)$) takes less than 15 minutes on a personal computer and requires 1.5 GBytes of memory. We also address the issue of the convergence of the series, providing an optimal convergence domain when $X$ and $Y$ are real or complex matrices.
Transferência de informa??o e transferência de tecnologia no modelo de comunica??o extensiva: a babel.com
Miranda,Antonio; Sime?o,Elmira;
Informaci?3n, cultura y sociedad , 2004,
Abstract: the automation of the communication techniques gives relevance to extensive communication where the focus is not only on the information storage but also on the dispersion and universal use of the information. the vision brought about by the theory of systems reveals the extensive model and different information practices where the institutions and individuals develop a collective role, depending on a policy of information transfer. the information systems, consequently, act in a production line that control and appraise policies, objectives and goals possible by formal and informal structures mediation for the treatment and dissemination of the contents. in a traditional scientific communication model, that privileges the information storage, bookstores, publishers and traditional libraries are the principal mediators in the production, storage and dissemination of documents. in opposition, the extensive communication is a dynamic information system, in a scenario of interactive and multidimensional stocks, characterized by the insert of tools that promotes the interactivity, the hypertextuality and the hypermidiation.
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